Biotechnology

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  Subject Areas on Research

  • 1028. Use of Antisense Oligonucleotides To Restore Activity in Mutant p53 
  • 104. Role of the HI Loop in the Adeno- Associated Virus (AAV) Life Cycle 
  • 1064. Haute Couture Vectors: Solving Clinical Problems with Custom Designed AAV Vectors 
  • 1088. Stem Cell Gene Therapy with No Pre-Conditioning for the ADA-Deficiency Patients Leads to Generalized Detoxification and Delayed, but Steady Hematological Reconstitution 
  • 14. Next Generation AAV Vectors for Limiting Systemic Leakage and Improving Safety Following CNS Administration 
  • 167. Genome Editing to Generate the First Mouse Model of Alpha-One Antitrypsin Deficiency, the Leading Cause of Genetic COPD 
  • 19. A New, Plasmid-Based Adenoviral Vectoring System Derived from the Highly Immunogenic, Human Ad4 Strain 
  • 2'-Deoxy-2'-fluoro-arabinonucleic acid: a valid alternative to DNA for biotechnological applications using charge transport. 
  • 211. Development of Helper-Dependent Adenovirus (HDAd) Vectors for Gene Therapy in the Mouse Model for Glycogen Storage Disease Type Ia (GSD-Ia) 
  • 219. Persistent Correction of Hyperphenylalaninemia Following Liver-Directed, rAAV2/8-Mediated Gene Therapy for Murine Phenylketonuria (PKU) 
  • 258. Phase I/IIa Study of TT-034, a DNA-Directed RNA Interference (ddRNAi) Agent Delivered as a Single Administration for the Treatment of Subjects with Chronic Hepatitis C Virus (HCV) 
  • 265. Polysialic Acid as a Novel Regulator of AAV Tropism in the Developing Brain 
  • 272. Nucleic Acid Scavenging Nanofibers as Anti-Inflammatory Meshes 
  • 30. Modulation of Intracellular Calcium Enhances AAV Transduction in the CNS 
  • 30. Phase II Clinical Trial of Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA-SCID) Using a γ-Retroviral Vector 
  • 302. Combinatorial Engineering of a Receptor Footprint on AAV Serotype 4 Yields Novel Vectors 
  • 311. In Vivo Zinc Finger Nuclease-Mediated Targeted Integration of a Glucose-6-Phosphatase Transgene Enhances Biochemical Correction in Mice with Glycogen Storage Disease Type IA 
  • 339. Sustained, High-Level Expression of Human Acid Alpha-Glucosidase and Correction of Glycogen Storage Disease Type II (GSD II) with an Adeno-Associated Virus 8 (AAV2/8) Vector Containing a Liver-Specific Promoter 
  • 38. Pharmacological Regulation of Vesicular Trafficking as a Strategy to Enhance Recombinant AAV Transduction 
  • 381. Prohypertrophic Agents Enhance the Response to Gene Therapy in Pompe Disease 
  • 397. Correction of the Dystrophin Gene By the CRISPR/Cas9 System in a Mouse Model of Muscular Dystrophy 
  • 41. U2 snRNP Spliceosome Proteins Block Recombinant AAV Vector Transduction 
  • 42. Differential Transduction Profiles of AAV Vectors in a Mouse Model of Human Glycosylation 
  • 427. Adenovirus Mediated GRP94/gp96 Expression in Treatment of Neuroblastoma 
  • 472. Low-Shear Sodding of an Implantable Expanded Polytetrafluoroethylene Scaffold with a Rat Adipose-Derived Stromal-Vascular Fraction 
  • 482. Local and Systemic Gene Editing in a Mouse Model of Duchenne Muscular Dystrophy 
  • 485. Targeted Epigenome Editing by CRISPR/Cas9-Based Repressors for Silencing of Distal Regulatory Elements 
  • 487. Liver-Targeted Gene Therapy in Glycogen Storage Disease Type Ia (GSD-Ia) Requires Widespread, Regulated Glucose-6-phosphatase 
  • 49. Minimum Effective Dose of Liver-Targeted Gene Therapy for Pompe Disease Reduced 10-Fold from Prior Estimates 
  • 504. Restoration of Dystrophin Expression by Gene Editing with S. aureus Cas9 in Models of Duchenne Muscular Dystrophy 
  • 563. Correction of Glycogen Storage Disease Type II by Systemic Delivery of an AAV2/8 Vector Containing a Muscle-Specific Promoter 
  • 586. Anti-HIV-1 Neutralizing Antibody Gene Delivery to Rhesus Macaques and Rodents: A Novel Vaccination Approach 
  • 59. Multiplex Gene Activation by CRISPR/Cas9-Based Transcription Factors for the Direct Conversion of Fibroblasts to a Neuronal Phenotype 
  • 61. Vascular Smooth Muscle Cell RNA Aptamers for the Treatment of Cardiovascular Disease 
  • 66. Identification and Characterization of a B Cell Aptamer That Targets Diffuse Large B Cell Lymphoma (DLBCL) and Chronic Myelogenous Leukemia (CML) 
  • 7. Adeno-Associated Virus Type 2 (AAV2) Contains an Integrin alpha5beta1 Recognition Sequence Essential for Viral Cell Entry 
  • 701. Long-Term Complications of Glycogen Storage Disease Type IA in the Dog Model Treated With Gene Replacement Therapy 
  • 727. Characterizing the Adeno-Associated Virus 1 Sialic Receptor Binding Site and Its Overlap with Antigenic Epitopes 
  • 739. Bioluminescent Virion Shells: A Novel Tool for Visualization of Viral Vectors in Animal Tissue 
  • 8. Further Characterization of U2 snRNP Mediated Restriction of AAV Vector Transduction 
  • 83. Cell_Type Specific Delivery of siRNAs with Aptamer_siRNA Chimeras 
  • 93. Development of AAVidua Vector for the Treatment of Cornea Associated Vision Loss in Bone Marrow Treated-Hurler Patients 
  • 954. High Intensity Focused Ultrasound (HIFU) Induced Trans-Gene Activation in Solid Tumors 
  • A CRISPR Screen Identifies Apical Polarity Determinant Crumbs 3 as an AAV Host Restriction Factor 
  • A Novel Aptamer Targeting Agent for Prostate Cancer 
  • A Single Intravenous Injection of an AAV-PHP. B Vector Encoding Human Acid alpha-Glucosidase Corrects Both Muscle and Brain Defects in Murine Pompe Disease 
  • A central role of RNA in developing therapeutic vaccines for cancer and infectious diseases 
  • A clinical attempt to treat JAK3-deficient SCID using retroviral-mediated gene transfer to bone marrow CD34+ cells 
  • A comparison of monoclonal antibody productivity in different hollow fiber bioreactors 
  • A cone-plate apparatus for the in vitro biochemical and molecular analysis of the effect of shear stress on adherent cells 
  • A cornucopia of strategies for the immunotherapy of cancer 
  • A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. 
  • A genetically engineered plasmid encoding a zinc finger VEGF-activating transcription factor induces angiogenesis in the rabbits with hind-limb ischemia 
  • A genomics approach to improve the analysis and design of strain selections. 
  • A kinetic analysis using fractals of cellular analyte-receptor binding and dissociation. 
  • A method for the organ explant culture of fish kidney tubules 
  • A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • A need for effective adjuvants. 
  • A new member of the short-chain dehydrogenases/reductases superfamily: purification, characterization and substrate specificity of a recombinant carbonyl reductase from Pichia stipitis. 
  • A new non-enzymatic method for isolating human intervertebral disc cells preserves the phenotype of nucleus pulposus cells. 
  • A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. 
  • A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate. 
  • A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling. 
  • A novel flow-perfusion bioreactor supports 3D dynamic cell culture. 
  • A novel thermostable branching enzyme from an extremely thermophilic bacterial species, Rhodothermus obamensis. 
  • A numerical analysis of forces exerted by laminar flow on spreading cells in a parallel plate flow chamber assay. 
  • A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma. 
  • A physical characterization of GAP A3 hybridoma cells: morphology, geometry, and mechanical properties. 
  • A pressure-mediated nonviral method for efficient arterial gene and oligonucleotide transfer. 
  • A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors. 
  • A roadmap for interpreting (13)C metabolite labeling patterns from cells. 
  • A small regulatory element from chromosome 19 enhances liver-specific gene expression. 
  • A synthetic biology challenge: making cells compute. 
  • A tubulin binding peptide targets glioma cells disrupting their microtubules, blocking migration, and inducing apoptosis. 
  • A tumour specific targeted radiotherapy/gene therapy for the treatment of malignant disease 
  • A year of successful cancer vaccines points to a path forward. 
  • AAV Gene Therapy in a Canine Model of MPS1 Prevents and Reverses Corneal Blindness 
  • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. 
  • AAV-Mediated Deletion of a Large Mutational Hotspot for Treatment of Duchenne Muscular Dystrophy 
  • AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice. 
  • APOE is a major susceptibility gene for Alzheimer's disease. 
  • Academic-industrial partnerships in drug discovery in the age of genomics. 
  • Activity of carbonic anhydrase immobilized on porous silica beads in organic media 
  • Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts. 
  • Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. 
  • Adeno-associated virus serotypes: vector toolkit for human gene therapy. 
  • Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma. 
  • Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress. 
  • Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function. 
  • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. 
  • Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. 
  • Adhesion mediated by bonds in series. 
  • Adjunctive beta 2-Agonist Therapy Enhances Trafficking of Acid alpha-Glucosidase to Lysosomes in the Skeletal Muscle of Mice with Pompe Disease 
  • Advances in CT technology. 
  • Advances in our understanding of ligand-activated nuclear receptors 
  • Advances in pharmacogenomic research and development. 
  • Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer. 
  • Advances in targeted genome editing. 
  • Advancing islet transplantation: from engraftment to the immune response. 
  • Aerobic biodegradation of organic compounds in hydraulic fracturing fluids. 
  • Affinity chromatography of endoglucanase of Trichoderma viride by concanavalin A-agarose. 
  • Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. 
  • Altering Tissue Glycan Patterns Improves the Transduction Profile of AAV9 Vectors 
  • Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene. 
  • An Economic Impact Analysis of the US Biobased Products Industry: A Report to the Congress of the United States of America 
  • An assay for human chorionic gonadotrophin using the capillary fill immunosensor. 
  • An autonomously self-assembling dendritic DNA nanostructure for target DNA detection. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • An emerging adeno-associated viral vector pipeline for cardiac gene therapy. 
  • An empirical analysis of the industrial bioeconomy: Implications for renewable resources and the environment 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • An experimental study on biomass air-steam gasification in a fluidized bed. 
  • An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. 
  • Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. 
  • Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue. 
  • Analysis of the rate-limiting step of an anaerobic biotrickling filter removing TCE vapors 
  • Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 
  • Antibody-antigen binding kinetics. A model for multivalency antibodies for large antigen systems. 
  • Antidote control of aptamer therapeutics: the road to a safer class of drug agents. 
  • Antigen-specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand. 
  • Antioxidant Gene Therapy Can Protect Hearing and Hair Cells from Ototoxicity 
  • Antioxidant properties of phenolics in Castanea sativa mill. Extracts 
  • Antisettlement and Narcotic Action of Analogues of Diterpene Marine Natural Product Antifoulants from Octocorals. 
  • Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. 
  • Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield. 
  • Application of a moving bed biofilm reactor for tertiary ammonia treatment in high temperature industrial wastewater. 
  • Application of an antibody biochip for p53 detection and cancer diagnosis. 
  • Applications of nanoparticles to diagnostics and therapeutics in colorectal cancer. 
  • Applications of nanotechnology to biotechnology commentary. 
  • Applying technologies towards safe and effective medicines. 
  • Approaches to HIV vaccine design. 
  • Aptamer-siRNA Chimera Inhibitors of Intimal Hyperplasia 
  • Aptamers in immunotherapy. 
  • Aquaporins and CSF Flux Are Critical Determinants of AAV Mediated CNS Gene Transfer 
  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. 
  • Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. 
  • Benzo[a]pyrene removal by Marasmiellus troyanus in soil microcosms 
  • Bezafibrate Enhances AAV Gene Therapy in Glycogen Storage Disease Type Ia 
  • Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. 
  • Biocatalytic coatings for air pollution control: a proof of concept study on VOC biodegradation. 
  • Bioengineered Skeletal Muscle With Functional Stem Cell Pool and Capacity for Vascular Integration and Maturation In Vivo 
  • Biological function made crystal clear — annotation of hypothetical proteins via structural genomics 
  • Biological waste air treatment in biofilters. 
  • Biological waste air treatment in biotrickling filters 
  • Biology by design: reduction and synthesis of cellular components and behaviour. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Biomass control in waste air biotrickling filters by protozoan predation. 
  • Biomaterializing the promise of cardiac tissue engineering. 
  • Biomaterials approach to expand and direct differentiation of stem cells. 
  • Biomechanical factors in tissue engineered meniscal repair. 
  • Biomechanics of vascular-stent interaction and in-stent restenosis: The key role of shear stress 
  • Biomedical implications of protein folding and misfolding. 
  • Biosynthesis of (S)-4-chloro-3-hydroxybutanoate ethyl using Escherichia coli co-expressing a novel NADH-dependent carbonyl reductase and a glucose dehydrogenase. 
  • Biotreatment of groundwater contaminated with MTBE: interaction of common environmental co-contaminants. 
  • Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA. 
  • Boosting, Not Breaking: CRISPR Activators Treat Disease Models. 
  • Brain cell technology: a valuable new resource for novel techniques. 
  • Breast cancer: integrating the patient with her genome. 
  • Broad host range vectors for stable genomic library construction. 
  • Broad-host-range vectors for protein expression across gram negative hosts. 
  • CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes. 
  • CRISPR-based methods for high-throughput annotation of regulatory DNA. 
  • CRISPR/Cas9-Based Transcriptional Repressors for Control of Human Gene Expression 
  • Capsid-Glycan Receptor Interactions Influence AAV Transport across the Blood-Brain Barrier 
  • Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure. 
  • Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. 
  • Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC. 
  • Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. 
  • Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method. 
  • Celiac disease-associated antibodies in type 1 diabetes patients in Cuba 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Cell-Targeted RNA-Based Therapies for Cardiovascular Disease 
  • Cellular uptake of neutral phosphorodiamidate morpholino oligomers. 
  • Cellulase and xylanase production by Aspergillus sp. G-393. Scientific note. 
  • Centrifugation without a balance tube 
  • Centromere round-up at the heterochromatin corral. 
  • Characteristics of yeast invertase immobilized on porous cellulose beads. 
  • Characterization of bimodal cell death of insect cells in a rotating- wall vessel and shaker flask 
  • Characterization of sugar mixtures utilization by an Escherichia coli mutant devoid of the phosphotransferase system. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Characterizing Essential Receptor Binding Residues for AAV1 
  • Chemical procedures for enzyme immobilization on porous cellulose beads. 
  • Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions. 
  • Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer. 
  • Clinical applications of dendritic cell vaccines. 
  • Co-opting biology to deliver drugs. 
  • Colloidal gold as a biocompatible immobilization matrix suitable for the fabrication of enzyme electrodes by electrodeposition. 
  • Colocalizing ribozymes with substrate RNAs to increase their efficacy as gene inhibitors. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Community crystal gazing. 
  • Comparative genomics as a tool for gene discovery. 
  • Comparing genome editing technologies 
  • Complete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria. 
  • Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease. 
  • Computer-controlled laser ablation: a convenient and versatile tool for micropatterning biofunctional synthetic surfaces for applications in biosensing and tissue engineering. 
  • Computing. Successes and challenges. 
  • Conspecific cues that induce spore settlement in the biofouling and green tide-forming alga Ulva tepida provide a potential aggregation mechanism 
  • Construction and co-expression of a polycistronic plasmid encoding carbonyl reductase and glucose dehydrogenase for production of ethyl (S)-4-chloro-3-hydroxybutanoate. 
  • Continuous operation of foamed emulsion bioreactors treating toluene vapors. 
  • Controlled gene delivery by DNA-gelatin nanospheres. 
  • Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease. 
  • Correction of Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients Through Genomic Excision of Exon 51 by Zinc Finger Nucleases 
  • Correction of Glycogen Storage Disease Type III with an AAV Vector Encoding a Bacterial Glycogen Debranching Enzyme 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. 
  • Correction of glycogen storage disease type II (GSD II) by intramuscular administration of an adeno-associated virus (AAV) vector pseudotyped as AAV6 
  • Correction of glycogen storage disease type II (GSD II) with an adeno-associated virus 8 (AAV2/8) vector 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Correction of glycogen storage disease type II by intramuscular administration of an adeno-associated virus 6 (AAV2/6) vector containing a muscle-specific promoter 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Corrective gene transfer into bone marrow CD34+cells for adenosine deaminase (ADA) deficiency: Results in four patients after one year of follow-up 
  • Corrigendum to "Efficacy of Helper-dependent Adenovirus Vector-mediated Gene Therapy in Murine Glycogen Storage Disease Type Ia". 
  • Critical issues in delivery of RNAi therapeutics in vivo. 
  • Current technology for the derivation of pluripotent stem cell lines from human embryos. 
  • Current trends in differential expression proteomics: isotopically coded tags. 
  • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. 
  • DNA patents and diagnostics: not a pretty picture. 
  • DNA polymorphisms generated by arbitrarily primed PCR in rice. 
  • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. 
  • Decarbonizing agriculture through the conversion of animal manure to dietary protein and ammonia fertilizer. 
  • Deficiency in MyD88 Signaling Results in Decreased Antibody Responses to Adeno-Associated Virus Vector Containing a CMV Enhancer/Chicken beta-Actin Cassette in Murine Pompe Disease 
  • Delivery of glucose-6-phosphatase in a canine model for glycogen storage disease, type Ia, with adeno-associated virus (AAV) vectors. 
  • Department of Health and Human Services National Institutes of Health Recombinant DNA Advisory Committee. Minutes of meeting March 8-10, 2000. 
  • Desensitization through Immunomodulatory Gene Therapy Suppresses the Antibody Response to Enzyme Replacement Therapy in Murine Pompe Disease 
  • Design Principles for AAV Mediated Circular RNA Expression in the Brain 
  • Detailed investigations of dissolved hydrogen and hydrogen mass transfer in a biotrickling filter for upgrading biogas. 
  • Development of AAV-shRNA vectors for human basal-like breast cancer therapy 
  • Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer. 
  • Development of a modified positive selection medium that allows to isolate Aspergillus oryzae strains cured of the integrated niaD-based plasmid. 
  • Development of adeno-associated virus (AAV) vectors for gene therapy in the mouse model for glycogen storage disease type Ia (GSD-Ia) 
  • Development of foamed emulsion bioreactor for air pollution control. 
  • Development of mammalian serum albumin affinity purification media by peptide phage display. 
  • Development of novel biotherapeutics for breast cancer: generation of function blocking antibodies against Notch1 ligands 
  • Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. 
  • Diagnosis of fungal infection: new technologies for the mycology laboratory. 
  • Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Digital image analysis for rapid quantification of total RNA and cDNA for SMART-PCR. 
  • Digital pathology in nephrology clinical trials, research, and pathology practice. 
  • Direct force measurements of the streptavidin-biotin interaction. 
  • Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels 
  • Discontinuation of PEG-ADA replacement therapy in a patient with ADA-deficiency previously treated with retroviral-mediated, T cell-directed gene therapy 
  • Discovery of a Neurotropic Footprint That Enables AAV Transport Across the Blood-Brain Barrier 
  • Disruption of Water Homeostasis Affects AAV Transport Across the Blood-Brain Barrier 
  • Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino. 
  • Double disruption of the proteinase genes, tppA and pepE, increases the production level of human lysozyme by Aspergillus oryzae. 
  • Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. 
  • Drag reducing properties of microalgal exopolymers. 
  • Drop-out restriction mapping: Using nested deletions and single restriction enzyme digestions to obtain high-resolution cosmid maps 
  • Duvoglustat HCl Increases Systemic and Tissue Exposure of Active Acid α-Glucosidase in Pompe Patients Co-administered with Alglucosidase α. 
  • Dystrophin Restoration in a Humanized Mouse Model of Duchenne Muscular Dystrophy by Gene Editing with S. Aureus Cas9 
  • Dystrophin Restoration in a Humanized Mouse Model of Duchenne Muscular Dystrophy by Gene Editing with S. aureus Cas9 
  • Early marine bacterial biofilm on a copper-based antifouling paint 
  • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. 
  • Editing out Five SERPINA1 Paralogs to Create a New Mouse Model of Genetic Emphysema 
  • Editorial overview - A cornucopia of strategies for the immunotherapy of cancer 
  • Editorial overview - A need for effective adjuvants 
  • Editorial overview: Fulfilling the promise of immunotherapy 
  • Editorial overview: Priming, boosting, measuring 
  • Editorial overview: What is a vaccine? 
  • Effect of AAV Gene Therapy on Hepatic Tumor Induced by Deficiency of Glucose-6-Phosphatase 
  • Effect of carbon source addition on toluene biodegradation by an Escherichia coli DH5alpha transconjugant harboring the TOL plasmid. 
  • Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor. 
  • Effect of pulp properties, drying technology, and sustainability on bath tissue performance and shelf price 
  • Effect of streptavidin RGD mutant on the adhesion of endothelial cells. 
  • Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines. 
  • Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels. 
  • Effects of medical research on health care and economy. 
  • Effects of unsteady state conditions on the biooxidation of methyl ethyl and methyl isobutyl ketone in continuous flow liquid phase cultures 
  • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. 
  • Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. 
  • Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia. 
  • Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model. 
  • Efficient assembly of de novo human artificial chromosomes from large genomic loci. 
  • Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Electron capture dissociation mass spectrometry in characterization of peptides and proteins. 
  • Emerging strategies for engineering microbial communities. 
  • Enabling Technologies for Personalized and Precision Medicine. 
  • Endophytic Phytoaugmentation: Treating Wastewater and Runoff Through Augmented Phytoremediation. 
  • Energy biotechnology in 2013: advanced technology development for breakthroughs in fuels and chemicals production. 
  • Engineered cell-cell communication and its applications. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineered transcription factors for therapeutic angiogenesis. 
  • Engineering A Humanized AAV8 Capsid through Iterative Structure-Guided Evolution 
  • Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. 
  • Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example. 
  • Engineering life: building a fab for biology. 
  • Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. 
  • Engineering microbial consortia: a new frontier in synthetic biology. 
  • Engineering microbial systems to explore ecological and evolutionary dynamics. 
  • Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells. 
  • Engineering multicellular systems by cell-cell communication. 
  • Engineering of a sugar-derivatized porous network for hepatocyte culture. 
  • Engineering skeletal muscle repair. 
  • Engineering superficial zone features in tissue engineered cartilage. 
  • Enhanced AAV vector transduction through genetic and pharmacological inhibition of U2 snRNP components 
  • Enhanced Molecular Volume of Conservatively Pegylated Hb: (SP-PEG5K)6-HbA is Non-Hypertensive 
  • Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade. 
  • Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II. 
  • Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. 
  • Enhanced oncolytic virotherapy through oxidative stress inhibition. 
  • Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide. 
  • Enhancement of targeted radiotherapy in neuroblastoma: a novel gene therapy approach 
  • Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. 
  • Enhancing immunogenicity by CpG DNA. 
  • Enzymatic RNA molecules 
  • Enzymatic deglycosylation of enfumafungin, a triterpene glycoside natural product, and its chemically synthesized analogues 
  • Erratum to Analysis of the rate-limiting step of an anaerobic biotrickling filter removing TCE vapors, [Process Biochem. (2010), 45, 549-555] 
  • Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia (Gene Therapy (2006) vol. 13 (1281-1289) 10.1038/sj.gt.3302774) 
  • Erratum: Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia (Gene Therapy (2006) vol. 13 (1281-1289) 10.1038/sj.gt.3302774)) 
  • Erratum: Reading Frame correction by targeted genome editing restores dystrophin expression in cells from duchenne muscular dystrophy patients (Molecular Therapy (2013) 21 (1718-1726) DOI: 10.1038/mt.2013.111) 
  • Error correction in gene synthesis technology. 
  • Evaluating the mycostimulation potential of select carbon amendments for the degradation of a model PAH by an ascomycete strain enriched from a superfund site. 
  • Evaluating whole transcriptome amplification for gene profiling experiments using RNA-Seq. 
  • Evaluation of tincture prepared from Jussiaea suffruticosa Linn. 
  • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 
  • Examining the behavior of crop-derived antibiotic resistance genes in anaerobic sludge batch reactors under thermophilic conditions. 
  • Exercise and health: can biotechnology confer similar benefits? 
  • Expanding the CNS Transduction Profile of AAV4 by Structure-Guided Evolution 
  • Exploring Novel Aptamer-Heparin Combinations to Improve Anticoagulation Therapy in Cardiopulmonary Bypass 
  • Expression of CRISPR-Cas9 Single Guide RNA's Using Small tRNA Promoters 
  • Expression of Naked Plasmid DNA Injected into the Afferent and Efferent Vessels of Rodent and Dog Livers 
  • FINDING TARGETS FOR FSH DYSTROPHY THERAPY 
  • Fibrillar peptide gels in biotechnology and biomedicine. 
  • Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy. 
  • Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. 
  • Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection. 
  • From crystal structure to clinic: highlights of the Tenth International Parvovirus Workshop. 
  • Fulfilling the promise of immunotherapy. 
  • Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. 
  • Functional advantages conferred by extracellular prokaryotic membrane vesicles. 
  • Functional properties of hemoglobin immobilized in coacervates prepared from gelatin A and polyanionic carbohydrates. 
  • Functionality of the TOL plasmid under varying environmental conditions following conjugal transfer. 
  • Future marketing drivers for the forest products industry 
  • Future vaccines and a global perspective. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. 
  • Gene Therapy for Heart Disease Using Electrically Active Fibroblasts 
  • Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes. 
  • Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture. 
  • Gene expression profiling of anticancer immune responses. 
  • Gene therapy for cardiovascular disease. 
  • Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill. 
  • Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. 
  • Gene therapy progress and prospects: RNA aptamers. 
  • Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. 
  • Generation of recombinant adeno-associated virus vectors by a complete adenovirus-mediated approach. 
  • Generation of species cross-reactive aptamers using "toggle" SELEX. 
  • Genes restoring redox balance in fermentation-deficient E. coli NZN111. 
  • Genetic engineering of mesenchymal stem cells and its application in human disease therapy. 
  • Genetic profiling and tailored therapy in asthma: are we there yet? 
  • Genetic studies: look no further than your own backyard. 
  • Genome-editing Technologies for Gene and Cell Therapy. 
  • Genome-scale analysis of anti-metabolite directed strain engineering. 
  • Genomics of Aspergillus oryzae. 
  • Genomics-based anti-cancer drug discovery - Preface 
  • Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain. 
  • Glycogen storage in multiple muscles of old GSD-II mice can be rapidly cleared after a single intravenous injection with a modified adenoviral vector expressing hGAA. 
  • Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. 
  • Grazing scar characteristics impact degree of fungal facilitation in spartina alterniflora leaves in a south american salt marsh 
  • Group I intron-mediated trans-splicing revision of mutant p53 RNA transcripts 
  • Growth factor enhanced retroviral gene transfer to the adult central nervous system 
  • Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo. 
  • HIV-1 Vif: counteracting innate antiretroviral defenses. 
  • HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. 
  • HVJ (Sendai virus)-cationic liposomes: a novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium 
  • Health care costs. 
  • Health innovation networks to help developing countries address neglected diseases. 
  • Hematopoietic Stem Cell Gene Therapy with Lentiviral Vector in 4 Patients with Cerebral X-Linked Adrenoleukodystrophy: Long-Term Outcome and Comparison of Efficacy with Allogeneic Hematopoietic Stem Cell Transplantation 
  • Hematopoietic stem cell gene therapy with lentiviral vector in 4 patients with cerebral X-linked adrenoleukodystrophy: long-term outcome and comparison of efficacy with allogeneic hematopoietic stem cell transplantation 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • High-Performance Biogas Upgrading Using a Biotrickling Filter and Hydrogenotrophic Methanogens. 
  • High-level production of heterologous proteins using untreated cane molasses and corn steep liquor in Escherichia coli medium. 
  • High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype. 
  • Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance. 
  • How changes in drug-safety regulations affect the way drug and biotech companies invest in innovation. 
  • How eco-evolutionary principles can guide tree breeding and tree biotechnology for enhanced productivity. 
  • Human Pluripotent Stem Cell-Derived Cardiac Tissue Patch for Use in Cell-Based Cardiac Therapy 
  • Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. 
  • Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6 
  • Human gene therapy and congress. 
  • Human interleukin-2 production in insect (Trichoplusia ni) larvae: effects and partial control of proteolysis. 
  • Hydrogels for brain repair after stroke: an emerging treatment option. 
  • Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • Identification and isolation of differentially expressed genes from very small tissue samples. 
  • Identification of a 21 amino acid peptide conferring 3-hydroxypropionic acid stress-tolerance to Escherichia coli. 
  • Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications. 
  • Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay. 
  • Identification of fungi associated with municipal compost using DNA-based techniques. 
  • Imaging Biomaterial-Tissue Interactions. 
  • Imaging Trafficking Dynamics of Ultra-Pure Single Adeno-Associated Virus in Live Cells 
  • Imaging of cell/substrate contacts on polymers by total internal reflection fluorescence microscopy. 
  • Immune Reconstitution after Gene Therapy for Adenosine Deaminase Deficient Severe Combined Immune Deficiency (ADA-SCID) 
  • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. 
  • Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunomodulatory gene therapy in lysosomal storage disorders. 
  • Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease. 
  • Immunotherapeutic targeting of Wilms' tumor protein. 
  • Immunotherapy of cancer with dendritic cell-based vaccines. 
  • Impaired clearance of accumulated lysosomal glycogen in advanced Pompe disease despite high-level vector-mediated transgene expression. 
  • Important cellular targets for antimicrobial photodynamic therapy. 
  • Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model. 
  • Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice. 
  • Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment. 
  • In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation. 
  • In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA. 
  • In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells. 
  • In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using non-primate lentiviral vectors 
  • Increased Frequency of Permanent Integration Following Liver-Directed Gene Therapy with rDNA-AAV2/8 In Murine Phenylketonuria 
  • Increasing the specificity of CRISPR systems with engineered RNA secondary structures. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity. 
  • Induction of stable RNA interference in mammalian cells. 
  • Inflammatory Killing of the Pancreas Induces Multiple Immune Checkpoints Which Protect from Autoimmunity but Which Can Be Manipulated To Achieve Anti Tumor Immunity 
  • Inhalation of an RNA Aptamer Targeting Extracellular Histones Protects from Acute Lung Injury 
  • Inhibition of aflatoxin production by trifluoperazine in Aspergillus parasiticus NRRL 2999 
  • Inhibition of barnacle larval settlement and crustacean toxicity of some hoplonemertine pyridyl alkaloids. 
  • Innate immune recognition of viruses and viral vectors. 
  • Innovative bioreactors. 
  • Inportance of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. 
  • Insertional analyses in rhesus monkey blood cells after non-myeloablative hematopoietic stem cell marking with a therapeutic onco-retroviral vector for X-linked chronic granulomatous disease 
  • Integrase-Deficient Lentiviral Vector for Efficient CRISPR/Cas9-Mediated Gene and Epigenome-Editing Applications 
  • Integration of cell-free protein coexpression with an enzyme-linked immunosorbent assay enables rapid analysis of protein-protein interactions directly from DNA. 
  • Integrins Play a Pivotal Role in Transvascular Transport and Tissue Uptake of AAV9 In Vivo 
  • Intellectual property. Patents, secrecy, and DNA. 
  • Into new territory: improved microbial synthesis through engineering of the essential metabolic network. 
  • Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. 
  • Intramolecular cross-linking of oxy hemoglobin by bis sulfosuccinimidyl suberate and sebacate: generation of cross-linked hemoglobin with reduced oxygen affinity. 
  • Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection. 
  • Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease. 
  • Investigation of cell kill in a targeted radiotherapy/gene therapy strategy utilising radiation induced biological bystander effects 
  • Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. 
  • In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia. 
  • Ion channel engineering for modulation and de novo generation of electrical excitability. 
  • Isolation and growth of human primary prostate epithelial cultures 
  • Isolation and insecticidal activity of mellamide from Aspergillus melleus. 
  • Isolation and optimization of murine IL-10 receptor blocking oligonucleotide aptamers using high-throughput sequencing. 
  • Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. 
  • Isolation, growth and differentiation of adult rabbit skeletal myoblasts in vitro 
  • Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. 
  • It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies. 
  • Keeping Sample Preparation Simple: Tips on How to Perform Proteomics Measurements with Consistency and Accuracy 
  • Kinetic studies and unstructured models of lymphocyte metabolism in fed-batch culture. 
  • Large scale purification of factor X by hydrophobic chromatography. 
  • Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers. 
  • Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. 
  • Learning from each other: Applying observations from anti-tumor, anti-pathogen and anti-toxin immunotherapy 
  • Lentiviral gene transduction of kidney. 
  • Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes. 
  • Liver-Mediated Gene Therapy with an Engineered Secretable GAA Transgene Results in Whole-Body Correction of Pompe Disease 
  • Long-Term Characterization of In Vivo Genome Editing in a Mouse Model of Duchenne Muscular Dystrophy 
  • Long-Term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy 
  • Long-Term Evaluation of Genome Editing Outcomes for Duchenne Muscular Dystrophy 
  • Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector. 
  • Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice. 
  • Long-term efficacy following readministration of an adeno-associated virus vector in dogs with glycogen storage disease type Ia. 
  • Long-term follow-up assessment of a phase 1 trial of angiogenic gene therapy using direct intramyocardial administration of an adenoviral vector expressing the VEGF121 cDNA for the treatment of diffuse coronary artery disease. 
  • Loop mediated isothermal amplification (LAMP) assay for detection of coconut root wilt disease and arecanut yellow leaf disease phytoplasma. 
  • Loperamide-based compounds as additives for biofouling management 
  • Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer. 
  • Lower critical solubility temperature materials as biofouling release agents 
  • Lymphatic Transport Mediates Systemic Leakage of Peripherally Administered AAV9 Vectors 
  • MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus. 
  • Macrophage colony-stimulating factor can modulate immune responses and attract dendritic cells in vivo. 
  • Making antisense of splicing. 
  • Mapping and Engineering Functional Domains of the Assembly Activating Protein of Adeno-Associated Viruses 
  • Mapping phenotypic landscapes using DNA micro-arrays. 
  • Mapping the Antigenic Structure of Adeno-Associated Virus Serotypes 8 and 9 
  • Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. 
  • Mass Spectrometric Identification of Host Factors that Restrict AAV Vector Genome Transcription 
  • Matrix-based gene delivery for tissue repair 
  • Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. 
  • Mechanism of Shortened Bones in Mucopolysaccharidosis VII 
  • Mediator-free amperometric determination of toxic substances based on their inhibition of immobilized horseradish peroxidase. 
  • Medical technologies for the diagnosis of prostate cancer. 
  • Medicine. The need for a global HIV vaccine enterprise. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Messenger RNA repair and restoration of protein function by spliceosome-mediated RNA trans-splicing. 
  • Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant. 
  • Metabolomics applied to diabetes research: moving from information to knowledge. 
  • Metabotropic glutamate receptors as targets for novel antipsychotic treatments. 
  • Metalloprotein design. 
  • Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Modeling of a foamed emulsion bioreactor: I. Model development and experimental validation. 
  • Modeling of a foamed emulsion bioreactor: II. model parametric sensitivity. 
  • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 
  • Modulation of CD4(+)CD25(+)Foxp3(+) Regulatory T Cells in the Recipients Is Necessary for Enhancing Anti-Tumor Immunity Following Stem Cell Transplantation 
  • Mold-casted non-degradable, islet macro-encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice. 
  • Molecular cloning and recombinant expression of a gene encoding a fungal immunomodulatory protein from Ganoderma lucidum in Pichia pastoris 
  • Monitoring cellular immune responses to cancer immunotherapy. 
  • Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. 
  • Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system. 
  • Multiple muscles in the AMD quail can be "cross-corrected" of pathologic glycogen accumulation after intravenous injection of an [E1-, polymerase-] adenovirus vector encoding human acid-alpha-glucosidase. 
  • Mutation Detection Following Non-Homologous End Joining (NHEJ): A Comparison of Different Semi Quantitative and Quantitative Methods 
  • Myocardial injury-induced fibroblast proliferation facilitates retroviral-mediated gene transfer to the rat heart in vivo. 
  • Naked DNA delivered intraportally expresses efficiently in hepatocytes. 
  • Nanopatterned polymer brushes: conformation, fabrication and applications. 
  • Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy. 
  • Natural killer cell activation and dendritic cell-based vaccines 
  • Neonatal rAAV2/8 Vector Administration Does Not Prevent Therapeutic Response To Repeat Vector Injection in Adult Pah(enu2/enu2) Mice 
  • Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. 
  • Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. 
  • Nitric oxids interactions with hemoglobin in vivo 
  • Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo. 
  • Noninvasive imaging of cationic lipid-mediated delivery of optical and PET reporter genes in living mice. 
  • Nonviral gene delivery from nonwoven fibrous scaffolds fabricated by interfacial complexation of polyelectrolytes. 
  • Novel Heterogeneous Glioblastoma Models to Optimize Human Tumoricidal Stem Cell Therapy 
  • Novel encapsulation of partially dehydrated protein microparticles in PLGA microspheres 
  • Novel integrase-defective lentiviral episomal vectors for gene transfer. 
  • Nuclear hormone receptors as targets for new drug discovery. 
  • Nucleic acid aptamers as adjuncts to vaccine development. 
  • Nucleic acid aptamers in therapeutic anticoagulation. Technology, development and clinical application. 
  • Nucleic-Acid Binding Polymers as Anti-Inflammatory Agents 
  • N‐acetylglucosamine and adenosine derivatized surfaces for cell culture: 3T3 fibroblast and chicken hepatocyte response 
  • On the road to effective vaccine development 
  • Optical immunosensing systems--meeting the market needs. 
  • Optical nanosensors and biological measurements 
  • Optimization of in vivo crosslinking technique for the study of AlpB-protein interactions in Lysobacter sp. XL1 cells 
  • Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. 
  • Overview of CT technologies for children. 
  • Oxygen-binding albumin: A novel approach to blood substitutes 
  • PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. 
  • Packaging of an AAV vector encoding human acid alpha-glucosidase for gene therapy in glycogen storage disease type II with a modified hybrid adenovirus-AAV vector. 
  • Pain assessment and treatment disparities: a virtual human technology investigation. 
  • Parallel mapping of genotypes to phenotypes contributing to overall biological fitness. 
  • Pathogenesis of Growth Failure in Murine and Canine Glycogen Storage Disease-Ia and Partial Reversal of Growth Failure Using Adeno-Associated Viral Vector Therapy 
  • Patient-specific iPSC-derived endothelial cells provide longterm phenotypic correction of hemophilia A 
  • Patterns of regulation from mRNA and protein time series. 
  • Peat accretion and phosphorus accumulation along a eutrophication gradient in the northern Everglades 
  • Peptide affinity reagents for AAV capsid recognition and purification. 
  • Performance and sustainability vs. the shelf price of tissue paper Kitchen Towels 
  • Performance evaluation of a full-scale innovative swine waste-to-energy system. 
  • Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. 
  • Persistent, therapeutically relevant levels of human granulocyte colony-stimulating factor in mice after systemic delivery of adeno-associated virus vectors. 
  • Personalized diagnostics and biosensors: a review of the biology and technology needed for personalized medicine. 
  • Personalized health care: from theory to practice. 
  • Personalized medicine: revolutionizing drug discovery and patient care. 
  • Perspectives on the development of anti-HIV vaccines. 
  • Pharmacogenetics and disease genetics of complex diseases. 
  • Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. 
  • Phase II Clinical Trial of Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immune Deficiency (ADA-SCID) 
  • Physical Positioning Dramatically Improves Brain Transduction after Intrathecal Infusion of AAV9 
  • Physical characteristics of porous cellulose beads as supporting material for immobilized enzymes. 
  • Picoliter DNA sequencing chemistry on an electrowetting-based digital microfluidic platform. 
  • Plant-centered biosystems in space environments: technological concepts for developing a plant genetic assessment and control system. 
  • Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells. 
  • Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis. 
  • Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency. 
  • Potential of an antibacterial ultraviolet-irradiated nylon film. 
  • Powerful ideas driven by simple tools: lessons from experimental embryology. 
  • Pre-emptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury, improves ventricular function and prolongs survival. 
  • Preclinical Development of New Therapy for Glycogen Storage Diseases. 
  • Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels. 
  • Preface 
  • Preincubation with endothelial cell monolayers increases gene transfer efficiency into human bone marrow CD34⁺ CD38^- progenitor cells 
  • Prenatal gene tranfer: scientific, medical, and ethical issues: a report of the Recombinant DNA Advisory Committee. 
  • Preparation and activity of carbonic anhydrase immobilized on porous silica beads and graphite rods. 
  • Preparation and performance of immobilized yeast cells in columns containing no inert carrier. 
  • Preparation of peptide-loaded dendritic cells for cancer immunotherapy. 
  • Prevalence and patterns of Transmitted Drug Resistance in HIV-Infected Adult Patients Initiating Antiretroviral Therapy in Hanoi, Vietnam 
  • Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure. 
  • Priming, boosting, measuring. 
  • Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial. 
  • Production of cytidine 5'-diphosphorylcholine with high utilization of ATP by whole cells of Saccharomyces cerevisiae. 
  • Programming microbial population dynamics by engineered cell-cell communication. 
  • Progress in Arabidopsis genome sequencing and functional genomics. 
  • Prostate cancer: status of current treatments and emerging antisense-based therapies. 
  • Protein engineering and the development of generic biosensors. 
  • Protein engineering approaches to biomaterials design. 
  • Protein patterning. 
  • Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin. 
  • Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration. 
  • Proteomics for monitoring immune responses to cancer vaccines. 
  • Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi. 
  • Purification of an elastin-like fusion protein by microfiltration. 
  • Purification of homogeneous forms of fungal peroxygenase. 
  • Quantitation of cell area on glass and fibronectin-coated surfaces by digital image analysis. 
  • Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum dot-FRET. 
  • REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis. 
  • RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin. 
  • RNA Transfected Dendritic Cell Vaccines Targeting Human Cytomegalovirus Antigens in Patients with Glioblastoma 
  • RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. 
  • RNA interference: silencing in the cytoplasm and nucleus. 
  • RNA repair as a novel approach to genetic therapy. 
  • RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods 
  • RNA transfected dendritic cells as cancer vaccines. 
  • RNF121 is a Key Transcriptional Regulator of AAV Genome Expression 
  • Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity. 
  • Rapid dissection of a complex phenotype through genomic-scale mapping of fitness altering genes. 
  • Rapidly regulating platelet activity in vivo with an antidote controlled platelet inhibitor. 
  • Rat hepatocyte morphology and function on lactose-derivatized polystyrene surfaces 
  • Re-Engineering Capsid-Glycan Interactions Expands the CNS Transduction Profile of AAV Serotype 4 
  • Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. 
  • Reading frame correction by targeted genome editing restores dystrophin expression in cells from duchenne muscular dystrophy patients 
  • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. 
  • Recombinant DNA Advisory Committee. Department of Health and Human Services. National Institutes of Health. Minutes of meeting. December 15-16, 1997. 
  • Recombinant DNA Advisory Committee. Department of Health and Human Services. National Institutes of Health. Minutes of meeting. March 10, 1998. 
  • Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies. 
  • Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype. 
  • Recombineering to homogeneity: extension of multiplex recombineering to large-scale genome editing. 
  • Recovery of pyruvic acid from biotransformation solutions 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Reduction of invasive bacteria in ethanol fermentations using bacteriophages. 
  • Regional-CNS MiniPromoters for AAV Are Identified in a High Through-Put Pipeline 
  • Regulation of plant root system architecture: implications for crop advancement. 
  • Relationship between human perception of softness and instrument measurements 
  • Relative gene expression quantification in a fungal gas-phase biofilter. 
  • Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing. 
  • Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord. 
  • Reporting Long Term Survival Following Precision Tumor-Targeted Gene Delivery to Advanced Chemotherapy-Resistant Malignancies: An Academic Milestone 
  • Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Respiratory Directed Gene Therapy to Silence SOD1 Prolongs Survival in the SOD1 ALS Mouse 
  • Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution 
  • Responsible Use of Human Gene-Editing Technologies. 
  • Retargeting mobile group II introns to repair mutant genes. 
  • Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-β? 
  • Review: Tissue engineering in the nervous system 
  • Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system 
  • Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. 
  • Rich before old? 
  • Risk management consideration in the bioeconomy 
  • Role of Vp2 in AAV packaging 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • Safety Testing for Replication-Competent Retrovirus Associated with Gibbon Ape Leukemia Virus-Pseudotyped Retroviral Vectors 
  • Salmeterol with Liver Depot Gene Therapy Enhances the Skeletal Muscle Response in Murine Pompe Disease. 
  • Salmeterol with Liver Depot Gene Therapy Reversed Biochemical and Autophagic Abnormalities of Skeletal Muscle in Pompe Disease 
  • Salmeterol, a Beta-Agonist, Enhances Therapeutic Efficacy in Pompe Gene Therapy 
  • Science and the law. Working through the patent problem. 
  • Selective modification of antigen-specific T cells by RNA electroporation. 
  • Sensitivity enhancement of optical immunosensors by the use of a surface plasmon resonance fluoroimmunoassay. 
  • Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation. 
  • Serial real-time luminescence imaging profiles differential kinetics and biodistibution of transgene expression from AAV serotype 1-5 vectors following adult and neonatal gene transfer 
  • Shear degradation as a probe of microalgal exopolymer structure and rheological properties 
  • Short-term cell/substrate contact dynamics of subconfluent endothelial cells following exposure to laminar flow. 
  • Sialic Acids and Erythrocyte Interactions Are Critical Determinants of Cardiopulmonary Tropism Displayed by AAV Serotype 4 
  • Signal-transduction cascades as targets for therapeutic intervention by natural products. 
  • Single- and dual-fractal analysis of hybridization binding kinetics: biosensor applications. 
  • Smooth Muscle Cell Targeted RNA Aptamers for the Treatment of Vascular Disease 
  • Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation. 
  • Solubilization of tricalcium phosphate by P(3HB) accumulating Azotobacter chroococcum MAL-201. 
  • South America: Industrial roundwood supply potential 
  • Split luciferase complementation assay for the analysis of G protein-coupled receptor ligand response in Saccharomyces cerevisiae. 
  • Spontaneous bacterial cell lysis and biofilm formation in the colon of the Cape Dune mole-rat and the laboratory rabbit. 
  • Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. 
  • Steady ongoing hematological and immunological reconstitution achieved in ADA-deficiency patients treated by stem cell gene therapy with no myelopreparative conditioning 
  • Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. 
  • Strategies for the multiplex mapping of genes to traits. 
  • Streptavidin-biotin binding energetics. 
  • Structural Mapping of AAV9 Antigenic Sites and the Engineering of Immune Escape Variants 
  • Structure-Guided Iterative Evolution of Antigenically Advanced AAV Variants for Therapeutic Gene Transfer 
  • Studies on the preparation of chitosan microcarriers cross-linked by oxidized lactose and culture of primary hepatocytes. 
  • Study of substrate specificity of RNR-exoribonucelases using hybrid proteins 
  • Substrate (gelatin) gel electrophoretic method for analysis of protease activity in insect (Sf-9) cells 
  • Successful immunization with a single injection of non-integrating lentiviral vector 
  • Successful immunization with a single injection of non-integrating lentiviral vector. 
  • Sustained correction of motoneuron histopathology following intramuscular delivery of AAV in pompe mice. 
  • Synchronous luminescence: A simple technique for the analysis of hydrolysis activity of the fragile histidine triad protein 
  • Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease. 
  • Synergistic and Tunable Gene Activation by Combinations of Synthetic Transcription Factors 
  • Synergistic effect of shear stress and streptavidin-biotin on the expression of endothelial vasodilator and cytoskeleton genes. 
  • Synergy of adoptive T-cell therapy and intratumoral suicide gene therapy is mediated by host NK cells. 
  • Synthetic Biology: Caught Between Property Rights, the Public Domain, and the Commons 
  • Synthetic Biology: Reports from CSHA 2016 and More. 
  • Systematic review of bioenergy perception studies 
  • Systemic Correction of Murine Glycogen Storage Disease Type IV by an AAV-Mediated Gene Therapy. 
  • Systemic Delivery of AAVB1-GAA Clears Glycogen and Prolongs Survival in a Mouse Model of Pompe Disease. 
  • Systemic Delivery of AAVB1-GAA Gene Therapy for Respiratory Pathology in Pompe Disease 
  • Systemic Expression of Translatable Circular Rnas Using Recombinant AAV Vectors 
  • Systemic and Persistent Muscle Gene Expression in Rhesus Monkeys with a Liver De-Targeted Adeno-Associated Virus Vector. 
  • Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts. 
  • Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes. 
  • Targeting 4-1BB costimulation to disseminated tumor lesions with bi-specific oligonucleotide aptamers. 
  • Targeting tumor vasculature with an oncolytic virus. 
  • Technology evaluation: BLP-25, Biomira Inc. 
  • Technology evaluation: CEA-TRICOM, Therion Biologics Corp. 
  • Technology evaluation: ISIS-2503, Isis Pharmaceuticals. 
  • Technology evaluation: Rexin-G, Epeius Biotechnologies. 
  • Technology evaluation: Stem-cell therapy, Aastrom Biosciences Inc. 
  • Technology evaluation: Theratope, Biomira Inc. 
  • Technology evaluation: VEGF165 gene therapy, Valentis Inc. 
  • Technology evaluation: gene therapy (IL-2), Valentis Inc. 
  • Technology evaluation: ipilimumab, Medarex/Bristol-Myers Squibb. 
  • The AAV vector toolkit: poised at the clinical crossroads. 
  • The Biobased Products Industry: Reflections and Insights from a Multi-Year Empirical and Modeling Evaluation for the Congress of the United States 
  • The Image Gently ALARA CT summit on new CT technologies for children. 
  • The New Epigenome-Editing Approach for Targeting Dysregulated SNCA Expression: Novel Target Validation for Next-Generation Drug Discovery 
  • The TLR9-MyD88 Pathway Is Critical for Adaptive Immune Responses to AAV Vectors in Gene Therapy 
  • The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing. 
  • The development of an immobilized lactate oxidase system for lactic acid analysis. 
  • The development of new biotechnologies using metalloprotein design. 
  • The development of optical nanosensors for biological measurements. 
  • The early years of single photon emission computed tomography (SPECT): an anthology of selected reminiscences. 
  • The effect of an applied potential on the activity of carbonic anhydrase immobilized on graphite rods. 
  • The effect of osmotic stress on the production of nukacin ISK-1 from Staphylococcus warneri ISK-1. 
  • The effect of packing hydrophilization on bacterial attachment and the relationship with the performance of biotrickling filters. 
  • The emergent industrial bioeconomy 
  • The impact of genomics on the biotechnology industry. 
  • The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. 
  • The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae. 
  • The oxypropylation of cork residues: preliminary results 
  • The perforin-dependent immunological synapse allows T-cell activation-dependent tumor targeting by MLV vector particles. 
  • The quantity and quality of worldwide new drug introductions, 1982-2003. 
  • The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors. 
  • The removal of volatile ketone mixtures from air in biofilters 
  • The role of single-cell analyses in understanding cell lineage commitment. 
  • The synthetic utility of KDPGal aldolase 
  • The transcapsidation of AAV serotypes 
  • The universality of lignocellulosic biomass liquefaction by plasma electrolysis under acidic conditions. 
  • Therapeutic Benefit of Autophagy Modulation in Pompe Disease. 
  • Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates. 
  • Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes 
  • Tissue Engineered Human Skeletal Muscle as a Pre-Clinical Model for AAV Treatment of Pompe Disease 
  • Tissue engineering of functional skeletal muscle: challenges and recent advances. 
  • Toluene degradation in the recycle liquid of biotrickling filters for air pollution control. 
  • Total RNA isolation by a rapid centrifugation method. 
  • Toward a blended ontology: applying knowledge systems to compare therapeutic and toxicological nanoscale domains. 
  • Training physicians for careers in clinical research: a tailored educational experience. 
  • Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo. 
  • Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. 
  • Transcriptional regulation of changes in growth, cell cycle, and gene expression of Saccharomyces cerevisiae due to changes in buoyancy. 
  • Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. 
  • Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes. 
  • Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. 
  • Transient depletion of kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles. 
  • Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. 
  • Transient-state behavior of a biofilter removing mixtures of vapors of MEK and MIBK from air 
  • Transient-state behavior of a biofilter removing mixtures of vapors of MEK and MIBK from air. 
  • Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. 
  • Translation of academic discovery into societal benefit: proposal for a balanced approach--part 1. 
  • Transmembrane transport of marker molecules and cell membrane kinetics during electropermeabilization 
  • Treatment of Sepsis by Neutralization of Extracellular Histones with Nucleic Acid Aptamers 
  • Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor. 
  • Tumoricidal Stem Cell Therapy Enables Killing in Novel Hybrid Models of Heterogeneous Glioblastoma 
  • Turning lemons into lemonade: learning from negative studies in cancer immunotherapy. 
  • U.S. Department of Health and Human Services National Institutes of Health Recombinant DNA Advisory Committee: Minutes of meeting: December 6, 2001 
  • Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli. 
  • Uncertain benefit: investigators' views and communications in early phase gene transfer trials. 
  • Understanding metabolism with flux analysis: From theory to application. 
  • Underwater life support based on immobilized oxygen carriers. 
  • Universal purification of AAV serotypes 1-5 modified to contain a heparin binding epitope 
  • Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's. 
  • Use of linear programming to -optimize the social, −environmental, and economic impacts of using woody feedstocks for pellet and -torrefied pellet production 
  • VSMC Specific Aptamer Ligands for the Next Generation of DES to Prevent Neointimal Formation 
  • VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment. 
  • Vector Genome Length and Self-Complementarity Affect AAV Capsid Uncoating 
  • Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice. 
  • Vesicles with transport capability isolated from cultured fibroblasts. 
  • Viruses for the treatment of malignant glioma. 
  • Visualizing nuclear migration during conidiophore development in Aspergillus nidulans and Aspergillus oryzae: multinucleation of conidia occurs through direct migration of plural nuclei from phialides and confers greater viability and early germination in Aspergillus oryzae. 
  • When is an adjuvant not an adjuvant? 
  • When is an adjuvant not an adjuvant? Overview. 
  • White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 1: Technology and Terminology. 
  • Whole-body correction of Pompe disease by AAV liver-mediated gene transfer of engineered secretable GAA transgenes 
  • Wide Spread Adenoviral Vector Delivery to a Cardiac Allograft Utilizing an Ex Vivo Perfusion Storage Strategy 
  • Wild-type adenoviruses from groups A-F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent. 
  • Wolfgang Barz [formula omitted] Coństitutive and Elicitation Induced Metabolism of Isoflavones and Pterocarpans in Chickpea (Cicer arietinum) Cell Suspension Cultures 
  • X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector. 
  • X-ray crystallographic studies of streptavidin mutants binding to biotin. 
  • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. 
  • Zero incidence of adeno-associated virus serotype 9 (AAV9) antibodies in a cohort of spinal muscular atrophy (SMA) type 1 patients screened in STR1VE, a pivotal phase 3 study of AVXS-101 
• 

  Keywords of People

  • Coronado Sroka, Eduardo, Student, Statistical Science
  • Diao, Yarui, Assistant Professor of Cell Biology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Science & Society
  • Ridley, David Blaine, Professor of the Practice of Business Adminstration, Duke Science & Society
  • Sexton, Steven E., Mark and Lynne Florian Assistant Professor of Public Policy, Economics