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Subject Areas on Research
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In Vitro
Metabolism of Isopropylated and tert
-Butylated Triarylphosphate Esters Using Human Liver Subcellular Fractions.
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A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
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A two one-sided tests procedure for assessment of individual bioequivalence.
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ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons.
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Absence of metabolite formation during nitroglycerin-induced relaxation of isolated blood vessels.
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Activation of cyclophosphamide for in vitro testing of cell sensitivity.
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Adrenocorticotropic hormone biotransformation, clearance, and catabolism.
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Advances in enzymology and related areas of molecular biology. Preface.
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Aging and cancer.
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Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography-electrospray mass spectrometry
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Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
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Bacterial conversion of folinic acid is required for antifolate resistance.
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Beta-arrestins and cell signaling.
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Biotransformation of HBCD in biological systems can confound temporal-trend studies.
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Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
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Biotransformation of sevoflurane.
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Bis(alkylamino)anthracenedione antineoplastic agent metabolic activation by NADPH-cytochrome P-450 reductase and NADH dehydrogenase: diminished activity relative to anthracyclines.
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Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo
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Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone.
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Chloroperoxidase-catalyzed halogenation of antipyrine, a drug substrate of liver microsomal cytochrome P-450.
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Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations.
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Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.
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Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
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Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats.
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Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus carpio).
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Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.
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Detection and characterization of a glutathione conjugate of ochratoxin A.
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Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio).
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Effect of CYP1A inhibition on the biotransformation of benzo[a]pyrene in two populations of Fundulus heteroclitus with different exposure histories.
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Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation.
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Effect of carbon source addition on toluene biodegradation by an Escherichia coli DH5alpha transconjugant harboring the TOL plasmid.
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Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs.
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Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow.
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Epimerization of an intermediary metabolite of norethynodrel by a 3 beta-hydroxy-delta 5(10)-steroid epimerase.
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Ethanol interferes with regeneration-associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity?
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Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.
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Gas chromatographic-mass spectrometric analysis of alfentanil metabolites. Application to human liver microsomal alfentanil biotransformation.
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Genetic bioaugmentation as an effective method for in situ bioremediation: functionality of catabolic plasmids following conjugal transfers.
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Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
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Hepatocyte uptake of alpha 1-proteinase inhibitor-trypsin complexes in vitro: evidence for a shared uptake mechanism for proteinase complexes of alpha 1-proteinase inhibitor and antithrombin III.
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Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
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Identification of in vitro rat metabolites of 1-phenylcyclohexene.
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Identifying genomic and developmental causes of adverse drug reactions in children.
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In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
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In vitro metabolism of cyclosporine A by human kidney CYP3A5.
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In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp.
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Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.
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Induction of hepatic CYP1A in channel catfish increases binding of 2-aminoanthracene to DNA in vitro and in vivo.
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Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism.
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Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.
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Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care.
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Metabolism and toxicity of the new anesthetic agents.
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Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice.
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Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
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Metabolism of norethynodrel by rat liver.
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Microbial hydroxylation and reduction of the diterpene psiadin.
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Molecular basis of the biological function of molybdenum: the relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2.
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Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes.
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New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.
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New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.
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Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity.
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Pathophysiology of the blood-brain barrier: animal models and methods.
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Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice.
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Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients.
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Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies.
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Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine.
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Population pharmacokinetics of lamivudine in adult human immunodeficiency virus-infected patients enrolled in two phase III clinical trials.
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Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.
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Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
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Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.
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Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene.
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Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.
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Sevoflurane, fluoride ion, and renal toxicity.
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Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells.
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Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
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Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
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Species-specific differences and structure-activity relationships in the debromination of PBDE congeners in three fish species.
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Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults.
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Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats.
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Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.
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Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response.
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The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases.
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The efficacy of the appetite suppressant, diethylpropion, is dependent on both when it is given (day vs. night) and under conditions of high fat dietary restriction.
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The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
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The metabolism of ethynodiol diacetate by rat and human liver.
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The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst.
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Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.
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Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.
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Transformation of pristine and citrate-functionalized CeO2 nanoparticles in a laboratory-scale activated sludge reactor.
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Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.
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Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice.
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Urinary metabolities of harmine in the rat and their inhibition of monoamine oxidase.
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Vaginal deployment and tenofovir delivery by microbicide gels.
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Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility.
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Keywords of People