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Subject Areas on Research
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3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.
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4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.
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A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method.
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A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
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ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice.
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Age-Related Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1.
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Angioedema induced by the angiotensin II blocker losartan.
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Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.
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Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.
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Bcl-xL is an oncogenic driver in colorectal cancer.
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Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation.
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Candesartan in heart failure--assessment of reduction in mortality and morbidity (CHARM): rationale and design. Charm-Programme Investigators.
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Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3.
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Comparative toxicity of polychlorinated biphenyl and polybrominated biphenyl in the rat liver: light and electron microscopic alterations after subacute dietary exposure.
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Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: Antimicrobial and biophysical properties.
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Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort.
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Demographic and dietary risk factors in relation to urinary metabolites of organophosphate flame retardants in toddlers.
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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K.
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Diphenyl Phosphate-Induced Toxicity During Embryonic Development.
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Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts.
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Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrolling 138,769 individuals.
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Efficacy, safety, and pharmacokinetics of candesartan cilexetil in hypertensive children aged 6 to 17 years.
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Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.
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Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process.
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In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia.
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Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat.
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Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes.
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International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction.
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Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites.
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Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer.
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Losartan in post-transplant erythrocytosis.
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Monitoring the ACTIVE-W trial: some issues in monitoring a noninferiority trial.
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NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats.
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New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.
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Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.
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Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.
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Randomized trial of candesartan cilexetil in the treatment of patients with congestive heart failure and a history of intolerance to angiotensin-converting enzyme inhibitors.
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Reclassifying heart failure: time for disruptive innovation?
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Role of cholinergic mechanisms in states of wakefulness and sleep.
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Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
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Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.
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Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
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Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
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The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.
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The association of urinary phosphorous-containing flame retardant metabolites and self-reported personal care and household product use among couples seeking fertility treatment.
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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
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The use of diaminobenzidine for spectrophotometric and acrylamide gel detection of sulfite oxidase and its applicability to hydrogen peroxide-generating enzymes.
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Thromboxane binding and signal transduction in rat glomerular mesangial cells.
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Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats.
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Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.
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Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine.