Bipolar Disorder

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  Subject Areas on Research

  • A case of intermittent delirious mania. 
  • A follow-up study of post partum illness, 1946-1978. 
  • A history of the concept of atypical depression. 
  • A multicenter, randomized, double-blind, placebo-controlled trial of extended-release carbamazepine capsules as monotherapy for bipolar disorder patients with manic or mixed episodes. 
  • A new and timely delusion: the complaint of having AIDS. 
  • A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder. 
  • A prospective study examining the effects of gender and sexual/physical abuse on mood outcomes in patients with co-occurring bipolar I and substance use disorders. 
  • A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. 
  • A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force. 
  • A statistical analysis of the classification of depression in a mixed community and clinical sample. 
  • Abnormal cortisol suppression in bipolar patients with simultaneous manic and depressive symptoms. 
  • Adjunctive use of olanzapine in mood disorders: five case reports. 
  • Affective disorders in five United States communities. 
  • Age of first onset of bipolar disorder: demographic, family history, and psychosocial correlates. 
  • Age-dependent reduction of amygdala volume in bipolar disorder. 
  • Alprazolam-induced manic reaction. 
  • Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. 
  • An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic review. 
  • An evidence-based medicine strategy for achieving remission in bipolar disorder. 
  • Anticipating DSM-V: opportunities and challenges for cognition and psychosis. 
  • Applications of TMS to therapy in psychiatry. 
  • Aripiprazole: pharmacology, efficacy, safety and tolerability. 
  • Associations between residence at birth and mental health disorders: a spatial analysis of retrospective cohort data. 
  • Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study. 
  • Atypical depression. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Bariatric surgery in patients with bipolar spectrum disorders: Selection factors, postoperative visit attendance, and weight outcomes. 
  • Behavior and emotion modulation deficits in preschoolers at risk for bipolar disorder. 
  • Behavioral response inhibition in psychotic disorders: diagnostic specificity, familiality and relation to generalized cognitive deficit. 
  • Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report. 
  • Bipolar Depression: Pregnancy, Postpartum, and Lactation. 
  • Bipolar Disorder and Dementia: Weighing the Evidence. 
  • Bipolar disorder is associated with HIV transmission risk behavior among patients in treatment for HIV. 
  • Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology. 
  • Brief pulse and ultrabrief pulse right unilateral electroconvulsive therapy (ECT) for major depression: efficacy, effectiveness, and cognitive effects. 
  • Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder. 
  • Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. 
  • Caudate volume measurement in older adults with bipolar disorder. 
  • Characterization of a Human-Specific Tandem Repeat Associated with Bipolar Disorder and Schizophrenia. 
  • Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy. 
  • Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. 
  • Clinical, demographic and social characteristics of psychotic depression. 
  • Cognitive burden of anticholinergic medications in psychotic disorders. 
  • Cognitive effects of quetiapine XR in patients with euthymic bipolar disorder. 
  • Collaborative mental health and primary care for bipolar disorder. 
  • Combining gene expression, demographic and clinical data in modeling disease: a case study of bipolar disorder and schizophrenia. 
  • Comments on "Addition of lamotrigine to valproic acid: a successful outcome in a case of rapid-cycling bipolar affective disorder". 
  • Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. 
  • Conceptual and methodological issues in designing a randomized, controlled treatment trial for geriatric bipolar disorder: GERI-BD. 
  • Convergent validity of the Timeline Followback for persons with comorbid psychiatric disorders engaged in residential substance use treatment. 
  • Convulsive threshold differences in right unilateral and bilateral ECT. 
  • Cortical and subcortical white matter abnormalities in adults with remitted first-episode mania revealed by Tract-Based Spatial Statistics. 
  • Cortical white matter microstructural abnormalities in bipolar disorder. 
  • Decision model for the acute treatment of mania. 
  • Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. 
  • Demographics, family history, premorbid functioning, developmental characteristics, and course of patients with deteriorated affective disorder. 
  • Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. 
  • Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. 
  • Development of an organic affective syndrome during a hyperbaric diving experiment. 
  • Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder. 
  • Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistence. 
  • Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder. 
  • ECT in bipolar and unipolar depression: differences in speed of response. 
  • ECT use in unipolar and bipolar depression. 
  • Effectiveness of antiepileptic drugs for the treatment of bipolar disorder: findings from a systematic review. 
  • Electroconvulsive Therapy and All-Cause Mortality in Texas, 1998-2013. 
  • Electroconvulsive Therapy in Pregnancy: Safety, Best Practices, and Barriers to Care. 
  • Electroconvulsive therapy is equally effective in unipolar and bipolar depression. 
  • Electroconvulsive therapy: an update. 
  • Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories. 
  • Embryonic mania. 
  • Evaluation of cognitive function in bipolar disorder using the Brief Assessment of Cognition in Affective Disorders (BAC-A). 
  • Evidence-based mental health use of anticonvulsants during pregnancy. 
  • Exceptionally high seizure threshold: ECT device limitations. 
  • Exercise as a treatment for depression and other psychiatric disorders: a review. 
  • Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder. 
  • Extended-release carbamazepine capsules as monotherapy for acute mania in bipolar disorder: a multicenter, randomized, double-blind, placebo-controlled trial. 
  • Extended-release carbamazepine capsules as monotherapy in bipolar disorder : pooled results from two randomised, double-blind, placebo-controlled trials. 
  • Eye-tracking, attention and amphetamine challenge. 
  • Factors that affect adherence to bipolar disorder treatments: a stated-preference approach. 
  • Familial leukoencephalopathy in bipolar disorder. 
  • Funeral mania in recurrent bipolar affective disorders: reports of three cases. 
  • GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder. 
  • Gabapentin in the treatment of mental illness: the echo chamber of the case series. 
  • General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial. 
  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. 
  • Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. 
  • Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. 
  • Gray and white matter brain volumes in older adults with bipolar disorder. 
  • HIV risk behavior among patients with co-occurring bipolar and substance use disorders: associations with mania and drug abuse. 
  • Harms are assessed inconsistently and reported inadequately Part 2: nonsystematic adverse events. 
  • Harms are assessed inconsistently and reported inadequately part 1: systematic adverse events. 
  • High-performance liquid chromatography of haloperidol in serum at the concentrations achieved during chronic therapy. 
  • Hippocampal volume measurement in older adults with bipolar disorder. 
  • How reviews covered the unfolding scientific story of gabapentin for bipolar disorder. 
  • Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review. 
  • Hyperintense lesions on magnetic resonance images in bipolar disorder. 
  • Hypomania following withdrawal of trazodone. 
  • Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder. 
  • Impaired Context Processing is Attributable to Global Neuropsychological Impairment in Schizophrenia and Psychotic Bipolar Disorder. 
  • Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania. 
  • Influence of Criminal Justice Involvement and Psychiatric Diagnoses on Treatment Costs Among Adults With Serious Mental Illness. 
  • Insight in schizophrenia and mania. 
  • Insight is greater in mixed than in pure manic episodes of bipolar I disorder. 
  • Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol. 
  • International randomized-controlled trial of transcranial Direct Current Stimulation in depression. 
  • Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. 
  • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 
  • Key updates in the clinical application of electroconvulsive therapy. 
  • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. 
  • Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature. 
  • Leukocytosis and hypoalbuminemia in mixed bipolar states: evidence for immune activation. 
  • Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. 
  • Lifetime perturbations of bipolar disorder. 
  • Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania. 
  • Lithium-induced nephrotic syndrome. 
  • Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 
  • Low-dimensional chaos in bipolar disorder? 
  • Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder. 
  • Magnetic resonance imaging abnormalities and psychiatric illness. 
  • Mania in Alzheimer's disease. 
  • Medical comorbidity in a bipolar outpatient clinical population. 
  • Medical comorbidity in bipolar disorder: re-prioritizing unmet needs. 
  • Medication preferences and adherence among individuals with severe mental illness and psychiatric advance directives. 
  • Medication-Assisted Treatment for Alcohol-Dependent Adults With Serious Mental Illness and Criminal Justice Involvement: Effects on Treatment Utilization and Outcomes. 
  • Metabolomics tools for identifying biomarkers for neuropsychiatric diseases. 
  • Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. 
  • Mood variability in adolescents: a study of depressed, nondepressed and comorbid patients. 
  • Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis. 
  • National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders. 
  • Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics. 
  • Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial. 
  • Neuropathology in affective illness. 
  • Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. 
  • Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders. 
  • Nuclear magnetic resonance spectroscopy: new insights into the pathophysiology of mood disorders. 
  • Nutrition and Bipolar Depression. 
  • Occurrence of subcortical hyperintensities in elderly subjects with mania. 
  • Opportunities for selective reporting of harms in randomized clinical trials: Selection criteria for non-systematic adverse events. 
  • Parental relationships and behavioral approach system dysregulation in young adults with bipolar disorder. 
  • Patterns of justice involvement among adults with schizophrenia and bipolar disorder: key risk factors. 
  • Patterns of pharmacotherapy and treatment response in elderly adults with bipolar disorder. 
  • Performance of a weight-related measure of Quality of Life in a psychiatric sample. 
  • Personality assessment inventory internalizing and externalizing structure in veterans with posttraumatic stress disorder: associations with aggression. 
  • Pharmacotherapy of bipolar disorder in old age: review and recommendations. 
  • Platelet monoamine oxidase activity and the classification of depression. 
  • Polypharmacy in pregnant women with major psychiatric illness: a pilot study. 
  • Practitioner review: the assessment of bipolar disorder in children and adolescents. 
  • Prevalence of HIV infection in a general psychiatric outpatient population. 
  • Prevalence of antithyroid antibodies in mood disorders. 
  • Prevalence of baseline lipid monitoring in patients prescribed second-generation antipsychotics during their index hospitalization: a retrospective cohort study. 
  • Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder. 
  • Prolactin-related and metabolic adverse effects of atypical antipsychotic agents. 
  • Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. 
  • Psychiatric and medical comorbidities of bipolar disorder. 
  • Psychotherapeutic Treatment of Bipolar Depression. 
  • Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study. 
  • Recurrent premenstrual decline in serum lithium concentration: clinical correlates and treatment implications. 
  • Reduced white matter integrity and verbal fluency impairment in young adults with bipolar disorder: a diffusion tensor imaging study. 
  • Reducing barriers to completing psychiatric advance directives. 
  • Regressing to Prior Response Preference After Set Switching Implicates Striatal Dysfunction Across Psychotic Disorders: Findings From the B-SNIP Study. 
  • Religiosity, depression, and quality of life in bipolar disorder: a two-year prospective study. 
  • Resting-state brain function in schizophrenia and psychotic bipolar probands and their first-degree relatives. 
  • Risk factors for early unplanned readmission in patients with bipolar disorder: A retrospective observational study. 
  • Role of treatment alliance in the clinical management of bipolar disorder: stronger alliances prospectively predict fewer manic symptoms. 
  • Scopolamine sleep treatment in private practise. 
  • Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT. 
  • Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold. 
  • Sleep disturbance in euthymic bipolar patients. 
  • Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. 
  • Sleep impairment, mood symptoms, and psychosocial functioning in adolescent bipolar disorder. 
  • Smoking and psychosis in patients with bipolar I disorder. 
  • Social support in elderly patients with bipolar disorder. 
  • Social support in late life mania: GERI-BD. 
  • Stressful life events in older bipolar patients. 
  • Structural changes in the brain of patients with bipolar affective disorder by MRI: a review of the literature. 
  • Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data. 
  • Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. 
  • Study design and methodology for a multicentre, randomised controlled trial of transcranial direct current stimulation as a treatment for unipolar and bipolar depression. 
  • Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects. 
  • Subtypes of mania determined by grade of membership analysis. 
  • Suicide Behaviors in Bipolar Disorder: A Review and Update for the Clinician. 
  • Suicide attempts in veterans with bipolar disorder during treatment with lithium, divalproex, and atypical antipsychotics. 
  • Suicide in pregnancy. 
  • Symptomatic remission in patients with bipolar mania: results from a double-blind, placebo-controlled trial of risperidone monotherapy. 
  • Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use. 
  • The Brief Assessment of Cognition In Affective Disorders (BAC-A):performance of patients with bipolar depression and healthy controls. 
  • The Challenge of Bipolar Depression in the 21st Century. 
  • The MATRICS consensus cognitive battery in patients with bipolar I disorder. 
  • The Use of Antidepressants in Bipolar Depression. 
  • The dexamethasone suppression test and quantitative cerebral anatomy in depression. 
  • The dexamethasone suppression test in borderline personality disorder. 
  • The effect of cognitive functioning on treatment attendance and adherence in comorbid bipolar disorder and cocaine dependence. 
  • The effect of surgery on intraocular pressure fluctuations with electroconvulsive therapy in a patient with severe glaucoma. 
  • The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. 
  • The highs and lows of amygdala reactivity in bipolar disorders. 
  • The importance of nicotinic acetylcholine receptors in schizophrenia, bipolar disorder and Tourette's syndrome. 
  • The intricate link between violence and mental disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. 
  • The relationship of bipolar disorder lifetime duration and vascular burden to cognition in older adults. 
  • The relationship of manic episodes and drug abuse to sexual risk behavior in patients with co-occurring bipolar and substance use disorders: a 15-month prospective analysis. 
  • The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials. 
  • Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. 
  • Treatment participation and medication adherence: effects on criminal justice costs of persons with mental illness. 
  • Unipolar depression does not moderate responses to the Sweet Taste Test. 
  • Unitary construct of generalized cognitive ability underlying BACS performance across psychotic disorders and in their first-degree relatives. 
  • Urinary excretion of biopterin and neopterin in psychiatric disorders. 
  • Volumetric brain imaging studies in the elderly with mood disorders. 
  • White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies. 
  • White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly. 
  • Who are the new users of antipsychotic medications? 
  • Working memory impairment in probands with schizoaffective disorder and first degree relatives of schizophrenia probands extend beyond deficits predicted by generalized neuropsychological impairment. 
  • Ziprasidone-associated mania: a case series and review of the mechanism. 
  • miR-149 and miR-29c as candidates for bipolar disorder biomarkers. 
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  Keywords of People

  • Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
  • McClintock, Shawn Michael, Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
  • Olsen, Maren Karine, Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics