Blood Preservation

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  Subject Areas on Research

  • 2-(Diethylhexyl)phthalate in blood bags: is this a public health issue? 
  • 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. 
  • A 3D-printed transfusion platform reveals beneficial effects of normoglycemic erythrocyte storage solutions and a novel rejuvenating solution. 
  • A comparison of adverse reaction rates for PAS C versus plasma platelet units. 
  • A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. 
  • A randomized controlled pilot study of VO2 max testing: a potential model for measuring relative in vivo efficacy of different red blood cell products. 
  • Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). 
  • Aldehyde dehydrogenase activity allows reliable EPC enumeration in stored peripheral blood samples. 
  • Alternatives in blood operations when choosing non-DEHP bags. 
  • Angiogenin-mediated tRNA cleavage as a novel feature of stored red blood cells. 
  • Automated thawing increases recovery of colony-forming units from banked cord blood unit grafts. 
  • Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles. 
  • Blood banks, biobanks, and the ethics of donation. 
  • Blood transfusion in trauma patients: unresolved questions. 
  • Clinical studies of erythrocyte outcomes and mortality: size really counts. 
  • Comparison of the platelet activation status of single-donor platelets obtained with two different cell separator technologies. 
  • Cryopreserved packed red blood cells in surgical patients: past, present, and future. 
  • Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies. 
  • Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion. 
  • Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. 
  • Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. 
  • Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery. 
  • Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism. 
  • Effects of red-cell storage duration on patients undergoing cardiac surgery. 
  • Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease. 
  • Ethical aspects of banking placental blood for transplantation. 
  • Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage. 
  • Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies. 
  • Evolution of adverse changes in stored RBCs. 
  • Exchange transfusion using washed red blood cells reconstituted with fresh-frozen plasma for treatment of severe hyperkalemia in the neonate. 
  • Expanding the platelet inventory to mitigate the impact of severe shortages. 
  • Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system. 
  • Factors affecting the risk of blood bank specimen hemolysis. 
  • Family-directed umbilical cord blood banking. 
  • Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. 
  • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. 
  • Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation. 
  • Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. 
  • Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. 
  • In vivo and in vitro characteristics of double units of RBCs collected by apheresis with a single in-line WBC-reduction filter. 
  • Incidence of allergic reactions with fresh frozen plasma or cryo-supernatant plasma in the treatment of thrombotic thrombocytopenic purpura. 
  • Increased transmigration of G-CSF-mobilized peripheral blood CD34+ cells after overnight storage at 37 degrees C. 
  • Inventory management strategies that reduce the age of red blood cell components at the time of transfusion. 
  • Lack of efficacy for conventional gamma irradiation of platelet concentrates to abrogate bacterial growth. 
  • Metabolomics evaluation of early-storage red blood cell rejuvenation at 4°C and 37°C. 
  • Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin. 
  • Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia. 
  • Not all red cell concentrate units are equivalent: international survey of processing and in vitro quality data. 
  • PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. 
  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. 
  • Prolonged red cell storage before transfusion increases extravascular hemolysis. 
  • Randomized controlled trial of 7, 28, vs 42 day stored red blood cell transfusion on oxygen delivery (VO2 max) and exercise duration. 
  • Randomized study of washing 40- to 42-day-stored red blood cells. 
  • Rapid freezing of whole blood or buffy coat samples for polymerase chain reaction and cell culture analysis: application to detection of human immunodeficiency virus in blood donor and recipient repositories. The Transfusion Safety Study Group. 
  • Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes. 
  • Red blood cell products: consideration of the discrepant temperature ranges permitted for storage versus transport. 
  • Reexamination of the chromium-51-labeled posttransfusion red blood cell recovery method. 
  • Rejuvenation solution as an adjunct cold storage solution maintains physiological haemoglobin oxygen affinity during early-storage period of red blood cells. 
  • Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity. 
  • Request for retraction. 
  • Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion. 
  • Septic risk increases with apheresis platelet storage time. 
  • Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial. 
  • Standardization of cytokine flow cytometry assays. 
  • Storage age of transfused platelets and outcomes after cardiac surgery. 
  • Storage characteristics of multiple-donor pooled red blood cells compared to single-donor red blood cell units. 
  • Storage of newborn stem cells for future use. 
  • Storing paraformaldehyde-fixed whole blood patient samples after chronic platelet glycoprotein IIb/IIIa blockade: core laboratory considerations. 
  • Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system. 
  • The Chemistry of Lyophilized Blood Products. 
  • The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). 
  • The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. 
  • The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation. 
  • The influence of pretransplant transfusions, using different blood products, on patient sensitization and renal allograft survival. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Umbilical cord blood: a novel alternative source of hematopoietic stem cells for bone marrow transplantation. 
  • Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood. 
  • Variability in the fibrinogen and von Willebrand factor content of cryoprecipitate. Implications for reducing donor exposure. 
  • Warming Up to Cold-stored Platelets. 
  • Why has Borrelia burgdorferi not been transmitted by blood transfusion? 
  • pH modulation ameliorates the red blood cell storage lesion in a murine model of transfusion. 
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  Keywords of People

  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery