Blood Proteins

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  Subject Areas on Research

  • A brief review. Poststreptococcal glomerulonephritis. 
  • A comparsion of polyurethane and silastic artificial hearts in 10 long survival experiments in calves. 
  • A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy. 
  • A multimarker multi-time point-based risk stratification strategy in acute heart failure: results from the RELAX-AHF trial. 
  • A new 440-kD isoform is the major ankyrin in neonatal rat brain. 
  • A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. 
  • Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell. 
  • Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. 
  • Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients. 
  • Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887. 
  • An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. 
  • An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. 
  • An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. 
  • Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry. 
  • Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. 
  • Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator. 
  • Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. 
  • Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm. 
  • Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure? 
  • Assay for free and total carnitine in human plasma using tandem mass spectrometry. 
  • Association between ankyrin and the cytoplasmic domain of band 3 isolated from the human erythrocyte membrane. 
  • Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. 
  • Binding of G protein beta gamma-subunits to pleckstrin homology domains. 
  • Blood group antigens on complement receptor/regulatory proteins. 
  • Blood-induced arterial segmental spasm. 
  • Blood-sample processing for the study of age-dependent gene expression in peripheral blood mononuclear cells. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • Carrier detection in Duchenne muscular dystrophy. 
  • Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency. 
  • Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C. 
  • Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80. 
  • Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. 
  • Clinical utility of erythrocyte sedimentation rate and plasma protein analysis in the elderly. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. 
  • Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass. 
  • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. 
  • Comparative analyses of mechanistic differences among antiestrogens. 
  • Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification. 
  • Connecting genetic risk to disease end points through the human blood plasma proteome. 
  • Decision tree classification of proteins identified by mass spectrometry of blood serum samples from people with and without lung cancer. 
  • Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. 
  • Demonstration of a relation between urinary digoxin-like immunoreactive substance and cardiac performance. 
  • Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting. 
  • Diagnostic protein discovery using proteolytic peptide targeting and identification. 
  • Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Digoxin-like immunoreactivity. 
  • Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. 
  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 
  • Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Diversity of ankyrins in the brain. 
  • Early biomarkers of stroke. 
  • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. 
  • Effect of actinomycin D on serum betalipoproteins of partially hepatectomized dogs. I. Proteins, lipids, triglycerides and cholesterol. 
  • Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of feeding plant proteins on plasma, liver, heart, aorta and brain lipids of rats. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Effects of anthropogenic disturbance on indri (Indri indri) health in Madagascar. 
  • Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. 
  • Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Electrophoretic evaluation of sera from dogs with cancer. 
  • Enhancement of experimental anaerobic infections by blood, hemoglobin, and hemostatic agents. 
  • Erythrocyte blood group antigens: polymorphisms of functionally important molecules. 
  • Evaluation of serum immunoglobulins by protein electrophoresis and rate nephelometry before and after therapeutic plasma exchange. 
  • Evaluation of zone electrophoresis of serum proteins performed on the Helena Laboratories rapid electrophoresis analyser. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Extravascular plasminogen activator and inhibitor activities detected at the site of a chronic mycobacterial-induced inflammation. 
  • FGF23: fashion or physiology? 
  • Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P. 
  • Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media. 
  • Further studies on platelet serotonin transporter binding in depression. 
  • G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. 
  • GW112, a novel antiapoptotic protein that promotes tumor growth. 
  • Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers. 
  • Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease. 
  • Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. 
  • High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients. 
  • Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding. 
  • Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2. 
  • Human erythrocyte spectrin: phosphorylation in intact cells and purification of the 32P-labeled protein in a non-aggregated state. 
  • Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis. 
  • Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV. 
  • Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. 
  • Immunoblot analyses of Candida albicans-associated antigens and antibodies in human sera. 
  • Immunoreactive substance P in human saliva. A possible marker of chronic pain. 
  • Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens. 
  • In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function. 
  • In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s). 
  • In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source. 
  • In vitro resistance to thrombin-induced platelet microbicidal protein in isolates of Staphylococcus aureus from endocarditis patients correlates with an intravascular device source. 
  • In vivo catabolism of alpha 1-antichymotrypsin is mediated by the Serpin receptor which binds alpha 1-proteinase inhibitor, antithrombin III and heparin cofactor II. 
  • In vivo metabolism of inter-alpha-trypsin inhibitor and its proteinase complexes: evidence for proteinase transfer to alpha 2-macroglobulin and alpha 1-proteinase inhibitor. 
  • Interaction of gold nanoparticles with common human blood proteins. 
  • Irrational exuberance in clinical proteomics. 
  • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. 
  • Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes. 
  • Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. 
  • Leprosy in a mangabey monkey--naturally acquired infection. 
  • Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia. 
  • Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. 
  • Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Mapping the domain structure of human erythrocyte adducin. 
  • Mapping the proteo-genomic convergence of human diseases. 
  • Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. 
  • Mitosis is required for production of murine leukemia virus and structural proteins during de novo infection. 
  • Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. 
  • Multimarker Risk Stratification in Patients With Acute Myocardial Infarction. 
  • Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. 
  • Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease. 
  • Nitrogen-sparing intravenous fluids in postperative patients. 
  • Nutritional parameters affecting erythrocyte polyamine levels in cancer patients. 
  • Obestatin and adropin in Prader-Willi syndrome and nonsyndromic obesity: Associations with weight, BMI-z, and HOMA-IR. 
  • Optimized lymphocyte protein extraction performed simultaneously with DNA and RNA isolation: application to the study of factors affecting DNA, RNA, and protein recovery from lymphocytes of the oldest individuals. 
  • Oxidatively modified proteins as plasma biomarkers in breast cancer. 
  • PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency. 
  • Pharmacokinetics of pentobarbital enantiomers as determined by enantioselective radioimmunoassay after administration of racemate to humans and rabbits. 
  • Phencyclidine disposition after intravenous and oral doses. 
  • Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. 
  • Plasma proteins as indices of response to nutritional therapy in cancer patients. 
  • Plasma proteomics of patients with non-valvular atrial fibrillation on chronic anti-coagulation with warfarin or a direct factor Xa inhibitor. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Possible protein binding displacement interaction between glibenclamide and metolazone. 
  • Practical considerations in the nutritional management of the cancer patient. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure. 
  • Prothrombin and beta 2-glycoprotein I frequently contribute to antiphospholipid antibody interactions with phospholipids and the generation of abnormal waveform profiles in coagulation assays. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Purification of glycopeptides of human plasma proteins by high-performance liquid chromatography. 
  • Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. 
  • Quantitative determination of total lipids in serum. 
  • Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate. 
  • Rapid degradation of puromycyl peptides in hepatoma cells and reticulocytes. 
  • Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors. 
  • Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. 
  • Relationship of prospective GHb to glycated serum proteins in incident diabetic retinopathy: implications of the glycation gap for mechanism of risk prediction. 
  • Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. 
  • Release of tissue plasminogen activator and its fast-acting inhibitor in defective fibrinolysis. 
  • Renal systems biology of patients with systemic inflammatory response syndrome. 
  • Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. 
  • Response to warfarin in hypothyroid rats. 
  • Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. 
  • Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. Quantitative determination with purified (32P)spectrin. 
  • Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins. 
  • Serum biomarker panels for the detection of pancreatic cancer. 
  • Serum enzyme alterations in hypothyroidism before and after treatment. 
  • Six-month survival of a calf with an artificial heart. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo. 
  • Steady-state serum levels of quinidine and active metabolites in cardiac patients with varying degrees of renal function. 
  • Stress and parental care in a wild Teleost fish: insights from exogenous supraphysiological cortisol implants. 
  • Study of diffusion in erythrocyte suspension using internal magnetic field inhomogeneity. 
  • Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. 
  • Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation. 
  • The effect of phosphatidylserine on the inhibition of human factor Xa by the plasma proteinase inhibitors. 
  • The importance of factor Xa regulatory pathways in vascular thromboresistance: focus on protein Z. 
  • The junctional complex of the membrane skeleton. 
  • The kinetics of immunoglobulin synthesis by pokeweed mitogen stimulated peripheral blood lymphocytes in multiple myeloma. 
  • The macrophage-mediated regulation of hepatocyte synthesis of antithrombin III and alpha 1-proteinase inhibitor. 
  • The membrane skeleton of human erythrocytes and its implications for more complex cells. 
  • The molecular basis for membrane - cytoskeleton association in human erythrocytes. 
  • The perfusion of isolated whole organs. 
  • The preparation and properties of an antiserum for the radioimmunoassay of serum conjugated cholic acid. 
  • The protein binding of timegadine determined by equilibrium dialysis. 
  • The relationship between ionized and total serum magnesium concentrations during abdominal surgery. 
  • The spectrin skeleton: from red cells to brain. 
  • The spectrin-actin junction of erythrocyte membrane skeletons. 
  • TiO₂ Nanoparticle-Induced Oxidation of the Plasma Membrane: Importance of the Protein Corona. 
  • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray. 
  • Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1. 
  • Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. 
  • Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts. 
  • Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. 
  • Urinary digoxin-like immunoreactive substance in pregnancy. Relation to urinary electrolytes. 
  • Use of gel filtration to examine the distribution of calcium among serum proteins. 
  • Utility of discovery approach using proteomics to create a biomarker profile for coronary microvascular dysfunction. 
  • Vasodilatory state of decompensated cirrhosis: relation to hepatic dysfunction, ascites, and vasoactive substances. 
  • What is blood and what is not? Caring for the Jehovah's Witness patient undergoing cardiac surgery. 
  • [Enzyme activity and hyperaminoacidemia arising in a case of essential hypoproteinemia]. 
  • [Hypoproteinemia and enzyme activity]. 
  • fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies. 
  • α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hoffman, Maureane, Professor of Pathology, Integrative Immunobiology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology