Blood Substitutes

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  Subject Areas on Research

  • A phase I/II study of polymerized bovine hemoglobin in adult patients with sickle cell disease not in crisis at the time of study. 
  • Accidental communities: race, emergency medicine, and the problem of polyheme. 
  • Acute normovolemic hemodilution. 
  • Alternatives to allogeneic blood transfusions. 
  • Anemia in patients undergoing percutaneous coronary intervention: current issues and future directions. 
  • Behavior of the copper band of cytochrome c oxidase in rat brain during FC-43-for-blood substitution. 
  • Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA. 
  • Blood substitutes: evolution and future applications. 
  • Carbodiimide-mediated coupling of benzenepentacarboxylate to human hemoglobin: structural and functional consequences. 
  • Carbon monoxide-cytochrome interactions in the brain of the fluorocarbon-perfused rat. 
  • Consequences of chemical modifications on the free radical reactions of human hemoglobin. 
  • Dissociation of ST segment elevation and regional wall motion with open-artery, intracoronary Fluosol. 
  • Effect of alpha(alpha)-cross-linked hemoglobin and pyridoxalated hemoglobin polyoxyethylene conjugate solutions on gastrointestinal regional perfusion in hemorrhagic shock. 
  • Effect of fluorocarbon-for-blood exchange on regional cerebral blood flow in rats. 
  • Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests. 
  • Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators. 
  • Extreme normovolemic hemodilution: how low can you go and other alternatives to transfusion? 
  • Feasibility of 19F imaging of perfluorochemical emulsions to measure myocardial vascular volume. 
  • Hemoglobin-based oxygen carriers (HBOCs): structural alterations that affect free radical generation. 
  • Hemoglobin-based oxygen carriers for reversing hypotension and shock: "NO" way, "NO" how? 
  • Hemoglobin-based oxygen-carrying solutions: close but still so far. 
  • Hextend, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase III clinical trial. Hextend Study Group. 
  • Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. TAMI 9 Research Group. 
  • Molecular controls of the oxygenation and redox reactions of hemoglobin. 
  • Oxygen carriers as blood substitutes. Past, present, and future. 
  • Oxygen therapeutics--current concepts. 
  • PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model. 
  • Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome? 
  • Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial. 
  • Proceedings From the Society for Advancement of Blood Management Annual Meeting 2017: Management Dilemmas of the Surgical Patient-When Blood Is Not an Option. 
  • Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol. 
  • Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol. 
  • S-nitrosylation and PEGylation of hemoglobin: toward a blood substitute that recapitulates blood. 
  • Temporal changes in the use of blood products for coronary artery bypass graft surgery in North America: an analysis of the Society of Thoracic Surgeons Adult Cardiac Database. 
  • The effect of the bovine hemoglobin oxygen therapeutic HBOC-201 on human neutrophil activation in vitro. 
  • The influence of crystalloid and colloid replacement solutions in acute normovolemic hemodilution: a preliminary survey of hemostatic markers. 
  • The nature of fluorocarbon enhanced cerebral oxygen transport. 
  • The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. 
  • The use of haemoglobin glutamer-250 (HBOC-201) as an oxygen bridge in patients with acute anaemia associated with surgical blood loss. 
  • Transabdominal oxygenation using perfluorocarbons. 
  • Use of turbidity-correction algorithm eliminates the effect of perflubron emulsion on CO-oximeter results. 
  • Ventricular assist devices and increased blood product utilization for cardiac transplantation. 
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  Keywords of People

  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic