Blood Transfusion

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  Subject Areas on Research

  • 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. 
  • 8. Hereditary angioedema. 
  • A change in anticoagulation monitoring improves safety, reduces transfusion, and reduces costs in infants on cardiopulmonary bypass. 
  • A comparison of donor-specific and random transfusions in living-related renal transplantation and their effect on steroid withdrawal. 
  • A model to predict risk of blood transfusion after gynecologic surgery. 
  • A randomized study comparing leukocyte-depleted versus packed red cell transfusions in prospective cadaver renal allograft recipients. 
  • Acid-base status of seriously wounded combat casualties. II. Resuscitation with stored blood. 
  • Acquired peanut hypersensitivity after transfusion. 
  • Actual 10-year survival following hepatectomy for hepatocellular carcinoma. 
  • Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery. 
  • Acute coronary syndromes: Blood transfusion in patients with acute MI and anaemia. 
  • Acute profound thrombocytopenia after C7E3 Fab (abciximab) therapy. 
  • Acute pulmonary decompensation due to amphotericin B in the absence of granulocyte transfusions. 
  • Adenosine deaminase and purine nucleoside phosphorylase deficiencies: evaluation of therapeutic interventions in eight patients. 
  • Adoption of Transradial Percutaneous Coronary Intervention and Outcomes According to Center Radial Volume in the Veterans Affairs Healthcare System Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program 
  • Aging and reactivation of latent murine cytomegalovirus. 
  • Allogeneic leukocytes but not therapeutic blood elements induce reactivation and dissemination of latent human immunodeficiency virus type 1 infection: implications for transfusion support of infected patients. 
  • Alloimmunization in sickle cell disease: changing antibody specificities and association with chronic pain and decreased survival. 
  • Alternate analysis strategies for retrospective assessment of outcomes with a male donor-only plasma policy. 
  • Amniotic fluid embolism presenting after uterine manipulation under general anesthesia: a case with a positive outcome. 
  • Anemia and blood transfusion in trauma patients admitted to the intensive care unit. 
  • Anemia in patients undergoing percutaneous coronary intervention: current issues and future directions. 
  • Anti-Jka that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions. 
  • Antibody-coated erythrocytes induce secretion of tumor necrosis factor by human monocytes: a mechanism for the production of fever by incompatible transfusions. 
  • Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome. 
  • Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. 
  • Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes. 
  • Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. 
  • Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. 
  • Bleeding as a predictor of mortality risk. 
  • Bleeding complications in patients with acute coronary syndrome undergoing early invasive management can be reduced with radial access, smaller sheath sizes, and timely sheath removal. 
  • Bleeding during thrombolytic therapy for acute myocardial infarction: mechanisms and management. 
  • Bleeding in patients undergoing percutaneous coronary intervention: the development of a clinical risk algorithm from the National Cardiovascular Data Registry. 
  • Bleeding risk associated with eptifibatide (Integrilin) bridging in thoracic surgery patients. 
  • Blood conservation in cardiac surgery. Preliminary results with an institutional commitment. 
  • Blood transfusion after percutaneous coronary intervention and risk of subsequent adverse outcomes: a systematic review and meta-analysis. 
  • Blood transfusion during acute myocardial infarction: association with mortality and variability across hospitals. 
  • Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. 
  • Bloodless Orthotopic Heart Transplantation in a Jehovah's Witness. 
  • CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation. 
  • Captopril-enhanced binding of PlA1 (HPA-1a) antibodies in posttransfusion purpura. 
  • Carboxyhemoglobin levels in banked blood. 
  • Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection. 
  • Clinical implications of the loss of vasoactive nitric oxide during red blood cell storage. 
  • Clinical use of oral contraceptives administered vaginally: a case report. 
  • Coagulation changes in elective surgery and trauma. 
  • Coagulopathy and inflammation in neonatal heart surgery: mechanisms and strategies. 
  • Comparative effectiveness of treatment strategies for severe splenic trauma in the pediatric population. 
  • Comparative effects of pregnancy, transfusion, and prior graft rejection on sensitization and renal transplant results. 
  • Comparison of the Trends in Risk Factors and Management of Severe Postpartum Hemorrhage Years 2000-2004 Versus 2005-2008 
  • Comparison of the costs and morbidity of percutaneous and open flank procedures. 
  • Complications of hysterectomy in women with von Willebrand disease. 
  • Complications of implantable venous access devices in patients with sickle cell disease. 
  • Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. 
  • Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. 
  • Cost analysis of abdominal, laparoscopic, and robotic-assisted myomectomies. 
  • Cost-minimization analysis of robotic-assisted, laparoscopic, and abdominal sacrocolpopexy. 
  • Costs and outcomes after cardiac surgery in patients refusing transfusion compared with those who do not: a case-matched study. 
  • Cryotherapy temperature differences after total knee arthroplasty: a prospective randomized trial. 
  • Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis: outcomes from a single tertiary institution. 
  • Definite hereditary hemorrhagic telangiectasia in a 60-year-old black Kenyan woman: a case report. 
  • Design of the silent cerebral infarct transfusion (SIT) trial. 
  • Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching. 
  • Development and validation of a generalizable model for predicting major transfusion during spine fusion surgery. 
  • Diabetes and early postoperative outcomes following lumbar fusion. 
  • Disseminated intravascular coagulation and renal failure: Production in the monkey with autologous red blood cell stroma. 
  • Does body mass index impact the outcomes of tubeless percutaneous nephrolithotomy? 
  • Early hemoglobin response and alternative metrics of efficacy with erythropoietic agents for chemotherapy-related anemia. 
  • Economic assessment of platelet glycoprotein IIb/IIIa inhibition for prevention of ischemic complications of high-risk coronary angioplasty. EPIC Investigators. 
  • Economic assessment of thrombocytopenia: CATCH Registry. 
  • Economic evaluation of weekly epoetin alfa versus biweekly darbepoetin alfa for chemotherapy-induced anaemia: evidence from a 16-week randomised trial. 
  • Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly. 
  • Effects of race and clinical factors on short-term outcomes of abdominal myomectomy. 
  • Efficacy and safety of enoxaparin compared with unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention in the Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial. 
  • Elective cholecystectomy in children with sickle hemoglobinopathies. Successful outcome using a preoperative transfusion regimen. 
  • Epoetin treatment of anemia associated with cancer therapy: a systematic review and meta-analysis of controlled clinical trials. 
  • Ethical aspects of banking placental blood for transplantation. 
  • Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry. 
  • Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection. 
  • Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion. 
  • Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. 
  • Favorable early and long-term prognosis following coronary bypass surgery therapy for myocardial infarction: results of a multicenter trial. TAMI Study Group. 
  • Four-cycle high-dose therapy with hematopoietic support for metastatic breast cancer: no improvement in outcomes compared with single-course high-dose therapy. 
  • Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. 
  • HTLV-III seroconversion associated with heat-treated factor VIII concentrate. 
  • Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. 
  • Hemolytic anemia secondary to modified blalock-taussig shunt. 
  • Hemolytic transfusion reactions caused by failure of commercial antiglobulin reagents to detect complement. 
  • Hemostasis using a bipolar sealer in primary unilateral total knee arthroplasty. 
  • Hepatitis C infection in children with hemophilia A and B. 
  • Hereditary angioedema: the clinical syndrome and its management. 
  • Hereditary angioedema: the use of fresh frozen plasma for prophylaxis in patients undergoing oral surgery. 
  • High prevalence of malaria parasitemia and anemia among hospitalized children in Rakai, Uganda. 
  • High-dose intravenous immunoglobulin for severe platelet alloimmunization. 
  • Hip arthroplasty after extracapsular hip fracture: a matched pair cohort analysis. 
  • How I use fibrinogen replacement therapy in acquired bleeding. 
  • How do North Carolina prenatal care providers counsel and test pregnant women for HIV? Survey measures knowledge of HIV testing benefits. 
  • How do we develop and implement a preoperative anemia clinic designed to improve perioperative outcomes and reduce cost? 
  • Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells. 
  • Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. 
  • Hydroxyurea: an alternative to transfusion therapy for stroke in sickle cell anemia. 
  • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. 
  • Immune hemolytic transfusion reactions in monkeys: activation of the kallikrein system. 
  • Immunoreconstitution. 
  • Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia. 
  • Impact of perioperative allogeneic and autologous blood transfusion on acute wound infection following total knee and total hip arthroplasty. 
  • Impact of preoperative neurological status on perioperative morbidity associated with anterior and posterior cervical fusion. 
  • Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. 
  • Implications of bleeding and blood transfusion in percutaneous coronary intervention. 
  • In vivo and in vitro characteristics of double units of RBCs collected by apheresis with a single in-line WBC-reduction filter. 
  • International variation in the use of blood transfusion in patients with non-ST-segment elevation acute coronary syndromes. 
  • Intraoperative autotransfusion in aortic surgery. 
  • Intraoperative fluid management during orthotopic liver transplantation. 
  • Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations. 
  • Invited commentary. 
  • Is old blood bad blood? 
  • Is there a transfusion effect in combined pancreas-kidney transplantation? 
  • Isoantibody specificity in post-transfusion purpura. 
  • Jehovah's Witnesses and cardiac surgery: a single institution's experience. 
  • Knowledge of hepatitis C virus screening in long-term pediatric cancer survivors: a report from the Childhood Cancer Survivor Study. 
  • Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies. 
  • Left hepatic trisectionectomy for hepatobiliary malignancy: results and an appraisal of its current role. 
  • Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. 
  • Leukocyte-reduced blood transfusions: perioperative indications, adverse effects, and cost analysis. 
  • Liver abscess following exchange transfusion for erythroblastosis fetalis. 
  • Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation. 
  • Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large-dose regimen. 
  • Malnutrition in liver transplant patients: preoperative subjective global assessment is predictive of outcome after liver transplantation. 
  • Management of abdominal aortic graft complications. 
  • Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial. 
  • Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. 
  • Many, but not all, outcome studies support exclusion of female plasma from the blood supply. 
  • Massive transfusion exceeding 50 units of blood products in trauma patients. 
  • Maternal outcomes associated with planned vaginal versus planned primary cesarean delivery. 
  • Morbidity and mortality after pancreaticoduodenectomy in patients with borderline resectable type C clinical classification. 
  • Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies. 
  • Multivariate analysis of donor-specific versus random transfusion protocols in haploidentical living-related transplants. 
  • Neonatal alloimmune thrombocytopenic purpura. 
  • Non-A, non-B hepatitis and chronic dialysis--another dilemma. 
  • Oral manifestations and dental management of patients with hereditary angioedema. 
  • Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. 
  • Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. 
  • Patients' attitudes regarding out-of-hospital blood transfusion. 
  • Percent body fat more associated with perioperative risks after total joint arthroplasty than body mass index. 
  • Perflubron emulsion (AF0144) augments harvesting of autologous blood: a phase II study in cardiac surgery. 
  • Perioperative Optimization of Geriatric Lower Extremity Bypass in the Era of Increased Performance Accountability. 
  • Perioperative Outcomes and Management in Pediatric Complex Cranial Vault Reconstruction: A Multicenter Study from the Pediatric Craniofacial Collaborative Group. 
  • Perioperative adverse events after minimally invasive abdominal sacrocolpopexy. 
  • Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. 
  • Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation. 
  • Physiologic correlates of intraoperative blood transfusion among patients undergoing major gastrointestinal operations. 
  • Plasma therapy in immunodeficiency diseases. 
  • Plasma therapy in immunodeficiency diseases. 
  • Plasma volume and sulfate spaces in acute combat casualties. 
  • Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG (TARGET-CABG) study. 
  • Practice pattern variability for myocardial revascularization: impact on resource use across 24 centers. 
  • Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation. 
  • Pregnancy associated with paroxysmal nocturnal hemoglobinuria. 
  • Preoperative coagulation testing on a gynecologic oncology service. 
  • Preoperative transarterial embolization of spinal column neoplasms. 
  • Prevalence of HTLV-I-associated T-cell lymphoma. 
  • Prevention and diagnosis of delayed haemolytic transfusion reactions. 
  • Prevention and treatment of coagulopathy in patients receiving massive transfusions. 
  • Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. 
  • Principles and problems of transfusion in sickle cell disease. 
  • Pro: low central venous pressure during liver transplantation--not too low. 
  • Prophylactic correction of the international normalized ratio in neurosurgery: a brief review of a brief literature. 
  • Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. 
  • Protocol adherence when managing massive bleeding following complex cardiac surgery: a study design pilot. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Recombinant activated factor VIIa treatment for refractory hemorrhage in infants. 
  • Red cell antigens as functional molecules and obstacles to transfusion. 
  • Reduction in blood transfusion in a cohort of infants having cardiac surgery with cardiopulmonary bypass after instituting a goal-directed transfusion policy. 
  • Reductions in blood loss with a bipolar sealer in total hip arthroplasty. 
  • Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. 
  • Renal allograft cell infiltrates associated with irreversible rejection. 
  • Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion. 
  • Results and morbidity of percutaneous nephrolithotripsy. 
  • Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history. 
  • S-nitrosylation therapy to improve oxygen delivery of banked blood. 
  • Safeguarding the administration of high-dose chemotherapy: a national practice survey by the American Society for Blood and Marrow Transplantation. 
  • Safety and antiplatelet effect of murine monoclonal antibody 7E3 Fab directed against platelet glycoprotein IIb/IIIa in patients undergoing elective coronary angioplasty. 
  • Serological evidence of cross infection in a dialysis unit hepatitis-B epidemic. 
  • Serum enzyme alterations after extensive surgical procedures. 
  • Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. 
  • Shear stress-associated acquired von Willebrand syndrome in patients with mitral regurgitation. 
  • Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts. 
  • Six-month follow-up of patients with in-hospital thrombocytopenia during heparin-based anticoagulation (from the Complications After Thrombocytopenia Caused by Heparin [CATCH] registry). 
  • Spontaneous adrenal hemorrhage with associated masses: etiology and management in 6 cases and a review of 133 reported cases. 
  • Storage age of transfused platelets and outcomes after cardiac surgery. 
  • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. 
  • Successful surgical outcome in children with sickle hemoglobinopathies: the Duke University experience. 
  • Supportive care of the marrow transplant recipient: the Seattle Experience. 
  • Systemic loxoscelism in a nonendemic area: a diagnostic challenge for the unsuspecting physician. 
  • The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. 
  • The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. 
  • The association of rapid volume expansion and intraventricular hemorrhage in the preterm infant. 
  • The cellular basis of traumatic bleeding. 
  • The clinical manifestations of cerebral malaria among Nigerian children with the sickle cell trait. 
  • The clinical significance of blood transfusion at the time of radical hysterectomy. 
  • The economic burden of anemia in cancer patients receiving chemotherapy. 
  • The effects of donor-specific blood transfusion enhancement of rat renal allografts on cytotoxic activity and phenotypes of peripheral blood lymphocytes, splenocytes, and graft-infiltrating cells. 
  • The effects of donor-specific blood transfusion enhancement of rat renal allografts on host NK cell responses. 
  • The implementation and efficacy of the Northwestern High Risk Spine Protocol. 
  • The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative. 
  • The influence of pretransplant transfusions, using different blood products, on patient sensitization and renal allograft survival. 
  • The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients. 
  • The relationship between transfusion and hypoxemia in combat casualties. 
  • The relationship of transfusion and presensitization with graft and patient survival. 
  • The role of RT1.a major histocompatibility antigens in prolonging the survival of hepatic allografts in the rat. 
  • The role of aprotinin in a blood-conservation program. 
  • The role of class I major histocompatibility complex antigens in prolonging the survival of hepatic allografts in the rat. 
  • The selection and evaluation of new chelating agents for the treatment of iron overload. 
  • The transfusion problem: role of aberrant S-nitrosylation. 
  • Time to coronary angiography and outcomes among patients with high-risk non ST-segment elevation acute coronary syndromes: results from the SYNERGY trial. 
  • Total blood transfusion and mortality after orthotopic liver transplantation. 
  • Total shoulder arthroplasty in patients with HIV infection: complications, comorbidities, and trends. 
  • Transfusion management in sickle cell disease. 
  • Transfusion of sickle cells may be a therapeutic option for patients suffering metastatic disease. 
  • Transfusion practice and outcomes in non-ST-segment elevation acute coronary syndromes. 
  • Transfusion practices for patients with sickle cell disease at a major academic medical center. 
  • Transfusion-related acute lung injury (TRALI) complicating colectomy for ulcerative colitis. 
  • Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease. 
  • Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model. 
  • Transplantation for polycystic kidney disease. 
  • Trends in anemia care in older patients approaching end-stage renal disease in the United States (1995-2010). 
  • Two cases of transfusion-associated graft-vs-host disease after open heart surgery. 
  • Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. 
  • Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest. 
  • Variation in Warfarin Use at Hospital Discharge After Isolated Bioprosthetic Mitral Valve Replacement: An Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database. 
  • Vincristine therapy for severe platelet alloimmunization. 
  • Visual loss after spine surgery: a population-based study. 
  • What Is the PROPPR Transfusion Strategy in Trauma Resuscitation? 
  • When clinical medicine collides with religion. 
  • Why do secondary cadaver renal transplants succeed? Results of the South-Eastern Organ Procurement Foundation prospective study, 1977-1982. 
  • Will submandibular TCD prevent stroke in children with sickle cell anemia? 
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  Keywords of People

  • Abbruzzese, James, Charles Johnson, M.D. Professor of Medicine, Medicine, Medical Oncology
  • Attarian, David Edward, Professor of Orthopaedic Surgery, Orthopaedics
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hoffman, Maureane Richardson, Professor of Pathology, Immunology
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery
  • Reed, Shelby Derene, Professor in Population Health Sciences, Duke Cancer Institute
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Zennadi, Rahima, Associate Professor in Medicine, Medicine, Hematology