Blood-Brain Barrier

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  Subject Areas on Research

  • A mechanism underlying the lack of a blood-brain barrier to peroxidase in virally induced brain tumors. 
  • A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke. 
  • A new model of the blood--brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions. 
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. 
  • ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. 
  • Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS. 
  • Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. 
  • Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles. 
  • Analytical and biological methods for probing the blood-brain barrier. 
  • Anatomic applications of xenon-enhanced CT scanning: visual image analysis and brain-blood partition coefficient studies in man. 
  • Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study. 
  • Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury. 
  • Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease. 
  • Applications of monoclonal antibodies in the diagnosis and treatment of primary brain tumors. 
  • Applications of nanotechnology to imaging and therapy of brain tumors. 
  • Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice. 
  • Blood-brain barrier disruption in immature Fischer 344 rats. 
  • Blood-brain barrier dysfunction after primary blast injury in vitro. 
  • Blood-brain barrier permeability and cognitive dysfunction after surgery - A pilot study. 
  • Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. 
  • Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes. 
  • Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. 
  • Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers. 
  • Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. 
  • Brain immunology and immunotherapy in brain tumours. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • Brain metastases in breast cancer. 
  • Breaking barriers in postoperative delirium. 
  • Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. 
  • Cerebral glucose transport and metabolism in preterm human infants. 
  • Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia. 
  • Chemotherapy of brain tumors. 
  • Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations. 
  • Cognitive dysfunction after cardiac surgery: revisiting etiology. 
  • Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers. 
  • Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats. 
  • Comparison of [125I]HIPDm and [125I]iodoantipyrine in quantifying regional cerebral blood flow in rats. 
  • Comparison of various methods for delivering radiolabeled monoclonal antibody to normal rat brain. 
  • Competitive apnea and its effect on the human brain: focus on the redox regulation of blood-brain barrier permeability and neuronal-parenchymal integrity. 
  • Complement activation contributes to perioperative neurocognitive disorders in mice. 
  • Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. 
  • Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. 
  • Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. 
  • Convection-enhanced delivery of therapeutics for brain disease, and its optimization. 
  • Correlation of neuropathologic findings, computerized tomographic and high-resolution ultrasound scans of canine avian sarcoma virus-induced brain tumors. 
  • Correlation of relative permeability and relative cerebral blood volume in high-grade cerebral neoplasms. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain. 
  • Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. 
  • Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. 
  • Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. 
  • Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. 
  • Development of an in vitro blood-brain barrier. 
  • Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. 
  • Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein. 
  • Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. 
  • Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury. 
  • Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. 
  • Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases. 
  • Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. 
  • Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. 
  • Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in malignant brain tumors: the Sherbrooke experience. 
  • Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. 
  • Experimental allergic encephalomyelitis in Lewis rats bearing avian sarcoma virus-induced brain tumors. 
  • Fluorescence imaging of blood-brain barrier disruption. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI. 
  • Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans. 
  • Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization. 
  • Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis. 
  • Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. 
  • Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication. 
  • Imaging of convection enhanced delivery of toxins in humans. 
  • Immunotherapy of malignant brain tumors. 
  • Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. 
  • In vivo imaging of intracranial human glioma xenografts comparing specific with nonspecific radiolabeled monoclonal antibodies. 
  • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. 
  • Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B. 
  • Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage. 
  • Innovations in design and delivery of chemotherapy for brain tumors. 
  • Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice. 
  • Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. 
  • L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. 
  • Laser ablation: Heating up the anti-tumor response in the intracranial compartment. 
  • Leukaemia hijacks a neural mechanism to invade the central nervous system. 
  • Long-term safety of combined intracerebral delivery of free gadolinium and targeted chemotherapeutic agent PRX321. 
  • Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma. 
  • Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier. 
  • Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. 
  • Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. 
  • MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats. 
  • Microvascular abnormalities in virally-induced canine brain tumors. Structural bases for altered blood-brain barrier function. 
  • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. 
  • Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses. 
  • Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. 
  • Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Mouse Glioblastoma Model. 
  • Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect. 
  • Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages. 
  • Neuroinflammation after surgery: from mechanisms to therapeutic targets. 
  • Neuroinflammation and Perioperative Neurocognitive Disorders. 
  • Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage. 
  • Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage. 
  • Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia. 
  • Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. 
  • Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. 
  • PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma? 
  • Pathophysiology of the blood-brain barrier: animal models and methods. 
  • Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging. 
  • Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. 
  • Prolonged Blood-Brain Barrier Disruption Following Laser Interstitial Ablation in Epilepsy: A Case Series with a Case Report of Postablation Optic Neuritis. 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice. 
  • Proteomic and immunologic analyses of brain tumor exosomes. 
  • RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors. 
  • Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. 
  • Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. 
  • Recent advances in the treatment of pediatric brain tumors. 
  • Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. 
  • Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. 
  • Regulation of cerebral glucose metabolism. 
  • Repeated primary blast injury causes delayed recovery, but not additive disruption, in an in vitro blood-brain barrier model. 
  • SERS nanosensors and nanoreporters: golden opportunities in biomedical applications. 
  • Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis. 
  • Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay. 
  • Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. 
  • Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats. 
  • Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice. 
  • Sympathohippocampal neurons are inside the blood--brain barrier. 
  • Syndecan-1 facilitates breast cancer metastasis to the brain. 
  • Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases. 
  • Targeted delivery in primary and metastatic brain tumors: summary report of the seventh annual meeting of the Blood-Brain Barrier Disruption Consortium. 
  • Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury. 
  • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. 
  • Technical modification in the intracarotid chemotherapy and osmotic blood-brain barrier disruption procedure to prevent the relapse of carboplatin-induced orbital pseudotumor. 
  • Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. 
  • The Evolving Modern Management of Brain Metastasis. 
  • The Preuss Foundation Seminar on vaccine therapy for malignant primary brain tumors. February 15-17, 1998, La Jolla, Calif. 
  • The blood-brain barrier/neurovascular unit in health and disease. 
  • The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. 
  • The impact of chronic blood-brain barrier breach on intracortical electrode function. 
  • The impact of modulating the blood-brain barrier on the electrophysiological and histological outcomes of intracortical electrodes. 
  • The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. 
  • The potential link between obstructive sleep apnea and postoperative neurocognitive disorders: current knowledge and possible mechanisms. 
  • The potential of monoclonal antibodies as carriers of radiation and drugs for immunodetection and therapy of brain tumors. 
  • The role of blood-brain barrier permeability in brain tumor imaging and therapeutics. 
  • Therapeutic approaches for HER2-positive brain metastases: circumventing the blood-brain barrier. 
  • Therapeutic strategies to improve drug delivery across the blood-brain barrier. 
  • Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening. 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Time Course and Size of Blood-Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury. 
  • Time until incident dementia among Medicare beneficiaries using centrally acting or non-centrally acting ACE inhibitors. 
  • Tissue linkage through adjoining basement membranes: The long and the short term of it. 
  • Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit. 
  • Treatment and prophylaxis of invasive candidiasis. 
  • Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle. 
  • Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma. 
  • Type III Interferons in Antiviral Defenses at Barrier Surfaces. 
  • Ultrasonic disruption of the blood-brain barrier enables in vivo functional mapping of the mouse barrel field cortex with manganese-enhanced MRI. 
  • Ultrasound-mediated drug delivery. 
  • Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. 
  • Vasoactive drugs produce selective changes in flow to experimental brain tumors. 
  • [Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila]. 
  • rAAV-compatible MiniPromoters for restricted expression in the brain and eye. 
  • αB-crystallin: a novel regulator of breast cancer metastasis to the brain. 
  • β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability. 
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  Keywords of People

  • Devinney, Michael, Assistant Professor of Anesthesiology, Anesthesiology, Critical Care Medicine
  • Fecci, Peter Edward, Professor of Neurosurgery, Biomedical Engineering
  • James, Michael Lucas, Professor of Anesthesiology, Anesthesiology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • Nightingale, Kathryn Radabaugh, Theo Pilkington Distinguished Professor of Biomedical Engineering, Biomedical Engineering
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Terrando, Niccolò, Associate Professor of Anesthesiology, Cell Biology