Bone Development

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  Subject Areas on Research

  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A study of calcium deposition in the skeleton of a dog using autoradiography. 
  • A survey of orthopaedic traumatologists concerning the use of bone growth stimulators. 
  • A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. 
  • APPOSITIONAL BONE FORMATION IN CANINE BONE: A QUANTITATIVE MICROSCOPIC STUDY USING TETRACYCLINE MARKERS. 
  • Altered skeletal maturation in moderate to severe cerebral palsy. 
  • An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. 
  • Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta). 
  • Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • Beta-catenin in the race to fracture repair: in it to Wnt. 
  • Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. 
  • Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix. 
  • Bone metabolism in childhood rheumatic disease. 
  • Bone mineral status in juvenile rheumatoid arthritis. 
  • Bone outcomes and technical measurement issues of bone health among children and adolescents: considerations for nutrition and physical activity intervention trials. 
  • Cartilage as an interposition material to prevent transphyseal bone bridge formation: an experimental model. 
  • Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. 
  • Delayed transition to new cell fates during cellular reprogramming. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Developmental pathways in musculoskeletal neoplasia: involvement of the Indian Hedgehog-parathyroid hormone-related protein pathway. 
  • Don't hedge your bets: hedgehog signaling as a central mediator of endochondral bone development and cartilage diseases. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Evidence of weaning stress and catch-up growth in the long bones of a central California Amerindian sample. 
  • Expression of genes for non-collagenous proteins during embryonic bone formation. 
  • Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant. 
  • Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha. 
  • Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. 
  • HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. 
  • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. 
  • Increasing weight-bearing physical activity and calcium intake for bone mass growth in children and adolescents: a review of intervention trials. 
  • Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. 
  • Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation. 
  • Low bone mass in behaviorally HIV-infected young men on antiretroviral therapy: Adolescent Trials Network Study 021B. 
  • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. 
  • Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3. 
  • Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development. 
  • Osteoporosis. 
  • Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. 
  • Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton. 
  • Parathyroid hormone-related protein regulates glioma-associated oncogene transcriptional activation: lessons learned from bone development and cartilage neoplasia. 
  • Plastic deformation in pediatric fractures: mechanism and treatment. 
  • Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice. 
  • Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach. 
  • Spinal bone density following spinal fusion. 
  • Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment. 
  • The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). 
  • Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density. 
  • Triiodothyronine stimulates maturation of porcine growth-plate cartilage in vitro. 
  • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. 
  • Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology