Boranes

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  Subject Areas on Research

  • Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. 
  • Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Borane-amine complexes--versatile reagents in the chemistry of nucleic acids and their analogs. 
  • Boranophosphates as mimics of natural phosphodiesters in DNA. 
  • Boron-containing oligodeoxyribonucleotide 14mer duplexes: enzymatic synthesis and melting studies. 
  • High potency silencing by single-stranded boranophosphate siRNA. 
  • Incorporation of ribonucleoside 5'-(alpha-P-borano)triphosphates into a 20-mer RNA by T7 RNA polymerase. 
  • Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design. 
  • One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: a potential prodrug candidate. 
  • Phenylalanine hydroxylase activity in mammalian cells. 
  • Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA. 
  • Synthesis and properties of novel triphosphate analogues: ribonucleoside and deoxyribonucleoside (alpha-P-borano, alpha-P-thio)triphosphates. 
  • Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate. 
  • Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide. 
  • Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates. 
  • The effect of a single boranophosphate substitution with defined configuration on the thermal stability and conformation of a DNA duplex. 
  • The synthesis and antineoplastic activity of 2'-deoxy-nucleoside-cyanoboranes in murine and human culture cells. 
  • Versatility of borane nucleic acids mimics for coding, decoding and modulating genetic information.