Boron Compounds

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  Subject Areas on Research

  • "Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomonophosphate as a Potential Thymidylate Synthase Inhibitor" 
  • Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. 
  • Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice. 
  • Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway. 
  • Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. 
  • Boranophosphate nucleic acids--a versatile DNA backbone. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Cholecystokinin excites interneurons in rat basolateral amygdala. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Conformational ensemble of the human TRPV3 ion channel. 
  • Conformational studies of dithymidine boranomonophosphate diastereoisomers. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Enantioselective diene Cyclization/Hydrosilylation catalyzed by optically active palladium bisoxazoline and pyridine-oxazoline complexes. 
  • Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles. 
  • Expression level is a key determinant of E2F1-mediated cell fate. 
  • Gamma-L-glutaminyl-3,4-benzoquinone. Structural studies and enzymatic synthesis. 
  • Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. 
  • Inflammatory linear verrucous epidermal nevus treated successfully with crisaborole ointment in a 5-year-old boy. 
  • Inhibition of endothelial activation: a new way to treat cerebral malaria? 
  • Introduction of the alpha-P-borano-group into deoxynucleoside triphosphates increases their selectivity to HIV-1 reverse transcriptase relative to DNA polymerases. 
  • LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A. 
  • LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells. 
  • Luminescent Difluoroboron β-Diketonate PLA-PEG Nanoparticle. 
  • Luminescent difluoroboron β-diketonate PEG-PLA oxygen nanosensors for tumor imaging. 
  • Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress. 
  • Multicolor in vitro translation. 
  • N7-cyanoborane-2'-deoxyguanosine 5'-triphosphate is a good substrate for DNA polymerase. 
  • Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate. 
  • Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies. 
  • Pore region of TRPV3 ion channel is specifically required for heat activation. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • RNA interference using boranophosphate siRNAs: structure-activity relationships. 
  • RNase H activation by stereoregular boranophosphate oligonucleotide. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Studies on base-boronated oligonucleotides. 2 (1). Incompatibility of DMT and cyanoborane groups during oligonucleotide synthesis. 
  • Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate. 
  • Synthesis of 5-(1-propynyl)-2'-deoxyuridine 5'-(alpha-P-borano)triphosphate and kinetic characterization as a substrate for mmlv reverse transcriptase. 
  • Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease. 
  • Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. 
  • Synthesis of new classes of boron-containing nucleotides. 
  • Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids. 
  • Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection. 
  • The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation. 
  • The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. 
  • Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology