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Subject Areas on Research
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2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans.
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4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors.
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5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression.
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A default mode of brain function.
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A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.
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A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease.
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A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin.
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A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs.
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A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors.
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A simple method for processing NMR spectra in which acquisition is delayed: applications to in vivo localized 31P NMR spectra acquired using the DRESS technique.
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A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration.
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Acquiring local field potential information from amperometric neurochemical recordings.
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Acute 5-HT reuptake blockade potentiates human amygdala reactivity.
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Acute stroke: evaluation with serial proton MR spectroscopic imaging.
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Adhesion between cerebroside bilayers.
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Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase.
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Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
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Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy.
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Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.
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Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
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Amine-aldehyde metabolites and alcoholism: fact, myth or uncertainty.
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An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves.
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Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems.
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Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
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Anxiety-like behaviors in mice lacking GIT2.
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Applications of a rat multiple tissue gene expression data set.
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Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.
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Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults.
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Association of brain ankyrin with brain membranes and isolation of active proteolytic fragments of membrane-associated ankyrin-binding protein(s).
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Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide.
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Atypical developmental patterns of brain chemistry in children with autism spectrum disorder.
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Autoimmunity to munc-18 in Rasmussen's encephalitis.
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Automated whole-brain N-acetylaspartate proton MRS quantification.
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Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain.
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Autoradiographic localization of benzomorphan binding sites in rat brain.
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Behavioral and neurochemical changes in folate-deficient mice.
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Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate.
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Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset.
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Behavioral and neurochemical effects of acute chlorpyrifos in rats: tolerance to prolonged inhibition of cholinesterase.
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Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.
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Biochemical and neuropathological assessment of triphenyl phosphite in rats.
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Brain Arachidonic Acid Incorporation and Turnover are not Altered in the Flinders Sensitive Line Rat Model of Human Depression.
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Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
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Brain and central haemodynamics and oxygenation during maximal exercise in humans.
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Brain catecholamines and memory modulation: effects of footshock, amygdala implantation, and stimulation.
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Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.
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Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia.
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Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin.
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Brain spectrin. Isolation of subunits and formation of hybrids with erythrocyte spectrin subunits.
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CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.
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Carbon monoxide actuates O(2)-limited heme degradation in the rat brain.
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Central nervous system distribution of inhaled toluene.
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Cerebral cortical microfluorometry at isosbestic wavelengths for correction of vascular artifact.
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Cerebral physiology in dogs after brain-tumor induction with Schmidt-Ruppin Rous sarcoma virus: experiences with radioiodinated normal and antiviral immunoglobulin G.
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Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage.
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Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.
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Cholinergic and adrenergic activating agents as antagonists of the EEG effects of hemicholinium-3.
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Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.
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Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.
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Clinical applications of neuroimaging in psychiatry.
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Cloning of DNA corresponding to rare transcripts of rat brain: evidence of transcriptional and post-transcriptional control and of the existence of nonpolyadenylated transcripts.
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Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.
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Comparison of PET oxygen extraction fraction methods for the prediction of stroke risk.
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Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos.
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Complexity of cytoplasmic polyadenylated and nonpolyadenylated rat brain ribonucleic acids.
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Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity.
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Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain.
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Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase.
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Controlling for activity-dependent genes and behavioral states is critical for determining brain relationships within and across species.
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Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats.
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Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.
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Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.
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Depletion of brain amines reverses blood pressure response to footshock in rat.
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Detection in human serum by radioimmunoassay of histidyl-proline diketopiperazine, a metabolite of thyrotropin-releasing hormone.
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Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.
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Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.
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Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?
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Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain.
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Differential localization of cholecystokinin-8 binding sites in the rat vs. the guinea pig brain.
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Differential time-course profiles of dopamine release and uptake changes induced by three dopamine uptake inhibitors.
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Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry.
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Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice.
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Distribution of brain iron accrual in adolescence: Evidence from cross-sectional and longitudinal analysis.
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Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
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Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.
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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
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Effect of blood pressure on A2 noradrenergic neurons.
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Effect of feeding plant proteins on plasma, liver, heart, aorta and brain lipids of rats.
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Effects of ELF fields on calcium-ion efflux from brain tissue in vitro.
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Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat.
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Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain.
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Effects of magnesium on the dynamic instability of individual microtubules.
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Effects of neonatal methylmercury exposure on development of nucleic acids and proteins in rat brain: regional specificity.
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Effects of physostigmine on rat brain acetylcholine, acetylcholinesterase and conditioned pole jumping.
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Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps.
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Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
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Electron microscopy of MAP 2 (microtubule-associated protein 2).
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Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.
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Exaggerated CpH methylation in the autism-affected brain.
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Exposure to environmental tobacco smoke during pregnancy in rats yields less effect on indices of brain cell number and size than does postnatal exposure.
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Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
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Expression of statin, a non-proliferation-dependent nuclear protein, in the postnatal rat brain: evidence for substantial retention of neuroglial proliferative capacity with aging.
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Expression of terminin in the rat brain during neuronal differentiation.
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Expression of terminin, a senescence-related cytoplasmic protein, in the aging rat brain.
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Expression of the non-proliferation-specific protein, statin, in grey matter neuroglia of the aging rat brain.
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Extensive changes in the expression of the opioid genes between humans and chimpanzees.
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Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology.
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Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors.
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Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders.
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Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.
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Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.
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G protein gamma subunits contain a 20-carbon isoprenoid.
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Generalized anxiety disorder: neurobiological and pharmacotherapeutic perspectives.
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Gray and white matter brain chemistry in young children with autism.
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Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
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High-performance liquid chromatography method for quantifying sphingomyelin in rat brain.
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Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.
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Human brain-structure resolved T(2) relaxation times of proton metabolites at 3 Tesla.
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Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier.
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Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.
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Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains.
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Identifying Synaptic Proteins by In Vivo BioID from Mouse Brain.
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Immunoreactive forms of erythrocyte spectrin and ankyrin in brain.
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Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain.
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Impaired Myelination in rats given excess vitamin A postnatally.
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In situ hybridization of adrenergic receptor mRNA in brain.
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In vivo measurement of regional brain tissue pH using positron emission tomography.
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Increased expression of p130 in Alzheimer disease.
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Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
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Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2.
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Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers.
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Is amyloid beta-protein glycated in Alzheimer's disease?
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Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes.
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Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity.
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Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
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Ligatin binds phosphohexose residues on acidic hydrolases.
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Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system.
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Linking variability in brain chemistry and circuit function through multimodal human neuroimaging.
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Lipid metabolism in hypervitaminosis A.
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Live imaging of mitosis in the developing mouse embryonic cortex.
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Localization and characterization of neuropeptide Y/peptide YY receptors in the brain of the smooth dogfish (Mustelis canis).
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Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology.
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Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.
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MR microscopy at 7.0 T: effects of brain iron.
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MRI of brain iron.
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Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models.
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Magnetic susceptibility of brain iron is associated with childhood spatial IQ.
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Manganese-porphyrin reactions with lipids and lipoproteins.
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Mercury-induced cognitive impairment in metallothionein-1/2 null mice.
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Metallothionein expression and neurocognitive function in mice.
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Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.
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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.
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Microglia, an in vivo source of reactive oxygen species in the brain.
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Microglial-neuronal interactions during neurodegenerative diseases.
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Microtubule surface lattice and subunit structure and observations on reassembly.
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Molecular taxonomy of major neuronal classes in the adult mouse forebrain.
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Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.
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Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
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N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.
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N-o-Methoxyphenylpiperazine: a simple blocker of dopaminergic receptors in the brain.
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Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.
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Neuronal cell death in Huntington's disease: a potential role for dopamine.
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Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
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Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure.
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Nicotine effects on learning in zebrafish: the role of dopaminergic systems.
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Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin.
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Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.
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Noninvasive optical inhibition with a red-shifted microbial rhodopsin.
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Novel localization of a G protein, Gz-alpha, in neurons of brain and retina.
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Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene.
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Obligatory role of thyroid hormones in development of peripheral sympathetic and central nervous system catecholaminergic neurons: effects of propylthiouracil-induced hypothyroidism on transmitter levels, turnover and release.
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Observation of coupled 1H metabolite resonances at long TE.
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Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue.
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Overexpression of androgen-binding protein/sex hormone-binding globulin in male transgenic mice: tissue distribution and phenotypic disorders.
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Peptide array X-linking (PAX): a new peptide-protein identification approach.
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Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.
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Perinatal dietary supplementation with a commercial soy lecithin preparation: effects on behavior and brain biochemistry in the developing rat.
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Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish.
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Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.
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Platelet mitochondrial complex I and I+III activities do not correlate with cerebral mitochondrial oxidative metabolism.
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Polyamine metabolism in different pathological states of the brain.
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Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status.
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Prediction of cognitive decline in early Alzheimer's disease.
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Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems.
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Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity.
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Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
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Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease.
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Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest.
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Proton magnetic resonance spectroscopy and gadolinium-DTPA perfusion imaging of asymptomatic MRI white matter lesions.
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Proton spectroscopy of human brain: effects of age and sex.
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Purification of G protein beta gamma from bovine brain.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380.
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Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference.
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Quantitative proton MR spectroscopic imaging of the human brain.
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Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations.
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Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain.
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Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.
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Rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbitone sodium.
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Reduced levels of human apoE4 protein in an animal model of cognitive impairment.
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Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats.
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Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain.
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Reproducibility of 3D proton spectroscopy in the human brain.
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Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain.
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Robust analysis of short echo time (1)H MRSI of human brain.
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Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
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Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.
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Sequence complexity of nuclear RNAs in adult rat tissues.
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Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat.
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Serial measurements of CT attenuation and specific gravity in experimental cerebral edema.
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Serotonin-lesion myoclonic syndromes. I. Neurochemical profile and S-1 receptor binding.
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Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.
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Sex differences in neurochemical effects of dopaminergic drugs in rat striatum.
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Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.
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Spectrin and ankyrin in brain.
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Steroid hormone induction of a specific translatable messenger RNA.
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Structure and cohesive properties of sphingomyelin/cholesterol bilayers.
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Synapsin I is a microtubule-bundling protein.
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T2 relaxation times of macromolecules and metabolites in the human brain at 9.4 T.
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TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.
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Tau induces formation of α-synuclein filaments with distinct molecular conformations.
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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
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The acute toxicity of drugs acting at cholinoceptive sites and twenty-four hour rhythms in brain acetylcholine.
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The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.
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The lens epithelium contains glial fibrillary acidic protein (GFAP).
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The spectrin skeleton: from red cells to brain.
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The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane.
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The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface.
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Toluene abuse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats.
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Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain.
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Transient postnatal elevation of norepinephrine content and turnover in brain regions of rats exposed to terbutaline prenatally: evidence for autoregulation of noradrenergic development?
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Twenty-four hour rhythms in the glycine content of rat hindbrain and spinal cord.
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Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats.
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Use of florbetapir-PET for imaging beta-amyloid pathology.
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Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge.
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Keywords of People
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Charles, Hal Cecil,
Adjunct Associate Professor in the Department of Radiology,
Radiology
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Erickson, Harold Paul,
James B. Duke Distinguished Professor Emeritus,
Cell Biology
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Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
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James, Michael Lucas,
Associate Professor of Anesthesiology,
Anesthesiology
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Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
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O'Connor, Christopher Michael,
Adjunct Professor in the Department of Medicine,
Medicine, Clinical Pharmacology
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Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology
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Wray, Gregory Allan,
Professor of Biology,
Evolutionary Anthropology