-
Subject Areas on Research
-
1999 update: ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction: Executive Summary and Recommendations: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction).
-
2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).
-
2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society.
-
A mathematical model for analysis of pharmacologically induced changes in the kinetics of cardiac muscle.
-
A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplasty.
-
Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.
-
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
-
Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
-
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.
-
Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury.
-
Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy.
-
Alternating hemiplegia of childhood.
-
Amlodipine in chronic heart failure.
-
Analysis of the risks associated with calcium channel blockade: implications for the obstetrician-gynecologist.
-
Antianginal medications and long-term outcomes after elective catheterization in patients with coronary artery disease.
-
Antihypertensive drug exposure in premature infants from 1997 to 2013.
-
Aspartate release from rat hippocampal synaptosomes.
-
Association Between Change in Central Nocturnal Blood Pressure and Urine Albumin-Creatinine Ratio by a Valsartan/Amlodipine Combination: A CPET Study.
-
Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs.
-
Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
-
Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+.
-
CLINICAL PRACTICE. Chronic Stable Angina.
-
Calcium antagonists and good results: association or causation?
-
Calcium antagonists: new therapy for congestive heart failure?
-
Calcium channel blockers and cancer.
-
Calcium channel blockers and mortality in elderly patients with myocardial infarction.
-
Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers.
-
Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.
-
Characteristics of treated hypertension in incident hemodialysis and peritoneal dialysis patients.
-
Cholecystokinin excites interneurons in rat basolateral amygdala.
-
Cilostazol to overcome high on-treatment platelet reactivity in korean patients treated with clopidogrel and calcium-channel blocker.
-
Circadian rhythm and sudden death in heart failure: results from Prospective Randomized Amlodipine Survival Trial.
-
Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1.
-
Clevidipine in adult cardiac surgical patients: a dose-finding study.
-
Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials.
-
Clevidipine rapidly and safely reduces blood pressure in acute intracerebral hemorrhage: the ACCELERATE trial.
-
Clinical Practice Guideline for the Management of Anal Fissures.
-
Clinical features and contemporary management of patients with low and preserved ejection fraction heart failure: baseline characteristics of patients in the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) programme.
-
Clinically important drug-disease interactions and their prevalence in older adults.
-
Combinations of beta-blockers and calcium channel blockers: a cause of malignant perioperative conduction disturbances?
-
Comparative effectiveness of pharmacotherapies for prevention of atrial fibrillation following coronary artery bypass surgery.
-
Comparison of intermittent versus continuous infusion antihypertensives in acute ischemic stroke.
-
Congestive heart failure.
-
Contrast nephrotoxicity.
-
Delayed right heart failure following lung transplantation.
-
Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells.
-
Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein.
-
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
-
Diltiazem as an alternative to beta-blocker in coronary artery computed tomography angiography.
-
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.
-
Editorial comment. The value of intensive medical management of distal ureteral calculi in an effort to facilitate spontaneous stone passage.
-
Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial. Prospective Randomized Amlodipine Survival Evaluation.
-
Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group.
-
Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2).
-
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
-
Effect of cocaine on intracellular calcium regulation in myometrium from pregnant women.
-
Effect of isradipine on cardiopulmonary baroreflex function, regional blood flow, and vascular responsiveness in hypertensive patients.
-
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial.
-
Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats.
-
Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.
-
Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.
-
Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).
-
Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
-
Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial.
-
Electrophysiological correlates of secretion in normal human parathyroid cells.
-
Endovascular management of cerebral vasospasm following aneurysm rupture: outcomes and predictors in 116 patients.
-
Ethacizin blockade of calcium channels: a test of the guarded receptor hypothesis.
-
Evolution of the clinical management of hypertension. Emerging role of "specific" vasodilators as initial therapy.
-
Extracellular Ca2+ mobilization in potential-dependent contraction of trachealis of maturing swine.
-
Good news for experimental concept but bad news for clinically effective therapy.
-
Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review.
-
Heart Failure and Atrial Fibrillation, Like Fire and Fury.
-
High-performance liquid chromatographic analysis of diltiazem and its metabolite in plasma.
-
High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
-
Hospital use and costs among patients with nonischemic cardiomyopathy in the first prospective randomized amlodipine survival evaluation study.
-
Hyperhidrosis in social anxiety disorder.
-
Hypertension Update: Hypertensive Emergency and Asymptomatic Severe Hypertension.
-
Hypertension Update: Resistant Hypertension.
-
Hypertension and diabetes and the Fosinopril versus Amlodipine Cardiovascular Events Trial (FACET). More ammunition against surrogate end points.
-
Identification of the components controlling inactivation of voltage-gated Ca2+ channels.
-
Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.
-
Improving the assessment of heart toxicity for all new drugs through translational regulatory science.
-
Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
-
Initial therapy of hypertension.
-
Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.
-
Intravenous nisoldipine in severe congestive heart failure.
-
Is rhythm control superior to rate control in patients with atrial fibrillation and congestive heart failure?
-
Is rhythm-control superior to rate-control in patients with atrial fibrillation and diastolic heart failure?
-
L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
-
Limiting impairment of muscle function following ischemia and reperfusion in rabbits.
-
Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth.
-
Lovastatin and coadministered antihypertensive/cardiovascular agents.
-
Luminal CCK-releasing factor stimulates CCK release from human intestinal endocrine and STC-1 cells.
-
Magnesium sulfate inhibits the oxytocin-induced production of inositol 1,4,5-trisphosphate in cultured human myometrial cells.
-
Management of Coronary Disease in Patients with Advanced Kidney Disease.
-
Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial.
-
Mechanisms of apparent affinity variation of guarded receptors.
-
Medical Expulsive Therapy is Useful for Urinary Calculi.
-
Medical approaches to prevention of restenosis after coronary angioplasty.
-
Medical therapy of stone disease: from prevention to promotion of passage options.
-
Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.
-
Misperceptions about beta-blockers and diuretics: a national survey of primary care physicians.
-
Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.
-
Myogenic constriction of human coronary arterioles.
-
Ocular melanoma in a Long Evans rat.
-
On the mechanism of action of antiarrhythmic agents.
-
Outpatient use of anticoagulants, rate-controlling drugs, and antiarrhythmic drugs for atrial fibrillation.
-
Parathyroid Hormone and the Use of Diuretics and Calcium-Channel Blockers: The Multi-Ethnic Study of Atherosclerosis.
-
Pharmacological and emerging therapies in the treatment of chronic angina.
-
Pharmacotherapy in Medicare beneficiaries with atrial fibrillation.
-
Pinaverium in Irritable Bowel Syndrome: Old Drug, New Tricks?
-
Postcoronary thrombolysis management.
-
Potential impact of evidence-based medicine in acute coronary syndromes: insights from GUSTO-IIb. Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes trial.
-
Predictors of survival after cardiac arrest in outpatient hemodialysis clinics.
-
Quality of life after coronary angioplasty or continued medical treatment for angina: three-year follow-up in the RITA-2 trial. Randomized Intervention Treatment of Angina.
-
Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats.
-
Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission.
-
Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.
-
Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels.
-
Relationship between heart failure treatment and development of worsening renal function among hospitalized patients.
-
Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.
-
Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999.
-
Rhythm versus rate control in the contemporary management of atrial fibrillation in-hospital.
-
Role of cytokines in the mechanism of action of amlodipine: the PRAISE Heart Failure Trial. Prospective Randomized Amlodipine Survival Evaluation.
-
Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study.
-
Role of taste aversion in calcium channel inhibitor-induced suppression of saccharin and alcohol drinking in rats.
-
SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials.
-
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.
-
Safety of nifedipine in angina pectoris: a meta-analysis.
-
Safety of nifedipine in patients with hypertension: a meta-analysis.
-
Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
-
Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size.
-
Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage.
-
Strategies for preventing diabetic nephropathy.
-
Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438.
-
Synaptic activation of presynaptic glutamate transporter currents in nerve terminals.
-
Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.
-
The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.
-
The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients.
-
The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
-
The effect of ionised magnesium on coagulation using thromboelastography.
-
The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial.
-
The electrophysiological effects of calcium channel blockade during standard hyperkalemic hypothermic cardioplegic arrest.
-
The ideal agent for perioperative hypertension and potential cytoprotective effects.
-
The interaction among sex, hemoglobin and outcomes in a specialty heart failure clinic.
-
The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node.
-
The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension.
-
The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.
-
The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
-
The utility of cone beam volume CT in the evaluation of thrombosed intracranial aneurysms in subarachnoid hemorrhage.
-
The vasodilator effects of clevidipine on human internal mammary artery.
-
Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors.
-
Tocolysis: A Review of the Literature.
-
Tocolytic treatment for the management of preterm labor: a review of the evidence.
-
Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial.
-
Treatment of cerebral vasospasm after subarachnoid hemorrhage--a review.
-
Use of calcium channel antagonists in myocardial revascularization procedures.
-
Use of evidence-based medical therapy in patients undergoing percutaneous coronary revascularization in the United States, Europe, and Canada. Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I) and Canadian Coronary Atherectomy Trial (CCAT) investigators.
-
Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect.
-
What have we learned from the calcium channel blocker controversy?
-
Zofenopril after anterior myocardial infarction.
-
[Calcium antagonists in the treatment of heart failure. Re-evaluation of therapeutic strategies].
-
pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.
-
Keywords of People
-
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
-
Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology
-
O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology