Calcium-Binding Proteins

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  Subject Areas on Research

  • 1,25-Dihydroxyvitamin D3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry. 
  • 80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A cloned calmodulin structural gene probe is complementary to DNA sequences from diverse species. 
  • A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. 
  • A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. 
  • A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis. 
  • A novel haplotype-sharing approach for genome-wide case-control association studies implicates the calpastatin gene in Parkinson's disease. 
  • A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans. 
  • A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. 
  • A second leaky splice-site mutation in the spastin gene. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • AIF-1 in the activated smooth muscle cell : spectator or participant? 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants. 
  • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. 
  • Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. 
  • Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. 
  • Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins. 
  • Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation. 
  • Biology of vascular calcification in renal disease. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Calcium binding proteins distinguish large and small cells of the ventral posterior and lateral geniculate nuclei of the prosimian galago and the tree shrew (Tupaia belangeri). 
  • Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium, calmodulin and cell proliferation. 
  • Calcium-activated tenderization of strip loin, top sirloin, and top round steaks in diverse genotypes of cattle. 
  • Calcium-binding proteins define interneurons in HVC of the zebra finch (Taeniopygia guttata). 
  • Calcium-myristoyl switches turn on new lights. 
  • Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. 
  • Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. 
  • Calmodulin as a mediator of hormone action and cell regulation. 
  • Calmodulin in bovine rod outer segments. 
  • Calmodulin in endocrine cells and its multiple roles in hormone action. 
  • Calmodulin in endocrine cells. 
  • Calmodulin regulation during the cell cycle of mammalian cells. 
  • Calmodulin regulation of excitation-contraction coupling in cardiac myocytes. 
  • Calmodulin--an intracellular calcium receptor. 
  • Calmodulin-stimulated protein kinase activity from rat pancreas. 
  • Calmodulin. Development and application of a sensitive radioimmunoassay. 
  • Calmodulin: properties, intracellular localization, and multiple roles in cell regulation. 
  • Calpain-mediated AQP2 proteolysis in inner medullary collecting duct. 
  • Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. 
  • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. 
  • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. 
  • Caspase-1-induced pyroptotic cell death. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Cerebral emboli and serum S100beta during cardiac operations. 
  • Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). 
  • Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. 
  • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. 
  • Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum. 
  • Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 
  • Clinical performance and utility of a DNA methylation urine test for bladder cancer. 
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Coronary artery disease and the thrombospondin single nucleotide polymorphisms. 
  • Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. 
  • Crystallization and preliminary X-ray investigation of calmodulin. 
  • Crystallographic studies of calmodulin. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. 
  • Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Design of a calcium-binding protein with desired structure in a cell adhesion molecule. 
  • Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. 
  • Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. 
  • Down with doublespeak: NAIP/NLRC4 inflammasomes get specific. 
  • Effect of Mts1 on the structure and activity of nonmuscle myosin II. 
  • Effects of in vivo and in vitro production of lactic acid on ionized, protein-bound, and complex-bound calcium in blood. 
  • Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. 
  • Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. 
  • Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. 
  • Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass. 
  • Factors regulating islet regeneration in the post-insulinoma NEDH rat. 
  • Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. 
  • Function and regulation of calmodulin in endocrine cells. 
  • Functional domains of the human vitamin D3 receptor regulate osteocalcin gene expression. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. 
  • Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. 
  • Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways. 
  • Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. 
  • Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary. 
  • Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders. 
  • Hedgehog activity, epithelial-mesenchymal transitions, and biliary dysmorphogenesis in biliary atresia. 
  • Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis. 
  • Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. 
  • Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. 
  • Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. 
  • Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. 
  • Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. 
  • Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins. 
  • Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome. 
  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. 
  • Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. 
  • Interactions between dystrophin and the sarcolemma membrane. 
  • Interactions of calmodulin with coated vesicles from brain. 
  • Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee. 
  • Investigation of NRXN1 deletions: clinical and molecular characterization. 
  • Isolation of the structural gene for calmodulin. 
  • Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. 
  • LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein. 
  • Localization of calmodulin in rat cerebellum by immunoelectron microscopy. 
  • Localization of three genes expressed in retina on mouse chromosome 11. 
  • Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor. 
  • Mechanisms of NOD-like receptor-associated inflammasome activation. 
  • Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. 
  • Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy. 
  • Modulation of platelet shape and membrane receptor binding by Ca2+-calmodulin complex. 
  • Molecular and physiological alterations in murine ventricular dysfunction. 
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 
  • Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae. 
  • NAIP inflammasomes give the NOD to bacterial ligands. 
  • NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation. 
  • NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis. 
  • NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. 
  • Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Nomenclature: vertebrate mediators of TGFbeta family signals. 
  • Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice. 
  • Notch3 pathway alterations in ovarian cancer. 
  • Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). 
  • Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil. 
  • Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels. 
  • PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing. 
  • Phase I Open-Label Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Dilpacimab in Patients with Advanced Solid Tumors. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. 
  • Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia. 
  • Primary blast injury causes cognitive impairments and hippocampal circuit alterations. 
  • Protein markers and differentiation in culture for Schlemm's canal endothelial cells. 
  • Pseudomonas aeruginosa activates caspase 1 through Ipaf. 
  • Radioimmunoassay of calmodulin. 
  • Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer. 
  • Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. 
  • Rational design of a calcium-binding protein. 
  • Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina. 
  • Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. 
  • Regulation by and of calmodulin in mammalian cells. 
  • Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells. 
  • Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling. 
  • Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP. 
  • Regulation of the renal Na+-H+ exchanger. 
  • Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. 
  • Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. 
  • Role of chaperones in antigen processing. 
  • S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. 
  • SNPs in CAST are associated with Parkinson disease: a confirmation study. 
  • STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes. 
  • Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. 
  • Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model. 
  • Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden. 
  • Serum soluble mesothelin-related protein (SMRP) and fibulin-3 levels correlate with baseline malignant pleural mesothelioma (MPM) tumor volumes but are not useful as biomarkers of response in an immunotherapy trial. 
  • Sex differences in microglial colonization of the developing rat brain. 
  • Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. 
  • Sites of interaction between kinase-related protein and smooth muscle myosin. 
  • Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Structural analysis, identification, and design of calcium-binding sites in proteins. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. 
  • TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. 
  • Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. 
  • The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. 
  • The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. 
  • The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. 
  • The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase. 
  • The effect of chronic caffeine administration on serum markers of bone mineral metabolism and bone histomorphometry in the rat. 
  • The genomic landscape of familial glioma. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. 
  • The possible physiologic importance of calcium complexes: an opinion. 
  • The proper localization of RESPONSIVE TO DESICCATION 20 in lipid droplets depends on their biogenesis induced by STRESS-RELATED PROTEINS in vegetative tissues. 
  • The role of Gla proteins in vascular calcification. 
  • The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. 
  • Transcriptional regulation of matrix gla protein. 
  • Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. 
  • Unphosphorylated gelsolin is localized in regions of cell-substratum contact or attachment in Rous sarcoma virus-transformed rat cells. 
  • Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer. 
  • Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. 
  • miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
  • α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Yadav, Vikas, Postdoctoral Associate, Molecular Genetics and Microbiology