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Subject Areas on Research
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A cloned calmodulin structural gene probe is complementary to DNA sequences from diverse species.
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A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
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A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
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A new erythrocyte membrane-associated protein with calmodulin binding activity. Identification and purification.
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A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites.
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Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C.
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Adducin: structure, function and regulation.
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Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.
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Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding.
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Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse.
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Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins.
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An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.
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Analysis of expression of multiple genes encoding calmodulin during spermatogenesis.
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Aquaporin 6 binds calmodulin in a calcium-dependent manner.
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Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes.
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Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin.
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Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex.
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Autoimmune epitopes in messenger RNA.
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Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase.
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Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene.
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Bacterial expression vectors for calmodulin.
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Bacterially synthesized vertebrate calmodulin is a specific substrate for ubiquitination.
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Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
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Biochemical characterization of the Ca2+ release channel of skeletal and cardiac sarcoplasmic reticulum.
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Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
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Ca(2+)-regulated serine protease associated with the nuclear scaffold.
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Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels.
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Ca2+-dependent regulator. Production and characterization of a monospecific antibody.
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Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.
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Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini.
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Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.
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Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.
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Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
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Calcium binding is required for calmodulin function in Aspergillus nidulans.
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Calcium binding peptide motifs from calmodulin confer divalent ion selectivity to elastin-like polypeptides.
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Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin.
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Calcium, calmodulin and cell cycle regulation.
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Calcium, calmodulin and cell proliferation.
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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth.
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Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens.
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Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes.
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Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells.
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Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
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Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.
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Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines.
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Calmodulin activation of target enzymes. Consequences of deletions in the central helix.
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Calmodulin and CaMKII as molecular switches for cardiac ion channels.
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Calmodulin and cell cycle control.
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Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression.
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Calmodulin as a mediator of hormone action and cell regulation.
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Calmodulin as a regulator of cell growth and gene expression.
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Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle.
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Calmodulin binds to caldesmon in an antiparallel manner.
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Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5.
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Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.
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Calmodulin in bovine rod outer segments.
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Calmodulin in endocrine cells and its multiple roles in hormone action.
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Calmodulin in endocrine cells.
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Calmodulin is intrinsically LESS effective than troponin C in activating skeletal muscle contraction.
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Calmodulin is involved in regulation of cell proliferation.
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Calmodulin is required for cell-cycle progression during G1 and mitosis.
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Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.
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Calmodulin limits pathogenic Na+ channel persistent current.
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Calmodulin mediates Ca2+ sensitivity of sodium channels.
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Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase.
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Calmodulin regulation during the cell cycle of mammalian cells.
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Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
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Calmodulin regulation of smooth-muscle myosin light-chain kinase.
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Calmodulin structure refined at 1.7 A resolution.
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Calmodulin supports both inactivation and facilitation of L-type calcium channels.
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Calmodulin, cell growth and gene expression.
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Calmodulin--an intracellular calcium receptor.
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Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation.
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Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
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Calmodulin-induced early-onset diabetes in transgenic mice.
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Calmodulin-microtubule association in cultured mammalian cells.
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Calmodulin-myosin light chain kinase inhibition changes fibroblast-populated collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction.
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Calmodulin-stimulated protein kinase activity from rat pancreas.
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Calmodulin. Development and application of a sensitive radioimmunoassay.
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Calmodulin: a prototypical calcium sensor.
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Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.
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Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle.
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Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase.
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Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.
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Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain.
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Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.
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Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide.
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Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.
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Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone.
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Chicken calmodulin promoter activity in proliferating and differentiated cells.
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Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.
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Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.
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Chronic sulpiride increased 3H-spiperone binding and calmodulin dependent phosphorylation in rat striatum.
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Control of microtubule assembly-disassembly by calcium-dependent regulator protein.
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Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans.
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Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro.
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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.
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Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.
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Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.
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Crystallization and preliminary X-ray investigation of calmodulin.
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Crystallographic studies of calmodulin.
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Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.
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Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).
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Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility.
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Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
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Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.
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Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation.
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Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras.
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Domain II of calmodulin is involved in activation of calcineurin.
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Drosophilia spectrin. I. Characterization of the purified protein.
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Effects of changes in calmodulin levels on cell proliferation.
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Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice.
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Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.
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Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix.
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Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells.
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Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
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Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor.
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Function and regulation of calmodulin in endocrine cells.
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Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.
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Functional domains of chicken gizzard myosin light chain kinase.
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Functional significance of the central helix in calmodulin.
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Genetically engineered calmodulins differentially activate target enzymes.
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Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary.
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H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.
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Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase.
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Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
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Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist.
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Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase.
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Identification of high-affinity calmodulin-binding proteins in rat liver.
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Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA.
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Identification of the components controlling inactivation of voltage-gated Ca2+ channels.
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Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon.
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Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone.
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In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis.
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Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.
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Interactions of calmodulin with coated vesicles from brain.
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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
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Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site.
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Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.
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Isolation and structural analysis of the chromosomal gene for chicken calmodulin.
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Isolation of the structural gene for calmodulin.
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KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.
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Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease.
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Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.
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Localization of calmodulin in rat cerebellum by immunoelectron microscopy.
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Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain.
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Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.
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Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.
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Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.
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Methods for analyzing bovine papilloma virus-based calmodulin expression vectors.
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
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Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
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Modulation of platelet shape and membrane receptor binding by Ca2+-calmodulin complex.
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Modulation of spectrin-actin assembly by erythrocyte adducin.
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Molecular analysis of calmodulin and smooth muscle myosin light chain kinase.
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Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels.
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Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels.
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Molecular mechanisms of action of calmodulin.
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Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.
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Myosin light chain kinase structure function analysis using bacterial expression.
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NMR studies of a complex of deuterated calmodulin with melittin.
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Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome.
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Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.
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Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
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Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.
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Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
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Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.
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Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex.
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Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.
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Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia.
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Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes.
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Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation.
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Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.
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Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas.
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Quantitation and significance of 125I-calmodulin binding to myosin light chain kinase and phosphorylase distributed on polyacrylamide gels.
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Radioimmunoassay of calmodulin.
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Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1.
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Regulation by and of calmodulin in mammalian cells.
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Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.
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Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.
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Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells.
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Regulation of microfilaments and microtubules by calcium and cyclic AMP.
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Regulation of protein kinases by pseudosubstrate prototopes.
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Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium.
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Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases.
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Regulation of smooth muscle myosin light chain kinase by calmodulin.
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Regulation of the cell cycle by calcium and calmodulin.
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Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP.
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Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II.
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Regulation of the testis sertoli cell by follicle stimulating hormone.
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Regulatory cascades involving calmodulin-dependent protein kinases.
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Regulatory functions of calmodulin.
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Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.
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Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
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Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
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Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis.
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Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.
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Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
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Structural analysis, identification, and design of calcium-binding sites in proteins.
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Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.
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Substrate specificity of Ca2+/CaM-dependent multifunctional protein kinases: comparison of isoenzymes from brain, liver and skeletal muscle.
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Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment.
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Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.
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Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.
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Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development.
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Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle.
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Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia.
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The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance.
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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
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The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase.
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The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.
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The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.
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The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation.
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The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism.
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The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus.
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The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene.
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The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.
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The structural organization of the chicken calmodulin gene.
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The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding.
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Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms.
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Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase.
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Three-dimensional structure of calmodulin.
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Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences.
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Troponin C modulates the activation of thin filaments by rigor cross-bridges.
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Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.
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X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.
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alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology