Calmodulin-Binding Proteins

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  Subject Areas on Research

  • (i, i + 4) Ion pairs stabilize helical peptides derived from smooth muscle caldesmon. 
  • A new erythrocyte membrane-associated protein with calmodulin binding activity. Identification and purification. 
  • A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments. 
  • A new millenium for spinal cord regeneration: growth-associated genes. 
  • A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. 
  • Adducin in erythrocyte precursor cells of rats and humans: expression and compartmentalization. 
  • Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. 
  • Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. 
  • Adducin: structure, function and regulation. 
  • Alpha-adducin dissociates from F-actin and spectrin during platelet activation. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition. 
  • Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in situ hybridization. 
  • Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. 
  • Calcineurin is required for virulence of Cryptococcus neoformans. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calmodulin binds to caldesmon in an antiparallel manner. 
  • Calmodulin in bovine rod outer segments. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Calspermin is a testis specific calmodulin-binding protein closely related to Ca2+/calmodulin-dependent protein kinases. 
  • Characterization of a major hepatic calmodulin acceptor protein (CAP-60). 
  • Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide. 
  • Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility. 
  • Desmoplastic small round cell tumor: using FISH as an ancillary technique to support cytologic diagnosis in an unusual case. 
  • Differential gene expression from a single transcription unit during spermatogenesis. 
  • Domain II of calmodulin is involved in activation of calcineurin. 
  • Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. 
  • Genetically engineered calmodulins differentially activate target enzymes. 
  • Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study. 
  • Identification of high-affinity calmodulin-binding proteins in rat liver. 
  • Identification of the functionally relevant calmodulin binding site in smooth muscle caldesmon. 
  • Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. 
  • Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm. 
  • Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. 
  • Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. 
  • Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. 
  • In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis. 
  • Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. 
  • Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. 
  • Mapping the domain structure of human erythrocyte adducin. 
  • Mechanical and chemical unfolding of a single protein: a comparison. 
  • Modulation of spectrin-actin assembly by erythrocyte adducin. 
  • Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. 
  • Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin. 
  • Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. 
  • Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. 
  • Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. 
  • Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle. 
  • Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex. 
  • Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. 
  • Primary structure and domain organization of human alpha and beta adducin. 
  • Protein kinase C phosphorylates a recently identified membrane skeleton-associated calmodulin-binding protein in human erythrocytes. 
  • Purification and properties of a multifunctional calcium/calmodulin-dependent protein kinase from rat pancreas. 
  • Putative calmodulin-binding domains in aflatoxin biosynthesis-regulatory proteins. 
  • Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression. 
  • Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products. 
  • Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. 
  • Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. 
  • Role of calcium in T-lymphocyte activation. 
  • Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells. 
  • Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. 
  • Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons. 
  • Spindle cell sarcoma of the vulva with myofibroblastic differentiation. 
  • Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin. 
  • Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia. 
  • Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. 
  • The C-terminal linker of Escherichia coli FtsZ functions as an intrinsically disordered peptide. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. 
  • The junctional complex of the membrane skeleton. 
  • Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon. 
  • Use of the 125I-labeled protein gel overlay technique to study calmodulin-binding proteins. 
  • vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering