Calsequestrin
-
Subject Areas on Research
- Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
- Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
- Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
- Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy.
- Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals.
- Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes.
- Modifier genes and heart failure.
- Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy.
- Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice.
- QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.
- Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.