Candida albicans

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  Subject Areas on Research

  • 4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. 
  • A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. 
  • A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. 
  • Aged-related physiological studies comparing Candida albicans chlamydospores to yeasts. 
  • An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. 
  • Analysis of cytoplasmic antigens of the yeast and mycelial phases of Candida albicans by two-dimensional electrophoresis. 
  • Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach. 
  • Antifungal catheter lock therapy for the management of a persistent Candida albicans bloodstream infection in an adult receiving hemodialysis. 
  • Aquaporin expression and freeze tolerance in Candida albicans. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Aryl-alkyl-lysines: Membrane-Active Fungicides That Act against Biofilms of Candida albicans. 
  • Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. 
  • Blood gene expression signatures predict invasive candidiasis. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. 
  • Calcineurin is essential for Candida albicans survival in serum and virulence. 
  • Calcineurin is essential for survival during membrane stress in Candida albicans. 
  • Calcineurin is required for Candida albicans to survive calcium stress in serum. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. 
  • Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans. 
  • Campafungins: Inhibitors of Candida albicans and Cryptococcus neoformans Hyphal Growth. 
  • Candida albicans reprioritizes metal handling during fluconazole stress. 
  • Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. 
  • Caspofungin for invasive candidiasis at a tertiary care medical center. 
  • Caspofungin for the treatment of azole resistant candidemia in a premature infant. 
  • Cell biology. A fungal Achilles' heel. 
  • Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. 
  • Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes. 
  • Clinical and immunologic features of selective IgA deficiency. 
  • Clonal and spontaneous origins of fluconazole resistance in Candida albicans. 
  • Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections. 
  • Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. 
  • Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans. 
  • Computationally guided high-throughput design of self-assembling drug nanoparticles. 
  • Controlled evaluation of BACTEC PLUS 27 and Roche Septi-Chek anaerobic blood culture bottles. 
  • Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. 
  • Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress. 
  • Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1. 
  • Cost savings with implementation of PNA FISH testing for identification of Candida albicans in blood cultures. 
  • Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. 
  • Cytosine deaminase MX cassettes as positive/negative selectable markers in Saccharomyces cerevisiae. 
  • Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. 
  • Depression of cell-mediated immunity in atopic eczema. 
  • Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts. 
  • Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. 
  • Effects of microgravity on the virulence of Listeria monocytogenes, Enterococcus faecalis, Candida albicans, and methicillin-resistant Staphylococcus aureus. 
  • Electron microscopy of young Candida albicans chlamydospores. 
  • Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. 
  • Empirical therapy for neonatal candidemia in very low birth weight infants. 
  • Endosymbiosis: the evil within. 
  • Enhanced macrophage tumoricidal activity and tumor suppression or regression caused by heat-killed Candida albicans. 
  • Epidemiological and mycological characteristics of candidemia in patients with hematological malignancies attending a tertiary-care center in India. 
  • Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. 
  • Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. 
  • Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats. 
  • Evaluation of in vitro antifungal activity of LY121019. 
  • Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans. 
  • Fluconazole prophylaxis for prevention of invasive candidiasis in infants. 
  • Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. 
  • Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. 
  • Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. 
  • Fungal mating: Candida albicans flips a switch to get in the mood. 
  • Fungal pathogens are platforms for discovering novel and conserved septin properties. 
  • Genetic structure of typical and atypical populations of Candida albicans from Africa. 
  • Geographical differences in human oral yeast flora. 
  • Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. 
  • Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. 
  • Heterologous URA3MX cassettes for gene replacement in Saccharomyces cerevisiae. 
  • Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants. 
  • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. 
  • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. 
  • Human dectin-1 deficiency and mucocutaneous fungal infections. 
  • Identification of cell cycle-regulated, putative hyphal genes in Candida albicans. 
  • Identification of clinical strains of Candida albicans by DNA fingerprinting with the polymerase chain reaction. 
  • Immunoblot analyses of Candida albicans-associated antigens and antibodies in human sera. 
  • Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. 
  • In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates. 
  • Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans. 
  • Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal. 
  • Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virus. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis. 
  • Microbial genetics: Love the one you're with. 
  • Molecular approaches to identify novel targets for future development of antifungal agents. 
  • Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination. 
  • Morphogenesis of Candida albicans and cytoplasmic proteins associated with differences in morphology, strain, or temperature. 
  • Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish. 
  • Multicenter evaluation of a Candida albicans peptide nucleic acid fluorescent in situ hybridization probe for characterization of yeast isolates from blood cultures. 
  • Multicenter evaluation of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual-color identification of C. albicans and C. glabrata directly from blood culture bottles. 
  • Multiplexed real-time polymerase chain reaction on a digital microfluidic platform. 
  • Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form. 
  • N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. 
  • Neonatal candidemia and end-organ damage: a critical appraisal of the literature using meta-analytic techniques. 
  • New Spins on Old Drugs: Enhancing Activity of Antifungals. 
  • Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase. 
  • On-demand release of Candida albicans biofilms from urinary catheters by mechanical surface deformation. 
  • Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy. 
  • PCR-restriction fragment length polymorphism (RFLP) analyses reveal both extensive clonality and local genetic differences in Candida albicans. 
  • PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. 
  • Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis. 
  • Persistence of the same Candida albicans strain despite fluconazole therapy. Documentation by pulsed-field gel electrophoresis. 
  • Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition. 
  • Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. 
  • Pleiotropic signaling pathways orchestrate yeast development. 
  • Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. 
  • Positive and negative selection LYS5MX gene replacement cassettes for use in Saccharomyces cerevisiae. 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Precipitins to Candida albicans in chronic mucocutaneous candidiasis studied by crossed immunoelectrophoresis with intermediate gel. Correlation with clinical and immunological findings. 
  • Predictors and outcomes of Candida bloodstream infection: eight-year surveillance, western Saudi Arabia. 
  • Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. 
  • Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis. 
  • Sex and virulence of human pathogenic fungi. 
  • Sexual reproduction and the evolution of microbial pathogens. 
  • Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. 
  • Sodium bicarbonate gels: a new promising strategy for the treatment of vulvovaginal candidosis. 
  • Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans 
  • Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics from Sphaerostilbella toxica. 
  • Strain variation and morphogenesis of yeast- and mycelial-phase Candida albicans in low-sulfate, synthetic medium. 
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. 
  • Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. 
  • Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. 
  • Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate. 
  • Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. 
  • Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis. 
  • Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. 
  • The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies. 
  • The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. 
  • The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. 
  • The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. 
  • The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. 
  • The release of acid phosphatase and polysaccharide- and protein-containing components from the surface of the dimorphic forms of Candida albicans by treatment with dithiothreitol. 
  • Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304. 
  • Trimorphic stepping stones pave the way to fungal virulence. 
  • Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. 
  • When to suspect fungal infection in neonates: A clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. 
  • Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp. 
  • Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans . 
  • [Genetic structure of geographically different populations of candida albicans]. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases