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Subject Areas on Research
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A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons.
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A rapid capsaicin-activated current in rat trigeminal ganglion neurons.
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Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae.
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Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1.
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Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1.
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Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons.
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Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors.
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Attenuation of acid induced oesophagitis in VR-1 deficient mice.
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Capsaicin activated currents in rat dorsal root ganglion cells.
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Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons.
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Capsaicin for the treatment of pain in Guillain-Barré syndrome.
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Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.
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Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.
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Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors.
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Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells.
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Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia.
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Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons.
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Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization.
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Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.
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Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.
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Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung.
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Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats.
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Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors.
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Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex.
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Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.
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Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves.
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Effects of intravesical prostaglandin E2
on bladder function are preserved in capsaicin-desensitized rats.
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Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model.
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Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature.
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Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).
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Gustatory effects of capsaicin that are independent of TRPV1 receptors.
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Heat-dependent opening of TRPV1 in the presence of capsaicin.
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IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice.
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Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel.
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Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch.
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Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.
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Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis.
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Intravesical capsaicin therapy: a review.
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Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity.
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Ion channels in analgesia research.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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Lessons from peppers and peppermint: the molecular logic of thermosensation.
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Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats.
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Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
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Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.
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Modulation of rat chorda tympani nerve activity by lingual nerve stimulation.
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Molecular assays for characterization of alternatively spliced isoforms of the u opioid receptor (MOR).
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Molecular basis for species-specific sensitivity to "hot" chili peppers.
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Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
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Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release.
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Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study.
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Neural responses to bitter compounds in rats.
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Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line.
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Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.
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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
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Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs.
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Opposite modulation of capsaicin-evoked substance P release by glutamate receptors.
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Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil.
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Pain modality- and sex-specific effects of COMT genetic functional variants.
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Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction.
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Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
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Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats.
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Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.
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Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons.
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Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats.
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SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
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Selectivity of lingual nerve fibers to chemical stimuli.
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Sensing hot and cold with TRP channels.
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Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels.
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Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells.
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Simultaneous reorganization in thalamocortical ensembles evolves over several hours after perioral capsaicin injections.
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Single Treatment With Capsaicin 8% Patch May Reduce Pain and Sleep Interference up to 12 Weeks in Patients With Painful Diabetic Peripheral Neuropathy.
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Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum.
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TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.
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TRPV1 receptors mediate particulate matter-induced apoptosis.
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TRPV1b, a functional human vanilloid receptor splice variant.
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The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat.
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The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.
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The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons.
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The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.
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The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.
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The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor.
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The salty and burning taste of capsaicin.
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Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.
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Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability.
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Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes.
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Utility of the Oral Capsaicin Test in Diagnosing Functional Dyspepsia.
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VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
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Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter.
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Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells.
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Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats.
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Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats.
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Voltage-gated ion channels in nociceptors: modulation by cGMP.
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