Capsaicin

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  Subject Areas on Research

  • A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons. 
  • A rapid capsaicin-activated current in rat trigeminal ganglion neurons. 
  • Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Capsaicin activated currents in rat dorsal root ganglion cells. 
  • Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons. 
  • Capsaicin for the treatment of pain in Guillain-Barré syndrome. 
  • Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons. 
  • Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. 
  • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. 
  • Capsaicin-induced currents with distinct desensitization and Ca2+ dependence in rat trigeminal ganglion cells. 
  • Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung. 
  • Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats. 
  • Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors. 
  • Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex. 
  • Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Effects of intravesical prostaglandin E₂ on bladder function are preserved in capsaicin-desensitized rats. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. 
  • Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE). 
  • Gustatory effects of capsaicin that are independent of TRPV1 receptors. 
  • Heat-dependent opening of TRPV1 in the presence of capsaicin. 
  • Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel. 
  • Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. 
  • Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. 
  • Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis. 
  • Intravesical capsaicin therapy: a review. 
  • Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity. 
  • Ion channels in analgesia research. 
  • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. 
  • Lessons from peppers and peppermint: the molecular logic of thermosensation. 
  • Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. 
  • Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. 
  • Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. 
  • Modulation of rat chorda tympani nerve activity by lingual nerve stimulation. 
  • Molecular basis for species-specific sensitivity to "hot" chili peppers. 
  • Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Negatively charged 2- and 10-microm particles activate vanilloid receptors, increase cAMP, and induce cytokine release. 
  • Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. 
  • Neural responses to bitter compounds in rats. 
  • Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Ontogeny of dry gas hyperpnea-induced bronchoconstriction in guinea pigs. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil. 
  • Pain modality- and sex-specific effects of COMT genetic functional variants. 
  • Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. 
  • Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • Selectivity of lingual nerve fibers to chemical stimuli. 
  • Sensing hot and cold with TRP channels. 
  • Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. 
  • Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. 
  • Simultaneous reorganization in thalamocortical ensembles evolves over several hours after perioral capsaicin injections. 
  • Single Treatment With Capsaicin 8% Patch May Reduce Pain and Sleep Interference up to 12 Weeks in Patients With Painful Diabetic Peripheral Neuropathy. 
  • Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. 
  • TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. 
  • TRPV1 receptors mediate particulate matter-induced apoptosis. 
  • TRPV1b, a functional human vanilloid receptor splice variant. 
  • The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. 
  • The influence of removing extracellular Ca2+ in the desensitization responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons. 
  • The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. 
  • The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide. 
  • The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor. 
  • The salty and burning taste of capsaicin. 
  • Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord. 
  • Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability. 
  • Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter. 
  • Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. 
  • Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. 
  • Voiding behavior in awake unrestrained untethered spontaneously hypertensive and Wistar control rats. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
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  Keywords of People

  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology