Capsid

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  Subject Areas on Research

  • A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes. 
  • Adeno-Associated Virus Capsid-Promoter Interactions in the Brain Translate from Rat to the Nonhuman Primate. 
  • Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo. 
  • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. 
  • Application of Epstein-Barr virus serology to the diagnosis and staging of North American patients with nasopharyngeal carcinoma. 
  • Bacteriophage capsids: tough nanoshells with complex elastic properties. 
  • Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 (CD4) and requires the intact variable-region-like domain. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release. 
  • Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site. 
  • Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. 
  • Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach. 
  • Combined assessment of Epstein-Barr virus viral capsid antigen and Epstein-Barr virus nuclear antigen-1 serology for post-transplant lymphoproliferative disorder risk stratification in adult solid organ transplant recipients. 
  • Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. 
  • Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. 
  • Deletion of the essential gene 24 from the bacteriophage T4 genome. 
  • Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. 
  • Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. 
  • Discrete fracture patterns of virus shells reveal mechanical building blocks. 
  • Engineering AAV receptor footprints for gene therapy. 
  • Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. 
  • Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Failure of viral shells. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. 
  • Glycan binding avidity determines the systemic fate of adeno-associated virus type 9. 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on surfaces of virus-producing murine and other mammalian species cell lines. 
  • Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. 
  • Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy. 
  • Intervening sequence between the leader region and the nucleopcapsid gene of vesicular stomatitis virus RNA. 
  • Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsids. 
  • Location and role of free cysteinyl residues in the Sindbis virus E1 and E2 glycoproteins. 
  • Mammalian C-type oncorna viruses. Relationships between structural virus and cell surface antigens and their possible significance in immunological defense mechanisms. 
  • Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production. 
  • Measles virus nucleocapsids: large-scale purification and use in radioimmunoassays. 
  • Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses. 
  • Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4. 
  • Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength. 
  • Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. 
  • Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. 
  • Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide. 
  • Peptide affinity reagents for AAV capsid recognition and purification. 
  • Pervasive tertiary structure in the dengue virus RNA genome. 
  • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. 
  • Probing the Link among Genomic Cargo, Contact Mechanics, and Nanoindentation in Recombinant Adeno-Associated Virus 2. 
  • Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. 
  • Receptor Switching in Newly Evolved Adeno-associated Viruses. 
  • Reengineered AAV vectors: old dog, new tricks. 
  • Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system. 
  • Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry. 
  • Rotavirus RNA polymerase requires the core shell protein to synthesize the double-stranded RNA genome. 
  • Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles. 
  • Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. 
  • Specificity and distribution of the determinants of the major glycoprotein (gp71) of murine oncornaviruses as detected by an in vitro cytotoxicity assay. 
  • Surface loop dynamics in adeno-associated virus capsid assembly. 
  • Swelling and softening of the cowpea chlorotic mottle virus in response to pH shifts. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • Topography of a flexible ribonucleoprotein helix: protein-protein contacts in Sendai virus nucleocapsids. 
  • Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection.