Carbohydrate Sequence

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  Subject Areas on Research

  • A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor. 
  • A comparison of the fine saccharide-binding specificity of Dioclea grandiflora lectin and concanavalin A. 
  • A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium. 
  • A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. 
  • Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro. 
  • Altered fine structures of corneal and skeletal keratan sulfate and chondroitin/dermatan sulfate in macular corneal dystrophy. 
  • Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry. 
  • Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. 
  • Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities. 
  • Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides. 
  • Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling. 
  • Crustacean peptide and peptide-like pheromones and kairomones. 
  • Development of an on-line preconcentration method for the analysis of pathogenic lipopolysaccharides using capillary electrophoresis-electrospray mass spectrometry. Application to small colony isolates. 
  • Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces. 
  • Ectopic expression of mucins in colorectal cancer metastasis. 
  • Energetics of lectin-carbohydrate binding. A microcalorimetric investigation of concanavalin A-oligomannoside complexation. 
  • Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity. 
  • Enzyme-catalyzed synthesis of carbohydrates. 
  • Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. 
  • Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases. 
  • Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. 
  • Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. 
  • Highly stretchable and tough hydrogels. 
  • Identification of sugar isomers by single-molecule force spectroscopy. 
  • In vivo growth conditions suppress the expression of ganglioside GM2 and favour that of lacto series gangliosides in the human glioma D-54MG cell line. 
  • Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor. 
  • Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. 
  • Lipoprotein(a) and its role in atherothrombotic disease. 
  • Metastatic behavior and cell surface properties of HT-29 human colon carcinoma variant cells selected for their differential expression of sialyl-dimeric Le(x)-antigen. 
  • Molecular dynamics simulations of forced conformational transitions in 1,6-linked polysaccharides. 
  • Monoclonal antibodies to malignant human gliomas. 
  • Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. 
  • Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides. 
  • Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. 
  • P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. 
  • Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition. 
  • Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. 
  • Receptors on hepatocytes that bind ligands containing fucosyl alpha 1,3 N-acetylglucosamine linkages. 
  • Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap. 
  • Sialyl-dimeric Lewis-X antigen expressed on mucin-like glycoproteins in colorectal cancer metastases. 
  • Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. 
  • Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. 
  • Surface structure of human mucin using X-ray photoelectron spectroscopy. 
  • The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity. 
  • The cluster glycoside effect. 
  • The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes. 
  • The humoral immune response in humans following ex vivo perfusion of porcine livers. 
  • The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs. 
  • The potential of xenotransplants. 
  • The role of natural anti-Gal alpha 1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. 
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  Keywords of People

  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology