Carbon Isotopes

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  Subject Areas on Research

  • 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). 
  • 15N, 13C and 1H backbone resonance assignments of an artificially engineered TEM-1/PSE-4 class A β-lactamase chimera and its deconvoluted mutant. 
  • 15N, 13C and 1H resonance assignments of FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus. 
  • A 'just-in-time' HN(CA)CO experiment for the backbone assignment of large proteins with high sensitivity. 
  • A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency. 
  • A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer. 
  • A dynamic leaf gas-exchange strategy is conserved in woody plants under changing ambient CO2 : evidence from carbon isotope discrimination in paleo and CO2 enrichment studies. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • A physicochemical study of fat absorption in rats. Limitation of methods in vitro. 
  • A radiochemical-high-performance liquid chromatographic assay for urate oxidase in human plasma. 
  • A reappraisal of the concept of an abnormality of glutamine metabolism in primary gout. 
  • A refocused and optimized HNCA: increased sensitivity and resolution in large macromolecules. 
  • A roadmap for interpreting (13)C metabolite labeling patterns from cells. 
  • A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice. 
  • An Ultrahigh Precision, High-Frequency Dissolved Inorganic Carbon Analyzer Based on Dual Isotope Dilution and Cavity Ring-Down Spectroscopy. 
  • An extractive removal step optimized for a high-throughput α-cellulose extraction method for δ13C and δ18O stable isotope ratio analysis in conifer tree rings. 
  • Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry. 
  • Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. 
  • Are mycoplasma membrane proteins affected by variations in membrane fatty acid composition? 
  • Assessment of sex steroid action in vitro. 
  • Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. 
  • Assignment of the 1H, 13C and 15N resonances of the LpxC deacetylase from Aquifex aeolicus in complex with the substrate-analog inhibitor TU-514. 
  • Backbone 1H, 13C, and 15N NMR assignments of the tail domain of vinculin. 
  • Bactericidal and opsonic properties of C4-deficient guinea pig serum. 
  • Benthic and pelagic pathways of methylmercury bioaccumulation in estuarine food webs of the northeast United States. 
  • Biosynthesis of the second (C2) and fourth (C4) components of complement in vitro by tissues isolated from guinea-pigs with genetically determined C4 deficiency. 
  • Changes in stable isotopic signatures of soil nitrogen and carbon during 40 years of forest development. 
  • Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. 
  • Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. 
  • Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. 
  • Collagenase and connective tissue metabolism in epidermolysis bullosa. 
  • Collagenase in bone of man. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Conformational analysis of a flexible oligosaccharide using residual dipolar couplings. 
  • Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms. 
  • Constructing atomic-resolution RNA structural ensembles using MD and motionally decoupled NMR RDCs. 
  • Crab regulation of cross-ecosystem resource transfer by marine foraging fire ants. 
  • DNA repair synthesis after x-irradiation in E. coli. 
  • Degradation of collagen by a human granulocyte collagenolytic system. 
  • Effect of FSH on protein biosynthesis in testes of the immature rat. 
  • Effect of antibiotics on the in vitro incorporation of acetate-14C into intestinal lipids. 
  • Effect of chemical modification of dihydrouridine in yeast transfer ribonucleic acid on amino acid acceptor activity and ribosomal binding. 
  • Effect of growth conditions on the ornithine decarboxylase activity of rat hepatoma cells. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain. 
  • Environmental aridity is associated with cytotype segregation and polyploidy occurrence in Brachypodium distachyon (Poaceae). 
  • Equilibrium binding of nucleotides to beef heart mitochondrial adenosine triphosphatase. 
  • Estimating relative changes of metabolic fluxes. 
  • Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. 
  • Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system. 
  • Extending the range of microsecond-to-millisecond chemical exchange detected in labeled and unlabeled nucleic acids by selective carbon R(1rho) NMR spectroscopy. 
  • Genetics of drought adaptation in Arabidopsis thaliana: I. Pleiotropy contributes to genetic correlations among ecological traits. 
  • Gossypol: subcellular localization and stimulation of rat liver microsomal oxidases. 
  • Hemlock woolly adelgid (Adelges tsugae) infestation affects water and carbon relations of eastern hemlock (Tsuga canadensis) and Carolina hemlock (Tsuga caroliniana). 
  • High-level 2H/13C/15N labeling of proteins for NMR studies. 
  • Human brain glycogen metabolism during and after hypoglycemia. 
  • Human granulocyte collagenase. 
  • Hydrolysis of template and newly synthesized deoxyribonucleic acid by the 3' to 5' exonuclease activity of the T4 deoxyribonucleic acid polymerase. 
  • Hyperpolarized carbon-carbon intermolecular multiple quantum coherences. 
  • Identification of metabolities of progesterone-4-14C in domestic sow urine. 
  • Immunoinhibition of intracellular protein digestion in macrophages. 
  • Implausibility of the vibrational theory of olfaction. 
  • Improved excitation pulse bandwidths using shaped pulses, with application to heteronuclear half filters in macromolecular NMR. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • Increasing hyperpolarized spin lifetimes through true singlet eigenstates. 
  • Induction of specific translatable messenger RNA's by oestrogen and progesterone. 
  • Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis. 
  • Insight into the CSA tensors of nucleobase carbons in RNA polynucleotides from solution measurements of residual CSA: towards new long-range orientational constraints. 
  • Insulin receptor of fat cells in insulin-resistant metabolic states. 
  • Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. 
  • Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle. 
  • Irreconcilable differences: fine-root life spans and soil carbon persistence. 
  • Isolation of a new RNA polymerase-binding protein from sporulating Bacillus subtilis. 
  • Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio). 
  • Isolation of protein factors from oviduct polysomes which stimulate protein synthesis. 
  • Isotopic imprints of mountaintop mining contaminants. 
  • Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications. 
  • Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine. 
  • Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity. 
  • Loss of the sigma activity of RNA polymerase of Bacillus subtilis during sporulation. 
  • Maturation of the adrenal medulla. I. Uptake and storage of amines in isolated storage vesicles of the rat. 
  • Measuring long-lived 13C2 state lifetimes at natural abundance. 
  • Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. 
  • Metabolic fate of gossypol: the metabolism of 14C-gossypol in rats. 
  • Metabolic fate of gossypol: the metabolism of gossypol-14C in laying hens. 
  • Metabolism of the aspartyl moiety of N-acetyl-L-aspartic acid in the rat brain. 
  • Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase. 
  • NMR studies of nucleic acid dynamics. 
  • Natural gas pipeline leaks across Washington, DC. 
  • Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. 
  • Nuclear RNA synthesis in sea urchin embryos. 
  • Nuclease activity in a fragment of bacteriophage T4 deoxyribonucleic acid polymerase induced by the amber mutant am B22. 
  • Optimal control based NCO and NCA experiments for spectral assignment in biological solid-state NMR spectroscopy. 
  • Phenylalanine hydroxylase activity in mammalian cells. 
  • Pigment formation from L-tryptophan by a particulate fraction from an Achromobacter species. 
  • Placental transport of free palmitic and linoleic acids in the guinea pig. 
  • Polypeptides of avian RNA tumor viruses. 1. Isolation and physical and chemical analysis. 
  • Polypeptides of avian RNA tumor viruses. II. Serological characterization. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Preparation of uniformly (13)C,(15)N-labeled recombinant human amylin for solid-state NMR investigation. 
  • Preparation, resonance assignment, and preliminary dynamics characterization of residue specific 13C/15N-labeled elongated DNA for the study of sequence-directed dynamics by NMR. 
  • Prevalence of Helicobacter pylori infection and associated factors among adults in Southern Brazil: a population-based cross-sectional study. 
  • Production and turnover of ectomycorrhizal extramatrical mycelial biomass and necromass under elevated CO2 and nitrogen fertilization. 
  • Protein biosynthesis in the testis. 3. Dual effect of glucose. 
  • Protein biosynthesis in the testis. I. Comparison between stimulation by FSH and glucose. 
  • Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose. 
  • Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone. 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification of serine-specific transfer ribonucleic acid from bakers' yeast. 
  • Rapid determination of protein folds using residual dipolar couplings. 
  • Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase. 
  • Recovery of rat adrenal amine stores after insulin administration. 
  • Regulation of translation and transcription of messenger RNA during early embryonic development. 
  • Resolving sugar puckers in RNA excited states exposes slow modes of repuckering dynamics. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes. 
  • Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution. 
  • Role of ATP in DNA synthesis in Escherichia coli. 
  • Sedimentation properties of yeast chromosomal DNA. 
  • Spatial distribution of bottlenose dolphins (Tursiops truncatus) inferred from stable isotopes and priority organic pollutants. 
  • Stable isotope analyses reveal previously unknown trophic mode diversity in the Hymenochaetales. 
  • Stable isotope ratios indicate diet and habitat use in New World monkeys. 
  • Steroid hormone induction of a specific translatable messenger RNA. 
  • Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes. 
  • Storage of hydrogen spin polarization in long-lived 13C2 singlet order and implications for hyperpolarized magnetic resonance imaging. 
  • Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study. 
  • Temporal variability in (13)C of respired CO(2) in a pine and a hardwood forest subject to similar climatic conditions. 
  • The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen. 
  • The absorption of oleic acid from emulsion and micellar solution. 
  • The absorption of tristearin and stearic acid and tripalmitin and palmitic acid. Studies on the rate-limiting steps in rats. 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The ideal percentage of K substitution by Na in Eucalyptus seedlings: Evidences from leaf carbon isotopic composition, leaf gas exchanges and plant growth. 
  • The influence of follicle-stimulating hormone on testicular phospholipids. 
  • The isolation of 20alpha- and 20beta-hydroxypregn-4-en-3-one from porcine corpora lutea. 
  • The kinetics of intramolecular distribution of 15N in uric acid after administration of (15N) glycine. A reappraisal of the significance of preferential labeling of N-(3+9) of uric acid in primary gout. 
  • The role of ribosomal subunits and 80-S monomers in polysome formation in an ascites tumour cell. 
  • The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins. 
  • Tracking the in vivo fate of recombinant polypeptides by isotopic labeling. 
  • Transient floral change and rapid global warming at the Paleocene-Eocene boundary. 
  • Two proteins of gene A of psiX174. 
  • Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • Viewpoints: diet and dietary adaptations in early hominins: the hard food perspective. 
  • he effect of inhibitors of protein synthesis on the level of ribosomal subunits in ascites cells. 
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  Keywords of People

  • Vengosh, Avner, Professor of Earth and Ocean Sciences, Duke University Energy Initiative