Cardiac Pacing, Artificial

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  Subject Areas on Research

  • 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 
  • A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. 
  • ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. 
  • ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summary. 
  • Abnormalities of cardiac sympathetic function in pacing-induced heart failure as assessed by [123I]metaiodobenzylguanidine scintigraphy. 
  • Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries. 
  • Acoustic radiation force impulse imaging of mechanical stiffness propagation in myocardial tissue. 
  • Activation in unipolar cardiac electrograms: a frequency analysis. 
  • Acute and long-term efficacy and safety of catheter cryoablation of the cavotricuspid isthmus for treatment of type 1 atrial flutter. 
  • Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. 
  • Adverse effects of first-degree AV-block in patients with sinus node dysfunction: data from the mode selection trial. 
  • Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure. 
  • An analysis of the effects of acetylcholine on conduction and refractoriness in the rabbit sinus node. 
  • Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging. 
  • Assessment of left ventricular pressure-volume relations using gated radionuclide angiography, echocardiography, and micromanometer pressure recordings. A new method for serial measurements of systolic and diastolic function in man. 
  • Association between hospital procedure volume and early complications after pacemaker implantation: results from a large, unselected, contemporary cohort of the German nationwide obligatory external quality assurance programme. 
  • Atrial fibrillation and stroke: it's not necessarily all about the rhythm. 
  • Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST). 
  • Beta adrenoceptor recovery after heart failure in the dog. 
  • Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure. 
  • Bistability and correlation with arrhythmogenesis in a model of the right atrium. 
  • Calculating endocardial potentials from epicardial potentials measured during external stimulation. 
  • Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure. 
  • Cardiac pacing strategies and post-implantation risk of atrial fibrillation and heart failure events in sinus node dysfunction patients: a collaborative analysis of over 6000 patients. 
  • Cardiac potential and potential gradient fields generated by single, combined, and sequential shocks during ventricular defibrillation. 
  • Cardiac resynchronization therapy in heart failure patients: an update. 
  • Cardiac resynchronization therapy reduces the risk of hospitalizations in patients with advanced heart failure: results from the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION) trial. 
  • Cardiac resynchronization therapy utilization for heart failure: findings from IMPROVE HF. 
  • Cardiac resynchronization therapy: Part 1--issues before device implantation. 
  • Cardiac resynchronization therapy: Part 2--issues during and after device implantation and unresolved questions. 
  • Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failure. 
  • Cardiac-resynchronization therapy for the prevention of heart-failure events. 
  • Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data. 
  • Characterization of refractoriness in the sinus node of the rabbit. 
  • Clinical lessons learned from experimental heart failure. 
  • Coexisting preexcitation syndrome and intermittent heart block presenting as neonatal seizures. 
  • Comparison of activation during ventricular fibrillation and following unsuccessful defibrillation shocks in open-chest dogs. 
  • Comparison of electrocardiogram and intrathoracic electrogram signals for detection of ischemic ST segment changes during normal sinus and ventricular paced rhythms. 
  • Comparison of medical therapy dosing in outpatients cared for in cardiology practices with heart failure and reduced ejection fraction with and without device therapy: report from IMPROVE HF. 
  • Comparison of transesophageal atrial pacing with anticholinergic drugs for the treatment of intraoperative bradycardia. 
  • Comparison of upper limit of vulnerability and defibrillation probability of success curves using a nonthoracotomy lead system. 
  • Complete heart block in fetal lambs. I. Technique and acute physiological response. 
  • Complications arising after implantation of DDD pacemakers: the MOST experience. 
  • Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics. 
  • Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections. 
  • Conduction disturbances caused by high current density electric fields. 
  • Contribution of atrioventricular synchrony to left ventricular systolic function in a closed-chest canine model of complete heart block: implications for single-chamber rate-variable cardiac pacing. 
  • Cryosurgical modification of retrograde atrioventricular conduction. Implications for the surgical treatment of atrioventricular nodal reentry tachycardia. 
  • Demonstration of coronary artery myogenic vasoconstriction in the awake dog. 
  • Device therapy in heart failure patients with chronic kidney disease. 
  • Direct His bundle pacing post AVN ablation. 
  • Distinction between metabolic and myogenic mechanisms of coronary hyperemic response to brief diastolic occlusion. 
  • Does a hypertonic saline load predict fluid retention in pacing induced heart failure? 
  • Early electrocardiographic diagnosis of acute myocardial infarction in the presence of ventricular paced rhythm. GUSTO-I investigators. 
  • Early recovery from heart failure: insights into the pathogenesis of experimental chronic pacing-induced heart failure. 
  • Effect of biventricular pacing during a ventricular sensed event. 
  • Effect of heart rate on Doppler indexes of systolic function in humans. 
  • Effect of pacing site on ventricular fibrillation initiation by shocks during the vulnerable period. 
  • Effect of rapid pacing and T-wave scanning on the relation between the defibrillation and upper-limit-of-vulnerability dose-response curves. 
  • Effects of acute tachycardia on left ventricular adenine nucleotide levels and subsequent tolerance to ischemia. 
  • Effects of atrial fibrillation on myocardial blood flow in the ischemic heart of the dog. 
  • Effects of distant potentials on unipolar electrograms in an animal model utilizing the right ventricular isolation procedure. 
  • Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trial. 
  • Electrophysiologic properties of the myocardial infarction border zone: effects of transient aortic occlusion. 
  • Electrophysiologic testing to identify patients with coronary artery disease who are at risk for sudden death. Multicenter Unsustained Tachycardia Trial Investigators. 
  • Emergency ventricular pacing from the esophagus in infancy. 
  • Emerging role of myocardial perfusion imaging to evaluate patients for cardiac resynchronization therapy. 
  • Endocardial and epicardial steroid lead pacing in the neonatal and paediatric age group. 
  • Endocardial atrial pacing lead implantation and midterm follow-up in young patients with sinus node dysfunction after the fontan procedure. 
  • Endothelial nitric oxide synthase increases in left atria of dogs with pacing-induced heart failure. 
  • Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure. 
  • Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs. 
  • Estimating defibrillation efficacy using combined upper limit of vulnerability and defibrillation testing. 
  • Evaluation of indices of left ventricular contractility and relaxation in evolving canine experimental heart failure. 
  • Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. 
  • Existence of bistability and correlation with arrhythmogenesis in paced sheep atria. 
  • Expanding the benefits of implantable cardioverter-defibrillator therapy: "is less more"? 
  • Experimental basis for QRS and T wave potentials in the WPW syndrome. The relation of epicardial to body surface potential distributions in the intact chimpanzee. 
  • Extending the use of the pacing pulmonary artery catheter for safe minimally invasive cardiac surgery. 
  • Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic canine cardiac muscle. 
  • Fibrillar collagen and remodeling of dilated canine left ventricle. 
  • First-degree AV block-an entirely benign finding or a potentially curable cause of cardiac disease? 
  • Force-frequency characteristics of the left ventricle in the conscious dog. 
  • Force-frequency relations in the failing rabbit heart and responses to adrenergic stimulation. 
  • Frequency- and orientation-dependent effects of mexiletine and quinidine on conduction in the intact dog heart. 
  • Functional consequences of the right ventricular isolation procedure. 
  • HRS/ACCF expert consensus statement on pacemaker device and mode selection. 
  • HRS/ACCF expert consensus statement on pacemaker device and mode selection. Developed in partnership between the Heart Rhythm Society (HRS) and the American College of Cardiology Foundation (ACCF) and in collaboration with the Society of Thoracic Surgeons. 
  • Have the results of randomized clinical trials of pacing altered the practice of cardiac pacing? 
  • Heart failure during cardiac pacing. 
  • Heart rate during spontaneous and induced paroxysmal supraventricular tachycardia. 
  • High and low strength nonsynchronized shocks given during canine ventricular tachycardia. 
  • High incidence of pacemaker syndrome in patients with sinus node dysfunction treated with ventricular-based pacing in the Mode Selection Trial (MOST). 
  • Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998. 
  • Highlights of Heart Rhythm 2004, the Annual Scientific Sessions of the Heart Rhythm Society: May 19 to 22, 2004, in San Francisco, California. 
  • Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana. 
  • Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007. 
  • How does intermittent pacing modify the response to rapid ventricular pacing in experimental heart failure? 
  • How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • Impact of enalapril therapy on in vitro coronary artery responsiveness in pacing-induced heart failure. 
  • Impact of peer review in reduction of permanent pacemaker implantations. 
  • Impact of rate-modulated pacing on quality of life and exercise capacity--evidence from the Advanced Elements of Pacing Randomized Controlled Trial (ADEPT). 
  • Importance of preexcited QRS morphology during induced atrial fibrillation to the diagnosis and localization of multiple accessory pathways. 
  • Incidence, Predictors, and Outcomes of Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Analysis From the U.S. Society of Thoracic Surgeons/American College of Cardiology TVT Registry. 
  • Indications for pacing in the treatment of bradyarrhythmias. Report of an independent study group. 
  • Influence of beta-adrenergic blockade upon hemodynamic response to exercise assessed by Doppler echocardiography. 
  • Interactions between extracellular stimuli and excitation waves in an atrial reentrant loop. 
  • Is the adaptation of right ventricular refractoriness to an abrupt increase in heart rate impaired in chronic heart failure? 
  • Left ventricular remodelling and disparate changes in contractility and relaxation during the development of and recovery from experimental heart failure. 
  • Long-term outcomes in leadless Micra transcatheter pacemakers with elevated thresholds at implantation: Results from the Micra Transcatheter Pacing System Global Clinical Trial. 
  • Management of pace-terminated ventricular arrhythmias. 
  • Mapping the electrical initiation of ventricular fibrillation. 
  • Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. 
  • Metaanalysis on effects of cardiac resynchronization therapy in heart failure patients with narrow QRS complex. 
  • Metabolic mediation of single brief diastolic occlusion reactive hyperemic responses. 
  • Microvolt T wave alternans inducibility in normal newborn puppies: effects of development. 
  • Mode of death in advanced heart failure: the Comparison of Medical, Pacing, and Defibrillation Therapies in Heart Failure (COMPANION) trial. 
  • Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol. 
  • Myocardial energetics and blood flow in acute rapid ventricular pacing. 
  • New York Heart Association functional class predicts exercise parameters in the current era. 
  • Nonpharmacologic therapy in heart failure: an overview. 
  • Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. 
  • On the trail of ventricular tachycardia or the adventure of the unspeckled band. 
  • Oral anticoagulation management in patients with atrial fibrillation undergoing cardiac implantable electronic device implantation. 
  • Origin of epicardial ST-T wave potentials in the intact dog. 
  • Outcomes Associated With Extraction Versus Capping and Abandoning Pacing and Defibrillator Leads. 
  • Outcomes associated with warfarin use in older patients with heart failure and atrial fibrillation and a cardiovascular implantable electronic device: findings from the ADHERE registry linked to Medicare claims. 
  • Paced QRS duration as a predictor for clinical heart failure events during right ventricular apical pacing in patients with idiopathic complete atrioventricular block: results from an observational cohort study (PREDICT-HF). 
  • Pacemaker implantation and quality of life in the Mode Selection Trial (MOST). 
  • Pacing as a Treatment for Reflex-Mediated (Vasovagal, Situational, or Carotid Sinus Hypersensitivity) Syncope: A Systematic Review for the 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • Pacing-induced heart failure in the dog: evaluation of peripheral vascular alpha-adrenoceptor subtypes. 
  • Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure. 
  • Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation. 
  • Pathophysiological role of changing atrial size and pressure in modulation of atrial natriuretic factor during evolving experimental heart failure. 
  • Pediatric electrophysiology. 
  • Percutaneous interventions in high-risk patients following Mustard repair of transposition of the great arteries. 
  • Permanent His-Bundle Pacing: An Adolescent with Promise. 
  • Plasma and cardiac tissue atrial and brain natriuretic peptides in experimental heart failure. 
  • Predicting the outcomes of electrophysiologic studies of patients with unexplained syncope: preliminary validation of a derived model. 
  • Prediction of sustained ventricular tachycardia inducible by programmed stimulation in patients with coronary artery disease. Utility of clinical variables. 
  • Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement: the PARTNER (Placement of AoRtic TraNscathetER Valves) trial and registry. 
  • Prevention of recurrent sudden cardiac arrest: role of provocative electropharmacologic testing. 
  • Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT). 
  • Procainamide administration during pregnancy. 
  • Prolongation of repolarization time by electric field stimulation with monophasic and biphasic shocks in open-chest dogs. 
  • Promoting Transparency in Trials: Lessons From the COMPANION Investigators. 
  • Propagation model using the DiFrancesco-Noble equations. Comparison to reported experimental results. 
  • Pulmonary vascular impedance analysis of adaptation to chronically elevated blood flow in the awake dog. 
  • Radiofrequency catheter ablation for the treatment of human type 1 atrial flutter. Identification of a critical zone in the reentrant circuit by endocardial mapping techniques. 
  • Rapid ventricular pacing for a basilar artery pseudoaneurysm in a pediatric patient: case report. 
  • Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure. 
  • Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies. 
  • Rationale and design of a randomized clinical trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with advanced heart failure: the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). 
  • Rationale, design, and baseline characteristics of a Program to Assess and Review Trending INformation and Evaluate CorRelation to Symptoms in Patients with Heart Failure (PARTNERS HF). 
  • Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure. 
  • Reduced ejection fraction, sudden cardiac death, and heart failure death in the mode selection trial (MOST): implications for device selection in elderly patients with sinus node disease. 
  • Relation of ejection fraction and inducible ventricular tachycardia to mode of death in patients with coronary artery disease: an analysis of patients enrolled in the multicenter unsustained tachycardia trial. 
  • Remote monitoring of cardiac implantable electronic devices (CIED). 
  • Reply: Echocardiographic Substrate for Biventricular Pacing. 
  • Resource utilization and costs in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programme. 
  • Response of atrial natriuretic factor to acute and chronic increases of atrial pressures in experimental heart failure in dogs. Role of changes in heart rate, atrial dimension, and cardiac tissue concentration. 
  • Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study. 
  • Right atrial appendage pacing: radiographic considerations. 
  • Right ventricular isolation procedures for nonischemic ventricular tachycardia. 
  • Robotic-assisted or minithoracotomy incision for left ventricular lead placement: a single-surgeon, single-center experience. 
  • Role of Mahaim fibers in cardiac arrhythmias in man. 
  • Safety of slow pathway ablation in patients with long PR interval: further evidence of fast and slow pathway interaction. 
  • Safety of transvenous cardiac resynchronization system implantation in patients with chronic heart failure: combined results of over 2,000 patients from a multicenter study program. 
  • Sequential echocardiographic-Doppler assessment of left ventricular remodelling and mitral regurgitation during evolving experimental heart failure. 
  • Spatial heterogeneity of restitution properties and the onset of alternans. 
  • Strategies to attenuate pathological remodeling in heart failure. 
  • Strength-interval curves in canine myocardium at very short cycle lengths. 
  • Structural remodelling in heart failure: gelatinase induction. 
  • Surgery for atrial fibrillation. 
  • Surgical management of chronic ectopic atrial tachycardia. 
  • Surgical treatment of supraventricular tachyarrhythmias. 
  • Surgically placed left ventricular leads provide similar outcomes to percutaneous leads in patients with failed coronary sinus lead placement. 
  • Survival in Women Versus Men Following Implantation of Pacemakers, Defibrillators, and Cardiac Resynchronization Therapy Devices in a Large, Nationwide Cohort. 
  • Temporal alterations in peripheral vascular responsiveness during both the development and recovery from pacing-induced heart failure. 
  • Temporary, catheter-induced block in accessory pathways. 
  • The comparative effects of drive and test stimulus intensity on myocardial excitability and vulnerability. 
  • The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts. 
  • The effects of atrial fibrillation on regional blood flow in the awake dog. 
  • The effects of local ventricular pacing on recovery from regional myocardial ischemia. 
  • The effects of ventricular pacing on left ventricular geometry, function, myocardial oxygen consumption, and efficiency of contraction in conscious dogs. 
  • The mode selection trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients. 
  • The noninvasive localization of ventricular pacing sites by radionuclide phase imaging. 
  • The restitution portrait: a new method for investigating rate-dependent restitution. 
  • The role of intrinsic and induced vulnerability in electrically induced cardiac arrhythmias. 
  • The surgical treatment of atrial fibrillation. II. Intraoperative electrophysiologic mapping and description of the electrophysiologic basis of atrial flutter and atrial fibrillation. 
  • Transcatheter Leadless Pacemaker Implantation for Complete Heart Block Following CoreValve Transcatheter Aortic Valve Replacement. 
  • Transient complete atrioventricular block following radiofrequency ablation of left free wall accessory pathway. 
  • Treatment crossovers did not affect randomized treatment comparisons in the Mode Selection Trial (MOST). 
  • Treatment of patients with myocardial infarction who present with a paced rhythm. 
  • Ultrasound accelerated catheter directed thrombolysis for pulmonary embolus and right heart thrombus secondary to transvenous pacing wires. 
  • Update on sick sinus syndrome, a cardiac disorder of aging. 
  • Use of ventricular synchronized triggered atrial pacing to facilitate hemodynamic support during mapping and catheter ablation of ventricular vachycardia. 
  • Ventricular arrhythmia inducibility predicts subsequent ICD activation in nonischemic cardiomyopathy patients: a DEFINITE substudy. 
  • Ventricular pacing can induce hemodynamically significant mitral valve regurgitation. 
  • Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. 
  • Ventricular tachycardia induced cardiomyopathy: improvement with radiofrequency ablation. 
  • Zones of atrial vulnerability. Relationships to basic cycle length. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Carboni, Michael Paul, Assistant Professor of Pediatrics, Pediatrics, Cardiology
  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Malkin, Robert A., Professor of the Practice in the Department of Biomedical Engineering, Duke Science & Society
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Neu, Wanda Krassowska, Professor of Biomedical Engineering, Biomedical Engineering
  • Patel, Uptal Dinesh, Adjunct Professor in the Department of Medicine, Medicine, Nephrology