Cardiopulmonary Bypass

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  Subject Areas on Research

  • "Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. 
  • A Multicenter Pilot Study Assessing Regional Cerebral Oxygen Desaturation Frequency During Cardiopulmonary Bypass and Responsiveness to an Intervention Algorithm. 
  • A bolus dose of 1.5 mg/kg amrinone effectively improves low cardiac output state following separation from cardiopulmonary bypass in cardiac surgical patients. 
  • A case series of recombinant platelet factor 4 for heparin reversal after cardiopulmonary bypass. 
  • A change in anticoagulation monitoring improves safety, reduces transfusion, and reduces costs in infants on cardiopulmonary bypass. 
  • A clinical comparison of mitral valve repair versus valve replacement in ischemic mitral regurgitation. 
  • A clinical evaluation of the Dideco Kids D100 neonatal oxygenator. 
  • A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study. 
  • A comparison of short- and long-term outcomes after off-pump and on-pump coronary artery bypass graft surgery with sternotomy. 
  • A diagnosis of heparin-induced thrombocytopenia with combined clinical and laboratory methods in cardiothoracic surgical intensive care unit patients. 
  • A method for perfusion of the leg during cardiopulmonary bypass via femoral cannulation. 
  • A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. 
  • A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper. 
  • A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). 
  • A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass. 
  • A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. 
  • A phase III, double-blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass. 
  • A pumping artificial lung. 
  • A randomized, double-blind, placebo-controlled study assessing the anti-inflammatory effects of ketamine in cardiac surgical patients. 
  • A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings. 
  • Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. 
  • Activated clotting time systems vary in precision and bias and are not interchangeable when following heparin management protocols during cardiopulmonary bypass. 
  • Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group. 
  • Acute functional consequences of left ventriculotomy. 
  • Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group. 
  • Acute renal injury and lowest hematocrit during cardiopulmonary bypass: not only a matter of cellular hypoxemia. 
  • Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression. 
  • Adrenal cortical carcinoma with vena cava tumor thrombus requiring cardiopulmonary bypass for resection. 
  • Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. 
  • Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. 
  • Altered expression and activation of mitogen-activated protein kinases in diabetic heart during cardioplegic arrest and cardiopulmonary bypass. 
  • Amrinone: its effect on vascular resistance and capacitance in human subjects. 
  • An Alternative Technique for Hemiarch Replacement Without Using Deep Hypothermic Circulatory Arrest. 
  • An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. 
  • An ultrafiltration technique for directly reinfusing residual cardiopulmonary bypass blood. 
  • Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. 
  • Andexanet Alfa Use in Patients Requiring Cardiopulmonary Bypass: Quo Vadis? 
  • Anesthesia for Lung Transplantation. 
  • Anesthetic management of a patient with a brain tumor for cardiac surgery. 
  • Angiotensin-converting enzyme inhibition alters the inflammatory and fibrinolytic response to cardiopulmonary bypass in children. 
  • Anticoagulant therapy during cardiopulmonary bypass. 
  • Anticoagulation management associated with extracorporeal circulation. 
  • Anticoagulation management during cardiopulmonary bypass: a survey of 54 North American institutions. 
  • Antithrombin deficiency in special clinical syndromes--Part II: cardiovascular surgery. 
  • Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass. 
  • Aortic subannular left ventricular aneurysm: a rare and surgically correctable cause of angina. 
  • Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. 
  • Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. 
  • Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass. 
  • Aprotinin is useful as a hemostatic agent in cardiopulmonary surgery: yes. 
  • Aprotinin use during cardiac surgery: recent alterations and effects on blood product utilization. 
  • Aprotinin versus tranexamic acid: the controversy continues. 
  • Argatroban for anticoagulation during cardiopulmonary bypass in an infant. 
  • Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction. 
  • Assessment of left ventricular functional preservation during isolated cardiac valve operations. 
  • Association of gender and lowest hematocrit on cardiopulmonary bypass with acute kidney injury and operative mortality in patients undergoing cardiac surgery. 
  • Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. 
  • Asymptomatic carotid artery stenosis and stroke in patients undergoing cardiopulmonary bypass. 
  • Atrial Fibrillation, Neurocognitive Decline and Gene Expression After Cardiopulmonary Bypass. 
  • Atrial fibrillation after cardiac surgery/cardiopulmonary bypass is associated with monocyte activation. 
  • Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state. 
  • Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. 
  • Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. 
  • Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest. 
  • Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest. 
  • CASE 12--2014. Inferior vena cava compression by retroperitoneal hematoma during cardiopulmonary bypass. 
  • Carboxyhemoglobinemia in a pediatric cardiopulmonary bypass patient derived from a contaminated unit of allogenic blood. 
  • Cardiac catheterization within 1 to 3 days of proximal aortic surgery is not associated with increased postoperative acute kidney injury. 
  • Cardiac cryosurgery: effects of myocardial temperature on cryolesion size. 
  • Cardiac gene delivery with cardiopulmonary bypass. 
  • Cardiac operations in patients with functioning renal allografts. 
  • Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database. 
  • Cardiopulmonary Bypass Decreases Activation of the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway in Diabetic Human Myocardium. 
  • Cardiopulmonary Bypass Management Complicated by a Stenotic Coronary Sinus and Cold Agglutinins. 
  • Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease. 
  • Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat. 
  • Cardiopulmonary bypass and the central nervous system: potential for cerebral protection. 
  • Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells. 
  • Cardiopulmonary bypass induces leukocyte-platelet adhesion. 
  • Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat. 
  • Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*. 
  • Cardiopulmonary bypass reduces the minimum alveolar concentration for isoflurane. 
  • Cardiopulmonary bypass time does not affect cerebral blood flow. 
  • Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping. 
  • Case 4-2011: malignant hyperthermia in cardiac surgery. 
  • Case 6--1998. Perioperative anesthetic management of a patient presenting for resection of a tracheal mass. 
  • Case 6--1999. Off-pump coronary artery bypass graft surgery. 
  • Case 6-2011: Aortic valve replacement in a patient with aortic stenosis, dilated cardiomyopathy, and renal dysfunction. 
  • Cerebral blood flow and metabolism during cardiopulmonary bypass. 
  • Cerebral blood flow values during cardiopulmonary bypass: relatively absolute or absolutely relative? 
  • Cerebral emboli and serum S100beta during cardiac operations. 
  • Cerebral metabolic effects of sequential periods of hypothermic circulatory arrest. 
  • Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI. 
  • Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144. 
  • Cerebral tumor necrosis factor alpha expression and long-term neurocognitive performance after cardiopulmonary bypass in rats. 
  • Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome. 
  • Changes in health-related quality of life in off-pump versus on-pump cardiac surgery: Veterans Affairs Randomized On/Off Bypass trial. 
  • Changes in regional myocardial function after coronary artery bypass graft surgery are predicted by intraoperative low-dose dobutamine echocardiography. 
  • Changing systems for measuring activated clotting times: impact on the clinical practice of heparin anticoagulation during cardiac surgery. 
  • Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate. 
  • Coagulation and fibrinolytic protein kinetics in cardiopulmonary bypass. 
  • Coagulation complicating cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia receiving the heparinoid, danaparoid sodium. 
  • Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa. 
  • Coagulopathy and inflammation in neonatal heart surgery: mechanisms and strategies. 
  • Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. 
  • Combined TMR and mitral valve replacement via left thoracotomy. 
  • Comparing two strategies of cardiopulmonary bypass cooling on jugular venous oxygen saturation in neonates and infants. 
  • Complement factor 1 inhibitor improves cardiopulmonary function in neonatal cardiopulmonary bypass. 
  • Con: Magnesium should not be administered to all coronary artery bypass graft surgery patients undergoing cardiopulmonary bypass. 
  • Con: Methylprednisolone is not indicated for patients during cardiopulmonary bypass. 
  • Conduction block after cardioplegic arrest: prevention by augmented atrial hypothermia. 
  • Continuous arterial and venous blood gas monitoring during cardiopulmonary bypass. 
  • Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery. 
  • Conversion From Off-Pump Coronary Artery Bypass Grafting to On-Pump Coronary Artery Bypass Grafting. 
  • Coronary artery bypass graft failure after on-pump and off-pump coronary artery bypass: findings from PREVENT IV. 
  • Coronary-Artery Bypass Grafting. 
  • Corrected transposition with severe intracardiac deformities with Wolff-Parkinson-White syndrome in a child. Electrophysiologic investigation and surgical correction. 
  • Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database. 
  • Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: a randomized, blinded clinical trial. 
  • Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. 
  • Design and performance of a physiologic pulsatile flow neonate-infant cardiopulmonary bypass system. 
  • Detection of unintentional partial superior vena cava occlusion during a bidirectional cavopulmonary anastomosis. 
  • Development of a novel blood-sparing agent in cardiac surgery: do we need another agent? 
  • Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass. 
  • Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. 
  • Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. 
  • Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis? 
  • Discordance in Grading Methods of Aortic Stenosis by Pre-Cardiopulmonary Bypass Transesophageal Echocardiography. 
  • Distal support for thoracic aneurysm repair. 
  • Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial. 
  • Dose dependent effects of cardiac beta2 adrenoceptor gene therapy. 
  • ECLS for preemies: the artificial placenta. 
  • Early and late forms of cyclosporine nephrotoxicity: studies in cardiac transplant recipients. 
  • Echo rounds: Intraoperative delineation of mitral annuloplasty dehiscence using three-dimensional transesophageal echocardiography. 
  • Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction. 
  • Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass. 
  • Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat. 
  • Effect of deep hypothermia and circulatory arrest on cerebral blood flow and metabolism. 
  • Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial. 
  • Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis. 
  • Effect of magnesium on dopamine-induced postischemic injury in the isolated rat heart. 
  • Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass. 
  • Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. 
  • Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. 
  • Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: a randomised, controlled study. 
  • Effects of C5 complement inhibitor pexelizumab on outcome in high-risk coronary artery bypass grafting: combined results from the PRIMO-CABG I and II trials. 
  • Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest. 
  • Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. 
  • Effects of cardiopulmonary bypass on eicosanoid metabolism during pediatric cardiovascular surgery. 
  • Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. 
  • Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass. 
  • Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass. 
  • Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection: A pilot study. 
  • Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study. 
  • Effects of sustained ventricular fibrillation on nonhypertrophied heart. 
  • Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass. 
  • Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial. 
  • Efficacy and safety of recombinant factor XIII on reducing blood transfusions in cardiac surgery: a randomized, placebo-controlled, multicenter clinical trial. 
  • Electrophysiologic effects of surgical isolation of the right ventricle. 
  • Emerging applications of aptamers for anticoagulation and hemostasis. 
  • Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. II. Effects on regional myocardial blood flow. 
  • Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. III. Effects on regional left ventricular function. 
  • Endovascular thoracic aortic aneurysm repair with concomitant myocardial and carotid revascularization. 
  • Enhancement of cardiac function by cyclocreatine in models of cardiopulmonary bypass. 
  • Error associated with the choice of an aortic cannula in measuring regional cerebral blood flow with microspheres during pulsatile CPB in a neonatal piglet model. 
  • Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. 
  • Evaluation of patients at risk for protamine reactions. 
  • Evaluation of the topical hemostatic efficacy and safety of TISSEEL VH S/D fibrin sealant compared with currently licensed TISSEEL VH in patients undergoing cardiac surgery: a phase 3, randomized, double-blind clinical study. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • Exposure of difficult left hilum in bilateral sequential lung transplantation. 
  • Factor XII deficiency and cardiopulmonary bypass: use of a novel modification of the activated clotting time to monitor anticoagulation. 
  • False-positive diagnosis of aortic dissection associated with femoral cardiopulmonary bypass. 
  • Feasibility of speckle-tracking echocardiography for assessment of left ventricular dysfunction after cardiopulmonary bypass. 
  • Feeling the heat. 
  • Genetic factors contribute to bleeding after cardiac surgery. 
  • Genetic polymorphisms and the risk of stroke after cardiac surgery. 
  • Glucose and outcome after cardiac surgery: what are the issues? 
  • Grading Aortic Stenosis With Mean Gradient and Aortic Valve Area: A Comparison Between Preoperative Transthoracic and Precardiopulmonary Bypass Transesophageal Echocardiography. 
  • Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats. 
  • Hemostatic agents and their safety. 
  • Heparin modifies the immunogenicity of positively charged proteins. 
  • Heparin neutralization by recombinant platelet factor 4 and protamine. 
  • Heparin neutralization with methylene blue, hexadimethrine, or vancomycin after cardiopulmonary bypass. 
  • Heparin resistance and antithrombin: should it still be called heparin resistance? 
  • Heparin therapy during cardiopulmonary bypass in children requires ongoing quality control. 
  • Heparin-Induced Thrombocytopenia: A Review for Cardiac Anesthesiologists and Intensivists. 
  • Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery. 
  • High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass. 
  • High-Velocity Jet in the Right Atrium: What Is the Diagnosis? 
  • Home surveillance program prevents interstage mortality after the Norwood procedure. 
  • How best to monitor for detection of myocardial ischemia? 
  • Hypothermia and operative mortality during on-pump coronary artery bypass grafting. 
  • Immediate versus delayed coronary grafting after streptokinase treatment. Postoperative blood loss and clinical results. 
  • Impact of Operative and Postoperative Factors on Neurodevelopmental Outcomes After Cardiac Operations. 
  • Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. 
  • Impact of residency status on perfusion times and outcomes for coronary artery bypass graft surgery. 
  • Improved clot formation by combined administration of activated factor VII (NovoSeven) and fibrinogen (Haemocomplettan P). 
  • Inadvertent development of subatmospheric airway pressure during cardiopulmonary bypass. 
  • Incidence and Impact of On-Cardiopulmonary Bypass Vasoplegia During Heart Transplantation. 
  • Incidental Cold Agglutinins in Cardiac Surgery: Intraoperative Surprises and Team-Based Problem-Solving Strategies During Cardiopulmonary Bypass. 
  • Increased anticoagulation during cardiopulmonary bypass by aprotinin. 
  • Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. 
  • Infant cardiopulmonary bypass: a procoagulant state. 
  • Inflammation and cardiopulmonary bypass. 
  • Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. 
  • Inflammatory response to cardiopulmonary bypass. 
  • Influence of the timing of cardiac catheterization and the amount of contrast media on acute renal failure after cardiac surgery. 
  • Inhaled nitric oxide results in deteriorating hemodynamics when administered during cardiopulmonary bypass in neonatal swine. 
  • Inhibition of complement activation by pexelizumab reduces death in patients undergoing combined aortic valve replacement and coronary artery bypass surgery. 
  • Intermittent perfusion protects the brain during deep hypothermic circulatory arrest. 
  • Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 
  • Intramyocardial air causes right ventricular dysfunction after repair of a congenital heart defect. 
  • Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients. 
  • Intraoperative echocardiography is indicated in high-risk coronary artery bypass grafting. 
  • Intraoperative physiologic variables and outcome in cardiac surgery: Part I. In-hospital mortality. 
  • Intraoperative prebypass and postbypass epicardial color flow imaging in the repair of atrioventricular septal defects. 
  • Intraoperative pulmonary artery stenting: an alternative technique for the management of pulmonary artery stenosis. 
  • Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations. 
  • Intraoperative vasoplegia: methylene blue to the rescue! 
  • Intravenous milrinone in cardiac surgery. 
  • Invited commentary. 
  • Invited commentary. 
  • Is there a long-term predictive value of intraoperative low-dose dobutamine echocardiography in patients who have coronary artery bypass graft surgery with cardiopulmonary bypass? 
  • Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass. 
  • Junctional tachycardia in infants and children after open heart surgery for congenital heart disease. 
  • Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation. 
  • Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial. 
  • Liquid lung ventilation reduces neutrophil sequestration in a neonatal swine model of cardiopulmonary bypass. 
  • Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass. 
  • Long-term outcome after biologic versus mechanical aortic valve replacement in 841 patients. 
  • Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. 
  • Longitudinal assessment of neurocognitive function in rats after cardiopulmonary bypass: evidence for long-term deficits. 
  • Low-flow cardiopulmonary bypass produces greater pulmonary dysfunction than circulatory arrest. 
  • Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender. 
  • Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study. 
  • Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large-dose regimen. 
  • Management and prevention of cardiovascular hemorrhage associated with mediastinitis. 
  • Management of patients with heparin-associated thrombocytopenia and thrombosis requiring cardiac surgery. 
  • Mannitol and dopamine in patients undergoing cardiopulmonary bypass: a randomized clinical trial. 
  • Measurement of myocardial perfusion by contrast echocardiography: application in the operating room. 
  • Mediastinitis after coronary artery bypass graft surgery. Risk factors and long-term survival. 
  • Metabolic deterioration during global ischemia as a function of time in the intact normal dog heart. 
  • Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. 
  • Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. 
  • Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: timing of dose is important. 
  • Mini-circuit cardiopulmonary bypass with vacuum assisted venous drainage: feasibility of an asanguineous prime in the neonate. 
  • Mitral surgery after prior cardiac operation: port-access versus sternotomy or thoracotomy. 
  • Modified ultrafiltration improves cerebral metabolic recovery after circulatory arrest. 
  • Modified ultrafiltration versus conventional ultrafiltration: a randomized prospective study in neonatal piglets. 
  • Modulation of platelet surface adhesion receptors during cardiopulmonary bypass. 
  • Monitoring of the electrical status of the ventricle during cardioplegic arrest. 
  • Monitoring the brain during cardiac surgery in children. 
  • Monitoring the jugular-venous oxyhemoglobin saturation as a decision aid for normothermic cardiopulmonary bypass. 
  • Myocardial blood flow and oxygen consumption in the empty-beating, fibrillating, and potassium-arrested hypertrophied canine heart. 
  • Myocardial function is normal after rapid cooling of the in vivo neonatal heart. 
  • Myogenic constriction of human coronary arterioles. 
  • Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery. 
  • Neurocognitive function after coronary-artery bypass surgery. 
  • Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass. 
  • Neurological injury during cardiopulmonary bypass in the rat. 
  • Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. 
  • New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. 
  • Noncardiogenic pulmonary edema and rhabdomyolsis after protamine administration in a patient with unrecognized McArdle's disease. 
  • Off-pump bypass surgery--ready for the big dance? 
  • Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity. 
  • Off-pump coronary bypass grafting is associated with less myocardial injury than coronary bypass surgery with cardiopulmonary bypass. 
  • Off-pump techniques benefit men and women and narrow the disparity in mortality after coronary bypass grafting. 
  • Off-pump versus on-pump coronary artery bypass surgery and postoperative renal dysfunction. 
  • On-pump versus off-pump coronary artery bypass surgery: cost-effectiveness analysis alongside a multisite trial. 
  • Optimizing liquid ventilation as a lung protection strategy for neonatal cardiopulmonary bypass: full functional residual capacity dosing is more effective than half functional residual capacity dosing. 
  • Outcomes of off-pump versus on-pump coronary artery bypass grafting: Impact of preoperative risk. 
  • Overview of clinical efficacy and safety of pharmacologic strategies for blood conservation. 
  • Oxidative stress and nerve function after cardiopulmonary bypass in patients with diabetes. 
  • Paroxysmal cold hemoglobinuria and cardiopulmonary bypass. 
  • Patterns of use of perioperative angiotensin-converting enzyme inhibitors in coronary artery bypass graft surgery with cardiopulmonary bypass: effects on in-hospital morbidity and mortality. 
  • Perflubron emulsion (AF0144) augments harvesting of autologous blood: a phase II study in cardiac surgery. 
  • Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome? 
  • Perioperative Corticosteroids in Children Undergoing Congenital Heart Surgery: Five Decades of Clinical Equipoise. 
  • Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. 
  • Perioperative hypothermia: use and therapeutic implications. 
  • Perioperative nesiritide and possible renal protection in patients with moderate to severe kidney dysfunction. 
  • Perioperative renal dysfunction and cardiovascular anesthesia: concerns and controversies. 
  • Perioperative temperature and cardiac surgery. 
  • Periventricular leukomalacia is common after neonatal cardiac surgery. 
  • Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. 
  • Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. 
  • Pharmacokinetics of amrinone during cardiac surgery. 
  • Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery. 
  • Pharmacokinetics of recombinant transgenic antithrombin in volunteers. 
  • Pharmacologic electroencephalographic suppression during cardiopulmonary bypass: a comparison of thiopental and isoflurane. 
  • Pharmacologic preservation of the hemostatic system during cardiac surgery. 
  • Pharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery: a randomized pilot feasibility trial. 
  • Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. 
  • Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. 
  • Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function. 
  • Platelet inhibitors and bleeding in cardiac surgical patients. 
  • Platelet inhibitors and cardiac surgery. 
  • Population pharmacokinetics of lidocaine administered during and after cardiac surgery. 
  • Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery. 
  • Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. 
  • Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery. 
  • Predicting and preventing adverse neurologic outcomes with cardiac surgery. 
  • Predicting and treating coagulopathies after cardiopulmonary bypass in children. 
  • Predicting mortality in patients with disseminated intravascular coagulation after cardiopulmonary bypass surgery by utilizing two scoring systems. 
  • Predictors of cardiac troponin release after mitral valve surgery. 
  • Predictors of cognitive decline after cardiac operation. 
  • Predictors of contemporary coronary artery bypass grafting outcomes. 
  • Predictors of inotrope use during separation from cardiopulmonary bypass. 
  • Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center. 
  • Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center. 
  • Preoperative gene expression may be associated with neurocognitive decline after cardiopulmonary bypass. 
  • Preoperative low molecular weight heparin reduces heparin responsiveness during cardiac surgery. 
  • Preoperative lymphopenia is a predictor of postoperative adverse outcomes in children with congenital heart disease. 
  • Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. 
  • Prevalence and repair of intraoperatively diagnosed patent foramen ovale and association with perioperative outcomes and long-term survival. 
  • Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. 
  • Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study. 
  • Pro: The Value of Modified Ultrafiltration in Children After Cardiopulmonary Bypass. 
  • Pro: Vasopressin is the vasoconstrictor of choice after cardiopulmonary bypass. 
  • Pro: arguments for use of barbiturates in infants and children undergoing deep hypothermic circulatory arrest. 
  • Prolonged postoperative respiratory support after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor? 
  • Prolonged pulmonary support after cardiac surgery: incidence, risk factors and outcomes: a retrospective cohort study. 
  • Prospective evaluation of risk of protamine reactions in patients with NPH insulin-dependent diabetes. 
  • Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. 
  • Protecting the brain in coronary artery bypass graft surgery. 
  • Proteomics of cerebral injury in a neonatal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. 
  • Quantification of the contractile response to injury: assessment of the work-length relationship in the intact heart. 
  • Randomized evaluation of fibrinogen vs placebo in complex cardiovascular surgery (REPLACE): a double-blind phase III study of haemostatic therapy. 
  • Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography. 
  • Recognition of reversible and irreversible myocardial injury by technetium pyrophosphate extraction kinetics. 
  • Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass. 
  • Recovery of cerebral metabolism and mitochondrial oxidation state is delayed after hypothermic circulatory arrest. 
  • Reduction in air bubble size using perfluorocarbons during cardiopulmonary bypass in the rat. 
  • Reduction in blood transfusion in a cohort of infants having cardiac surgery with cardiopulmonary bypass after instituting a goal-directed transfusion policy. 
  • Regional blood flow during pulsatile cardiopulmonary bypass and after circulatory arrest in an infant model. 
  • Relationship between serum lactate and ionized calcium in open-heart surgery. 
  • Relationship of LV compliance to coronary artery perfusion pressure in potassium-arrested canine heart during cardiopulmonary bypass. 
  • Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. 
  • Renal artery stenosis is not associated with the development of acute renal failure following coronary artery bypass grafting. 
  • Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat. 
  • Renal medullary hypoxia during experimental cardiopulmonary bypass: a pilot study. 
  • Replacement of continuous-flow left ventricular assist device via left subcostal incision. 
  • Repletion of factor XIII following cardiopulmonary bypass using a recombinant A-subunit homodimer. A preliminary report. 
  • Reply: To PMID 23673070. 
  • Reply: To PMID 24266946. 
  • Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance. 
  • Results with an algorithmic approach to hybrid repair of the aortic arch. 
  • Right ventricular rupture during off-pump coronary bypass surgery. 
  • Right ventricular sensitivity to metabolic injury during cardiopulmonary bypass. 
  • Risk factors for mortality and morbidity after the neonatal Blalock-Taussig shunt procedure. 
  • Risk index for perioperative renal dysfunction/failure: critical dependence on pulse pressure hypertension. 
  • Robotic Mitral Valve Repair in Older Individuals: An Analysis of The Society of Thoracic Surgeons Database. 
  • Routine use of intraoperative epicardial echocardiography and Doppler color flow imaging to guide and evaluate repair of congenital heart lesions. A prospective study. 
  • S-Nitrosohemoglobin Levels and Patient Outcome After Transfusion During Pediatric Bypass Surgery. 
  • S100beta and postcardiac surgery neurological dysfunction: reasons to disregard any link. 
  • Serum lactates correlate with mortality after operations for complex congenital heart disease. 
  • Skeletal muscle grafts applied to the heart. A word of caution. 
  • Soluble alpha2-macroglobulin receptor is increased in endotracheal aspirates from infants and children after cardiopulmonary bypass. 
  • Staged correction of pulmonary atresia and absent right pulmonary artery. 
  • Surgery. Translating trials to clinical practice in cardiac surgery. 
  • Surgical ablation of atrial fibrillation trends and outcomes in North America. 
  • Surgical resection for isolated cardiac metastases. 
  • Surgical treatment of acute ascending aortic dissection. 
  • Surviving a transfixing cardiac injury caused by a stingray barb. 
  • Synchronous rhythmical vasomotion in the human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass. 
  • Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial. 
  • The "sandblasting" effect of aortic cannula on arch atheroma during cardiopulmonary bypass. 
  • The Association of Aortic Valve Pathology With Renal Resistive Index as a Kidney Injury Biomarker. 
  • The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass. 
  • The association of epsilon-aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patients. 
  • The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery. 
  • The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass. 
  • The current practice of intra-aortic balloon counterpulsation: results from the Benchmark Registry. 
  • The effect of aprotinin on activated protein C-mediated downregulation of endogenous thrombin generation. 
  • The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass. 
  • The effect of cardiopulmonary bypass and inspired oxygen concentration on left ventricular contrast opacification with optison, a second-generation ultrasound contrast agent. 
  • The effect of milrinone on hemodynamics and left ventricular function after emergence from cardiopulmonary bypass. 
  • The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. 
  • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. 
  • The effects of cardiopulmonary bypass on coagulation. 
  • The effects of milrinone on platelets in patients undergoing cardiac surgery. 
  • The in vitro effects of antithrombin III on the activated coagulation time in patients on heparin therapy. 
  • The inflammatory response to cardiopulmonary bypass. 
  • The influence of xenon, nitrous oxide and nitrogen on gas bubble expansion during cardiopulmonary bypass. 
  • The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery. 
  • The plasma supplemented modified activated clotting time for monitoring of heparinization during cardiopulmonary bypass: a pilot investigation. 
  • The relationship between immediate outcome after cardiac surgery, homogeneous cardioplegia delivery, and ejection fraction. 
  • The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery. 
  • The risk of acute kidney injury with co-occurrence of anemia and hypotension during cardiopulmonary bypass relative to anemia alone. 
  • The safety of induced ventricular fibrillation during cardiopulmonary bypass in nonhypertrophied hearts. 
  • The systemic inflammatory response to cardiopulmonary bypass: pathophysiological, therapeutic, and pharmacological considerations. 
  • The type of aortic cannula and membrane oxygenator affect the pulsatile waveform morphology produced by a neonate-infant cardiopulmonary bypass system in vivo. 
  • The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. 
  • The utility of transesophageal echocardiography and Doppler color flow imaging in patients undergoing cardiac valve surgery. 
  • The year in cardiothoracic and vascular anesthesia: selected highlights from 2013. 
  • Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis. 
  • Time limits for submersion of canine left ventricular biopsies in cold isopentane. 
  • Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline. 
  • Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass. 
  • Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery. 
  • Transplantation of high panel-reactive antibody left ventricular assist device patients without crossmatch using on-bypass pheresis and alemtuzumab. 
  • Treatment of non-cardiogenic pulmonary edema following cardiopulmonary bypass with veno-venous extracorporeal membrane oxygenation. 
  • Two-stage total cardioaortic replacement for end-stage heart and aortic disease in Marfan syndrome: case report and review of the literature. 
  • Unreliability of hemodynamic indexes of left ventricular size during cardiac surgery. 
  • Unusual cause of superior vena cava syndrome diagnosed with transesophageal echocardiography. 
  • Urine NGAL as a biomarker of kidney damage after on- and off-pump coronary artery bypass graft surgery: a prospective pilot study. 
  • Use of Adjuncts Reduces Cardiopulmonary Bypass Time During Minimally Invasive Aortic Valve Replacement. 
  • Use of cardiopulmonary bypass in studies of the circulation. 
  • Using Zero Balance Ultrafiltration with Dialysate as a Replacement Fluid for Hyperkalemia during Cardiopulmonary Bypass. 
  • Using Zero-Balance Ultrafiltration With Dialysate as a Replacement Solution for Toxin and Eptifibatide Removal on a Dialysis-Dependent Patient During Cardiopulmonary Bypass. 
  • Utility of concomitant tricuspid valve procedures for patients undergoing implantation of a continuous-flow left ventricular device. 
  • Venous admixture to radial artery blood samples during cardiopulmonary bypass. 
  • Warming during cardiopulmonary bypass is associated with jugular bulb desaturation. 
  • Xenon and the inflammatory response to cardiopulmonary bypass in the rat. 
  • Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. 
  • beta2 adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery. 
  • epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. 
  • pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in a piglet model of aortopulmonary collaterals. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Barbeito, Atilio, Associate Professor of Anesthesiology, Anesthesiology
  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology