Cardiovascular Agents

• 

  Subject Areas on Research

  • "Hot" unstable angina--is it worse than subacute unstable angina? Results from the GUARANTEE Registry. 
  • "How can SCAI and industry partners increase adherence and educate interventionalists on optimal medical therapy?" 
  • 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society for Vascular Medicine, and Society for Vascular Surgery. 
  • 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 
  • 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 
  • 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. 
  • 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 
  • 3-year follow-up of the SISR (Sirolimus-Eluting Stents Versus Vascular Brachytherapy for In-Stent Restenosis) trial. 
  • A health literacy pilot intervention to improve medication adherence using Meducation® technology. 
  • A new era of prospective real-world safety evaluation primary report of XIENCE V USA (XIENCE V Everolimus Eluting Coronary Stent System condition-of-approval post-market study). 
  • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. 
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). 
  • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). 
  • Aborted myocardial infarction in ST-elevation myocardial infarction: insights from the STrategic Reperfusion Early After Myocardial infarction trial. 
  • Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. 
  • Acute ischemic syndromes. 
  • Adenosine for myocardial protection in acute myocardial infarction. 
  • Adenosine-induced transient asystole for intracranial aneurysm surgery: a retrospective review. 
  • Adverse drug events in high risk older outpatients. 
  • Age and persistent use of cardiovascular medication after acute coronary syndrome: results from medication applied and sustained over time. 
  • American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. 
  • Antianginal therapy before percutaneous coronary intervention. 
  • Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. 
  • Association of Patient Enrollment in Medicare Part D With Outcomes After Acute Myocardial Infarction. 
  • BNP-guided heart failure therapy in older patients. 
  • BNP-guided therapy for heart failure. 
  • Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era. 
  • Benefits and Risks of Extended Dual Antiplatelet Therapy After Everolimus-Eluting Stents. 
  • Brand vs generic adverse event reporting patterns: An authorized generic-controlled evaluation of cardiovascular medications. 
  • Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy. 
  • Calcineurin signaling in human cardiac hypertrophy. 
  • Cardiac allograft vasculopathy: A review. 
  • Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction. 
  • Cardiovascular Disease and HIV: Pathophysiology, Treatment Considerations, and Nursing Implications. 
  • Cardiovascular Drug Pricing: Less Innovation for More Access? 
  • Cardiovascular Medications and Fractures: Dodging Complexity. 
  • Cardiovascular drug development: is it dead or just hibernating? 
  • Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program. 
  • Changes in patterns of coronary revascularization strategies for patients with acute coronary syndromes (from the CRUSADE Quality Improvement Initiative). 
  • Characteristics of clinical trials evaluating cardiovascular therapies for Coronavirus Disease 2019 Registered on ClinicalTrials.gov: a cross sectional analysis. 
  • Clinical application of cardiovascular pharmacogenetics. 
  • Clinical outcomes in real-world patients with acute myocardial infarction receiving XIENCE V® everolimus-eluting stents: one-year results from the XIENCE V USA study. 
  • Clinical outcomes in real-world patients with bifurcation lesions receiving Xience V everolimus-eluting stents: Four-year results from the Xience V USA study. 
  • Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. 
  • Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. 
  • Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) 4 Study Group. 
  • Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus. 
  • Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-coronary artery bypass for one-vessel proximal left anterior descending coronary artery disease. 
  • Comparison of performance on Hospital Compare process measures and patient outcomes between hospitals that do and do not participate in Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines. 
  • Complement activation and cardiac surgery: a novel target for improving outcomes. 
  • Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. 
  • Contemporary incidence and predictors of stent thrombosis and other major adverse cardiac events in the year after XIENCE V implantation: results from the 8,061-patient XIENCE V United States study. 
  • Contemporary therapy of acute ST-elevation myocardial infarction. 
  • Cost of ventricular assist devices: can we afford the progress? 
  • Criteria for dose-finding in two-stage seamless adaptive design. 
  • Current and novel pharmacologic approaches in advanced heart failure. 
  • Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative. 
  • Day vs night: Does time of presentation matter in acute heart failure? A secondary analysis from the RELAX-AHF trial. 
  • Decongestion in acute heart failure. 
  • Determination of the falloff constant (k(f)) from modeling biochemical marker release: a new variable for discriminating therapies. 
  • Developing Breakthrough Drugs for Heart Failure: Lessons Learned From the Cystic Fibrosis Experience. 
  • Developing New Treatments for Heart Failure: Focus on the Heart. 
  • Disease management of congestive heart failure. 
  • Does ranolazine have a place in the treatment of acute coronary syndromes? 
  • Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome. 
  • Drug Development for Heart Failure With Preserved Ejection Fraction: What Pieces Are Missing From the Puzzle? 
  • Drug-eluting versus bare-metal stents in the treatment of patients with ST-segment elevation myocardial infarction. 
  • Drug-induced lung injury. 
  • Early intravenous heart failure therapy and outcomes among older patients hospitalized for acute decompensated heart failure: findings from the Acute Decompensated Heart Failure Registry Emergency Module (ADHERE-EM). 
  • Economic end points in phase II trials. 
  • Economics and cost-effectiveness in evaluating the value of cardiovascular therapies. Evaluating the economic implications of cardiovascular therapeutics. 
  • Economics and cost-effectiveness in evaluating the value of cardiovascular therapies. Statistical issues in cost-effectiveness analysis. 
  • Effect of angina under-recognition on treatment in outpatients with stable ischaemic heart disease. 
  • Effects of Exercise Training With and Without Ranolazine on Peak Oxygen Consumption, Daily Physical Activity, and Quality of Life in Patients With Chronic Stable Angina Pectoris. 
  • Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial. 
  • Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF. 
  • Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. 
  • Emerging treatment options to improve cardiovascular outcomes in patients with acute coronary syndrome: focus on losmapimod. 
  • Enabling social listening for cardiac safety monitoring: Proceedings from a drug information association-cardiac safety research consortium cosponsored think tank. 
  • Endpoints in Heart Failure Drug Development: History and Future. 
  • Enhancement of cardiac function by cyclocreatine in models of cardiopulmonary bypass. 
  • Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs. 
  • Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial. 
  • Evidence-based therapy prescription in high-cardiovascular risk patients: the REACT study. 
  • Extended-release ranolazine: critical evaluation of its use in stable angina. 
  • Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI. 
  • Few Disparities in Baseline Laboratory Testing After the Diuretic or Digoxin Initiation by Medicare Fee-For-Service Beneficiaries. 
  • Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial. 
  • Future of Personalized Cardiovascular Medicine: JACC State-of-the-Art Review. 
  • Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. 
  • G-Protein-Coupled Receptors in Heart Disease. 
  • Gender differences in the treatment of non-ST-segment elevation myocardial infarction. 
  • Growth differentiation factor 15 (GDF-15) in patients admitted for acute heart failure: results from the RELAX-AHF study. 
  • Guideline adherence after ST-segment elevation versus non-ST segment elevation myocardial infarction. 
  • Guideline-Appropriate Care and In-Hospital Outcomes in Patients With Heart Failure in Teaching and Nonteaching Hospitals: Findings From Get With The Guidelines-Heart Failure. 
  • Guideline-Directed Medical Therapy and Survival Following Hospitalization in Patients with Heart Failure. 
  • Haemoconcentration, renal function, and post-discharge outcomes among patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial. 
  • High-resolution CT of drug-induced lung disease. 
  • Hospital percutaneous coronary intervention appropriateness and in-hospital procedural outcomes: insights from the NCDR. 
  • Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial. 
  • ISCHEMIA: Establishing the Primary End Point. 
  • Impact of Bridge to Transplantation With Continuous-Flow Left Ventricular Assist Devices on Posttransplantation Mortality. 
  • Implications of Using Different Definitions on Outcomes in Worsening Heart Failure. 
  • In-hospital and 1-year outcomes among unselected percutaneous coronary intervention patients treated with either sirolimus- or paclitaxel-eluting stents: results from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry. 
  • Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy. 
  • Indications for pacing in the treatment of bradyarrhythmias. Report of an independent study group. 
  • Influence of renal function on the use of guideline-recommended therapies for patients with heart failure. 
  • Inotropic drugs and neurohormonal antagonists in the treatment of HF in the elderly. 
  • International variation in the use of evidence-based medicines for acute coronary syndromes. 
  • Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. 
  • Intramyocardial, autologous CD34+ cell therapy for refractory angina. 
  • Is heart failure guideline adherence being underestimated? The impact of therapeutic contraindications. 
  • Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction. 
  • Issues with care in the elderly patient presenting with acute ischemia. 
  • Late safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent compared with a paclitaxel-eluting stent in patients with de novo coronary lesions: 2-year follow-up from the ENDEAVOR IV trial (Randomized, Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Taxus Paclitaxel-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). 
  • Late-term clinical outcomes with zotarolimus- and sirolimus-eluting stents. 5-year follow-up of the ENDEAVOR III (A Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). 
  • Lessons learned from clinical trials in acute heart failure: phase 3 drug trials. 
  • Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial. 
  • Long-Term Mortality of Older Patients With Acute Myocardial Infarction Treated in US Clinical Practice. 
  • Long-term clinical and economic analysis of the Endeavor zotarolimus-eluting stent versus the cypher sirolimus-eluting stent: 3-year results from the ENDEAVOR III trial (Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). 
  • Long-term efficacy and safety of Zotarolimus-eluting stent in patients with diabetes mellitus: pooled 5-year results from the ENDEAVOR III and IV trials. 
  • Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy. 
  • Lower extremity amputation in peripheral artery disease: improving patient outcomes. 
  • Machine Learning Methods Improve Prognostication, Identify Clinically Distinct Phenotypes, and Detect Heterogeneity in Response to Therapy in a Large Cohort of Heart Failure Patients. 
  • Management and outcomes of patients presenting with STEMI by use of chronic oral anticoagulation: results from the GRACE registry. 
  • Management of Persistent Angina After Myocardial Infarction Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study. 
  • Management of cocaine-associated chest pain and myocardial infarction: a scientific statement from the American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology. 
  • Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum. 
  • Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial. 
  • Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. 
  • Medical and surgical management of coronary artery disease in women. 
  • Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures. 
  • Medication adherence: a call for action. 
  • Medication dosing for heart failure with reduced ejection fraction - opportunities and challenges. 
  • Medication non-adherence after myocardial infarction: an exploration of modifying factors. 
  • Meeting report ESC forum on drug eluting stents, European Heart House, Nice, 27-28 September 2007. 
  • Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. 
  • Metaanalysis and review of heart failure disease management randomized controlled clinical trials. 
  • Metabolic efficiency with ranolazine for less ischemia in non-ST elevation acute coronary syndromes (MERLIN TIMI-36) study. 
  • Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference. 
  • New precompetitive paradigms: focus on cardiac safety. 
  • Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide. 
  • Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. 
  • Outpatient management of heart failure in the United States, 2006-2008. 
  • PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories): Overview of Design and Rationale of an International Prospective Peripheral Arterial Disease Study. 
  • Paroxysmal high-grade atrioventricular block and syncope in a previously healthy child: what is the mechanism? 
  • Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure. 
  • Patient management after noninvasive cardiac imaging results from SPARC (Study of myocardial perfusion and coronary anatomy imaging roles in coronary artery disease). 
  • Patient-centered adherence intervention after acute coronary syndrome hospitalization. 
  • Patterns and outcomes of drug-eluting coronary stent use in clinical practice. 
  • Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. 
  • Pediatric cardiovascular drug trials, lessons learned. 
  • Percutaneous coronary intervention for older adults who present with syncope and coronary artery disease? Insights from the National Cardiovascular Data Registry. 
  • Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery. 
  • Perioperative management of drug therapy, clinical considerations. 
  • Persistence of evidence-based medication use after discharge from academic versus nonacademic hospitals among patients with non-ST-segment elevation myocardial infarction. 
  • Personalized Therapeutic Approach: Gun Control for Shotgun Therapy. 
  • Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. 
  • Pharmacogenetics in heart failure trials. 
  • Pharmacological and emerging therapies in the treatment of chronic angina. 
  • Pharmacological properties of tropyl benzilate hydrochloride (BAT) and its N-allyl derivative (NTB). 
  • Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. 
  • Pharmacotherapy in chronic kidney disease patients presenting with acute coronary syndrome: a scientific statement from the American Heart Association. 
  • Pheochromocytoma complicated with cardiomyopathy after delivery--a case report and literature review. 
  • PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. 
  • Polypill Trials for Stroke Prevention-Main Results, Critical Appraisal, and Implications for US Population. 
  • Porphyrin-Based SOD Mimic MnTnBu OE -2-PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis. 
  • Prediction and prevention of chemotherapy-induced cardiomyopathy: can it be done? 
  • Prediction of Residual Risk by Ceramide-Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy. 
  • Predictors and etiologies of 30-day readmissions in patients with non-ST-elevation acute coronary syndrome. 
  • Predictors of contemporary coronary artery bypass grafting outcomes. 
  • Predictors of long-term adherence to evidence-based cardiovascular disease medications in outpatients with stable atherothrombotic disease: findings from the REACH Registry. 
  • Predictors of outcome and the lack of effect of percutaneous coronary intervention across the risk strata in patients with persistent total occlusion after myocardial infarction: Results from the OAT (Occluded Artery Trial) study. 
  • PredischaRge initiation of Ivabradine in the ManagEment of Heart Failure: Results of the PRIME-HF Trial. 
  • Proceedings of the 99th meeting of the Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee. May 29th and 30th, 2003. 
  • Process of care performance measures and long-term outcomes in patients hospitalized with heart failure. 
  • Provisional stenting versus routine stenting: is it worth the price? 
  • Psychometric Properties of the Four-Item Morisky Green Levine Medication Adherence Scale among Atherosclerosis Risk in Communities (ARIC) Study Participants. 
  • Public Health Impact of the Centers for Medicare and Medicaid Services Decision on Pass-Through Add-On Payments for Drug-Coated Balloons: A Call to Action. 
  • Pulmonary drug toxicity: radiologic and pathologic manifestations. 
  • Putting the Acute Coronary Syndrome in Context After 80 Years of Age. 
  • Quality of care and in-hospital outcomes in patients with coronary heart disease in rural and urban hospitals (from Get With the Guidelines-Coronary Artery Disease Program). 
  • Quantifying the utility of taking pills for cardiovascular prevention. 
  • Quantifying the utility of taking pills for preventing adverse health outcomes: a cross-sectional survey. 
  • Racial and Ethnic Differences in Biomarkers, Health Status, and Cardiac Remodeling in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan. 
  • Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines?). 
  • Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial. 
  • Ranolazine for Treatment of Angina or Dyspnea in Hypertrophic Cardiomyopathy Patients (RHYME). 
  • Ranolazine in High-Risk Patients With Implanted Cardioverter-Defibrillators: The RAID Trial. 
  • Rational use of medications: if Canada can't do it ... 
  • Rationale and Design of the VITALITY-HFpEF Trial. 
  • Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations. 
  • Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure. 
  • Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank. 
  • Recurrence of local anesthetic cardiac toxicity or hypokalemia? 
  • Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF. 
  • Renal function, concomitant medication use and outcomes following acute coronary syndromes. 
  • Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. 
  • Report from the 94th Cardiovascular and Renal Drugs Advisory Committee Meeting, October 11, 2001. 
  • Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase. 
  • Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. 
  • Results of the Chronic Heart Failure Intervention to Improve MEdication Adherence study: A randomized intervention in high-risk patients. 
  • SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention. 
  • Sample size and interim analysis issues for dose selection. 
  • Selection of surgical or percutaneous coronary intervention provides differential longevity benefit. 
  • Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial. 
  • Sex-related differences in the use and adverse effects of angiotensin-converting enzyme inhibitors in heart failure: the study of patients intolerant of converting enzyme inhibitors registry. 
  • Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort. 
  • Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. 
  • Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. 
  • Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium. 
  • Standardizing care for acute decompensated heart failure in a large megatrial: the approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF). 
  • Strategic lessons from the clinical event classification process for the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. 
  • Study Design and Rationale of EXPLORER-HCM: Evaluation of Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy. 
  • Surgical correction of aortic valve insufficiency after left ventricular assist device implantation. 
  • Sustained low clinical event rates in real-world patients receiving everolimus-eluting coronary stent system from a large, prospective, condition of approval study: 2-year clinical outcomes from the XIENCE V USA Study. 
  • Sustained ventricular tachycardia and ventricular fibrillation complicating non-ST-segment-elevation acute coronary syndromes. 
  • Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans. 
  • Targeting Natriuretic Peptide Levels in Heart Failure with Therapy: Does "X" Really Mark the Spot? 
  • Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial. 
  • Temporal Trends in Utilization of Cardiac Therapies and Outcomes for Myocardial Infarction by Degree of Chronic Kidney Disease: A Report From the NCDR Chest Pain-MI Registry. 
  • Temporal trends for secondary prevention measures among patients hospitalized with coronary artery disease. 
  • The "final" 5-year follow-up from the ENDEAVOR IV trial comparing a zotarolimus-eluting stent with a paclitaxel-eluting stent. 
  • The Cardiac Safety Research Consortium enters its second decade: An invitation to participate. 
  • The FDA in the 21st Century: How Is the FDA Responding to the New World? A Focus on Cardiovascular Drug Development. 
  • The NCDR ACTION Registry-GWTG: transforming contemporary acute myocardial infarction clinical care. 
  • The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment. 
  • The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction. 
  • The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study. 
  • The disconnect between phase II and phase III trials of drugs for heart failure. 
  • The effect of dementia on outcomes and process of care for Medicare beneficiaries admitted with acute myocardial infarction. 
  • The impact of medication use in a multicomponent intervention: results from the WISEWOMAN program. 
  • The meanings associated with medicines in heart failure patients. 
  • The neurohormonal network in the RAAS can bend before breaking. 
  • The prevalence, predictors and outcomes of guideline-directed medical therapy in patients with acute myocardial infarction undergoing PCI, an analysis from the PROMETHEUS registry. 
  • The process of bringing new drug-eluting stents to market will they see the light of day? 
  • The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. 
  • The role of clinical nonfatal end points in cardiovascular phase II/III clinical trials. 
  • The usage patterns of cardiac bedside markers employing point-of-care testing for troponin in non-ST-segment elevation acute coronary syndrome: results from CRUSADE. 
  • The use of vasoactive agents via peripheral intravenous access during transport of critically III infants and children. 
  • The year in cardiovascular surgery. 
  • Therapy insight: how changes in renal function with increasing age affect cardiovascular drug prescribing. 
  • Timing of Postdischarge Follow-Up and Medication Adherence Among Patients With Heart Failure. 
  • Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure. 
  • Translation of acute coronary syndrome therapies: from evidence to routine clinical practice. 
  • Treatment of non-ST-elevation acute coronary syndrome in the elderly: current practice and future opportunities. 
  • Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion. 
  • Trends in isolated coronary artery bypass grafting: an analysis of the Society of Thoracic Surgeons adult cardiac surgery database. 
  • Troponin measurements during drug development--considerations for monitoring and management of potential cardiotoxicity: an educational collaboration among the Cardiac Safety Research Consortium, the Duke Clinical Research Institute, and the US Food and Drug Administration. 
  • Update on perioperative care of the cardiac patient for noncardiac surgery. 
  • Use of Pharmacogenetic Information in the Treatment of Cardiovascular Disease. 
  • Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials. 
  • Use of global coronary heart disease risk assessment in practice: a cross-sectional survey of a sample of U.S. physicians. 
  • Use of guideline-recommended therapies for heart failure in the Medicare population. 
  • Using measures of disease progression to determine therapeutic effect: a sirens' song. 
  • What can heart failure trialists learn from oncology trialists? 
  • Whatever happened to the polypill? 
• 

  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Curtis, Lesley H., Professor in Population Health Sciences, Medicine, General Internal Medicine
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology