Carnitine O-Acetyltransferase

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  Subject Areas on Research

  • Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise. 
  • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. 
  • Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. 
  • Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure. 
  • Multiple mass isotopomer tracing of acetyl-CoA metabolism in Langendorff-perfused rat hearts: channeling of acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase. 
  • Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 
  • Obesity and lipid stress inhibit carnitine acetyltransferase activity. 
  • The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.