Catechol O-Methyltransferase

• 

  Subject Areas on Research

  • (3H)norepinephrine binding: unrelated to catechol-O-methyl transferase. 
  • A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. 
  • Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children. 
  • Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders. 
  • Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen. 
  • Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery. 
  • Biopsychosocial Influences on Shoulder Pain: Analyzing the Temporal Ordering of Postoperative Recovery. 
  • Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings. 
  • Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes. 
  • Biopsychosocial influence on shoulder pain: Rationale and protocol for a pre-clinical trial. 
  • COMT Diplotype Amplifies Effect of Stress on Risk of Temporomandibular Pain. 
  • COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. 
  • COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk of Neurocognitive Impairment in Men Living With HIV. 
  • COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. 
  • COMT gene locus: new functional variants. 
  • COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals. 
  • COMT158 polymorphism and hostility. 
  • Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. 
  • Catechol O-methyltransferase in red blood cells of schizophrenic, depressed, and normal human subjects. 
  • Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. 
  • Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. 
  • Catechol-O-methyltransferase activity and classification of depression. 
  • Catechol-O-methyltransferase and breast cancer risk. 
  • Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. 
  • Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. 
  • Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat. 
  • Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase. 
  • Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. 
  • Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome. 
  • Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant. 
  • Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. 
  • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. 
  • Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. 
  • Estrogen metabolism within the lung and its modulation by tobacco smoke. 
  • Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings. 
  • Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. 
  • Genetic basis for individual variations in pain perception and the development of a chronic pain condition. 
  • Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis. 
  • Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. 
  • Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. 
  • Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. 
  • Human Genetic Variability Contributes to Postoperative Morphine Consumption. 
  • Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. 
  • Identification of neurogenetic pathways of risk for psychopathology. 
  • Imaging genomics. 
  • Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. 
  • Influence of psychological factors on risk of temporomandibular disorders. 
  • Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. 
  • Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice. 
  • Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs. 
  • Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. 
  • Modification of COMT-dependent pain sensitivity by psychological stress and sex. 
  • Modification of depression by COMT val158met polymorphism in children exposed to early severe psychosocial deprivation. 
  • Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. 
  • Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. 
  • Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. 
  • Neurocognitive effects of transcranial direct current stimulation (tDCS) in unipolar and bipolar depression: Findings from an international randomized controlled trial. 
  • Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation. 
  • Pain modality- and sex-specific effects of COMT genetic functional variants. 
  • Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors. 
  • Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype. 
  • Red blood cell catechol O-methyl transferase and response to imipramine in unipolar depressive women. 
  • Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. 
  • Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. 
  • Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study. 
  • Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms. 
  • Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. 
  • Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation. 
  • The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults. 
  • The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults. 
  • The what, where, and when of catechol-O-methyltransferase. 
  • Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis. 
  • Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. 
  • β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.