Catecholamines

• 

  Subject Areas on Research

  • (3H)-Propranolol binding sites in myocardial membranes: nonidentity with beta adrenergic receptors. 
  • (3H)norepinephrine binding and lipolysis by isolated fat cells. 
  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A desensitized state of the beta adrenergic receptor not associated with high-affinity agonist occupancy. 
  • A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. 
  • A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus. 
  • Accelerated development of rat sympathetic neurotransmission caused by neonatal triiodothyronine administration. 
  • Acute and chronic effects of nicotine on synthesis and storage of catecholamines in the rat adrenal medulla. 
  • Acute brain death alters left ventricular myocardial gene expression. 
  • Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group. 
  • Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitization Group. 
  • Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines. 
  • Adrenal medullary storage vesicles of the spontaneously hypertensive rat. 
  • Adrenal physiology and pharmacology. 
  • Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. 
  • Adrenergic receptors in the heart. 
  • Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. 
  • Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. 
  • Affinity chromatography of adrenergic receptors and binding proteins. 
  • Age-related changes in brain catecholamine responses to a single footshock. 
  • All-or-none secretion of adrenal medullary storage vesicle contents in the rat. 
  • Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles. 
  • Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems. 
  • An electrophysiological study of the forebrain projection of nucleus commissuralis: preliminary identification of presumed A2 catecholaminergic neurons. 
  • An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine. 
  • An intracellular opiate receptor. 
  • An intrinsic adrenergic system in mammalian heart. 
  • Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines. 
  • Angiotensin II for the Treatment of Vasodilatory Shock. 
  • Antidepressant response to electroconvulsive therapy is sustained after catecholamine depletion. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. 
  • Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study. 
  • Attenuation of epileptogenesis: proactive effect of a single epinephrine injection of amygdaloid kindling. 
  • Beta-adrenergic receptors: recognition and regulation. 
  • Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity. 
  • Biobehavioral basis of coronary-prone behavior in middle-aged men. Part I: Evidence for chronic SNS activation in Type As. 
  • Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity. 
  • Brain and central haemodynamics and oxygenation during maximal exercise in humans. 
  • Brain catecholamines and memory modulation: effects of footshock, amygdala implantation, and stimulation. 
  • Breast cancer patients have improved immune and neuroendocrine functions following massage therapy. 
  • Caffeine affects cardiovascular and neuroendocrine activation at work and home. 
  • Cardiac Dysfunction After Neurologic Injury: What Do We Know and Where Are We Going? 
  • Cardiac adrenergic receptors. 
  • Cardiac hypertrophy: role of G protein-coupled receptors. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. 
  • Catecholamine binding to the beta-adrenergic receptor. 
  • Catecholamine content of the carotid body in cats ventilated with 8 - 40% oxygen. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholamine synthesis, storage and release in adrenal medulla and whole brain during acute and chronic methadone administration. 
  • Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. 
  • Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. 
  • Catecholamine-secreting paraganglioma of the thoracic spinal column: report of an unusual case and review of the literature. 
  • Catecholaminergic regulation of opiate-stimulated growth hormone secretion in the developing rat. 
  • Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. 
  • Catecholamines, cardiac beta-adrenergic receptors, and heart failure. 
  • Central and sympatho-adrenal responses to insulin in adult and neonatal rats. 
  • Central catecholaminergic lesions in the developing rat: effects of cardiac noradrenaline levels, turnover and release. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Cholinergic and monoaminergic innervation of the cat's thalamus: comparison of the lateral geniculate nucleus with other principal sensory nuclei. 
  • Chronic morphine administration alters epinephrine uptake in rat adrenal storage vesicles. 
  • Cocaine-exposed preterm neonates show behavioral and hormonal differences. 
  • Combined Tc-99m sestamibi first-pass radionuclide angiography and cardiac SPECT imaging during arbutamine infusion delivered by a computerized closed-loop system. 
  • Combined catecholamine and indoleamine depletion following response to ECT. 
  • Commentary. Molecular pharmacology of beta-adrenergic receptors--a status report. 
  • Coronary revascularization and circulatory support strategies in patients with myocardial infarction, multi-vessel coronary artery disease, and cardiogenic shock: Insights from an international survey. 
  • DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. 
  • Deficiency of dopamine-beta-hydroxylase. A new mechanism for normotensive pheochromocytomas. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Depletion of brain amines reverses blood pressure response to footshock in rat. 
  • Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. 
  • Development of central and peripheral catecholaminergic systems in rats addicted perinatally to methadone. 
  • Development of nicotinic responses in the rat adrenal medulla and long-term effects of neonatal nicotine administration. 
  • Developmental effects of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines. 
  • Diagnosis and management of pheochromocytoma. 
  • Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Direct binding studies of adrenergic receptors: biochemical, physiologic, and clinical implications. 
  • Do catecholamines contribute to the effects of neonatal hypoxia on development of brain and heart? Influence of concurrent alpha-adrenergic blockade on ornithine decarboxylase activity. 
  • Dopamine and dobutamine in septic shock. A comparison. 
  • Dopamine mediates vagal modulation of the immune system by electroacupuncture. 
  • Drug-resistant effect of adenine nucleotides and magnesium on catecholamine efflux from isolated adrenal medullary storage vesicles. 
  • Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain. 
  • Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. 
  • Editorial: Smoking, catecholamines, and the heart. 
  • Effect of beta-adrenergic blockade and sympathetic stimulation on canine bronchial mast cell response to immune degranulation in vivo. 
  • Effect of maternal smoking on fetal catecholamine concentrations at birth. 
  • Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes. 
  • Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover. 
  • Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. 
  • Effects of chronic chlorisondamine administration on the sympatho-adrenal axis. 
  • Effects of chronic nicotine administration on the denervated rat adrenal medulla. 
  • Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat. 
  • Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and on beta-adrenergic receptors. 
  • Effects of maternal ethanol ingestion on development of adrenal catecholamines and dopamine-beta-hydroxylase in the offspring. 
  • Effects of moderate and high glycemic index meals on metabolism and exercise performance. 
  • Effects of morphine on the rat adrenal medulla. 
  • Effects of neurochemicals upon a dinoflagellate photoresponse. 
  • Effects of postnatal reserpine administration on sympatho-adrenal development in the rat. 
  • Effects of prenatal reserpine administration on development of the rat adrenal medulla and central nervous system. 
  • Effects of pulsatile perfusion on human saphenous vein vasoreactivity: a preliminary report. 
  • Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat. 
  • Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles. 
  • Endocrine changes and metabolic responses in a validated canine brain death model. 
  • Epinephrine proactive retardation of amygdala-kindled epileptogenesis. 
  • Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress. 
  • Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. 
  • Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems. 
  • Falsely elevated urinary excretion of catecholamines and metanephrines in patients receiving labetalol therapy. 
  • Functional integrity of desensitized beta-adrenergic receptors. 
  • Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. 
  • Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes. 
  • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. 
  • Glomus jugulare tumors with intracranial extension. 
  • Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity. 
  • Glycemic response to stress is altered in euglycemic Pima Indians. 
  • Hemodynamic and metabolic responses to exercise after alpha 1-, beta 1-, and nonselective beta-adrenoceptor blockade in man. 
  • Hepatic fibrogenesis requires sympathetic neurotransmitters. 
  • Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity. 
  • High spinal anesthesia for cardiac surgery: effects on beta-adrenergic receptor function, stress response, and hemodynamics. 
  • Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism. 
  • Hormonal and hemodynamic changes in a validated animal model of brain death. 
  • Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women. 
  • Hyperkalemia: treatment options. 
  • Hypertension After Severe Traumatic Brain Injury: Friend or Foe? 
  • Identification and characterization of adrenergic receptors and catecholamine-stimulated adenylate cyclase in hog pial membranes. 
  • Identification and regulation of alpha- and beta-adrenergic receptors. 
  • Identification and regulation of beta-adrenergic receptors. 
  • Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. 
  • Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography. 
  • Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal. 
  • In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions. 
  • Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variables. 
  • Inhibition of human immunodeficiency virus type 1 replication and cytopathicity by synthetic soluble catecholamine melanins in vitro. 
  • Isolated beta-adrenergic binding sites: a potential assay vehicle for catecholamines. 
  • Isolated hormone receptors: physiologic and clinical implications. 
  • Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Letter: Carotid body chemoreceptors. 
  • Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. 
  • Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome. 
  • Massage therapy effects on depressed pregnant women. 
  • Maturation of the adrenal medulla--IV. Effects of morphine. 
  • Maturation of the adrenal medulla. I. Uptake and storage of amines in isolated storage vesicles of the rat. 
  • Maturation of the adrenal medulla. II. Content and properties of catecholamine storage vesicles of the rat. 
  • Maturation of the adrenal medulla. III. Practical and theoretical considerations of age-dependent alterations in kinetics of incorporation of catecholamines and non-catecholamines. 
  • Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. 
  • Mechanisms underlying cardiovascular defense reaction evoked by dorsal periaqueductal gray stimulation. 
  • Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation. 
  • Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors. 
  • Morphine-reserpine interactions in the adrenal medulla. 
  • Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. 
  • Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems. 
  • Neonatal methylmercury poisoning in the rat: effects on development of peripheral sympathetic nervous system. Neuronal participation in methylmercury-induced cardiac and renal overgrowth. 
  • Neural factors in the development of renal function: effect of neonatal central catecholaminergic lesions with 6-hydroxydopamine. 
  • Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. 
  • Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. 
  • Neurotensin interacts with dopaminergic neurons in rat brain. 
  • Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • Nicotine effects on learning in zebrafish: the role of dopaminergic systems. 
  • Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion? 
  • Non-neurogenic mechanism for reserpine-induced release of catecholamines from the adrenal medulla of neonatal rats: possible modulation by opiate receptors. 
  • Nondialytic management of hyperkalemia and pulmonary edema among end-stage renal disease patients: an evaluation of the evidence. 
  • Ontogeny of adrenomedullary responses to hypoxia and hypoglycemia: role of splanchnic innervation. 
  • Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances? 
  • Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. 
  • Physiological determinants of hyperreactivity to stress in borderline hypertension. 
  • Physiological receptors as physicochemical entities. 
  • Post-traumatic stress disorder in women: current concepts and treatments. 
  • Postural exercise abnormalities in symptomatic patients with mitral valve prolapse. 
  • Precocious development of sympatho-adrenal function in rats whose mothers received methadone. 
  • Predictors of inotrope use during separation from cardiopulmonary bypass. 
  • Predisposition to arrhythmias: electrolytes, uremic fibrosis, other factors. 
  • Premature development of cardiac sympathetic neurotransmission in the fetal alcohol syndrome. 
  • Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems. 
  • Prenatal maternal biochemistry predicts neonatal biochemistry. 
  • Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity. 
  • Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans. 
  • Psychopharmacology of pediatric posttraumatic stress disorder. 
  • Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase. 
  • Rat brain amines, blood histamine and glucose levels in relationship to circadian changes in sleep induced by pentobarbitone sodium. 
  • Recovery of rat adrenal amine stores after insulin administration. 
  • Regional brain catecholamines and memory: effects of footshock, amygdala implantation, and stimulation. 
  • Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. 
  • Regulation of adenylate cyclase-coupled beta adrenergic receptor binding sites by beta adrenergic catecholamines in vitro. 
  • Regulation of beta-adrenergic receptors by steroid hormones. 
  • Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat. 
  • Relative right versus left frontal EEG in neonates. 
  • Reserpine-like effects of harmine on isolated adrenal medullary vesicles. 
  • Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats. 
  • Role of carotid body catecholamines in chemoreceptor function. 
  • Role of glucocorticoids in tuning hindbrain stress integration. 
  • Role of leptin in fat regulation. 
  • Role of ornithine decarboxylase and the polyamines in nervous system development: a review. 
  • Role of stress in the etiology and treatment of diabetes mellitus. 
  • Selectivity of dobutamine for adrenergic receptor subtypes: in vitro analysis by radioligand binding. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Structure and function of beta-adrenergic receptors: regulation at the molecular level. 
  • Structure and function of cholera toxin and hormone receptors. 
  • Support of the perioperative failing heart with preexisting ventricular dysfunction: currently available options. 
  • Sympathetic response to intracranial NGF infusion in the absence of afferent input: axonal sprouting without neurotransmitter production. 
  • Sympatho-adrenal development in perinatally addicted rats. 
  • Sympathohippocampal neurons are inside the blood--brain barrier. 
  • Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. 
  • Techniques for the study of the biochemical basis of drug action. 
  • The "stress" of being born. 
  • The beta-adrenergic receptor and adenylate cyclase. 
  • The beta-adrenergic receptor in heart failure. 
  • The beta-adrenergic receptor. 
  • The cardiac-sympathetic axis as a teratological model. 
  • The concentration of catecholamines in the turtle heart and vagal escape. 
  • The influence of hyperglycemia on outcome of cerebral infarction. 
  • The isolated perfused frog eye: a useful preparation for the investigation of drug effects on retinal function. 
  • The psychiatric use of electrically induced seizures. 
  • The role of neural input in the effects of morphine on the rat adrenal medulla. 
  • The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals. 
  • Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. 
  • Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users. 
  • Uptake of catecholamines by storage vesicles. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. 
  • Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. 
  • Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. 
  • Why is depression bad for the failing heart? A review of the mechanistic relationship between depression and heart failure. 
  • beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. 
  • p-Chlorophenylalanine-induced enhancement of the effects of morphine on the adrenal medulla. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology