Cell Communication

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  Subject Areas on Research

  • A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior. 
  • A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens. 
  • A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)-Cell Interaction and the Resultant Bioeffects at the Single-cell Level. 
  • A bio-inspired spatial patterning circuit. 
  • A computer model of engineered cardiac monolayers. 
  • A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes. 
  • A review of three-dimensional in vitro tissue models for drug discovery and transport studies. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • Aberrant interaction of B-cell lymphocytic leukemia cells with antibody coated polyacrylamide beads. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Activated lymphocytes promote endothelial cell detachment from matrix: a role for modulation of endothelial cell beta 1 integrin affinity. 
  • Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis. 
  • Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. 
  • Adducin: Ca++-dependent association with sites of cell-cell contact. 
  • Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium. 
  • Alcohol-related trafficking accidents. 
  • An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • Astrocytes in chronic pain and itch. 
  • Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes. 
  • Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche. 
  • Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. 
  • Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. 
  • CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. 
  • Cell Biology of Astrocyte-Synapse Interactions. 
  • Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. 
  • Cell death and control of cell survival in the oligodendrocyte lineage. 
  • Cell death in the oligodendrocyte lineage. 
  • Cell interactions and endoderm differentiation in cultured mouse embryos. 
  • Cell lineage conversion in the sea urchin embryo. 
  • Cell polarity and morphogenesis: new technologies and new findings. 
  • Cell recognition processes in the differentiation of embryonic sea urchins. 
  • Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 
  • Cell-cell interactions and the regulation of testis function. 
  • Cellular Vmax reflects both membrane properties and the load presented by adjoining cells. 
  • Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. 
  • Cellular interactions in hemostasis. 
  • Characterizing functional stem cell-cardiomyocyte interactions. 
  • Chemotherapy and the bone marrow stroma. 
  • Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions. 
  • Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. 
  • Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. 
  • Computer simulations of neuron-glia interactions mediated by ion flux. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Control of lens epithelial cell survival. 
  • Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. 
  • Crosstalk Between T and B Cells in the Germinal Center After Transplantation. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties. 
  • Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. 
  • Data acquisition and analysis system for intracellular neuronal signals. 
  • Decoding biological principles using gene circuits. 
  • Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds. 
  • Designing zonal organization into tissue-engineered cartilage. 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Differential activity of protein kinase C in alveolar and peritoneal macrophages. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Dynamic localization of C. elegans TPR-GoLoco proteins mediates mitotic spindle orientation by extrinsic signaling. 
  • Dynamic reciprocity between cells and their microenvironment in reproduction. 
  • Dynamics of thin filopodia during sea urchin gastrulation. 
  • EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases. 
  • Effects of radiation on the levels of MMP-2, MMP-9 and TIMP-1 during morphogenic glial-endothelial cell interactions. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Embryo dissociation, cell isolation, and cell reassociation. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Engineered cell-cell communication and its applications. 
  • Engineering multicellular systems by cell-cell communication. 
  • Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells. 
  • Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction. 
  • Extracellular matrix ligand and stiffness modulate immature nucleus pulposus cell-cell interactions. 
  • Factors controlling cardiac neural crest cell migration. 
  • Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. 
  • Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells. 
  • Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. 
  • Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes. 
  • Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk. 
  • Functional specialization of beta-arrestin interactions revealed by proteomic analysis. 
  • Functions of skin-resident γδ T cells. 
  • Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury. 
  • Gastrulation. 
  • Guidance of stem cell fate on 2D patterned surfaces. 
  • HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. 
  • Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells. 
  • Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. 
  • Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices. 
  • Homogenization of syncytial tissues. 
  • Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. 
  • Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts. 
  • Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • Human thymic epithelial cells directly induce activation of autologous immature thymocytes. 
  • Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications. 
  • Hydrogen peroxide in adaptation. 
  • IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. 
  • Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology. 
  • Immune responses of human lymphocytes in vitro. 
  • In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing. 
  • Incorporating histology into a 3D microscopic computer model of myocardium to study propagation at a cellular level. 
  • Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue. 
  • Independent component analyses for quantifying neuronal ensemble interactions. 
  • Induction of sodium channel clustering by oligodendrocytes. 
  • Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis. 
  • Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. 
  • Intercellular communication during plant development. 
  • Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury. 
  • Intermediate filament associated proteins. 
  • Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta. 
  • Involvement of histocompatibility antigens in embryonic cell recognition events. 
  • Isolated trout liver cells: establishing short-term primary cultures exhibiting cell-to-cell interactions. 
  • Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia. 
  • Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. 
  • Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. 
  • Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. 
  • Linking immune responses with fibrosis in allergic eye disease. 
  • Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. 
  • Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons. 
  • Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. 
  • Mating in wild yeast: delayed interest in sex after spore germination. 
  • Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow. 
  • Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. 
  • Membrane domains based on ankyrin and spectrin associated with cell-cell interactions. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation. 
  • Microparticles as mediators of cellular cross-talk in inflammatory disease. 
  • Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. 
  • Modulation of endothelial cell morphogenesis in vitro by MMP-9 during glial-endothelial cell interactions. 
  • Molecular therapies for vascular diseases. 
  • Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells. 
  • Monocytes prime autoreactive T cells after myocardial infarction. 
  • Morphogenesis. 
  • Morphological assessment of immunologically relevant cells in the thymus. 
  • Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. 
  • Mutual information, Fisher information, and population coding. 
  • N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. 
  • Nanoparticle-Cell Interactions: Relevance for Public Health. 
  • Natural killer cell-endothelial cell interactions in xenotransplantation. 
  • Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. 
  • Neuron/glia relationships observed over intervals of several months in living mice. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Neuropods. 
  • Not just another hole in the wall: understanding intercellular protein trafficking. 
  • On gap junction structure. 
  • Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading. 
  • Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. 
  • Out of Eden: stem cells and their niches. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. 
  • Parent stem cells can serve as niches for their daughter cells. 
  • Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. 
  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. 
  • Plasminogen activator inhibitor-1 regulates myoendothelial junction formation. 
  • Platelet functions beyond hemostasis. 
  • Platelet procoagulant complex assembly in a tissue factor-initiated system. 
  • Polarity and stratification of the epidermis. 
  • Polarized Exosome Release from the Retinal Pigmented Epithelium. 
  • Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. 
  • Programming microbial population dynamics by engineered cell-cell communication. 
  • Prolonged dark adaptation changes connexin expression in the mouse retina. 
  • Quantifying electrical interactions between cardiomyocytes and other cells in micropatterned cell pairs. 
  • RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. 
  • Real-time observation of leukocyte-endothelium interactions in tissue-engineered blood vessel. 
  • Reconstructing the engram: simultaneous, multisite, many single neuron recordings. 
  • Regulation of neurogenesis and neuronal differentiation in primary and immortalized cells from mouse olfactory epithelium. 
  • Regulation of the immune response. I. Regulatory cell equilibrium in the "virgin" state. 
  • Regulatory B10 cell development and function. 
  • Retinoic acid-mediated gene expression in transgenic reporter zebrafish. 
  • Revising messages traveling along the cellular information superhighway. 
  • Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature. 
  • Role of delays in shaping spatiotemporal dynamics of neuronal activity in large networks. 
  • Role of natural killer cell function in dendritic cell-based vaccines. 
  • Role of repulsive factors in vascularization dynamics. 
  • Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. 
  • Roles of exosomes in the normal and diseased eye. 
  • Roles of wingless in patterning the larval epidermis of Drosophila. 
  • Schwann cell influence on motor neuron regeneration accuracy. 
  • Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. 
  • Signaling in and out: control of cell division and differentiation in the shoot and root. 
  • Size and ionic currents of unexcitable cells coupled to cardiomyocytes distinctly modulate cardiac action potential shape and pacemaking activity in micropatterned cell pairs. 
  • Soluble factors elaborated by human brain endothelial cells induce the concomitant expansion of purified human BM CD34+CD38- cells and SCID-repopulating cells. 
  • Species differences take shape at nanoparticles: protein corona made of the native repertoire assists cellular interaction. 
  • Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. 
  • Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. 
  • Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. 
  • Structural features of the terminal loop region of frog retinal rod outer segment disk membranes: III. Implications of the terminal loop complex for disk morphogenesis, membrane fusion, and cell surface interactions. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes. 
  • Switching mechanisms and bout times in a pair of reciprocally inhibitory neurons. 
  • Targeted disruption of Müller cell metabolism induces photoreceptor dysmorphogenesis. 
  • Tension and robustness in multitasking cellular networks. 
  • The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. 
  • The changing view of neural specificity. 
  • The diversity and plasticity of adult hepatic progenitor cells and their niche. 
  • The effect of temperature variation in vitro on platelet-leukocyte interactions and individual prothrombotic potential. 
  • The engine driving the ship: metabolic steering of cell proliferation and death. 
  • The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity. 
  • The great balancing act: regulation and fate of antiviral T-cell interactions. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • The role of functionally distinct helper T lymphocyte subpopulations in the induction of human B cell differentiation. 
  • The structural organization and protein composition of lens fiber junctions. 
  • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. 
  • Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. 
  • Three-dimensional traction force microscopy: a new tool for quantifying cell-matrix interactions. 
  • Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. 
  • Tissue linkage through adjoining basement membranes: The long and the short term of it. 
  • Towards a Dynamic Understanding of Cadherin-Based Mechanobiology. 
  • Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. 
  • Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans. 
  • Vascular morphogenesis: tales of two syndromes. 
  • Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. 
  • When cells tell their neighbors which direction to divide. 
  • Whole-genome positive selection and habitat-driven evolution in a shallow and a deep-sea urchin. 
  • [IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells]. 
  • eNOS-overexpressing endothelial cells inhibit platelet aggregation and smooth muscle cell proliferation in vitro. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bohorquez, Diego V., Assistant Professor in Medicine, Neurobiology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Henriquez, Craig S., Professor of Biomedical Engineering, Pratt School of Engineering
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering