Cell Compartmentation

• 

  Subject Areas on Research

  • A human protein related to yeast Cdc6p. 
  • A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. 
  • A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Analysis of the globose basal cell compartment in rat olfactory epithelium using GBC-1, a new monoclonal antibody against globose basal cells. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation. 
  • Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. 
  • Cell polarity in sea urchin embryos: reorientation of cells occurs quickly in aggregates. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Ceramide synthase. 
  • Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. 
  • Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes. 
  • Colocalizing ribozymes with substrate RNAs to increase their efficacy as gene inhibitors. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Compartmental responses to acute osmotic stress in Leishmania major result in rapid loss of Na+ and Cl-. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. 
  • Compartmentalized nitrosation and nitration in mitochondria. 
  • Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins. 
  • Distinct electric potentials in soma and neurite membranes. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Effect of vanadate on intracellular distribution and function of 10-nm filaments. 
  • Effects of stimulation frequency on potassium activity and cell volume in cardiac tissue. 
  • Elemental microanalysis of organelles in proximal tubules. I. Alterations in transport and metabolism. 
  • Elemental microanalysis of organelles in proximal tubules. II. Effects of oxygen deprivation. 
  • Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. 
  • Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis. 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. 
  • Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. 
  • Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary. 
  • Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. 
  • Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. 
  • Identification of cellular protein phosphatase-1 regulators. 
  • In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin. 
  • Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis. 
  • Ion microanalysis of cells. 
  • La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. 
  • Like night and day: rods and cones have different pigment regeneration pathways. 
  • Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells. 
  • Localization and characterization of the src-gene product of Rous sarcoma virus. 
  • Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. 
  • Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Motor proteins 1: kinesins. 
  • Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells. 
  • Oncogenic activation of c-ABL by mutation within its last exon. 
  • Phenotypic subpopulations of macrophages and dendritic cells in human spleen. 
  • Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. 
  • Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. 
  • Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution. 
  • Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking. 
  • Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor. 
  • RNA Controls PolyQ Protein Phase Transitions. 
  • Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. 
  • Requirement for the vasa RNA helicase in gurken mRNA localization. 
  • Stage- and ribosome-specific alterations in nascent chain-Sec61p interactions accompany translocation across the ER membrane. 
  • Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state. 
  • Structural and elemental characterization of heart cells grown in a collagen matrix. 
  • Structure and function of beta-adrenergic receptors: regulation at the molecular level. 
  • Suppressor of fused negatively regulates beta-catenin signaling. 
  • Synthetic biology: Division of logic labour. 
  • Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells. 
  • The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia. 
  • The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation. 
  • The actin membrane skeleton in Drosophila development. 
  • The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. 
  • The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment. 
  • The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. 
  • Tissue linkage through adjoining basement membranes: The long and the short term of it. 
  • Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. 
  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. 
  • cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes. 
  • mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology