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Subject Areas on Research
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4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro.
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A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor.
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A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis.
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A bistable Rb-E2F switch underlies the restriction point.
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A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
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A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis.
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A festival of cell-cycle controls.
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A generalized model for multi-marker analysis of cell cycle progression in synchrony experiments.
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A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation.
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A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest.
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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
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A monitor for bud emergence in the yeast morphogenesis checkpoint.
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A morphogenesis checkpoint monitors the actin cytoskeleton in yeast.
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A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences.
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A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.
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A new trick for Cyclin-Cdk: activation of STAT.
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A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage.
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A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy.
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A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.
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A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.
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A prospective view on phosphatases and replicative senescence.
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A suppressor of cln3 for size control.
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A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus.
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A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia.
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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.
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Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
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Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell.
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Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status.
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Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1.
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Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.
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Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes.
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Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin.
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An Arabidopsis kinase cascade influences auxin-responsive cell expansion.
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An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1.
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An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials.
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An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation.
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Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.
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Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases.
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Analysis of the cell cycle using Xenopus egg extracts.
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Analyzing cell cycle checkpoints after ionizing radiation.
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Analyzing transcription dynamics during the budding yeast cell cycle.
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Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes.
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Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells.
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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
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Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter.
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Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy.
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Apoptosis in Xenopus egg extracts.
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Archaeal cells share common size control with bacteria despite noisier growth and division.
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Architecture and inherent robustness of a bacterial cell-cycle control system.
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Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest.
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Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.
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Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.
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Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
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Aven-dependent activation of ATM following DNA damage.
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BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.
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Barriers to productive transfection of trabecular meshwork cells.
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Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
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Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.
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Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules.
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Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.
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Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program.
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Building and re-building the heart by cardiomyocyte proliferation.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation.
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CD20: a regulator of cell-cycle progression of B lymphocytes.
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CD40 expression by human fibroblasts.
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CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies.
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Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
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Calcium, calmodulin and cell cycle regulation.
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Calmodulin and cell cycle control.
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Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression.
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Calmodulin as a mediator of hormone action and cell regulation.
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Calmodulin is involved in regulation of cell proliferation.
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Calmodulin regulation during the cell cycle of mammalian cells.
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Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.
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Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation.
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Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
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Cardiac progenitors and the embryonic cell cycle.
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Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo.
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Caspases and kinases in a death grip.
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Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
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Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.
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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
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Cell Polarity in Yeast.
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Cell biology: A BID for the pathway.
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Cell cycle analysis of budding yeast using SYTOX Green.
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Cell cycle control and cancer.
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Cell cycle control in the terminally differentiated myocyte. A platform for myocardial repair?
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Cell cycle control of BRCA2.
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Cell cycle control of morphogenesis in budding yeast.
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
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Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
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Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts.
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Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression.
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Cell cycle progression: new therapeutic target for vascular proliferative disease.
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Cell cycle regulation of human pancreatic cancer by tamoxifen.
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Cell cycle studies of cyclocreatine, a new anticancer agent.
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Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity.
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Cell cycle-dependent regulation of smooth muscle cell activation.
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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587).
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Cell cycle-regulated transcription: effectively using a genomics toolbox.
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Cell cycle. Checking two steps.
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Cell cycle: Flies teach an old dogma new tricks.
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Cell-Cycle Regulators and Cell Death in Immunity.
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Cell-cycle checkpoints and cancer.
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Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse.
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Cellular and molecular studies in brain and nervous system oncology.
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Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins.
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Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.
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Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells.
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Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
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Characterization of dependencies between growth and division in budding yeast.
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Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4.
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Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin.
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Checkpoint controls and cancer. Introduction.
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Choreography of the transcriptome, photophysiology, and cell cycle of a minimal photoautotroph, prochlorococcus.
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Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle.
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Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review).
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
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Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions.
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Coexistent naïve phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood.
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Combining targeted agents with modern radiotherapy in soft tissue sarcomas.
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Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae.
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Complex response of breast epithelial cell lines to topoisomerase inhibitors.
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Composition and dynamics of the Caenorhabditis elegans early embryonic transcriptome.
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Comprehensive molecular characterization of urothelial bladder carcinoma.
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Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation.
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Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans.
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Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence.
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Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin.
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Control of Swe1p degradation by the morphogenesis checkpoint.
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Correlation of follicular diameter with oocyte recovery and maturity at the time of transvaginal follicular aspiration.
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Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.
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Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.
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Cycling in the Cell Fate Landscape.
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Cytokinesis.
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DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.
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DNA replication and progression through the cell cycle.
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Daughter-specific transcription factors regulate cell size control in budding yeast.
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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
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Dendritic cell maturation in active immunotherapy strategies.
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Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data.
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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
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Detecting separate time scales in genetic expression data.
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Determinants of Swe1p degradation in Saccharomyces cerevisiae.
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Determining centromere identity: cyclical stories and forking paths.
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Development of germ cells in the mouse.
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Development of novel targeted therapies in the treatment of malignant glioma.
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Developmental Biology: Embryos Need to Control Their Nucleotides Just Right.
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Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.
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Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.
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Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.
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Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells of the budding yeast S. cerevisiae.
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Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
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Discovery of thiophene inhibitors of polo-like kinase.
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Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects.
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Distinct responses to reduplicated chromosomes require distinct Mad2 responses.
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Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.
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Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.
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Distinctions in the specificity of E2F function revealed by gene expression signatures.
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Divergent regulation of functionally distinct γ-tubulin complexes during differentiation.
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Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.
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Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.
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Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.
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E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
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E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
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EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules.
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ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation.
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Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking.
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Eavesdropping on the cytoskeleton: progress and controversy in the yeast morphogenesis checkpoint.
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Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
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Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae.
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Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.
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Effects of mutant Ran/TC4 proteins on cell cycle progression.
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Electrical inhibition of lens epithelial cell proliferation: an additional factor in secondary cataract?
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Emerging therapeutic targets for soft tissue sarcoma.
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Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease.
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Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.
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Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.
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Error-prone polyploid mitosis during normal Drosophila development.
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Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy.
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Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.
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Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen.
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Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.
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Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.
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Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells.
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Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium.
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Expression of renal cell protein markers is dependent on initial mechanical culture conditions.
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Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
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Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.
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Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
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FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy.
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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
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FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.
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Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.
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Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.
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Flow cytometric analysis of DNA content in budding yeast.
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Fragments of ATM which have dominant-negative or complementing activity.
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From ODES to language-based, executable models of biological systems.
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Function and regulation of calmodulin in endocrine cells.
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Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.
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Functions of fission yeast orp2 in DNA replication and checkpoint control.
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Fusigenic viral liposome for gene therapy in cardiovascular diseases.
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Future horizons in cardiovascular molecular therapeutics.
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G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder.
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Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
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Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis.
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Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.
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Genetic interactions among regulators of septin organization.
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Genome accessibility is widely preserved and locally modulated during mitosis.
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Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation.
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Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly.
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Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
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Genomic instability and endoreduplication triggered by RAD17 deletion.
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Global control of cell-cycle transcription by coupled CDK and network oscillators.
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Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains.
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Granular presence of terminin is the marker to distinguish between the senescent and quiescent states.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
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High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV.
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Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
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Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
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Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex.
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Hydroxyurea synchronization increases mitotic yield in human glioma cell lines.
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IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.
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IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis.
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IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells.
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IFNgamma induction of p21WAF1 in prostate cancer cells: role in cell cycle, alteration of phenotype and invasive potential.
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IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1.
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Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
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Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing.
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Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening.
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Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.
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Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase.
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Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle.
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Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1.
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Improved flow cytometric analysis of the budding yeast cell cycle.
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In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1.
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In vitro cell cycle arrest induced by using artificial DNA templates.
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In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.
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Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.
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Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum.
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Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration.
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Informative structure priors: joint learning of dynamic regulatory networks from multiple types of data.
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Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth.
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Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
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Initial amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of embryonic duck hepatocytes is increased by cell cycle progression.
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Initiation of SV40 DNA replication: mechanism and control.
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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
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Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.
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Interplay between septin organization, cell cycle and cell shape in yeast.
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Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.
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Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.
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Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis.
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Ionizing radiation activates the ATM kinase throughout the cell cycle.
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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
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Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation.
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Isolation and initial characterization of the BRCA2 promoter.
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Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.
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Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid.
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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
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Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae.
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Long-term contractile activity and thyroid hormone supplementation produce engineered rat myocardium with adult-like structure and function.
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Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas.
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Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells.
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Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
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MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
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Mating in wild yeast: delayed interest in sex after spore germination.
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Measuring time during early embryonic development.
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Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts.
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Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis.
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Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.
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Membrane-bound progesterone receptor expression in human aortic endothelial cells.
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Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism.
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Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation.
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Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.
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MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.
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Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells.
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Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
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Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed.
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Molecular mechanisms of transforming growth factor-beta signaling.
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Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression.
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Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment.
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Morphogenesis and the cell cycle.
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Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins.
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Multi-step control of spindle pole body duplication by cyclin-dependent kinase.
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Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
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Multiple roles of ATM in monitoring and maintaining DNA integrity.
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Multiple signaling pathways involving ATM.
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Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis.
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NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
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Need radioprotection? A MEPE/OF45 mimetic may do the job.
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Network calisthenics: control of E2F dynamics in cell cycle entry.
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Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.
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Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis.
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Nuclear DNA study of vaginal and cervical squamous cell abnormalities in DES exposed progeny.
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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells.
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Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.
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Nuclear tyrosine kinases: from Abl to WEE1.
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Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote.
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Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.
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Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints.
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Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.
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Origin of bistability underlying mammalian cell cycle entry.
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Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
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Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6.
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P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
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P53, cell cycle control and apoptosis: implications for cancer.
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P53: a determinant of the cell cycle response to DNA damage.
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PIN1, the cell cycle and cancer.
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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.
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PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
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Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells.
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Parametric modeling of cellular state transitions as measured with flow cytometry.
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Participation of p53 protein in the cellular response to DNA damage.
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Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.
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Phenotypic and cell cycle properties of human oligodendrocytes in vitro.
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Phosphatases driving mitosis: pushing the gas and lifting the brakes.
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Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesis.
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Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis.
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Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint.
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Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.
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Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
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Pin1 regulates the timing of mammalian primordial germ cell proliferation.
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Polarity establishment in yeast.
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Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.
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Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.
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Positive feedback of G1 cyclins ensures coherent cell cycle entry.
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Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis.
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Post-transcriptional RNA regulons affecting cell cycle and proliferation.
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Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
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Potential landscape and flux framework of nonequilibrium networks: robustness, dissipation, and coherence of biochemical oscillations.
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Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect.
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Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.
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Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
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Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals.
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Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin.
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Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
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Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy.
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Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis.
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Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.
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Protein phosphatase 2A: a panoply of enzymes.
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Protein phosphatase 5 is required for ATR-mediated checkpoint activation.
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Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.
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Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi.
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Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain.
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RB regulates transcription of the p21/WAF1/CIP1 gene.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling.
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Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression.
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Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008).
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Reconciling conflicting models for global control of cell-cycle transcription.
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Reentry into the cell cycle of differentiated skeletal myocytes.
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Regulation by and of calmodulin in mammalian cells.
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Regulation of DNA replication in S phase nuclei by ATP and ADP pools.
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Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.
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Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
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Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes.
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Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
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Regulation of the cell cycle by calcium and calmodulin.
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Regulatory functions of calmodulin.
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Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control.
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Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.
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Relationship of the demonstration of intermediate filament protein to kinetics of three human neuroepithelial tumor cell lines. Lack of neural-related proteins in most cells in S phase: a double-labeled immunohistochemical study on matrix cultures.
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Reliability of transcriptional cycles and the yeast cell-cycle oscillator.
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Rendering the leukemia cell susceptible to attack.
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Replicative senescence revisited.
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Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia.
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Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
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Requirement of the prolyl isomerase Pin1 for the replication checkpoint.
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Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
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Reversing the Warburg effect as a treatment for glioblastoma.
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Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells.
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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis.
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Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
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Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.
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Role of Computational Modeling in Understanding Cell Cycle Oscillators.
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Role of mRNA Gestation and Senescence in Noise Reduction during the Cell Cycle.
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Role of mRNA gestation and senescence in noise reduction during the cell cycle.
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Role of the aryl hydrocarbon receptor in cell cycle regulation.
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Role of transforming growth factor beta in human disease.
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Rumenectomy-induced proliferation in duodenal villous epithelium is mechanistically related to the disappearance of statin, a non-proliferation-specific nuclear protein.
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Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos.
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Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.
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Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.
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Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae.
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Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans.
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Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation.
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Signal-transduction cascades as targets for therapeutic intervention by natural products.
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Signaling by the transforming growth factor-beta receptors.
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Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.
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Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.
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Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2.
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Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation.
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Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth.
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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
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Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.
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Statin expression in the untreated and SarCNU-exposed human glioma cell line, SK-MG-1.
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Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state.
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Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone.
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Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
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Stochastic E2F activation and reconciliation of phenomenological cell-cycle models.
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Stochastic Petri Net extension of a yeast cell cycle model.
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Structural analysis of a yeast centromere.
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Studies on scaffold attachment sites and their relation to genome function.
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Studies on the regulation and specificity of the DNA-untwisting enzyme.
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Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway.
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TBX5 is required for embryonic cardiac cell cycle progression.
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Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
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Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.
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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
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Tension and robustness in multitasking cellular networks.
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Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction.
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The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro.
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The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth.
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The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells.
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The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
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The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.
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The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.
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The Local Edge Machine: inference of dynamic models of gene regulation.
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The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
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The TP53 tumor suppressor and autophagy in malignant lymphoma.
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The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis.
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The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.
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The beta-interferon-mediated antimitogenic state resembles the anti-viral state.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
-
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
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The differential expression of statin in the nuclei of human colonic crypts adjacent to a cancer: an immunohistochemical study.
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The engine driving the ship: metabolic steering of cell proliferation and death.
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The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study.
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The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology.
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The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint.
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The many substrates and functions of ATM.
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The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p.
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The morphogenesis checkpoint: how yeast cells watch their figures.
-
The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.
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The peptidyl-prolyl isomerase Pin1.
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The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice.
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The presence of parvalbumin in a nonmuscle cell line attenuates progression through mitosis.
-
The regulation of DNA topoisomerase II by casein kinase II.
-
The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle.
-
The role of p53 in cell-cycle control and apoptosis: implications for cancer.
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The structure of a primitive kinetochore.
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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The tetraspanin superfamily member NET-6 is a new tumor suppressor gene.
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Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.
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Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC.
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Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit.
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To die or grow: Parkinson's disease and cancer.
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Topoisomerase II levels during granulocytic maturation in vitro and in vivo.
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Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.
-
Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators.
-
Transcriptional regulation of changes in growth, cell cycle, and gene expression of Saccharomyces cerevisiae due to changes in buoyancy.
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Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.
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Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry.
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Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.
-
Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation.
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Trisomy 8 mosaicism: selective growth advantage of normal cells vs. growth disadvantage of trisomy 8 cells.
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Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.
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Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.
-
Tumor physiology and cell kinetics.
-
Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.
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Tumor-suppressor p53: implications for tumor development and prognosis.
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Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia.
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Ubiquitylation of p53 by the APC/C inhibitor Trim39.
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Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis.
-
Update in podocyte biology: putting one's best foot forward.
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VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression.
-
Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.
-
Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC.
-
Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.
-
Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery.
-
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
-
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.
-
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
-
c-Myc is required for maintenance of glioma cancer stem cells.
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hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.
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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
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n-Butyrate, a cell cycle blocker, inhibits early amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of duck hepatocytes.
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p38 MAPK in development and cancer.
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p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.
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p53 and ATM: cell cycle, cell death, and cancer.
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p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
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p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
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p53: a two-faced cancer gene.
-
Keywords of People
-
Allori, Alexander C,
Assistant Professor of Surgery,
Surgery, Plastic, Maxillofacial, and Oral Surgery
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Ciofani, Maria,
Associate Professor of Immunology,
Immunology
-
Fox, Donald T,
Associate Professor of Pharmacology & Cancer Biology,
Duke Science & Society
-
Gordan, Raluca Mihaela,
Associate Professor in Biostatistics & Bioinformatics,
Computer Science
-
Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
-
Lagoo, Anand Shreeram,
Professor of Pathology,
Pathology
-
Lew, Daniel Julio,
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology,
Cell Biology
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Pharmacology & Cancer Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Sullivan, Beth Ann,
Professor of Molecular Genetics and Microbiology,
Duke Science & Society