Cell Cycle

• 

  Subject Areas on Research

  • 4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro. 
  • A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. 
  • A bistable Rb-E2F switch underlies the restriction point. 
  • A caudal proliferating growth center contributes to both poles of the forming heart tube. 
  • A cell cycle checkpoint monitors cell morphogenesis in budding yeast. 
  • A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. 
  • A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. 
  • A generalized model for multi-marker analysis of cell cycle progression in synchrony experiments. 
  • A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A maximum entropy algorithm for rhythmic analysis of genome-wide expression patterns. 
  • A monitor for bud emergence in the yeast morphogenesis checkpoint. 
  • A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. 
  • A mutation of the yeast gene encoding PCNA destabilizes both microsatellite and minisatellite DNA sequences. 
  • A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A prospective view on phosphatases and replicative senescence. 
  • A role for Myc in facilitating transcription activation by E2F1. 
  • A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. 
  • A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirus. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. 
  • Absence of phosphatidylinositol (PI)-linked proteins in a very early human multipotential haematopoietic marrow cell. 
  • Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. 
  • Adenovirus E1A: transcription regulation and alteration of cell growth control. 
  • Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • An RNA polymerase III-dependent heterochromatin barrier at fission yeast centromere 1. 
  • An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials. 
  • An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the cell cycle using Xenopus egg extracts. 
  • Analyzing cell cycle checkpoints after ionizing radiation. 
  • Analyzing transcription dynamics during the budding yeast cell cycle. 
  • Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. 
  • Antisense oligonucleotides directed at cell cycle regulatory genes as strategy for restenosis therapy. 
  • Architecture and inherent robustness of a bacterial cell-cycle control system. 
  • Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions. 
  • Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. 
  • Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. 
  • Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Aven-dependent activation of ATM following DNA damage. 
  • Barriers to productive transfection of trabecular meshwork cells. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. 
  • Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. 
  • Biology of tumors and head and neck cancer chemotherapy. 
  • Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells. 
  • CD20: a regulator of cell-cycle progression of B lymphocytes. 
  • CD40 expression by human fibroblasts. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. 
  • Calcium, calmodulin and cell cycle regulation. 
  • Calmodulin and cell cycle control. 
  • Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. 
  • Calmodulin as a mediator of hormone action and cell regulation. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calmodulin regulation during the cell cycle of mammalian cells. 
  • Calmodulin: properties, intracellular localization, and multiple roles in cell regulation. 
  • Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. 
  • Cardiac progenitors and the embryonic cell cycle. 
  • Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo. 
  • Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. 
  • Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cell Polarity in Yeast. 
  • Cell biology: A BID for the pathway. 
  • Cell cycle Start is coupled to entry into the yeast metabolic cycle across diverse strains and growth rates. 
  • Cell cycle analysis of budding yeast using SYTOX Green. 
  • Cell cycle control and cancer. 
  • Cell cycle control in the terminally differentiated myocyte. A platform for myocardial repair? 
  • Cell cycle control of BRCA2. 
  • Cell cycle control of morphogenesis in budding yeast. 
  • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. 
  • Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. 
  • Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. 
  • Cell cycle kinetic effects of tamoxifen on human breast cancer cells. Flow cytometric analyses of DNA content, BrdU labeling, Ki-67, PCNA, and statin expression. 
  • Cell cycle progression: new therapeutic target for vascular proliferative disease. 
  • Cell cycle regulated phosphorylation of the telomere-associated protein TIN2. 
  • Cell cycle regulation of human pancreatic cancer by tamoxifen. 
  • Cell cycle studies of cyclocreatine, a new anticancer agent. 
  • Cell cycle targets of the DNA tumor viruses. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Cell cycle-dependent regulation of smooth muscle cell activation. 
  • Cell cycle-regulated transcription: Effectively using a genomics toolbox 
  • Cell cycle-regulated transcription: effectively using a genomics toolbox. 
  • Cell cycle. Checking two steps. 
  • Cell-Cycle Regulators and Cell Death in Immunity. 
  • Cell-cycle checkpoints and cancer. 
  • Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. 
  • Cellular and molecular studies in brain and nervous system oncology. 
  • Centrosome and spindle function of the Drosophila Ncd microtubule motor visualized in live embryos using Ncd-GFP fusion proteins. 
  • Characterization and expression of the unique calmodulin gene of Aspergillus nidulans. 
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Characterization of dependencies between growth and division in budding yeast. 
  • Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin. 
  • Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobinuria. 
  • Checkpoint controls and cancer. Introduction. 
  • Chromium(VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA cross-links and S-phase blockade of cell cycle. 
  • Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review). 
  • Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. 
  • Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. 
  • Co-regulation of B-Myb expression by E2F1 and EGF receptor. 
  • Coexistent naïve phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. 
  • Combining targeted agents with modern radiotherapy in soft tissue sarcomas. 
  • Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. 
  • Comparative proteomic analysis of colon cancer cells in response to oxaliplatin treatment. 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. 
  • Comprehensive molecular characterization of urothelial bladder carcinoma. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Control of Swe1p degradation by the morphogenesis checkpoint. 
  • Correlation of follicular diameter with oocyte recovery and maturity at the time of transvaginal follicular aspiration. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. 
  • Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. 
  • Cycling in the Cell Fate Landscape. 
  • Cytokinesis. 
  • DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. 
  • De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome. 
  • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 
  • Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta. 
  • Dendritic cell maturation in active immunotherapy strategies. 
  • Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. 
  • Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. 
  • Detecting separate time scales in genetic expression data. 
  • Determinants of Swe1p degradation in Saccharomyces cerevisiae. 
  • Determining centromere identity: cyclical stories and forking paths. 
  • Development of novel targeted therapies in the treatment of malignant glioma. 
  • Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. 
  • Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex. 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects. 
  • Distinct responses to reduplicated chromosomes require distinct Mad2 responses. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. 
  • Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • E2F transcription factor is a target for the RB protein and the cyclin A protein. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • Early activation and cell cycle entry of resting B cells after Fab-anti-Ig treatment: role of receptor crosslinking. 
  • Eavesdropping on the cytoskeleton: progress and controversy in the yeast morphogenesis checkpoint. 
  • Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells. 
  • Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. 
  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation. 
  • Electrical inhibition of lens epithelial cell proliferation: an additional factor in secondary cataract? 
  • Emerging therapeutic targets for soft tissue sarcoma. 
  • Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. 
  • Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. 
  • Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Expression of cell cycle related proteins--proliferating cell nuclear antigen (PCNA) and statin--during adaptation and de-adaptation of EUE cells to a hypertonic medium. 
  • Expression of renal cell protein markers is dependent on initial mechanical culture conditions. 
  • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. 
  • FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. 
  • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. 
  • FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Flow cytometric analysis of DNA content in budding yeast. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • Function and regulation of calmodulin in endocrine cells. 
  • Functional analysis of E2F transcription factor. 
  • Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Future horizons in cardiovascular molecular therapeutics. 
  • G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. 
  • Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. 
  • Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma. 
  • Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Generation of autologous Epstein-Barr virus-specific cytotoxic T cells for adoptive immunotherapy in solid organ transplant recipients. 
  • Genetic interactions among regulators of septin organization. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome-wide analysis of re-replication reveals inhibitory controls that target multiple stages of replication initiation. 
  • Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Global control of cell-cycle transcription by coupled CDK and network oscillators. 
  • Granular presence of terminin is the marker to distinguish between the senescent and quiescent states. 
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis. 
  • Growth of a malignant human urothelial cell line (J82) in a serum-free medium (HMRI-1) developed previously for normal human urothelium. 
  • Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. 
  • High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV. 
  • Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. 
  • Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. 
  • Human X chromosomes: synchrony of DNA replication in diploid and triploid fibroblasts with multiple active or inactive X chromosomes. 
  • Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex. 
  • Hydroxyurea synchronization increases mitotic yield in human glioma cell lines. 
  • IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. 
  • IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis. 
  • IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. 
  • IFNgamma induction of p21WAF1 in prostate cancer cells: role in cell cycle, alteration of phenotype and invasive potential. 
  • IFNgamma inhibition of cell growth in glioblastomas correlates with increased levels of the cyclin dependent kinase inhibitor p21WAF1/CIP1. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing. 
  • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. 
  • Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. 
  • Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. 
  • Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling. 
  • Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle. 
  • Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1. 
  • Improved inference of mutation rates: I. An integral representation for the Luria-Delbrück distribution. 
  • Improved inference of mutation rates: II. Generalization of the Luria-Delbrück distribution for realistic cell-cycle time distributions. 
  • In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. 
  • Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. 
  • Influence of silicone (PDMS) surface texture on human skin fibroblast proliferation as determined by cell cycle analysis. 
  • Informative structure priors: joint learning of dynamic regulatory networks from multiple types of data. 
  • Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth. 
  • Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance. 
  • Initial amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of embryonic duck hepatocytes is increased by cell cycle progression. 
  • Initiation of SV40 DNA replication: mechanism and control. 
  • Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. 
  • Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interplay between septin organization, cell cycle and cell shape in yeast. 
  • Intramolecular recombination as a source of mitochondrial chromosome heteromorphism in Neurospora. 
  • Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast. 
  • Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans. 
  • Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. 
  • Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation. 
  • Isolation and initial characterization of the BRCA2 promoter. 
  • Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. 
  • Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. 
  • Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas. 
  • Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse. 
  • Measuring time during early embryonic development. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis. 
  • Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. 
  • Membrane-bound progesterone receptor expression in human aortic endothelial cells. 
  • Metabolic cooperation between vascular endothelial cells and smooth muscle cells in co-culture: changes in low density lipoprotein metabolism. 
  • Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation. 
  • Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model. 
  • MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. 
  • Mitotic waves in the early embryogenesis of Drosophila: Bistability traded for speed. 
  • Molecular mechanisms of transforming growth factor-beta signaling. 
  • Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression. 
  • Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment. 
  • Morphogenesis and the cell cycle. 
  • Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. 
  • Morphologic analysis correlates with gene expression changes in cultured F344 rat mesothelial cells. 
  • Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. 
  • Multiple roles of ATM in monitoring and maintaining DNA integrity. 
  • Multiple signaling pathways involving ATM. 
  • Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis. 
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. 
  • Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. 
  • Network calisthenics: control of E2F dynamics in cell cycle entry. 
  • Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1. 
  • Non-parametric estimation of a time-dependent predictive accuracy curve. 
  • Noninactivation of a selectable human X-linked gene that complements a murine temperature-sensitive cell cycle defect. 
  • Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis. 
  • Nuclear DNA study of vaginal and cervical squamous cell abnormalities in DES exposed progeny. 
  • Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. 
  • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. 
  • Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. 
  • Nuclear tyrosine kinases: from Abl to WEE1. 
  • Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • Origin of bistability underlying mammalian cell cycle entry. 
  • Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. 
  • P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. 
  • P53, cell cycle control and apoptosis: implications for cancer. 
  • P53: a determinant of the cell cycle response to DNA damage. 
  • PIN1, the cell cycle and cancer. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. 
  • Parallel pathways of gene regulation: homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. 
  • Parametric modeling of cellular state transitions as measured with flow cytometry. 
  • Participation of p53 protein in the cellular response to DNA damage. 
  • Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture. 
  • Phenotypic and cell cycle properties of human oligodendrocytes in vitro. 
  • Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. 
  • Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect. 
  • Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesis. 
  • Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. 
  • Phosphorylation-independent inhibition of Cdc28p by the tyrosine kinase Swe1p in the morphogenesis checkpoint. 
  • Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells. 
  • Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. 
  • Pin1 regulates the timing of mammalian primordial germ cell proliferation. 
  • Polarity establishment in yeast. 
  • Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. 
  • Positive feedback of G1 cyclins ensures coherent cell cycle entry. 
  • Possible role of cell cycle-dependent morphology, geometry, and mechanical properties in tumor cell metastasis. 
  • Post-transcriptional RNA regulons affecting cell cycle and proliferation. 
  • Potential landscape and flux framework of nonequilibrium networks: robustness, dissipation, and coherence of biochemical oscillations. 
  • Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. 
  • Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes. 
  • Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. 
  • Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals. 
  • Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin. 
  • Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. 
  • Prognostic factors in resectable pancreatic cancer: p53 and bcl-2. 
  • Prognostic utility of cell cycle progression score in men with prostate cancer after primary external beam radiation therapy. 
  • Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis. 
  • Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans. 
  • Protective effect of deoxyribonucleosides on UV-irradiated human peripheral blood T-lymphocytes: possibilities for the selective killing of either cycling or non-cycling cells. 
  • Protein phosphatase 2A: a panoply of enzymes. 
  • Protein phosphatase 5 is required for ATR-mediated checkpoint activation. 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • RB regulates transcription of the p21/WAF1/CIP1 gene. 
  • RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases. 
  • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. 
  • Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling. 
  • Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. 
  • Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008). 
  • Reentry into the cell cycle of differentiated skeletal myocytes. 
  • Regional localization of CCG1 gene which complements hamster cell cycle mutation BN462 to Xq11-Xq13. 
  • Regulation by and of calmodulin in mammalian cells. 
  • Regulation of DNA replication in S phase nuclei by ATP and ADP pools. 
  • Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. 
  • Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. 
  • Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. 
  • Regulation of the cell cycle by calcium and calmodulin. 
  • Regulatory functions of calmodulin. 
  • Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. 
  • Relationship of the demonstration of intermediate filament protein to kinetics of three human neuroepithelial tumor cell lines. Lack of neural-related proteins in most cells in S phase: a double-labeled immunohistochemical study on matrix cultures. 
  • Reliability of transcriptional cycles and the yeast cell-cycle oscillator. 
  • Rendering the leukemia cell susceptible to attack. 
  • Replication timing of DNA sequences associated with human centromeres and telomeres. 
  • Replicative senescence revisited. 
  • Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia. 
  • Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Reticuloendothelial clearance of radiolabelled pneumococci in experimental bacteremia: correlation of changes in clearance rates, sequestration patterns, and opsonization requirements at different phases of the bacterial growth cycle. 
  • Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. 
  • Reversible, p16-mediated cell cycle arrest as protection from chemotherapy. 
  • Reversing the Warburg effect as a treatment for glioblastoma. 
  • Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells. 
  • Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. 
  • Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation. 
  • Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. 
  • Role of the aryl hydrocarbon receptor in cell cycle regulation. 
  • Role of transforming growth factor beta in human disease. 
  • Rumenectomy-induced proliferation in duodenal villous epithelium is mechanistically related to the disappearance of statin, a non-proliferation-specific nuclear protein. 
  • Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. 
  • Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. 
  • Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. 
  • Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. 
  • Signal-transduction cascades as targets for therapeutic intervention by natural products. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. 
  • Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development. 
  • Statin expression in the untreated and SarCNU-exposed human glioma cell line, SK-MG-1. 
  • Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state. 
  • Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone. 
  • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. 
  • Stochastic E2F activation and reconciliation of phenomenological cell-cycle models. 
  • Studies on the regulation and specificity of the DNA-untwisting enzyme. 
  • Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. 
  • TBX5 is required for embryonic cardiac cell cycle progression. 
  • Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. 
  • Targeting Akt3 signaling in malignant melanoma using isoselenocyanates. 
  • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. 
  • Temporal control of cell cycle gene expression mediated by E2F transcription factors. 
  • Tension and robustness in multitasking cellular networks. 
  • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. 
  • The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro. 
  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. 
  • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. 
  • The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. 
  • The COOH terminus of p18INK4C distinguishes function from p16INK4A. 
  • The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. 
  • The Local Edge Machine: inference of dynamic models of gene regulation. 
  • The beta-interferon-mediated antimitogenic state resembles the anti-viral state. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The differential expression of statin in the nuclei of human colonic crypts adjacent to a cancer: an immunohistochemical study. 
  • The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study. 
  • The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology. 
  • The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. 
  • The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. 
  • The many substrates and functions of ATM. 
  • The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. 
  • The morphogenesis checkpoint: how yeast cells watch their figures. 
  • The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. 
  • The peptidyl-prolyl isomerase Pin1. 
  • The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice. 
  • The presence of parvalbumin in a nonmuscle cell line attenuates progression through mitosis. 
  • The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. 
  • The role of p53 in cell-cycle control and apoptosis: implications for cancer. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The tetraspanin superfamily member NET-6 is a new tumor suppressor gene. 
  • Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. 
  • To die or grow: Parkinson's disease and cancer. 
  • Topoisomerase II levels during granulocytic maturation in vitro and in vivo. 
  • Topology and control of the cell-cycle-regulated transcriptional circuitry. 
  • Transcription network and cyclin/CDKs: The yin and yang of cell cy 
  • Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. 
  • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. 
  • Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. 
  • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. 
  • Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. 
  • Tumor physiology and cell kinetics. 
  • Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine. 
  • Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle. 
  • Tumor-suppressor p53: implications for tumor development and prognosis. 
  • Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia. 
  • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 
  • Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. 
  • Update in podocyte biology: putting one's best foot forward. 
  • VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. 
  • Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. 
  • Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. 
  • Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud. 
  • Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. 
  • [In vitro inhibitory effect of dibenzoxanthene CY-B12 on proliferation of tumor cell lines and its possible mechanisms]. 
  • c-Myc is required for maintenance of glioma cancer stem cells. 
  • hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation. 
  • n-Butyrate, a cell cycle blocker, inhibits early amplification of duck hepatitis B virus covalently closed circular DNA after in vitro infection of duck hepatocytes. 
  • p38 MAPK in development and cancer. 
  • p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
  • p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. 
  • p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. 
  • p53: a two-faced cancer gene. 
• 

  Keywords of People

  • Allori, Alexander C, Assistant Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Fox, Donald T, Assistant Professor of Pharmacology & Cancer Biology, Duke Science & Society
  • Gordan, Raluca Mihaela, Assistant Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hutson, Mary Redmond, Assistant Professor of Pediatrics, Pediatrics, Neonatology
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Lew, Daniel Julio, James B. Duke Professor of Pharmacology and Cancer Biology, Cell Biology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society