Cell Fusion

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  Subject Areas on Research

  • A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition. 
  • Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. 
  • Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. 
  • Antifusion activity in sera from persons infected with human immunodeficiency virus type 1. 
  • Apogamic development of plasmodia in the myxomycete Physarum polycephalum: a cinematographic analysis. 
  • Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. 
  • Cellular functions of metallo-endoproteinases. 
  • Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. 
  • Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. 
  • Conversion of diploidy to haploidy. 
  • Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells. 
  • Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types. 
  • Dendritic cell-tumor cell fusion vaccines. 
  • Detection of anti-human cell antibodies in sera from macaques immunized with whole inactivated virus. 
  • Effect of interferon on murine leukemia virus infection. II. Synthesis of viral components in exogenous infection. 
  • Effect of vanadate on intracellular distribution and function of 10-nm filaments. 
  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. 
  • Functional characterization of the human placental fusogenic membrane protein syncytin 2. 
  • Functional integrity of desensitized beta-adrenergic receptors. 
  • Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy. 
  • Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient. 
  • Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans. 
  • HIV vaccines. Magic of the occult? 
  • HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Immunization of normal human splenocytes in vitro to produce human monoclonal antibodies to cellular antigens. 
  • Immunogenicity of dendritic-tumor fusion hybrids and their utility in cancer immunotherapy. 
  • Immunotherapy of established murine squamous cell carcinoma using fused dendritic-tumor cell hybrids. 
  • Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids. 
  • Inhibition of human immunodeficiency virus type 1 replication and cytopathicity by synthetic soluble catecholamine melanins in vitro. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion. 
  • Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Monoclonal antibodies binding renal renin. 
  • Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. 
  • Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4. 
  • PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. 
  • Paracrine mechanisms in adult stem cell signaling and therapy. 
  • Persistent coinfection of T lymphocytes with HTLV-II and HIV and the role of syncytium formation in HIV-induced cytopathic effect. 
  • Physical and biological properties of cationic triesters of phosphatidylcholine. 
  • Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120. 
  • Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. 
  • Production of cloned goats from enucleated oocytes injected with cumulus cell nuclei or fused with cumulus cells. 
  • Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Rat myoblast fusion requires metalloendoprotease activity. 
  • Relationship between movement and aggregation of centrioles in syncytia and formation of microtubule bundles. 
  • Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein. 
  • Restoration of differentiation and suppression of tumorigenicity in somatic cell hybrids of human squamous carcinoma cells and keratinocytes. 
  • Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564. 
  • Specific blockers of myoblast fusion inhibit a soluble and not the membrane-associated metalloendoprotease in myoblasts. 
  • Specificity of cell-cell interactions in sea urchin embryos. Appearance of new cell-surface determinants at gastrulation. 
  • Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. 
  • Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives. 
  • The ability of HIV type 1 to use CCR-3 as a coreceptor is controlled by envelope V1/V2 sequences acting in conjunction with a CCR-5 tropic V3 loop. 
  • The role of dynamin in HIV type 1 Env-mediated cell-cell fusion. 
  • The soluble metalloendoprotease required in myoblast fusion remains intracellular. 
  • Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells. 
  • Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines. 
  • Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. 
  • Tumor-dendritic cell fusion as a basis for cancer immunotherapy. 
  • Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. 
  • Use of heterohybridomas in xenotransplantation. 
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  Keywords of People

  • Lee, Walter T, Associate Professor of Surgery, Radiation Oncology