Cell Line, Transformed

• 

  Subject Areas on Research

  • 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator. 
  • 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. 
  • A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. 
  • A functional alternative splicing mutation in human tryptophan hydroxylase-2. 
  • A missense mutation in exon 4 of the human adenosine deaminase gene causes severe combined immunodeficiency. 
  • A novel human cancer culture model for the study of prostate cancer. 
  • A novel mutation in IFN-gamma receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states. 
  • A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation. 
  • A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. 
  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. 
  • Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines. 
  • Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms. 
  • Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery. 
  • Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis. 
  • Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Autocrine growth stimulation by transforming growth factor alpha in asbestos-transformed rat mesothelial cells. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons. 
  • Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. 
  • CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. 
  • CD8+ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from beta-chemokines. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of angiotensin II-receptor subtypes in podocytes. 
  • Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes. 
  • Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • DNA repair in lymphoblastoid cell lines from patients with head and neck cancer. 
  • Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. 
  • Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. 
  • Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand.. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Development of a multiplex PCR assay for the simultaneous detection and discrimination of HIV-1, HIV-2, HTLV-I and HTLV-II. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature. 
  • Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line. 
  • Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins. 
  • Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Establishment of stably EBV-transformed cell lines from residual clinical blood samples for use in performance evaluation and quality assurance in molecular genetic testing. 
  • Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay. 
  • Evaluation of the paracrine and endocrine effects of genitourinary tumor produced growth factors. 
  • Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. 
  • Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage. 
  • Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. 
  • Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. 
  • G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. 
  • Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells. 
  • Genetic induction of tumorigenesis in swine. 
  • Glucocorticoid metabolism in proximal tubules modulates angiotensin II-induced electrolyte transport. 
  • Glycosyl-phosphatidylinositol anchor synthesis in paroxysmal nocturnal hemoglobinuria: partial or complete defect in an early step. 
  • Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. 
  • Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. 
  • Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. 
  • Guidelines for the welfare and use of animals in cancer research. 
  • Heme oxygenase-1 is upregulated in the kidney of angiotensin II-induced hypertensive rats : possible role in renoprotection. 
  • Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual. 
  • High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. 
  • High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells. 
  • Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. 
  • Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Immortalized rat proximal tubule cell lines expressing components of the renin-angiotensin system. 
  • Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. 
  • Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). 
  • In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). 
  • In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells. 
  • Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes. 
  • Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 
  • Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. 
  • Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. 
  • Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells. 
  • Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose. 
  • Interaction of FANCD2 and NBS1 in the DNA damage response. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. 
  • Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. 
  • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. 
  • Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. 
  • Mismatch repair deficiency in phenotypically normal human cells. 
  • Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization. 
  • Molecular analysis of thymopentin binding to HLA-DR molecules. 
  • Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates. 
  • Molecular basis for paradoxical carriers of adenosine deaminase (ADA) deficiency that show extremely low levels of ADA activity in peripheral blood cells without immunodeficiency. 
  • Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. 
  • Molecular genetic mechanisms of allelic specific regulation of murine Comt expression. 
  • Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells. 
  • Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. 
  • Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology. 
  • Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. 
  • Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. 
  • Mutational analysis of the PTEN gene in human uterine sarcomas. 
  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. 
  • N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. 
  • Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. 
  • Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1. 
  • Novel human bronchial epithelial cell lines for cystic fibrosis research. 
  • Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Nuclear phosphatase PPM1G in cellular survival and neural development. 
  • Over-expression of cyclin D1 regulates Cdk4 protein synthesis. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • PGC-1beta in the regulation of hepatic glucose and energy metabolism. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. 
  • Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function. 
  • Pore region of TRPV3 ion channel is specifically required for heat activation. 
  • Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. 
  • Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations. 
  • Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. 
  • Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase. 
  • Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. 
  • Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. 
  • Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. 
  • Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback. 
  • Re-orientation and faster, directed migration of lens epithelial cells in a physiological electric field. 
  • Receptor class desensitization of leukocyte chemoattractant receptors. 
  • Regulation of apoptosis in S49 cells. 
  • Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). 
  • Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. 
  • Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. 
  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes. 
  • Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. 
  • Retroviral protein P15E and tumorigenesis. Expression is neither required nor sufficient for tumor development. 
  • Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. 
  • SERS-based plasmonic nanobiosensing in single living cells. 
  • SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. 
  • SOD2 polymorphisms: unmasking the effect of polymorphism on splicing. 
  • Safety and immunogenicity of an HLA-based HIV envelope polyvalent synthetic peptide immunogen. DATRI 010 Study Group. Division of AIDS Treatment Research Initiative. 
  • Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting. 
  • Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. 
  • SplicerEX: a tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data. 
  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins. 
  • Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells. 
  • T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity. 
  • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. 
  • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy. 
  • The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells. 
  • Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1. 
  • Transformation of rat tracheal epithelial cells to immortal growth variants by particulate and soluble nickel compounds. 
  • Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Tumour maintenance is mediated by eNOS. 
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome. 
  • alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons. 
  • c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA. 
  • cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology