Cell Membrane Permeability

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  Subject Areas on Research

  • A dynamic numerical method for models of renal tubules. 
  • A novel intracellular protein delivery platform based on single-protein nanocapsules. 
  • A radioiodinated MIBG-octreotate conjugate exhibiting enhanced uptake and retention in SSTR2-expressing tumor cells. 
  • A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA. 
  • Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. 
  • An efficient numerical method for distributed-loop models of the urine concentrating mechanism. 
  • Antiarrhythmic drug action. Blockade of the inward sodium current. 
  • Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. 
  • Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement. 
  • Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. 
  • Arsenic trioxide uptake by human and rat aquaglyceroporins. 
  • Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro. 
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells. 
  • Central Ca++-channel blockade reverses ethanol-induced poikilothermia in the rat. 
  • Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes. 
  • Characterization of purified endosomes containing the antidiuretic hormone-sensitive water channel from rat renal papilla. 
  • Chemistry. Nanomaterials for drug delivery. 
  • Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx. 
  • Chrysotile asbestos and H2O2 increase permeability of alveolar epithelium. 
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. 
  • Co-culture of primary pulmonary cells to model alveolar injury and translocation of proteins. 
  • Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. 
  • Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Computed tomography of virally induced canine brain tumors: a preliminary report. 
  • Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes. 
  • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. 
  • Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. 
  • Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Disorders of cell volume regulation. I. Effects of inhibition of plasma membrane adenosine triphosphatase with ouabain. 
  • Effect of anti-acetylcholine receptor Fab fragments from goats on functional membrane-bound receptor. 
  • Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells. 
  • Electro-mechanical permeabilization of lipid vesicles. Role of membrane tension and compressibility. 
  • Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. 
  • Estrogen regulation of aquaporins in the mouse uterus: potential roles in uterine water movement. 
  • Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume. 
  • Extracellular potassium in the mammalian central nervous system. 
  • Ficoll is not a rigid sphere. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • Fura-2 transport in toad urinary bladder epithelium: effects of antidiuretic hormone, colchicine and osmotic gradients. 
  • GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. 
  • GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. 
  • Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model. 
  • Glutamine transport into isolated renal membrane vesicles from normal and acidotic rats. 
  • Glutathione S-transferase fusion proteins mimic receptor dimerization in permeabilized cells. 
  • Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. 
  • Hyperexcitability following moderate hypoxia in hippocampal tissue slices. 
  • Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. 
  • Induction of IL-6 expression by mechanical stress in the trabecular meshwork. 
  • Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells. 
  • Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. 
  • Interaction of the antifolate antibiotic trimethoprim with phosphatidylcholine membranes: a 13C and 31P nuclear magnetic resonance study. 
  • Intestinal iron absorption: current concepts circa 2000. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Iron metabolism and cell membranes. II. The relationship of ferritin to the cytocavitary network in rat hepatic parenchymal cells. 
  • Isolated hormone receptors: physiologic and clinical implications. 
  • Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. 
  • K channel subconductance levels result from heteromeric pore conformations. 
  • Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells. 
  • Modeling electroporation in a single cell. 
  • Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. 
  • Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. 
  • Multi-resolution 3D visualization of the early stages of cellular uptake of peptide-coated nanoparticles. 
  • Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. 
  • Multistability in tubuloglomerular feedback and spectral complexity in spontaneously hypertensive rats. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • Numerical simulation of propagating concentration profiles in renal tubules. 
  • Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. 
  • Optical imaging of intracellular chloride in living brain slices. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Over-pressure suppresses ultrasonic-induced drug uptake. 
  • Permeability properties of the mammalian bladder apical membrane. 
  • Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. 
  • Protecting the permeability pore and mitochondrial biogenesis. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. 
  • Ring-Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post-Polymerization Modification. 
  • Role of membrane curvature in mechanoelectrical transduction: ion carriers nonactin and valinomycin sense changes in integral bending energy. 
  • S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. 
  • Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay. 
  • Singular perturbation analysis of the pore creation transient. 
  • Smooth muscle growth and cholesterol accumulation in atherogenesis. 
  • Spermine. A regulator of mitochondrial calcium cycling. 
  • Stimulation of aquaporin-mediated fluid transport by cyclic GMP in human retinal pigment epithelium in vitro. 
  • Structural and functional response of toad urinary bladder to LiCl. 
  • Structure of supported bilayers composed of lipopolysaccharides and bacterial phospholipids: raft formation and implications for bacterial resistance. 
  • Study of rat renal brush border membrane vesicles by flow cytometry. 
  • Succinylcholine-induced hyperkalemia: effects of succinylcholine on resting potentials and electrolyte distributions in normal and denervated muscle. 
  • Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors. 
  • Tension-stabilized pores in giant vesicles: determination of pore size and pore line tension. 
  • Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The aquaporins, blueprints for cellular plumbing systems. 
  • The blood-brain barrier/neurovascular unit in health and disease. 
  • The distribution of intimal white blood cells in the normal rabbit aorta. 
  • The effect of aldosterone on water and electrolyte composition of incubated rat diaphragms. 
  • The ionic mechanism of the slow outward current in Aplysia neurons. 
  • The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. 
  • The water permeability of lens aquaporin-0 depends on its lipid bilayer environment. 
  • Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1. 
  • Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. 
  • Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy. 
  • Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane. 
  • Using confocal microscopy and the fluorescent indicator, 6-methoxy-N-ethylquinolinium iodide, to measure changes in intracellular chloride. 
  • Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons. 
  • β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability. 
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  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Karhausen, Jorn, Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic