Cell Nucleus

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  Subject Areas on Research

  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • A 3D numerical study of the effect of channel height on leukocyte deformation and adhesion in parallel-plate flow chambers. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. 
  • A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm. 
  • A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. 
  • A cytonuclear incompatibility causes anther sterility in Mimulus hybrids. 
  • A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. 
  • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A human protein related to yeast Cdc6p. 
  • A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A multigene phylogenetic synthesis for the class Lecanoromycetes (Ascomycota): 1307 fungi representing 1139 infrageneric taxa, 317 genera and 66 families. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A phylogeny of Adelanthaceae (Jungermanniales, Marchantiophyta) based on nuclear and chloroplast DNA markers, with comments on classification, cryptic speciation and biogeography. 
  • A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. 
  • A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II. 
  • A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles. 
  • A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. 
  • A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • A subgroup of murine monoclonal anti-deoxyribonucleic acid antibodies traverse the cytoplasm and enter the nucleus in a time-and temperature- dependent manner. 
  • ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • AgSwe1p regulates mitosis in response to morphogenesis and nutrients in multinucleated Ashbya gossypii cells. 
  • Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. 
  • Allotetraploid Mimulus sookensis are highly interfertile despite independent origins. 
  • Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • An activity necessary for in vitro transcription is a DNase inhibitor. 
  • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. 
  • An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. 
  • An expanded view of inositol signaling. 
  • An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • An ultrastructural study of the developing urogenital tract in early human fetuses. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Analyses of promoter-proximal pausing by RNA polymerase II on the hsp70 heat shock gene promoter in a Drosophila nuclear extract. 
  • Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. 
  • Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms. 
  • Apoptosis in the cervix of pregnant rats in association with cervical softening. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. 
  • Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. 
  • Apoptotic nuclease assays. 
  • Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. 
  • Application of the T-matrix method to determine the structure of spheroidal cell nuclei with angle-resolved light scattering. 
  • Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. 
  • Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • Autoimmunity: the nuclear arsenal of autoimmunity. 
  • Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements. 
  • Benign vaginal rhabdomyoma: a light and electron microscopic study. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestins and cell signaling. 
  • Biochemical actions of follice-stimulating hormone in the sertoli cell of the rat testis. 
  • Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero. 
  • Biochemical mechanisms of hormone receptor-effector coupling. Introduction. 
  • Biochemistry. A glucose-to-gene link. 
  • Biolistic nuclear transformation of Saccharomyces cerevisiae and other fungi. 
  • Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. 
  • Bisphenol A affects androgen receptor function via multiple mechanisms. 
  • Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. 
  • CD34 immunohistochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. 
  • Candidate counterparts of Sézary cells and adult T-cell lymphoma-leukaemia cells in normal peripheral blood: an ultrastructural study with the immunogold method and monoclonal antibodies. 
  • Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. 
  • Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish. 
  • Cell adhesion protein expression in melanocytic matricoma. 
  • Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. 
  • Cell number and distribution in human and rat airways. 
  • Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. 
  • Cellular organization and substructure measured using angle-resolved low-coherence interferometry. 
  • Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases. 
  • Changes in hairy cells after alpha-interferon treatment as measured by flow cytometry. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of 57 kDa statin as a true marker for growth arrest in tissue by its disappearance from regenerating liver. 
  • Characterization of monoclonal antibodies to Acanthamoeba myosin-I that cross-react with both myosin-II and low molecular mass nuclear proteins. 
  • Characterization of nuclear angiotensin-II-binding sites in rat liver and comparison with plasma membrane receptors. 
  • Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain. 
  • Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. 
  • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 
  • Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma. 
  • Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. 
  • Clinicopathologic correlations in the oligodendroglioma. 
  • Clustered nuclei maintain autonomy and nucleocytoplasmic ratio control in a syncytium. 
  • Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. 
  • Communal living: the role of polyploidy and syncytia in tissue biology. 
  • Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA. 
  • Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions? 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I. 
  • Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. 
  • Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. 
  • Cospeciation of gut microbiota with hominids. 
  • Crossover interference on nucleolus organizing region-bearing chromosomes in Arabidopsis. 
  • Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Cytology of clear-cell adenocarcinoma of genital tract in young females: review of 95 cases from the registry. 
  • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. 
  • Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • DEK expression in Merkel cell carcinoma and small cell carcinoma. 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DNA polymerase delta is required for human mismatch repair in vitro. 
  • DNA-dependent activation of the hMutSalpha ATPase. 
  • DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. 
  • Dancing genomes: fungal nuclear positioning. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. 
  • Delimiting species without nuclear monophyly in Madagascar's mouse lemurs. 
  • Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells. 
  • Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations. 
  • Detection of dysplasia in Barrett's esophagus with in vivo depth-resolved nuclear morphology measurements. 
  • Detection of intestinal dysplasia using angle-resolved low coherence interferometry. 
  • Diagnosis of anaplastic large-cell lymphoma, including multifocal osseous KI-1 lymphoma, by fine-needle aspiration biopsy. 
  • Difference between mitochondrial RNase P and nuclear RNase P. 
  • Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus. 
  • Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer. 
  • Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication. 
  • Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 
  • Differential replication of ribosomal gene repeats in polytene nuclei of Drosophila. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. 
  • Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. 
  • Disappearance of statin, a protein marker for non-proliferating and senescent cells, following serum-stimulated cell cycle entry. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distribution of 5-methyldeoxycytidine in products of staphylococcal nuclease digestion of nuclei and purified DNA. 
  • Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts. 
  • Does terbutaline damage the developing heart? 
  • Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • Dynamic shuttling and intranuclear mobility of nuclear hormone receptors. 
  • EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus. 
  • Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Editorial: The Role of Nuclear Molecules in the Pathogenesis of Autoimmune Disease. 
  • Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct. 
  • Effect of lipopolysaccharide administration on the number, phenotype and content of nuclear molecules in blood microparticles of normal human subjects. 
  • Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. 
  • Effects of age and rapid high-pressure fixation on the morphology of Schlemm's canal. 
  • Effects of cyclic adenosine 3': 5'-monophosphate on phosphoprotein kinase and phosphatase fractions prepared from rat liver nuclei. 
  • Effects of estrogen on very low density lipoproteins (VLDL) synthesis in avian liver slices in vitro: lack of correlation with nuclear estrogen receptors. 
  • Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. 
  • Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells. 
  • Efficiency, selectivity, and robustness of nucleocytoplasmic transport. 
  • Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Endogenous polymers of ADP-ribose are associated with the nuclear matrix. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211 At. 
  • Engineering gene expression and protein synthesis by modulation of nuclear shape. 
  • Engineering key components in a synthetic eukaryotic signal transduction pathway. 
  • Enhancement of the ncdD microtubule motor mutant by mutants of alpha Tub67C. 
  • Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction. 
  • Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. 
  • Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. 
  • Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. 
  • Estrogen modulation of nuclear matrix-associated steroid hormone binding. 
  • Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix. 
  • Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. 
  • Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. 
  • Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. 
  • Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action. 
  • Evidence that myosin does not contribute to force production in chromosome movement. 
  • Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant, "subfossil" koala lemur Megaladapis edwardsi. 
  • Exfoliative cytopathologic studies in organ transplantation. V. The diagnosis of rejection in the immediate postoperative period. 
  • Exon circularization in mammalian nuclear extracts. 
  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes. 
  • Experimental verification of T-matrix-based inverse light scattering analysis for assessing structure of spheroids as models of cell nuclei. 
  • Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. 
  • Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. 
  • Expression of nuclear estrogen-binding sites within developing human fetal vagina and urogenital sinus. 
  • Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. 
  • FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis 
  • FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. 
  • Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology. 
  • Feasibility of field-based light scattering spectroscopy. 
  • Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. 
  • Female steroid hormones and target cell nuclei. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fibrillar systems in cell motility. 
  • Fine needle aspiration biopsy of metastatic melanoma. A morphologic analysis of 174 cases. 
  • Fine structure of a radiation-induced osteogenic sarcoma. 
  • Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis. 
  • Fine-needle aspiration cytology findings in a case of aggressive angiomyxoma: a case report and review of the literature. 
  • Fine-needle aspiration of neural lesions. 
  • Fine-needle aspiration of papillary thyroid carcinoma: distinguishing between cases that performed well and those that performed poorly in the College of American Pathologists Nongynecologic Cytology Program. 
  • Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells. 
  • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Forebrain nuclei linked to woodpecker territorial drum displays mirror those that enable vocal learning in songbirds. 
  • Formalizing morphologically cryptic biological entities: new insights from DNA taxonomy, hybridization, and biogeography in the leafy liverwort Porella platyphylla (Jungermanniopsida, Porellales). 
  • Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts. 
  • Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. 
  • Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. 
  • GW112, a novel antiapoptotic protein that promotes tumor growth. 
  • Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genetic variation in the spread of Drosophila subobscura from a nonequilibrium population. 
  • Genome-wide chromatin state transitions associated with developmental and environmental cues. 
  • Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera. 
  • Genome-wide significant risk associations for mucinous ovarian carcinoma. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Giant cell interstitial pneumonia in a hard-metal worker. Cytologic, histologic and analytical electron microscopic investigation. 
  • Giant cell tumor of rib masquerading as thymoma: a diagnostic pitfall in needle core biopsy of the mediastinum. 
  • Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids. 
  • Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Going the distance: Neocentromeres make long-range contacts with heterochromatin. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system. 
  • Heat shock-induced appearance of RNA polymerase II in karyoskeletal protein-enriched (nuclear "matrix") fractions correlates with transcriptional shutdown in Drosophila melanogaster. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • Hepatocellular expression of glucose-6-phosphatase is unaltered during hepatic regeneration. 
  • Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells. 
  • High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays. 
  • High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma. 
  • High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. 
  • High-mobility group box 1 (HMGB1) protein: friend and foe. 
  • High-resolution mapping and characterization of open chromatin across the genome. 
  • Histochemical localization of Statin--a non-proliferation-specific nuclear protein--in nuclei of normal and abnormal human thyroid tissue. 
  • Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Human embryos derived from in vitro and in vivo matured oocytes: analysis for chromosomal abnormalities and nuclear morphology. 
  • Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. 
  • Hypermutability and mismatch repair deficiency in RER+ tumor cells. 
  • Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase. 
  • Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Immature excitatory neurons develop during adolescence in the human amygdala. 
  • Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies. 
  • Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. 
  • Immunohistochemical expression of mutant p53 oncogene in transitional mucosa adjacent to human colon cancer. 
  • Impaired Chloroplast Biogenesis in Immutans, an Arabidopsis Variegation Mutant, Modifies Developmental Programming, Cell Wall Composition and Resistance to Pseudomonas syringae. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • In situ cryofixation of kidney for electron probe X-ray microanalysis. 
  • In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometry. 
  • In vivo identification of a negative regulatory element in the mouse renin gene using direct gene transfer. 
  • In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans 
  • Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. 
  • Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. 
  • Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor. 
  • Induction of protein secretory pathway is required for systemic acquired resistance. 
  • Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels. 
  • Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer. 
  • Inhibition of Human Adenovirus Replication by the Importin α/β1 Nuclear Import Inhibitor Ivermectin. 
  • Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). 
  • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. 
  • Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. 
  • Inositol phosphate multikinase dependent transcriptional control. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. 
  • Inositol polyphosphate kinases: regulators of nuclear function. 
  • Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. 
  • Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. 
  • Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. 
  • Intermediate filament associated proteins. 
  • Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. 
  • Intranuclear inclusion bodies. 
  • Intranuclear inclusions in Bence Jones lambda plasma cell myeloma. 
  • Involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia. 
  • Ion beam etching effects in biological microanalysis. 
  • Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression. 
  • Is the nuclear refractive index lower than cytoplasm? Validation of phase measurements and implications for light scattering technologies. 
  • Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. 
  • Isolated trout liver cells: establishing short-term primary cultures exhibiting cell-to-cell interactions. 
  • Isolation of human sequences that replicate autonomously in human cells. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • Keap1 modification and nuclear accumulation in response to S-nitrosocysteine. 
  • Kinesin-5 Kip1 is a bi-directional motor that stabilizes microtubules and tracks their plus-ends in vivo. 
  • Kinetics of protein import into isolated Xenopus oocyte nuclei. 
  • LITE microscopy: Tilted light-sheet excitation of model organisms offers high resolution and low photobleaching. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometry. 
  • Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Light scattering measurements of subcellular structure provide noninvasive early detection of chemotherapy-induced apoptosis. 
  • Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells. 
  • Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast. 
  • Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation. 
  • Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling. 
  • Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. 
  • Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. 
  • Low-copy nuclear sequence data confirm complex patterns of farina evolution in notholaenid ferns (Pteridaceae) 
  • LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo. 
  • MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression. 
  • Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Mapping oxidative DNA damage at nucleotide level. 
  • Measuring Cellular Ploidy In Situ by Light Microscopy. 
  • Mechanical regulation of nuclear structure and function. 
  • Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanism of Dual Targeting of the Phytochrome Signaling Component HEMERA/pTAC12 to Plastids and the Nucleus. 
  • Mechanism of estrogen action: early transcriptional and translational events. 
  • Meningeal mycosis fungoides: clinical and cellular characteristics. 
  • Meningeal mycosis fungoides: cytologic and ultrastructural aspects. 
  • Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. 
  • Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. 
  • Micronuclei in binucleated lymphocytes of mice following exposure to gamma radiation. 
  • Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. 
  • Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. 
  • Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. 
  • Mitochondrial localization and characterization of 99Tc-SESTAMIBI in heart cells by electron probe X-ray microanalysis and 99Tc-NMR spectroscopy. 
  • Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. 
  • Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. 
  • Modulation of nuclear statin expression in rat thyroid follicle cell following administration of thyroid stimulating hormone. 
  • Molecular biology of nuclear autoantigens. 
  • Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. 
  • Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Molecular insights into the phylogeny and subgeneric classification of Frullania Raddi (Frullaniaceae, Porellales). 
  • Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor. 
  • Molecular mechanisms of dominant negative activity by nuclear hormone receptors. 
  • Molecular phylogenetic analysis of the Papionina using concatenation and species tree methods. 
  • Molecular phylogeny of the Blastocladiomycota (Fungi) based on nuclear ribosomal DNA. 
  • Molecular phylogeny of the Entomophthoromycota: 
  • Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma. 
  • Mouse liver cell culture. I. Hepatocyte isolation. 
  • Mouse liver cell culture. II. Primary culture. 
  • Multiple Recurrent Fibromatosis With Cranial Fasciitis Characteristics in a Pediatric Patient. 
  • Multiple nuclear loci reveal patterns of incomplete lineage sorting and complex species history within western mouse lemurs (Microcebus). 
  • Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter. 
  • Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. 
  • MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. 
  • Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. 
  • NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. 
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. 
  • NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. 
  • NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53. 
  • Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. 
  • New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. 
  • New insights into thyroid hormone action. 
  • Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage. 
  • Nonlinear osmotic properties of the cell nucleus. 
  • Novel mitochondrial derived Nuclear Excisosome degrades nuclei during differentiation of prosimian Galago (bush baby) monkey lenses. 
  • Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. 
  • Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. 
  • Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis. 
  • Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock. 
  • Nuclear RNA synthesis in sea urchin embryos. 
  • Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas. 
  • Nuclear anarchy: asynchronous mitosis in multinucleated fungal hyphae. 
  • Nuclear autonomy in multinucleate fungi. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Nuclear chromatin determination in amniotic fluid cells for prenatal sex prediction in the macaque. 
  • Nuclear cytoplasmic shuttling by thyroid hormone receptors. multiple protein interactions are required for nuclear retention. 
  • Nuclear deformation during breast cancer cell transmigration. 
  • Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. 
  • Nuclear estrogen receptor in the avian liver: correlation with biologic response. 
  • Nuclear export of mammalian PERIOD proteins. 
  • Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cells. 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Nuclear grade and necrosis predict prognosis in malignant epithelioid pleural mesothelioma: a multi-institutional study. 
  • Nuclear hormone receptors as targets for new drug discovery. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. 
  • Nuclear inositol signaling: a structural and functional approach. 
  • Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. 
  • Nuclear localization of NPR1 is required for activation of PR gene expression. 
  • Nuclear localization of autoantibodies. Novel insights into protein translocation and cellular function. 
  • Nuclear morphology measurements with angle-resolved low coherence interferometry for application to cell biology and early cancer detection. 
  • Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. 
  • Nuclear protein localization. 
  • Nuclear responses to depletion of mitochondrial DNA in human cells. 
  • Nuclear ribosomal DNA sequence variation and evolution of spotted marsh-orchids (Dactylorhiza maculata group) 
  • Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae. 
  • Nuclear transport kinetics in microarrays of nuclear envelope patches. 
  • Nuclear tyrosine kinases: from Abl to WEE1. 
  • Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana. 
  • Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events. 
  • Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • Observations on cell volume, ultrastructure, mitochondrial conformation and vital-dye uptake in Ehrlich ascites tumor cells. Effects of inhibiting energy production and function of the plasma membrane. 
  • Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. 
  • One species or at least eight? Delimitation and distribution of Frullania tamarisci (L.) Dumort. s. l. (Jungermanniopsida, Porellales) inferred from nuclear and chloroplast DNA markers. 
  • Optical High Content Nanoscopy of Epigenetic Marks Decodes Phenotypic Divergence in Stem Cells. 
  • Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma. 
  • Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. 
  • Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • PCR based determination of mitochondrial DNA copy number in multiple species. 
  • PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage. 
  • PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. 
  • PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex. 
  • Paget's disease of the breast masquerading as squamous cell carcinoma on cytology: a case report. 
  • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. 
  • Parc-ing p53 in the cytoplasm. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. 
  • Phenotypic characterization of gamma interferon-induced human monocyte polykaryons. 
  • Phosphorus-based SAHA analogues as histone deacetylase inhibitors. 
  • Phosphorylation and functions of the RNA polymerase II CTD. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Phosphorylation-dependent control of ZIPK nuclear import is species specific. 
  • Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. 
  • Phylogenetic and biogeographic relationships of eastern Asian and eastern North American disjunct Suillus species (fungi) as inferred from nuclear ribosomal RNA ITS sequences. 
  • Phylogeny, biogeography, and processes of molecular differentiation in Quercus subgenus Quercus (Fagaceae). 
  • Phylogeography of the arid-adapted Malagasy bullfrog, Laliostoma labrosum, influenced by past connectivity and habitat stability. 
  • Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. 
  • Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells. 
  • Ploidy variation in multinucleate cells changes under stress. 
  • Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens. 
  • Post-translational modifications regulate the ticking of the circadian clock. 
  • Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis. 
  • Pressure effects on flow channels in the lining endothelium of Schlemm's canal. A quantitative study by transmission electron microscopy. 
  • Processing of nuclear heterogeneous RNA: recent developments. 
  • Prognostic factors in resectable pancreatic cancer: p53 and bcl-2. 
  • Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. 
  • Prognostic value of the diagnostic criteria distinguishing endometrial stromal sarcoma, low grade from undifferentiated endometrial sarcoma, 2 entities within the invasive endometrial stromal neoplasia family. 
  • Proliferative activity of colonic mucosa at different distances from primary adenocarcinoma as determined by the presence of statin: a nonproliferation-specific nuclear protein. 
  • Properties of a Drosophila RNA polymerase II elongation factor. 
  • Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. 
  • Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. 
  • Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation. 
  • Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. 
  • Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. 
  • Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. 
  • Purification and biochemical characterization of statin, a nonproliferation specific protein from rat liver. 
  • Purification of the three nuclear RNA polymerases from Neurospora crassa. 
  • QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. 
  • RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • RNA synthesis in liver nuclei of young rats fed varying amounts of vitamin A. 
  • RYK-mediated filopodial pathfinding facilitates midgut elongation. 
  • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. 
  • Racial diversity with high nucleated cell counts and CD34 counts achieved in a national network of cord blood banks. 
  • Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic. 
  • Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells. 
  • Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding. 
  • Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. 
  • Recombinant human gamma-interferon induces human monocyte polykaryon formation. 
  • Reconciling Conflicting Phylogenies in the Origin of Sweet Potato and Dispersal to Polynesia. 
  • Redox rhythm reinforces the circadian clock to gate immune response 
  • Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. 
  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. 
  • Regulation of apoptosis in Xenopus egg extracts. 
  • Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. 
  • Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. 
  • Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. 
  • Regulation of nuclear processes by inositol polyphosphates. 
  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. 
  • Regulation of translation and transcription of messenger RNA during early embryonic development. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Relationship between movement and aggregation of centrioles in syncytia and formation of microtubule bundles. 
  • Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system. 
  • Reply to Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features. 
  • Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. 
  • Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. 
  • Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. 
  • Resolution of the ordinal phylogeny of mosses using targeted exons from organellar and nuclear genomes. 
  • Resolving Arthropod Phylogeny: Exploring Phylogenetic Signal within 41 kb of Protein-Coding Nuclear Gene Sequence 
  • Respiratory muscle involvement in infantile myotonic dystrophy. 
  • Response to Comment on "Is the nuclear refractive index lower than cytoplasm? Validation of phase measurements and implications for light scattering technologies": A Comment on "How a phase image of a cell with nucleus refractive index smaller than that of the cytoplasm should look like?", e201800033. 
  • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. 
  • Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. 
  • Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology. 
  • Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. 
  • Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. 
  • SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. 
  • Saccharomyces cerevisiae Ntg1p and Ntg2p: broad specificity N-glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria. 
  • Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. 
  • Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. 
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. 
  • Sequence complexity of nuclear RNAs in adult rat tissues. 
  • Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation. 
  • Sequential activation of splenic nuclear RNA polymerases by erythropoietin. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains. 
  • Signals from dying hepatocytes trigger growth of liver progenitors. 
  • Simian virus 40-induced retinopathy in the rat. 
  • Single-cell genomics identifies cell type-specific molecular changes in autism. 
  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. 
  • Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. 
  • SnapShot: Mammalian Sirtuins. 
  • Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. 
  • Spatial frequency-domain multiplexed microscopy for simultaneous, single-camera, one-shot, fluorescent, and quantitative-phase imaging 
  • Species delimitation in lemurs: multiple genetic loci reveal low levels of species diversity in the genus Cheirogaleus. 
  • Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage. 
  • Stability of nuclear triiodothyronine binding sites. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Stem cell differentiation indicated by noninvasive photonic characterization and fractal analysis of subcellular architecture. 
  • Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. 
  • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. 
  • Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. 
  • Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis. 
  • Structural basis for the proinflammatory cytokine activity of high mobility group box 1. 
  • Structural studies on Neurospora RNA polymerases and associated proteins. 
  • Study of apoptosis in vitro using the Xenopus egg extract reconstitution system. 
  • Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. 
  • Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases. 
  • Suggesting the cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A retrospective analysis of atypical and suspicious nodules. 
  • Super-Resolution Optical Fluctuation Bio-Imaging with Dual-Color Carbon Nanodots. 
  • Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabpl). Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice. 
  • Surface projections of titanium substrates increase antithrombotic endothelial function in response to shear stress. 
  • Surface-enhanced Raman scattering detection and tracking of nanoprobes: enhanced uptake and nuclear targeting in single cells. 
  • Surgical resection of locally advanced granular cell tumor of the orbit. 
  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. 
  • Systemic lupus erythematosus and related diseases. 
  • T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. 
  • Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer. 
  • Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. 
  • Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. 
  • The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells. 
  • The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). 
  • The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. 
  • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. 
  • The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. 
  • The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. 
  • The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells. 
  • The bacterial effector HopM1 suppresses PAMP-triggered oxidative burst and stomatal immunity. 
  • The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 
  • The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. 
  • The composition and morphology of yeast nuclear scaffolds. 
  • The enduring enigma of nuclear translation. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The intestinal tuft cell nanostructure in 3D. 
  • The mechanism of steroid-hormone regulation of transcription of specific eukaryotic genes. 
  • The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. 
  • The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. 
  • The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus. 
  • The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors. 
  • The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The role of protein synthesis in striatal long-term depression. 
  • The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cells. 
  • The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans. 
  • The translocation of nuclear molecules during inflammation and cell death. 
  • The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. 
  • Three-dimensional reconstruction and quantitative analysis of rat lung type II cells: a computer-based study. 
  • Toluene abuse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats. 
  • Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. 
  • Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling. 
  • Transcription of spacer sequences flanking the rat 45S ribosomal DNA gene. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. 
  • Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells. 
  • Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein-1. 
  • Transcriptome-mining for single-copy nuclear markers in ferns 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons. 
  • Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. 
  • Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors. 
  • Tubular arrays on electron microscopy not specific. 
  • Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. 
  • Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. 
  • Two new loci, PLEIADE and HYADE, implicate organ-specific regulation of cytokinesis in Arabidopsis. 
  • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. 
  • Ultrastructural changes accompanying secretion and cell death in the molting glands of an insect (Oncopeltus). 
  • Uniparental nuclear inheritance following bisexual mating in fungi. 
  • Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins. 
  • Use of the 125I-labeled protein gel overlay technique to study calmodulin-binding proteins. 
  • Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. 
  • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. 
  • WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection. 
  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. 
  • Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • p53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy. 
  • p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering