Cell Survival

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  Subject Areas on Research

  • 4-Fluorobenzylamine and phenylalanine methyl ester conjugates of 2-nitroimidazole: evaluation as hypoxic cell radiosensitizers. 
  • ^* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. 
  • A TCP model incorporating setup uncertainty and tumor cell density variation in microscopic extension to guide treatment planning. 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A colony color method identifies the vulnerability of mitochondria to oxidative damage. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A deadly game of musical chairs: survival of cells transplanted for myocardial repair. 
  • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. 
  • A method for the continuous calculation of the age of labeled red blood cells. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel approach to the measurement of different in vitro leukaemic cell growth parameters: the use of PKH GL fluorescent probes. 
  • A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. 
  • A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures. 
  • A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy. 
  • A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. 
  • A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. 
  • A novel mouse model of red blood cell storage and posttransfusion in vivo survival. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion. 
  • A relationship between behavior, neurotrophin expression, and new neuron survival. 
  • A reliable method for isolation of viable porcine islet cells. 
  • A roadmap for interpreting (13)C metabolite labeling patterns from cells. 
  • A role for Rac3 GTPase in the regulation of autophagy. 
  • A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. 
  • A survival guide to early T cell development. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • A vacuolar-H(+) -pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of Toxoplasma gondii. 
  • AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. 
  • AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. 
  • ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. 
  • ATM--a key determinant of multiple cellular responses to irradiation. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival. 
  • Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells. 
  • Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. 
  • Acoustic separation of circulating tumor cells. 
  • Acoustofluidic Droplet Sorter Based on Single Phase Focused Transducers. 
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. 
  • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family. 
  • Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. 
  • Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo. 
  • Acute toxicity of lead particulates on pulmonary alveolar macrophages. Ultrastructural and microanalytical studies. 
  • Adenosine nucleotides in bile. 
  • Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability. 
  • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. 
  • Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. 
  • Age-related increase in phorbol myristate acetate-induced lymphocyte adhesion to vascular endothelium. 
  • Air bubble-associated endothelial trauma in descemet stripping automated endothelial keratoplasty. 
  • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. 
  • Akt is required for Stat5 activation and mammary differentiation. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 
  • Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. 
  • Akt1 and Akt2 promote peripheral B-cell maturation and survival. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • Altered rate of DNA replication in ageing human fibroblast cultures. 
  • Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins. 
  • Amelioration of the cytotoxic effects of chemotherapeutic agents by grape seed proanthocyanidin extract. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. 
  • Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. 
  • An adaptable mesocosm platform for performing integrated assessments of nanomaterial risk in complex environmental systems. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • An enzyme-linked immunosorbent assay for estrogenicity using primary hepatocyte cultures from the channel catfish (Ictalurus punctatus). 
  • An expanded risk prediction model for lung cancer. 
  • An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. 
  • An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. 
  • An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. 
  • An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules 
  • Analysis and isolation of renal tubular cells by flow cytometry. 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Androgens promote prostate cancer cell growth through induction of autophagy. 
  • Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch. 
  • Angiopoietin-1 enhances skeletal muscle regeneration in mice. 
  • Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. 
  • Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line. 
  • Anti-epidermal-cell-surface pemphigus antibody detaches viable epidermal cells from culture plates by activation of proteinase. 
  • Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. 
  • Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. 
  • Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage. 
  • Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens. 
  • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. 
  • Antibody-targeted photodynamic therapy. 
  • Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. 
  • Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. 
  • Antioxidant defense mechanisms in cultured pleural mesothelial cells. 
  • Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. 
  • Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Application of a unique monoclonal antibody as a marker for nonproliferating subpopulations of cells of some tissue. 
  • Application of magnetic resonance microscopy to tissue engineering: a polylactide model. 
  • Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis. 
  • Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies. 
  • Articular chondrocyte tenascin-C production and assembly into de novo extracellular matrix. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Assessment of cadaveric organ viability during pulsatile perfusion using infrared imaging. 
  • Assessment of myocardial viability by cardiovascular magnetic resonance imaging. 
  • Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture. 
  • Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury. 
  • Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. 
  • Autophagy and mechanotransduction in outflow pathway cells. 
  • Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. 
  • B-cell homeostasis: digital survival or analog growth? 
  • BET bromodomain inhibition of MYC-amplified medulloblastoma. 
  • Bacterial lipopolysaccharides and mycoplasmal lipoglycans: a comparison between their abilities to induce macrophage-mediated tumor cell killing and Limulus amebocyte lysate clotting. 
  • Bacterial temporal dynamics enable optimal design of antibiotic treatment. 
  • Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. 
  • Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells. 
  • Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia. 
  • Biocompatible hydrogels by oxime Click chemistry 
  • Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars. 
  • Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer. 
  • Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death. 
  • Biological effects of desert dust in respiratory epithelial cells and a murine model. 
  • Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration. 
  • Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • Buthionine sulfoximine induction of gamma-L-glutamyl-L-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicity in human glioma cells. 
  • Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis. 
  • CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation. 
  • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. 
  • CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. 
  • CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation. 
  • CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. 
  • CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Camptothecin analogues with enhanced antitumor activity at acidic pH. 
  • Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. 
  • Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. 
  • Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study. 
  • Carbohydrate metabolism in transforming lymphocytes from the aged. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. 
  • Caspase-8-mediated apoptosis in human RPE cells. 
  • Caspases and IAPs: a dance of death ensures cell survival. 
  • Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge. 
  • Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity. 
  • Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. 
  • Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial. 
  • Cell cycle studies of cyclocreatine, a new anticancer agent. 
  • Cell death and control of cell survival in the oligodendrocyte lineage. 
  • Cell death in age-related macular degeneration. 
  • Cell death in cortical development: How much? Why? So what? 
  • Cell dissociation techniques in human breast cancer--variations in tumor cell viability and DNA ploidy. 
  • Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. 
  • Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors. 
  • Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival. 
  • Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells. 
  • Characterization of a microcarrier cell culture system for 23Na MR spectroscopy studies. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials. 
  • Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus. 
  • Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. 
  • Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Chromium genotoxicity: A double-edged sword. 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Clastogenicity of lead chromate particles in hamster and human cells. 
  • Cloning and molecular characterization of a cDNA clone to statin, a protein specifically expressed in nonproliferating quiescent and senescent fibroblasts. 
  • Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia. 
  • Common responses of tumors and wounds to hypoxia. 
  • Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma. 
  • Comparison of the Viability and Yield of Adipose-Derived Stem Cells (ASCs) from Different Donor Areas. 
  • Comparison of the efficacy of a two-day and a five-day schedule for infusing intravenous gamma globulin in the treatment of immune thrombocytopenic purpura in adults. 
  • Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response. 
  • Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. 
  • Concentration-Dependent Dual Role of Thrombin in Protection of Cultured Rat Cortical Neurons. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Construction, imaging, and analysis of FRET-based tension sensors in living cells. 
  • Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statin. 
  • Control of lens epithelial cell survival. 
  • Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. 
  • Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection. 
  • Creatine supplementation reduces doxorubicin-induced cardiomyocellular injury. 
  • Cryopreservation of neurospheres derived from human glioblastoma multiforme. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Cryopreserving whole blood for functional assays using viable lymphocytes in molecular epidemiology studies. 
  • Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cyclic loading alters biomechanical properties and secretion of PGE2 and NO from tendon explants. 
  • Cyclocreatine in cancer chemotherapy. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia. 
  • Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency. 
  • Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU). 
  • Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. 
  • Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. 
  • Cytotoxic, antifouling bromotyramines: a synthetic study on simple marine natural products and Their analogues. 
  • Cytotoxicity and thermomechanical behavior of biomedical shape-memory polymer networks post-sterilization. 
  • Cytotoxicity of alpha-particle-emitting m-[211At]astatobenzylguanidine on human neuroblastoma cells. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • DNA copy number evolution in Drosophila cell lines. 
  • DNA damage responses in prokaryotes: regulating gene expression, modulating growth patterns, and manipulating replication forks. 
  • DNA repair and epidemiology of basal cell carcinoma. 
  • DNA-protein cross-links induced by nickel compounds in intact cultured mammalian cells. 
  • Dabigatran abrogates brain endothelial cell permeability in response to thrombin. 
  • Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Dedifferentiation of committed epithelial cells into stem cells in vivo. 
  • Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV. 
  • Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival. 
  • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. 
  • Delineating the requirements for spontaneous DNA damage resistance pathways in genome maintenance and viability in Saccharomyces cerevisiae. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Dendritic development of Purkinje and granule cells in the cerebellar cortex of rats treated postnatally with alpha-difluoromethylornithine. 
  • Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Dependence of germinal center B cells on expression of CD21/CD35 for survival. 
  • Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. 
  • Descemet-stripping automated endothelial keratoplasty (DSAEK): effect of nontoxic gentian violet marking pen on DSAEK donor tissue viability by using vital dye assay. 
  • Descemet-stripping automated endothelial keratoplasty: effect of anterior lamellar corneal tissue-on/-off storage condition on Descemet-stripping automated endothelial keratoplasty donor tissue. 
  • Descemet-stripping automated endothelial keratoplasty: effect of inserting forceps on DSAEK donor tissue viability by using an in vitro delivery model and vital dye assay. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs 
  • Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells. 
  • Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization. 
  • Development of a contemporary globally diverse HIV viral panel by the EQAPOL program. 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors. 
  • Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus. 
  • Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. 
  • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. 
  • Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. 
  • Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells. 
  • Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines. 
  • Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants 
  • Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces 
  • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. 
  • Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. 
  • Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. 
  • Disappearance of statin, a protein marker for non-proliferating and senescent cells, following serum-stimulated cell cycle entry. 
  • Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. 
  • Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer. 
  • Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. 
  • Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes. 
  • Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. 
  • Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. 
  • Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. 
  • Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor. 
  • Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer. 
  • Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. 
  • Docetaxel enhances tumor radioresponse in vivo. 
  • Does neurotropin-3 have a therapeutic implication in major depression? 
  • Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Doxorubicin-loaded protease-activated near-infrared fluorescent polymeric nanoparticles for imaging and therapy of cancer. 
  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. 
  • Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for Pathological Responsive Ultrasound Imaging and T2-Weighted Magnetic Resonance Imaging. 
  • Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice. 
  • Dye-coupling in three-dimensional histoculture of rat lingual frenulum. 
  • Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. 
  • Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. 
  • Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. 
  • E proteins in lymphocyte development and lymphoid diseases. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. 
  • EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. 
  • ER stress modulates cellular metabolism. 
  • Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor. 
  • Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate. 
  • Effect of ionizing radiation on thymidine uptake, differentiation, and VEGFR2 receptor expression in endothelial cells: the role of VEGF(165). 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of molecular characteristics on cellular uptake, subcellular localization, and phototoxicity of Zn(II) N-alkylpyridylporphyrins. 
  • Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. 
  • Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells. 
  • Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. 
  • Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers. 
  • Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. 
  • Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions. 
  • Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae. 
  • Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat). 
  • Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Effects of the combination of TRC105 and bevacizumab on endothelial cell biology. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Effects of titanium particle size on osteoblast functions in vitro and in vivo. 
  • Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. 
  • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. 
  • Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea. 
  • Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration. 
  • Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain. 
  • Energy dispersive x-ray microanalysis of vital dye (erythrosin B) stained cells. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study. 
  • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. 
  • Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus. 
  • Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy. 
  • EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells. 
  • Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials. 
  • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 
  • Estimation of cell survival in tumours heated to nonuniform temperature distributions. 
  • Estimation of cell survival in tumours heated to nonuniform temperature distributions. 
  • Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. 
  • Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering. 
  • Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. 
  • Evaluation of arylmethylaminopropanediols by a novel in vitro pharmacodynamic assay: correlation with antitumor activity in vivo. 
  • Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation. 
  • Evans blue nanocarriers visually demarcate margins of invasive gliomas. 
  • Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. 
  • Evidence of severe mitochondrial oxidative stress and a protective effect of low oxygen in mouse models of inherited photoreceptor degeneration. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction. 
  • Excision repair is required for genotoxin-induced mutagenesis in mammalian cells. 
  • Experimental method for the hyperthermic treatment of cells in tissue culture: initial application to pancreatic cancer cells. 
  • Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Extended survival time following pseudorabies virus injection labels the suprapontine neural network controlling the bladder and urethra in the rat. 
  • Extracellular low pH affects circadian rhythm expression in human primary fibroblasts. 
  • Extracellular release of ATP mediated by cyclic mechanical stress leads to mobilization of AA in trabecular meshwork cells. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. 
  • Factors influencing hyperthermic enhancement of drug cytotoxicity. 
  • Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability. 
  • Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease. 
  • Feasibility of vitrification as a storage method for tissue-engineered blood vessels. 
  • Fecal leukocytes in stool specimens submitted for Clostridium difficile toxin assay. 
  • Fibroblasts that express aromatic amino acid decarboxylase have increased sensitivity to the synergistic cytotoxicity of L-dopa and manganese. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Filling a GAP(DH) in caspase-independent cell death. 
  • Flow perfusion maintains ex vivo bone viability: a novel model for bone biology research. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescent viability stains overestimate chondrocyte viability in osteoarticular allografts. 
  • Fluoresein diacetate uptake to determine the viability of human fetal cerebral cortical cells. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 
  • Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. 
  • Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. 
  • Formation and maintenance of synaptic connections in autonomic ganglia. 
  • Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response. 
  • Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. 
  • Fragments of ATM which have dominant-negative or complementing activity. 
  • From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events. 
  • Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. 
  • Functional and structural changes in mammalian sympathetic neurones following interruption of their axons. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. 
  • Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). 
  • Further defining housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues". 
  • G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. 
  • G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. 
  • GATA4 and the two sides of gene expression reprogramming. 
  • GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. 
  • GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Glaucoma, apoptosis, and neuroprotection. 
  • Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. 
  • Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders. 
  • Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. 
  • Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury. 
  • Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models. 
  • Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Granular presence of terminin is the marker to distinguish between the senescent and quiescent states. 
  • Growth factors can influence cell growth and survival through effects on glucose metabolism. 
  • Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. 
  • Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. 
  • HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool. 
  • HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells. 
  • Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. 
  • Hematopoietic stem cells convert into liver cells within days without fusion. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hepatic fibrogenesis requires sympathetic neurotransmitters. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Heterogeneity of calcium compartmentation: electron probe analysis of renal tubules. 
  • High intensity focused ultrasound-induced gene activation in solid tumors. 
  • High intensity focused ultrasound-induced gene activation in sublethally injured tumor cells in vitro. 
  • High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. 
  • Highly photostable fluorescent labeling of proteins in live cells using exchangeable coiled coils heterodimerization. 
  • Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. 
  • Homeostatic control of lymphocyte survival: potential origins and implications. 
  • Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium. 
  • Hormonal and metabolic regulation of human chondrosarcoma in vitro. 
  • How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability? 
  • Human RPE expression of cell survival factors. 
  • Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. 
  • Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins. 
  • Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts. 
  • Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity. 
  • Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes. 
  • Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein. 
  • Human umbilical cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications. 
  • Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability. 
  • Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. 
  • Hydroxyethyl starch as a substitute for dextran 40 for thawing peripheral blood progenitor cell products. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hyperthermia: an overview of current progress and problems. 
  • Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies. 
  • Hypoxia in the thymus: role of oxygen tension in thymocyte survival. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • I Will Survive: How NPR1 Condensation Promotes Plant Cell Survival. 
  • IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. 
  • IL-15 regulates homeostasis and terminal maturation of NKT cells. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • IRF4 addiction in multiple myeloma. 
  • Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening. 
  • Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro. 
  • Imine hydrogels with tunable degradability for tissue engineering 
  • Immune lymphocyte survival after chemotherapy and radiation. 
  • Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. 
  • Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors. 
  • Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. 
  • Impact of Specimen Heterogeneity on Biomarkers in Repository Samples from Patients with Acute Myeloid Leukemia: A SWOG Report. 
  • Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. 
  • Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. 
  • Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation. 
  • Improving sensitivity and specificity of capturing and detecting targeted cancer cells with anti-biofouling polymer coated magnetic iron oxide nanoparticles. 
  • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. 
  • In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity. 
  • In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components. 
  • In vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumor cells expressing the sodium/iodide symporter. 
  • In vitro cytotoxicity of 211At-labeled trastuzumab in human breast cancer cell lines: effect of specific activity and HER2 receptor heterogeneity on survival fraction. 
  • In vitro determinants of asbestos fiber toxicity: effect on the relative toxicity of Libby amphibole in primary human airway epithelial cells. 
  • In vitro determination of thymidine-3H labeling index in human solid tumors. 
  • In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. 
  • In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor. 
  • In vitro synergism between hybrid immunotoxins and chemotherapeutic drugs: relevance to immunotherapy of prostate carcinoma. 
  • In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma. 
  • In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. 
  • In-cell NMR spectroscopy in Escherichia coli. 
  • Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. 
  • Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. 
  • Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. 
  • Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro. 
  • Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery. 
  • Induction of apoptotic cell death by particulate lead chromate: differential effects of vitamins C and E on genotoxicity and survival. 
  • Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. 
  • Induction of differentiation in human myeloblastic leukemia ML-1 cells by heptachlor, a chlorinated hydrocarbon insecticide. 
  • Induction of immune activation by a novel immunomodulatory oligonucleotide without thymocyte apoptosis. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies. 
  • Inflammatory mechanisms in diabetes: lessons from the beta-cell. 
  • Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage. 
  • Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents. 
  • Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis. 
  • Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma. 
  • Inhibition of cultured human RPE cell proliferation and lysyl hydroxylase activity by hydroxy derivatives of minoxidil. 
  • Inhibition of human subconjunctival fibroblast proliferation by immunotoxin. 
  • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. 
  • Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers. 
  • Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy. 
  • Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Initiating cellular stress responses. 
  • Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy. 
  • Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia. 
  • Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. 
  • Integrin involvement in freeze resistance of androgen-insensitive prostate cancer. 
  • Interaction of macrophages and lymphocytes for lymphokine production and cellular proliferation. 
  • Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. 
  • Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. 
  • Interleukin-15 increases hepatic regenerative activity. 
  • Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma. 
  • Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP5+ and MnTnHex-2-PyP5+ regulated by their porphyrin ring substituents. 
  • Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity. 
  • Intrinsically determined cell death of developing cortical interneurons. 
  • Introduction: tumor as an organ. 
  • Ionizing radiation activates the ATM kinase throughout the cell cycle. 
  • Iron metabolism and cell membranes. III. Iron-induced alterations in HeLa cells. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Isolation and Characterization of Human Lung Myeloid Cells. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Isolation of embryonic chick motoneurons and their survival in vitro. 
  • Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. 
  • Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. 
  • Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. 
  • Issues critical to the successful application of cryosurgical ablation of the prostate. 
  • JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma. 
  • Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. 
  • Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function. 
  • L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 
  • LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. 
  • Laminin alpha 2 enables glioblastoma stem cell growth. 
  • Large fresh osteochondral allografts of the knee: a systematic clinical and basic science review of the literature. 
  • Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. 
  • Lesions of excitatory pathways reduce hippocampal cell death after transient forebrain ischemia in the gerbil. 
  • Lessons from Yeast on How to Avoid Stress Eating. 
  • Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs. 
  • Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells. 
  • Life, death, and the metabolically controlled protein acetylome. 
  • Long- and short-lived murine hematopoietic stem cell clones individually identified with retroviral integration markers. 
  • Long-term survival of influenza virus infected club cells drives immunopathology. 
  • Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance. 
  • Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. 
  • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. 
  • Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. 
  • Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy. 
  • Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. 
  • Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB. 
  • MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21. 
  • MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival. 
  • MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. 
  • MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. 
  • Macrophage response to methacrylate conversion using a gradient approach. 
  • Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression. 
  • Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. 
  • Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes. 
  • Magnesium Catalyzed Polymerization of End Functionalized Poly(propylene maleate) and Poly(propylene fumarate) for 3D Printing of Bioactive Scaffolds. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. 
  • Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases. 
  • Mast cell stabilization improves survival by preventing apoptosis in sepsis. 
  • Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam. 
  • Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer. 
  • Maximizing the retention of antigen specific lymphocyte function after cryopreservation. 
  • Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. 
  • Measurement of posttransfusion red cell survival with the biotin label. 
  • Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival. 
  • Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate. 
  • Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP. 
  • Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells. 
  • Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells. 
  • Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. 
  • Meta-iodobenzylguanidine derivatives containing a second guanidine moiety. 
  • Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. 
  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. 
  • Metabolic regulation of Akt: roles reversed. 
  • Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. 
  • Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. 
  • Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. 
  • Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics. 
  • Method for decellularizing skeletal muscle without detergents or proteolytic enzymes. 
  • MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. 
  • Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. 
  • MicroRNAs associated to single drug components of R-CHOP identifies diffuse large B-cell lymphoma patients with poor outcome and adds prognostic value to the international prognostic index. 
  • Microdosimetric analysis of alpha-particle-emitting targeted radiotherapeutics using histological images. 
  • Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. 
  • Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels. 
  • Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells. 
  • Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy. 
  • Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress. 
  • Model of creation and evolution of stable electropores for DNA delivery. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Modification of a commercial cell sorter to support efficient and reliable preparation of ALDH-bright cells for clinical use. 
  • Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. 
  • Mold-casted non-degradable, islet macro-encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice. 
  • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. 
  • Monensin enhances the cytotoxic effect of antitransferrin receptor immunotoxin on cultured RPE cells. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Motor neuron target selectivity and survival after prolonged axotomy. 
  • Mouse liver cell culture. II. Primary culture. 
  • Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology. 
  • Moving beyond microbiome-wide associations to causal microbe identification. 
  • Multifunctional Abl kinases in health and disease. 
  • Multilayer microfluidic PEGDA hydrogels. 
  • Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. 
  • Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice. 
  • Myocardium and BMP signaling are required for endocardial differentiation. 
  • N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • NDRG4 is required for cell cycle progression and survival in glioblastoma cells. 
  • NO inhibits hyperoxia-induced NF-κB activation in neonatal pulmonary microvascular endothelial cells. 
  • Nano-C60 cytotoxicity is due to lipid peroxidation. 
  • Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. 
  • Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway. 
  • Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. 
  • Neonatal W-mutant mice are favorable hosts for tracking development of marked hematopoietic stem cells. 
  • Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels. 
  • Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. 
  • Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia. 
  • Neuronal competition. 
  • Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB. 
  • Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. 
  • Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • New drug development in metastatic prostate cancer. 
  • New phorbol ester derivatives as potent anti-HIV agents. 
  • New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. 
  • Newborn baboon serum lacks natural anti-pig xenoantibody. 
  • Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. 
  • Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes. 
  • Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. 
  • Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. 
  • Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells. 
  • Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Novel delivery method to reduce endothelial injury in descemet stripping automated endothelial keratoplasty. 
  • Novel light-driven functional AgNPs induce cancer death at extra low concentrations. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. 
  • Nuclear phosphatase PPM1G in cellular survival and neural development. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines. 
  • Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. 
  • Oestrogen receptors enhance dopamine neurone survival in rat midbrain. 
  • Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells. 
  • Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways. 
  • Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. 
  • Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells. 
  • Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • P53, cell cycle control and apoptosis: implications for cancer. 
  • PAX3-FOXO1 fusion gene in rhabdomyosarcoma. 
  • PI3K/Akt and apoptosis: size matters. 
  • PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration. 
  • PTEN hamartoma tumor syndromes. 
  • Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. 
  • Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells. 
  • Pentablock copolymer dexamethasone nanoformulations elevate MYOC: in vitro liberation, activity and safety in human trabecular meshwork cells. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Peptide-derivatized shell-cross-linked nanoparticles. 2. Biocompatibility evaluation. 
  • Peptidyl membrane-interactive molecules are cytotoxic to prostatic cancer cells in vitro. 
  • Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies. 
  • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. 
  • Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence. 
  • Persistent coinfection of T lymphocytes with HTLV-II and HIV and the role of syncytium formation in HIV-induced cytopathic effect. 
  • Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. 
  • Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. 
  • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. 
  • Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. 
  • Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. 
  • Photosensitizing action of isomeric zinc N-methylpyridylporphyrins in human carcinoma cells. 
  • Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL). 
  • Physiological consequences of programmed necrosis, an alternative form of cell demise. 
  • Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels. 
  • Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. 
  • Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. 
  • Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways. 
  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. 
  • Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. 
  • Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. 
  • Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. 
  • Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. 
  • Post-illumination cellular effects of photodynamic treatment. 
  • Postfreeze viability of human epithelial carcinoma cells in quaternary solutions. 
  • Postfreeze viability of human renal epithelial carcinoma cells related to phase transformations in ternary solutions. 
  • Postischemic diazepam is neuroprotective in the gerbil hippocampus. 
  • Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. 
  • Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. 
  • Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway. 
  • Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. 
  • Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. 
  • Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy. 
  • Preclinical efficacy of MEK inhibition in Nras-mutant AML. 
  • Pregnancy following transfer of ooplasm from cryopreserved-thawed donor oocytes into recipient oocytes. 
  • Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines. 
  • Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2. 
  • Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus. 
  • PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease. 
  • Protease activity of normal and PHA stimulated human lymphocytes. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions 
  • Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. 
  • Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. 
  • Protection from oxidation enhances the survival of cultured mesencephalic neurons. 
  • Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide. 
  • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. 
  • Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells. 
  • Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles. 
  • Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. 
  • Purification and partial characterization of a human hematopoietic precursor population. 
  • Quality assurance program for peripheral blood mononuclear cell cryopreservation. 
  • Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. 
  • Quantitative estimation of cryopreservation viability in rat fetal hippocampal cells. 
  • Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus. 
  • Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics. 
  • RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. 
  • RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. 
  • RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival. 
  • RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. 
  • RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors. 
  • RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. 
  • Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. 
  • Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate. 
  • Radiation-induced biologic bystander effect elicited in vitro by targeted radiopharmaceuticals labeled with alpha-, beta-, and auger electron-emitting radionuclides. 
  • Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. 
  • Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. 
  • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Rapid deformation of "passive" polymorphonuclear leukocytes: the effects of pentoxifylline. 
  • Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. 
  • Rate of change in central corneal thickness: a viability indicator for conventional drainage tissues in organ culture. 
  • Rationalization of thermal injury quantification methods: application to skin burns. 
  • Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation. 
  • Recruitment of host progenitor cells in rat liver transplants. 
  • Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. 
  • Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. 
  • Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme. 
  • Reduced cell death in skin flaps in rats treated with difluoromethylornithine. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Refining the role of BRCA1 in combating oxidative stress. 
  • Regression of U-87 MG human glioblastomas in nude mice after treatment with a cytotoxic somatostatin analog AN-238. 
  • Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. 
  • Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. 
  • Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. 
  • Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma. 
  • Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. 
  • Regulation of steady-state neutrophil homeostasis by macrophages. 
  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. 
  • Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. 
  • Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells. 
  • Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model. 
  • Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study. 
  • Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. 
  • Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations. 
  • Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes. 
  • Resistance of pancreatic carcinoma cells is reversed by coculturing NK-like T cells with dendritic cells pulsed with tumor-derived RNA and CA 19-9. 
  • Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure. 
  • Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR. 
  • Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival. 
  • Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells. 
  • Retinal ganglion cells and axons survive optic nerve transection. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. 
  • Rheological properties of living cytoplasm: a preliminary investigation of squid axoplasm (Loligo pealei). 
  • Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival. 
  • Ring-opening polymerization of prodrugs: a versatile approach to prepare well-defined drug-loaded nanoparticles. 
  • Role for hedgehog signaling in hepatic stellate cell activation and viability. 
  • Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. 
  • Role of Increased n-acetylaspartate Levels in Cancer. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. 
  • Role of germinal centers for the induction of broadly-reactive memory B cells. 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • Role of the Fas-signaling pathway in photoreceptor neuroprotection. 
  • Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. 
  • Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. 
  • S-Adenosylhomocysteine metabolism in adenosine deaminase deficient cells. 
  • SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. 
  • STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models. 
  • STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. 
  • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. 
  • SUMO2/3 conjugation is an endogenous neuroprotective mechanism. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. 
  • Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles. 
  • Selective neocortical and thalamic cell death in the gerbil after transient ischemia. 
  • Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study. 
  • Self-assembled Lipid Nanoparticles for Ratiometric Codelivery of Cisplatin and siRNA Targeting XPF to Combat Drug Resistance in Lung Cancer. 
  • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. 
  • Seven-transmembrane receptor signaling through beta-arrestin. 
  • Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. 
  • Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. 
  • Signal transduction. Three paths to stress relief. 
  • Signaling pathway for apoptosis: a racetrack for life or death. 
  • Significantly enhanced pregnancy rates per cycle through cryopreservation and thaw of pronuclear stage oocytes. 
  • Silver impairs neurodevelopment: studies in PC12 cells. 
  • Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. 
  • Silver nanowire interactions with primary human alveolar type-II epithelial cell secretions: contrasting bioreactivity with human alveolar type-I and type-II epithelial cells. 
  • Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts. 
  • Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage. 
  • Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy. 
  • Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. 
  • Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation. 
  • Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. 
  • Some properties of a DNA-unwinding protein unique to lymphocytes from chronic lymphocytic leukemia. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy. 
  • Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment. 
  • Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. 
  • Sperm transport in the reproductive tract of the female rabbit: II. The sustained phase of transport. 
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. 
  • Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. 
  • Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. 
  • Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum. 
  • Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. 
  • Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. 
  • Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. 
  • Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. 
  • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. 
  • Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism. 
  • Suppression of the NF-κB pathway by diesel exhaust particles impairs human antimycobacterial immunity. 
  • Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery. 
  • Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. 
  • Survival of allografted pancreatic islets in the subretinal space in rats. 
  • Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. 
  • Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. 
  • Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells. 
  • Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues. 
  • Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents. 
  • Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds. 
  • Synthesis and biological evaluation of largazole zinc-binding group analogs. 
  • Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 
  • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. 
  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. 
  • Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain 
  • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways. 
  • TGF-β Family Signaling in the Control of Cell Proliferation and Survival. 
  • TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist. 
  • TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons. 
  • Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival. 
  • Targeting A20 decreases glioma stem cell survival and tumor growth. 
  • Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome. 
  • Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. 
  • Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases. 
  • Targeting cancer stem cells through L1CAM suppresses glioma growth. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. 
  • Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs. 
  • Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling. 
  • Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. 
  • The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis. 
  • The Biology of Pulmonary Metastasis. 
  • The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved human peripheral blood mononuclear cells. 
  • The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. 
  • The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The PSA(-/lo) prostate cancer cell population harbors self-renewing long-term tumor-propagating cells that resist castration. 
  • The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. 
  • The Survival of Cone Photoreceptors in Retinitis Pigmentosa. 
  • The accelerated repopulation of a murine fibrosarcoma, FSA-II, during the fractionated irradiation and the linear-quadratic model. 
  • The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. 
  • The antiproliferative effect of a transferrin-toxin on human retinal pigment epithelial cells and rabbit fibroblasts. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The biocompatibility of titanium cardiovascular devices seeded with autologous blood-derived endothelial progenitor cells: EPC-seeded antithrombotic Ti implants. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The corneal epithelium after optisol-GS storage. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells. 
  • The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro. 
  • The effect of cigarette smoke extract on trophoblast cell viability and migration: the role of adrenomedullin. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effect of enzymatically degradable poly (ethylene glycol) hydrogels on smooth muscle cell phenotype 
  • The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. 
  • The effect of surface agitation on ultrasound-mediated gene transfer in vitro 
  • The effects of intraocular lidocaine on the corneal endothelium. 
  • The epicardium as a hub for heart regeneration. 
  • The genetic regulation of pigment cell development. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival. 
  • The homozygous CX3CR1-M280 mutation impairs human monocyte survival. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The human thymic microenvironment during organ culture. 
  • The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation. 
  • The ideal agent for perioperative hypertension and potential cytoprotective effects. 
  • The importance of Bcl-xL in the survival of human RPE cells. 
  • The importance of LAT in the activation, homeostasis, and regulatory function of T cells. 
  • The in vitro radiosensitization of human glioblastoma with pentoxifylline. 
  • The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells. 
  • The metabolic life and times of a T-cell. 
  • The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. 
  • The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. 
  • The role of Bcl-xL in mouse RPE cell survival. 
  • The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells. 
  • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine. 
  • The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. 
  • The role of protein kinase C in laminin-mediated neurite outgrowth. 
  • The roles of telomeres and telomerase in cell life span. 
  • The secreted metalloprotease ADAMTS20 is required for melanoblast survival. 
  • The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. 
  • The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. 
  • The transcriptional response of the islet to pregnancy in mice. 
  • Therapeutic analysis of in vitro and in vivo brain tumor models. 
  • Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer. 
  • Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. 
  • Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans. 
  • Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation. 
  • Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening. 
  • Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening. 
  • Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides. 
  • Thymosin fraction 5 inhibits the proliferation of the rat neuroendocrine MMQ pituitary adenoma and C6 glioma cell lines in vitro. 
  • Tie2 (to) Abl: Signaling to endothelial cell survival. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis. 
  • Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. 
  • Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target. 
  • Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon. 
  • Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. 
  • Transcription errors induce proteotoxic stress and shorten cellular lifespan. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. 
  • Transcriptomic analysis of peripheral blood mononuclear cells in rapid progressors in early HIV infection identifies a signature closely correlated with disease progression. 
  • Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine. 
  • Transscleral diffusion of ethacrynic acid and sodium fluorescein. 
  • Treatment of human spermatozoa with seminal plasma inhibits protein tyrosine phosphorylation. 
  • Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus. 
  • TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. 
  • TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus. 
  • Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus. 
  • Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. 
  • Tumor resistance in rats immunized to fetal tissues. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • Two new ursane-type triterpenoid saponins from Elsholtzia bodinieri. 
  • Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. 
  • UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • Ultrastructural changes accompanying secretion and cell death in the molting glands of an insect (Oncopeltus). 
  • Ultrastructure and x-ray microanalysis of macrophages exposed to cadmium chloride. 
  • Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity. 
  • Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. 
  • Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation. 
  • Use of quinones in brain-tumor therapy: preliminary results of preclinical laboratory investigations. 
  • Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels 
  • Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter. 
  • Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. 
  • Viability assessment by delayed enhancement cardiovascular magnetic resonance: will low-dose dobutamine dull the shine? 
  • Viability of cancer cells exposed to pulsed electric fields: the role of pulse charge. 
  • Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells. 
  • Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration. 
  • Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel. 
  • Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. 
  • Visual impairment in an optineurin mouse model of primary open-angle glaucoma. 
  • Vitamin K3 inhibition of malignant murine cell growth and human tumor colony formation. 
  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. 
  • WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. 
  • What keeps a resting T cell alive? 
  • Why Do Osteochondral Allografts Survive? Comparative Analysis of Cartilage Biochemical Properties Unveils a Molecular Basis for Durability. 
  • Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation. 
  • Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. 
  • XIAP as target for therapeutic apoptosis in prostate cancer. 
  • Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. 
  • Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53. 
  • c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. 
  • miR-19 is a key oncogenic component of mir-17-92. 
  • p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. 
  • pH modulation ameliorates the red blood cell storage lesion in a murine model of transfusion. 
  • xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. 
  • β-Arrestin-biased AT1R stimulation promotes cell survival during acute cardiac injury. 
  • βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1. 
• 

  Keywords of People

  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Meyer, Joel, Associate Professor of Environmental Genomics in the Division of Environmental Sciences and Policy, Nicholas Institute-Energy Initiative
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology