Central Nervous System

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  Subject Areas on Research

  • "Fibrositis" syndrome. 
  • 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. 
  • 6-hydroxydopamine destruction of central adrenergic neurones prevents or reverses developing DOCA-salt hypertension in rats. 
  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. 
  • A Monte Carlo model reveals independent signaling at central glutamatergic synapses. 
  • A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3. 
  • A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. 
  • A comparison of chemical and electrical synaptic transmission between single sensory cells and a motoneurone in the central nervous system of the leech. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A reappraisal of the results of stopping therapy in childhood leukemia. 
  • A syndrome of concurrent central and peripheral nervous system involvement due to Epstein-Barr virus infection. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system. 
  • Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. 
  • Adverse events after discontinuing medications in elderly outpatients. 
  • Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems. 
  • An electron-microscopic study of a physiologically identified motoneurone in the leech C.N.S. after injection of the fluorescent dye Procion yellow. 
  • An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage. 
  • Anabolic steroids. 
  • Analysis of primary central nervous system large B-cell lymphoma in the era of high-grade B-cell lymphoma: Detection of two cases with MYC and BCL6 rearrangements in a cohort of 12 cases. 
  • Angiographically defined primary angiitis of the CNS: is it really benign? 
  • Apolipoprotein E and the CNS response to injury. 
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. 
  • Apparatus for long-term ventricular access in the awake canine. 
  • Applications of a rat multiple tissue gene expression data set. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Associations among central nervous system serotonergic function and neuroticism are moderated by gender. 
  • Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. 
  • Breaking barriers in postoperative delirium. 
  • Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. 
  • CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. 
  • CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. 
  • CNS inflammation and bone marrow neuropathy in type 1 diabetes. 
  • CNS location of uterine-related neurons revealed by trans-synaptic tracing with pseudorabies virus and their relation to estrogen receptor-immunoreactive neurons. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites. 
  • Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. 
  • Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology. 
  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. 
  • Central and peripheral expression of galanin in response to inflammation. 
  • Central command and the increase in middle cerebral artery blood flow velocity during static arm exercise in women. 
  • Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats. 
  • Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. 
  • Central nervous system distribution of inhaled toluene. 
  • Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. 
  • Central nervous system modulation of respiratory function in the critically ill. 
  • Central nervous system oxygen toxicity during 100% oxygen breathing at normobaric pressure. 
  • Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men. 
  • Changes in spontaneous activity and CNS morphology associated with conductive and sensorineural hearing loss in chickens. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia. 
  • Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. 
  • Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. 
  • Chondroitin sulfate glycosaminoglycans for CNS homeostasis-implications for material design. 
  • Clinical applications of a peptide-based vaccine for glioblastoma. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. 
  • Comparative tolerance of IFN beta-1a regimens in patients with relapsing multiple sclerosis. The EVIDENCE study. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Corollary discharge across the animal kingdom. 
  • Cytokines and cognition--the case for a head-to-toe inflammatory paradigm. 
  • Design and evaluation of leukaemia trials. 
  • Determinants of poliovirus neurovirulence. 
  • Development of the single microelectrode current and voltage clamp for central nervous system neurons. 
  • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. 
  • EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages. 
  • Effective effectors: How T cells access and infiltrate the central nervous system. 
  • Effects of cranial radiation in children with high risk T cell acute lymphoblastic leukemia: a Pediatric Oncology Group report. 
  • Electroneuroprostheses: past and present uses in man. 
  • Emerging Role of PD-1 in the Central Nervous System and Brain Diseases. 
  • Emerging roles for telomerase in neuronal development and apoptosis. 
  • Emerging roles of Dectin-1 in noninfectious settings and in the CNS. 
  • Excitation of central nervous system neurons by nonuniform electric fields. 
  • Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • FDG PET/CT in patients with HIV. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons? 
  • Fat hormones pull their weight in the CNS. 
  • Fetal nicotinic overload, blunted sympathetic responsivity, and obesity. 
  • Firing rate of the noisy quadratic integrate-and-fire neuron. 
  • From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity. 
  • Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. 
  • Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. 
  • Genomic Views of Transcriptional Enhancers: Essential Determinants of Cellular Identity and Activity-Dependent Responses in the CNS. 
  • Globoid cell leukodystrophy (Krabbe disease): normal umbilical cord blood galactocerebrosidase activity and polymorphic mutations. 
  • Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic. 
  • Hemostasis and alterations of the central nervous system. 
  • High-affinity binding of [3H]acetylcholine to muscarinic cholinergic receptors. 
  • High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma. 
  • Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. 
  • Host immune responses in the central nervous system during fungal infections. 
  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. 
  • Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. 
  • Immediate and delayed neurotoxicity after mechlorethamine preparation for bone marrow transplantation. 
  • Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development. 
  • Immunology of transplantation in the central nervous system. 
  • Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults. 
  • Induction of nitric oxide in cultured microglia: evidence for a cytoprotective role. 
  • Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. 
  • Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). 
  • Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology. 
  • Investigation of central pain processing in shoulder pain: converging results from 2 musculoskeletal pain models. 
  • Is There a Role for Immunotherapy in Central Nervous System Cancers? 
  • Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. 
  • Kv3.1b is a novel component of CNS nodes. 
  • Large vessel vasculitis of the central nervous system in systemic lupus erythematosus: report and review of the literature. 
  • Leukaemia hijacks a neural mechanism to invade the central nervous system. 
  • Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion. 
  • Localization of specific binding sites for atrial natriuretic factor in the central nervous system of rat, guinea pig, cat and human. 
  • Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. 
  • Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. 
  • Lower central nervous system serotonergic function and risk of cardiovascular disease: where are we, what's next? 
  • Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. 
  • Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection. 
  • MAP kinase and pain. 
  • Maturation of central nervous system control of growth hormone secretion in rats. 
  • Maturation of sympathetic neurotransmission in the rat heart. VI. The effect of neonatal central catecholaminergic lesions. 
  • Mechanism of injury-provoked poliomyelitis. 
  • Meperidine: a critical review. 
  • Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. 
  • Methods for gene transfer to the central nervous system. 
  • Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain. 
  • Microsurgical management of 53 jugular foramen schwannomas: lessons learned incorporated into a modified grading system. 
  • Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses. 
  • Monosynaptic chemical and electrical connexions between sensory and motor cells in the central nervous system of the leech. 
  • Motor systems: understanding motor circuits: where bottom-up meets top-down. 
  • Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis. 
  • Myeloid Cells in the Central Nervous System. 
  • NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. 
  • Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 levels in human amniotic fluid. 
  • Neuroimmunology in 2017: The central nervous system: privileged by immune connections. 
  • Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. 
  • Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates. 
  • New azacannabinoids highly active in the central nervous system. 
  • New concepts in macrophage ontogeny in the adult neural retina. 
  • New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system. 
  • New roles of carboxypeptidase E in endocrine and neural function and cancer. 
  • New routes to early memories. 
  • New ways in which GLP-1 can regulate glucose homeostasis. 
  • Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity. 
  • Numb antagonizes Notch signaling to specify sibling neuron cell fates. 
  • Nutrient tasting and signaling mechanisms in the gut. IV. There is more to taste than meets the tongue. 
  • OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. 
  • Observations on the effect of hypotonic solutions on the myelin sheath in the central nervous system. 
  • Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. 
  • Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS). 
  • Outcomes Associated With Thiotepa-Based Conditioning in Patients With Primary Central Nervous System Lymphoma After Autologous Hematopoietic Cell Transplant. 
  • Overcoming endogenous constraints on neuronal regeneration 
  • Pathophysiology of Hypertension: The Mosaic Theory and Beyond. 
  • Pathophysiology of experimental renovascular hypertension. 
  • Patterns of mortality and causes of death in polytrauma patients--has anything changed? 
  • Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases. 
  • Pleiotropic function of TRPV4 ion channels in the central nervous system. 
  • Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection. 
  • Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression. 
  • Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration. 
  • Production and role of cytokines in the CNS of mice with acute viral encephalomyelitis. 
  • Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. 
  • Protein kinases as potential targets for the treatment of pathological pain. 
  • Prox 1, a prospero-related homeobox gene expressed during mouse development. 
  • Psychological problems associated with drug therapy in childhood asthma. 
  • Pulse magnetization elicits differential gene expression in the central nervous system of the Caribbean spiny lobster, Panulirus argus. 
  • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. 
  • Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis. 
  • Research challenges in central nervous system manifestations of inborn errors of metabolism. 
  • Response assessment criteria for brain metastases: proposal from the RANO group. 
  • Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats. 
  • Retinal oximetry measures systemic hypoxia in central nervous system vessels in chronic obstructive pulmonary disease. 
  • Rocky Mountain spotted fever in childhood. 
  • Role of astrocytes in synapse formation and maturation. 
  • Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. 
  • Rupture, reconstruction, and rehabilitation: A multi-disciplinary review of mechanisms for central nervous system adaptations following anterior cruciate ligament injury. 
  • Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial. 
  • Second cessation of therapy in childhood lymphocytic leukemia. 
  • Selective microstimulation of central nervous system neurons. 
  • Serotonin-related gene polymorphisms and central nervous system serotonin function. 
  • Sex steroids, APOE genotype and the innate immune system. 
  • Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. 
  • Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. 
  • Solid organ transplant donors with central nervous system infection. 
  • Sonographic evaluation of fetal CNS: technical and interpretive pitfalls. 
  • Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis. 
  • Sprouting of noradrenergic fibers in hippocampus after medial septal lesions: contributions of the central and peripheral nervous systems. 
  • Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. 
  • Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. 
  • Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. 
  • TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. 
  • TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. 
  • TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. 
  • Tau is essential to beta -amyloid-induced neurotoxicity. 
  • The AAV vector toolkit: poised at the clinical crossroads. 
  • The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. 
  • The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients. 
  • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. 
  • The cardiac-sympathetic axis as a teratological model. 
  • The cellular and physiological mechanism of wing-body scaling in Manduca sexta. 
  • The distribution of synapses on a physiologically identified motor neuron in the central nervous system of the leech. An electron microscope study after the injection of the fluorescent dye procion yellow. 
  • The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. 
  • The emerging multifaceted roles of nitric oxide. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues. 
  • The liver--a potential new player in islet regeneration? 
  • The new era of Pompe disease: advances in the detection, understanding of the phenotypic spectrum, pathophysiology, and management. 
  • The pharmacology and function of central GABAB receptors. 
  • The pharmacology of methotrexate. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis. 
  • The role of thrombin and protease-activated receptors in pain mechanisms. 
  • The role of tregs in glioma-mediated immunosuppression: potential target for intervention. 
  • The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. 
  • The use of a panel of monoclonal antibodies in the evaluation of cytologic specimens from the central nervous system. 
  • The use of zebrafish (Danio rerio) as a model system in neurobehavioral toxicology. 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Thrombospondins as key regulators of synaptogenesis in the central nervous system. 
  • Time-varying Spectral Index of Electrodermal Activity to Predict Central Nervous System Oxygen Toxicity Symptoms in Divers: Preliminary results. 
  • Toward Functional Restoration of the Central Nervous System: A Review of Translational Neuroscience Principles. 
  • Treatment and prophylaxis of invasive candidiasis. 
  • Updating Neuroimmune Targets in Central Nervous System Dysfunction. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. 
  • Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation. 
  • Utility of postmortem magnetic resonance imaging in clinical neuropathology. 
  • Variation in response to hyperbaric oxygen among inbred strains of mice. 
  • [Receptor-ligand reaction in the central nervous system (principal problems and prospects for development)]. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Georgiades, Anastasia, Research Scientist, Psychology & Neuroscience
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • James, Michael Lucas, Professor of Anesthesiology, Anesthesiology
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Nicolelis, Miguel Angelo L., Professor Emeritus of Neurobiology, Neurobiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Schmehl, Meredith, Student, Neurobiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering