Centromere

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  Subject Areas on Research

  • A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10. 
  • A genetic memory initiates the epigenetic loop necessary to preserve centromere position. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia. 
  • Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae. 
  • Analysis of centromeric activity in Robertsonian translocations: implications for a functional acrocentric hierarchy. 
  • Analysis of the junction between ribosomal RNA genes and single-copy chromosomal sequences in the yeast Saccharomyces cerevisiae. 
  • Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants. 
  • Bacterial plasmid partition machinery: a minimalist approach to survival. 
  • Cellular Dynamics and Genomic Identity of Centromeres in Cereal Blast Fungus. 
  • Centromere Silencing Mechanisms. 
  • Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromere scission drives chromosome shuffling and reproductive isolation. 
  • Centromeres of human chromosomes. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. 
  • Chromatin conformation of yeast centromeres 
  • Chromosome segregation. Programmed to stay together. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae). 
  • Complete genomic and epigenetic maps of human centromeres. 
  • Conditional dicentric chromosomes in yeast. 
  • Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions. 
  • DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. 
  • De Novo Centromere Formation: One's Company, Two's a Crowd. 
  • Determining centromere identity: cyclical stories and forking paths. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres. 
  • Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii. 
  • Epigenomics of centromere assembly and function. 
  • Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. 
  • Evidence for structural heterogeneity from molecular cytogenetic analysis of dicentric Robertsonian translocations. 
  • Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis. 
  • Finishing the euchromatic sequence of the human genome. 
  • Five pillars of centromeric chromatin in fungal pathogens. 
  • Foreword: the centromere and kinetochore in creatures great and small. 
  • Functional epialleles at an endogenous human centromere. 
  • Genetic manipulation of centromere function. 
  • Genetic mapping of Ty elements in Saccharomyces cerevisiae. 
  • Genomic and Epigenetic Foundations of Neocentromere Formation. 
  • Genomic and functional variation of human centromeres. 
  • Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells. 
  • Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles. 
  • Going the distance: Neocentromeres make long-range contacts with heterochromatin. 
  • HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses. 
  • Histone H3K4 methylation keeps centromeres open for business. 
  • Histone modifications within the human X centromere region. 
  • How the kinetochore couples microtubule force and centromere stretch to move chromosomes. 
  • Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C. 
  • Human centromere repositioning within euchromatin after partial chromosome deletion. 
  • Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus). 
  • Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. 
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. 
  • Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. 
  • Islands of speciation or mirages in the desert? Examining the role of restricted recombination in maintaining species. 
  • Linkage of Tunisian autosomal recessive Duchenne-like muscular dystrophy to the pericentromeric region of chromosome 13q. 
  • Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. 
  • Loss of centromere function drives karyotype evolution in closely related Malassezia species. 
  • Meiotic recombination within the centromere of a yeast chromosome. 
  • Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. 
  • Mitotic recombination within the centromere of a yeast chromosome. 
  • Molecular Analysis of pSK1 par: A Novel Plasmid Partitioning System Encoded by Staphylococcal Multiresistance Plasmids. 
  • Neocentromeres: a place for everything and everything in its place. 
  • Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 
  • Preferential re-replication of Drosophila heterochromatin in the absence of geminin. 
  • RNAi is a critical determinant of centromere evolution in closely related fungi. 
  • Recombination between heterologous human acrocentric chromosomes. 
  • Regulation of mitotic chromosome cohesion by Haspin and Aurora B. 
  • Segrosome structure revealed by a complex of ParR with centromere DNA. 
  • Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae. 
  • Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes. 
  • Stable dicentric X chromosomes with two functional centromeres. 
  • Structural analysis of a yeast centromere. 
  • Structural and functional dynamics of human centromeric chromatin. 
  • Structural biology of plasmid partition: uncovering the molecular mechanisms of DNA segregation. 
  • Structural biology of plasmid segregation proteins. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages. 
  • Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. 
  • Telomere-to-telomere assembly of a complete human X chromosome. 
  • The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. 
  • The DNA sequence of the human X chromosome. 
  • The evolutionary dynamics of alpha-satellite. 
  • The process of kinetochore assembly in yeasts. 
  • The structure of a primitive kinetochore. 
  • Three probands with autistic disorder and isodicentric chromosome 15. 
  • Variegated aneuploidy in two siblings: phenotype, genotype, CENP-E analysis, and literature review. 
  • α satellite DNA variation and function of the human centromere. 
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  Keywords of People

  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology
  • Yadav, Vikas, Postdoctoral Associate, Molecular Genetics and Microbiology