Ceramides

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  Subject Areas on Research

  • A ceramide-centric view of insulin resistance. 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. 
  • Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. 
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. 
  • CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. 
  • CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. 
  • Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. 
  • Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. 
  • Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. 
  • Ceramide synthase. 
  • Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. 
  • Ceramides and glucosylceramides are independent antagonists of insulin signaling. 
  • Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. 
  • Ceramides as modulators of cellular and whole-body metabolism. 
  • Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. 
  • Enzymes of ceramide biosynthesis. 
  • Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. 
  • Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. 
  • Growth-dependent regulation of cellular ceramides in human T-cells. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • In vitro toxicology of fumonisins and the mechanistic implications. 
  • Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. 
  • Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. 
  • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. 
  • Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease. 
  • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. 
  • Modulation of cell growth and differentiation by ceramide. 
  • N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Programmed cell death induced by ceramide. 
  • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. 
  • Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action. 
  • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 
  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Upregulation of Bcl-2 and elevation of ceramide in Batten disease. 
  • X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma