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Subject Areas on Research
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A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults.
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A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).
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A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.
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Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis.
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Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.
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Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro.
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Apoptotic sphingolipid signaling by ceramides in lung endothelial cells.
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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
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Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death.
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Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.
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Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.
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Ceramide synthase.
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Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.
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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.
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Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells.
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Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus.
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Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide.
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Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension.
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Characterizing human mesenchymal stromal cells' immune-modulatory potency using targeted lipidomic profiling of sphingolipids.
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Convergent evolution of bacterial ceramide synthesis.
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Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
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Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants.
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Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation.
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Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
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Enzymes of ceramide biosynthesis.
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Glucose availability and glycolytic metabolism dictate glycosphingolipid levels.
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Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells.
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Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
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Growth-dependent regulation of cellular ceramides in human T-cells.
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Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.
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High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers.
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Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
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Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
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In vitro toxicology of fumonisins and the mechanistic implications.
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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
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Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
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Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease.
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Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression.
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Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry.
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Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.
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Modulation of cell growth and differentiation by ceramide.
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Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
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N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
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Novel ceramide analogs as potential chemotherapeutic agents in breast cancer.
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Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease.
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Prediction of Residual Risk by Ceramide-Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy.
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Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
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Programmed cell death induced by ceramide.
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Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.
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SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
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Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.
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Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion.
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Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
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Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
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Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding.
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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
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Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
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TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.
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The CLN3 gene is a novel molecular target for cancer drug discovery.
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Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
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Upregulation of Bcl-2 and elevation of ceramide in Batten disease.
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X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains.
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Keywords of People