Ceramides

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  Subject Areas on Research

  • A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults. 
  • A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β). 
  • A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. 
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. 
  • Alpha-glycosylceramides enhance the antitumor cytotoxicity of hepatic lymphocytes obtained from cancer patients by activating CD3-CD56+ NK cells in vitro. 
  • Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. 
  • Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. 
  • Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. 
  • Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. 
  • Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. 
  • Ceramide synthase. 
  • Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. 
  • Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. 
  • Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. 
  • Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension. 
  • Characterizing human mesenchymal stromal cells' immune-modulatory potency using targeted lipidomic profiling of sphingolipids. 
  • Convergent evolution of bacterial ceramide synthesis. 
  • Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Early-pregnancy prediction of risk for pre-eclampsia using maternal blood leptin/ceramide ratio: discovery and confirmation. 
  • Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. 
  • Enzymes of ceramide biosynthesis. 
  • Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. 
  • Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells. 
  • Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. 
  • Growth-dependent regulation of cellular ceramides in human T-cells. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers. 
  • Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • In vitro toxicology of fumonisins and the mechanistic implications. 
  • Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. 
  • Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. 
  • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. 
  • Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease. 
  • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. 
  • Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry. 
  • Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects. 
  • Modulation of cell growth and differentiation by ceramide. 
  • Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease. 
  • N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. 
  • Prediction of Residual Risk by Ceramide-Phospholipid Score in Patients With Stable Coronary Heart Disease on Optimal Medical Therapy. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Programmed cell death induced by ceramide. 
  • Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS. 
  • SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. 
  • Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action. 
  • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 
  • Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. 
  • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 
  • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • The CLN3 gene is a novel molecular target for cancer drug discovery. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Upregulation of Bcl-2 and elevation of ceramide in Batten disease. 
  • X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Cell Biology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma