Cerebellar Neoplasms

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  Subject Areas on Research

  • "Large cell/anaplastic" medulloblastomas: a Pediatric Oncology Group Study. 
  • A case of Ollier's disease associated with two intracranial gliomas. 
  • A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma. 
  • A recurrent cerebellar lesion in a young boy. 
  • Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide. 
  • Alexander's law revisited. 
  • Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • An animal model of MYC-driven medulloblastoma. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. 
  • BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line. 
  • CD155 is a putative therapeutic target in medulloblastoma. 
  • Calcifying pseudoneoplasm of the cerebellopontine angle: case report. 
  • Cerebellar malignant fibrous histiocytoma: case report and literature review. 
  • Cerebellopontine angle craniopharyngioma: case report and literature review. 
  • Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation. 
  • Characterization of chromosome 17 abnormalities in medulloblastomas. 
  • Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. 
  • Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma. 
  • Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch. 
  • Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma. 
  • Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. 
  • Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations. 
  • Complete preoperative embolization of hemangioblastoma vessels with Onyx 18. 
  • Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. 
  • Conversations on mutism: risk stratification for cerebellar mutism based on medulloblastoma subtype. 
  • Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma. 
  • Cyclophosphamide resistance in medulloblastoma. 
  • Determination of gangliosides in six human primary medulloblastomas. 
  • Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. 
  • Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study. 
  • Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts. 
  • Distribution of type VI collagen in human gliomas: comparison with fibronectin and glioma-mesenchymal matrix glycoprotein. 
  • Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma. 
  • Efficacy of high-dose chemotherapy or standard salvage therapy in patients with recurrent medulloblastoma. 
  • Efficacy of vincristine and cyclophosphamide in the therapy of recurrent medulloblastoma. 
  • Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging. 
  • Examination of risk factors for intellectual and academic outcomes following treatment for pediatric medulloblastoma. 
  • Failure of human rhombic lip differentiation underlies medulloblastoma formation. 
  • False-positive spinal MR findings for subarachnoid spread of primary CNS tumor in postoperative pediatric patients. 
  • Fine-needle aspiration diagnosis of medulloblastoma metastatic to the pelvis. 
  • Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Gd-DTPA-enhanced MR imaging of leptomeningeal spread of primary intracranial CNS tumor in children. 
  • Gender differences in facial expression recognition in survivors of pediatric brain tumors. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. 
  • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. 
  • Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations. 
  • Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma. 
  • High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031). 
  • Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. 
  • Hydrocephalus as a possible additional contributor to cognitive outcome in survivors of pediatric medulloblastoma. 
  • IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. 
  • INTRACRANIAL TUMORS IN INFANCY AND CHILDHOOD. A CLINICAL STUDY OF TWENTY CASES. 
  • Immunolocalization of monoclonal antibody-defined extracellular matrix antigens in human brain tumors. 
  • Impact of radiation technique upon the outcome of treatment for medulloblastoma. 
  • In vitro versus in vivo correlations of chemosensitivity of human medulloblastoma. 
  • Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934. 
  • Inflammatory lesion mimicking a metastatic ependymoma. 
  • Infrequent p53 gene mutations in medulloblastomas. 
  • Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis? 
  • Isolated, giant cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome: case report. 
  • Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. 
  • Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study. 
  • Long-term neurologic health and psychosocial function of adult survivors of childhood medulloblastoma/PNET: a report from the Childhood Cancer Survivor Study. 
  • Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. 
  • MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma. 
  • MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study. 
  • MRI of gangliocytoma of cerebellum and spinal cord. 
  • Machine Assist for Pediatric Posterior Fossa Tumor Diagnosis: A Multinational Study. 
  • March 2000: A 16 year old female with a cerebellar mass. 
  • Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy. 
  • Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Medulloblastoma: the Duke University Medical Center experience. 
  • Medulloblastoma: tumor biological and clinical perspectives. 
  • Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. 
  • Meta-[131I]iodobenzylguanidine uptake and meta-[211At]astatobenzylguanidine treatment in human medulloblastoma cell lines. 
  • Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. 
  • Mixed hemangioblastoma and ependymoma collision tumor of the cerebellum. 
  • Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. 
  • Molecular correlates of cerebellar mutism syndrome in medulloblastoma. 
  • Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. 
  • Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR). 
  • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 
  • Multiple-fraction-per-day external beam radiotherapy for adults with supratentorial malignant gliomas. 
  • Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. 
  • Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. 
  • Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study. 
  • OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. 
  • Outcome and prognostic factors in adult cerebellar glioblastoma. 
  • Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03). 
  • Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. 
  • Patterns of care in adult medulloblastoma: results of an international online survey. 
  • Pediatric radiation oncology. 
  • Perioperative Assessment of Cerebellar Masses and the Potential for Cerebellar Cognitive Affective Syndrome. 
  • Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms. 
  • Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma. 
  • Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. 
  • Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma. 
  • Posterior fossa syndrome and long-term neuropsychological outcomes among children treated for medulloblastoma on a multi-institutional, prospective study. 
  • Postradiation cerebellar necrosis mimicking tumor: MR appearance. 
  • Preradiation chemotherapy in advanced medulloblastoma. A Pediatric Oncology Group pilot study. 
  • Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. 
  • Production and characterization of two ependymoma xenografts. 
  • Prognostic implications of chromosome 17p deletions in human medulloblastomas. 
  • Propionibacterium shunt nephritis in two adolescents with medulloblastoma. 
  • Radiomic Phenotypes Distinguish Atypical Teratoid/Rhabdoid Tumors from Medulloblastoma. 
  • Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. 
  • Recurrent intracranial Masson's vegetant intravascular hemangioendothelioma. Case report and review of the literature. 
  • Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11). 
  • Response of recurrent medulloblastoma to low-dose oral etoposide. 
  • Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor. 
  • Retrospective family study of childhood medulloblastoma. 
  • Reversal of radiation-induced neutropenia by granulocyte colony-stimulating factor. 
  • Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. 
  • Social functioning and facial expression recognition in survivors of pediatric brain tumors. 
  • Somatic mutations in VHL germline deletion kindred correlate with mild phenotype. 
  • Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome. 
  • Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. 
  • Stereotactic radiosurgery for recurrent pediatric brain tumors: clinical outcomes and toxicity. 
  • Structural chromosomal abnormalities in human medulloblastoma. 
  • Subfrontal recurrence of medulloblastoma. 
  • Subgroup and subtype-specific outcomes in adult medulloblastoma. 
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes. 
  • Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide. 
  • Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children. 
  • Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. 
  • Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation. 
  • The clinical importance of medulloblastoma extent of resection: a systematic review. 
  • The fallacy of the localized supratentorial malignant glioma. 
  • The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide. 
  • The genetic landscape of the childhood cancer medulloblastoma. 
  • The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival. 
  • The transcriptional landscape of Shh medulloblastoma. 
  • Torticollis acquired in late infancy due to a cerebellar gangliocytoma. 
  • Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. 
  • Treatment of patients with recurrent primary brain tumors with AZQ. 
  • Use of apparent diffusion coefficient values for diagnosis of pediatric posterior fossa tumors. 
  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. 
  • Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma. 
  • White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor. 
  • Working memory abilities among children treated for medulloblastoma: parent report and child performance. 
  • [18F]fluorodeoxyglucose-positron emission tomography in patients with medulloblastoma. 
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  Keywords of People

  • Buckley, Anne Frances, Assistant Professor of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology