Chelating Agents

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  Subject Areas on Research

  • "Off-the-Shelf" K2-EDTA for Calcific Band Keratopathy. 
  • A New, Second Generation Trithiol Bifunctional Chelate for 72,77As: Trithiol(b)-(Ser)2-RM2. 
  • A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation. 
  • A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation. 
  • A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting. 
  • ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. 
  • Amelioration of metal-induced toxicity in Caenorhabditis elegans: utility of chelating agents in the bioremediation of metals. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • Application of metal coordination chemistry to explore and manipulate cell biology. 
  • Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1. 
  • Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids. 
  • Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: role for clumping factor B. 
  • Chelation therapy and cardiovascular outcomes--in reply. 
  • Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with ⁵⁷ Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors. 
  • Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. 
  • Chemistry and biology of copper-chelatin. 
  • Clawing back: broadening the notion of metal chelators in medicine. 
  • Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. 
  • Contrast-enhanced magnetic resonance angiography: first-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate. 
  • Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. 
  • Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors. 
  • Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Copper-chelatin: purification and properties of a copper-binding protein from rat liver. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Current status of metals as therapeutic targets in Alzheimer's disease. 
  • Design of the Trial to Assess Chelation Therapy (TACT). 
  • Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients. 
  • Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. 
  • EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy. 
  • Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial. 
  • Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayers. 
  • Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD. 
  • Effects of genotype and environment on the antioxidant properties of hard winter wheat bran. 
  • Effects of phosphate binders in moderate CKD. 
  • Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation. 
  • Evidence basis for integrated management of mineral metabolism in patients with end-stage renal disease. 
  • Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Fibroblast growth factor 23 and the future of phosphorus management. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation. 
  • Incremental cost-utility of sevelamer relative to calcium carbonate for treatment of hyperphosphatemia among pre-dialysis chronic kidney disease patients. 
  • Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I. 
  • Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Is intravenous urography necessary in the assessment of renal duplex system in children? 
  • Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus). 
  • LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH). 
  • Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands. 
  • Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium. 
  • Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH. 
  • Mechanism of palladium-catalyzed diene cyclization/hydrosilylation: direct observation of intramolecular carbometalation. 
  • Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. 
  • Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. 
  • Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis. 
  • Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium. 
  • Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease. 
  • Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress. 
  • Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Non-cholinergic strategies for treating and preventing Alzheimer's disease. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos. 
  • Pharmacological activity of metal binding agents that alter copper bioavailability. 
  • Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease. 
  • Positive outcome after intentional overdose of dabigatran. 
  • Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways. 
  • Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease. 
  • Responses to propofol in the pulmonary vascular bed of the rat. 
  • Safety and efficacy of succimer in toddlers with blood lead levels of 20-44 microg/dL. Treatment of Lead-Exposed Children (TLC) Trial Group. 
  • Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. 
  • Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle. 
  • Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx. 
  • State-of-the-Art Management of Hyperphosphatemia in Patients With CKD: An NKF-KDOQI Controversies Perspective. 
  • Stimulus-Responsive Prochelators for Manipulating Cellular Metals. 
  • Straight and curved conformations of FtsZ are regulated by GTP hydrolysis. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction. 
  • The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT). 
  • The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT). 
  • The mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans 
  • The selection and evaluation of new chelating agents for the treatment of iron overload. 
  • The soluble metalloendoprotease required in myoblast fusion remains intracellular. 
  • The trial to assess chelation therapy 2 (TACT2): Rationale and design. 
  • Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress. 
  • Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. 
  • Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals. 
  • Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines. 
  • Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts. 
  • Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans . 
  • Zinc transporter ZIP7 is a novel determinant of ferroptosis. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Field, Greg D., Adjunct Associate Professor of Neurobiology, Neurobiology
  • Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering