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Subject Areas on Research
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"Off-the-Shelf" K2-EDTA for Calcific Band Keratopathy.
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A New, Second Generation Trithiol Bifunctional Chelate for 72,77As: Trithiol(b)-(Ser)2-RM2.
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A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.
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A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.
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A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.
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ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase.
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Amelioration of metal-induced toxicity in Caenorhabditis elegans: utility of chelating agents in the bioremediation of metals.
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An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.
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Application of metal coordination chemistry to explore and manipulate cell biology.
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Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo-β-Lactamase NDM-1.
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Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids.
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Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: role for clumping factor B.
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Chelation therapy and cardiovascular outcomes--in reply.
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Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57
Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors.
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Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.
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Chemistry and biology of copper-chelatin.
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Clawing back: broadening the notion of metal chelators in medicine.
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Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site.
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Contrast-enhanced magnetic resonance angiography: first-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate.
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Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release.
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Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
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Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer.
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Copper is required for oncogenic BRAF signalling and tumorigenesis.
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Copper-chelatin: purification and properties of a copper-binding protein from rat liver.
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Crucial role of copper in detection of metal-coordinating odorants.
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Current status of metals as therapeutic targets in Alzheimer's disease.
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Design of the Trial to Assess Chelation Therapy (TACT).
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Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients.
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Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.
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EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.
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Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.
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Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayers.
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Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD.
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Effects of genotype and environment on the antioxidant properties of hard winter wheat bran.
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Effects of phosphate binders in moderate CKD.
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Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation.
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Evidence basis for integrated management of mineral metabolism in patients with end-stage renal disease.
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Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
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Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal.
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Fibroblast growth factor 23 and the future of phosphorus management.
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Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling.
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Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation.
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Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.
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Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation.
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Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation.
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Incremental cost-utility of sevelamer relative to calcium carbonate for treatment of hyperphosphatemia among pre-dialysis chronic kidney disease patients.
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Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.
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Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption.
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Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure.
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Is intravenous urography necessary in the assessment of renal duplex system in children?
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Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus).
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LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).
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Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.
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Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.
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Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
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Mechanism of palladium-catalyzed diene cyclization/hydrosilylation: direct observation of intramolecular carbometalation.
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Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
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Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
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Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.
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Microvilli elongate in response to hydrogen peroxide and to perturbations of intracellular calcium.
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Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
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Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.
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Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress.
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Nitroxyl anion regulation of the NMDA receptor.
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Non-cholinergic strategies for treating and preventing Alzheimer's disease.
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Oxidants, antioxidants and the ischemic brain.
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Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos.
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Pharmacological activity of metal binding agents that alter copper bioavailability.
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Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease.
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Positive outcome after intentional overdose of dabigatran.
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Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.
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Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.
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Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
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Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
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Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease.
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Responses to propofol in the pulmonary vascular bed of the rat.
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Safety and efficacy of succimer in toddlers with blood lead levels of 20-44 microg/dL. Treatment of Lead-Exposed Children (TLC) Trial Group.
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
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Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle.
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Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx.
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State-of-the-Art Management of Hyperphosphatemia in Patients With CKD: An NKF-KDOQI Controversies Perspective.
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Stimulus-Responsive Prochelators for Manipulating Cellular Metals.
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Straight and curved conformations of FtsZ are regulated by GTP hydrolysis.
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Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.
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The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction.
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The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial.
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The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.
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The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT).
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The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).
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The mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans
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The selection and evaluation of new chelating agents for the treatment of iron overload.
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The soluble metalloendoprotease required in myoblast fusion remains intracellular.
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The trial to assess chelation therapy 2 (TACT2): Rationale and design.
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Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.
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Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial.
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Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals.
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Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.
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Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
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Zinc Binding Inhibits Cellular Uptake and Antifungal Activity of Histatin-5 in Candida albicans
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Zinc transporter ZIP7 is a novel determinant of ferroptosis.
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Keywords of People