Chelating Agents
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Subject Areas on Research
- "Off-the-Shelf" K2-EDTA for Calcific Band Keratopathy.
- A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots.
- A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.
- A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.
- A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.
- ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase.
- Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction.
- Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse.
- Amelioration of metal-induced toxicity in Caenorhabditis elegans: utility of chelating agents in the bioremediation of metals.
- An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.
- Application of metal coordination chemistry to explore and manipulate cell biology.
- Bioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluid.
- Catecholamine stimulated myocardial adenylate cyclase: effects of phospholipase digestion and the role of membrane lipids.
- Changes in interferon-regulatory factor-1 mRNA levels after transient ischemia in rat brain.
- Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: role for clumping factor B.
- Chelation therapy and cardiovascular outcomes--in reply.
- Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with 57Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors.
- Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.
- Chemistry and biology of copper-chelatin.
- Clawing back: broadening the notion of metal chelators in medicine.
- Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site.
- Conditions associated with ER dysfunction activate homer 1a expression.
- Contrast-enhanced magnetic resonance angiography: first-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate.
- Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release.
- Copper Chelation Inhibits BRAFV600E-Driven Melanomagenesis and Counters Resistance to BRAFV600E and MEK1/2 Inhibitors.
- Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer.
- Copper is required for oncogenic BRAF signalling and tumorigenesis.
- Copper-chelatin: purification and properties of a copper-binding protein from rat liver.
- Crucial role of copper in detection of metal-coordinating odorants.
- Current status of metals as therapeutic targets in Alzheimer's disease.
- Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization.
- Design of the Trial to Assess Chelation Therapy (TACT).
- Development of an experimental system for the study of urethral biomechanical function.
- Diethyldithiocarbamate potentiates the effects of protamine sulphate in the isolated rat uterus.
- Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases.
- EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy.
- Editorial: Thalassemia major: a problem of iron overload.
- Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction: the TACT randomized trial.
- Effect of hydrostatic pressure gradients and Na2EDTA on permeability of human Schlemm's canal cell monolayers.
- Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD.
- Effects of genotype and environment on the antioxidant properties of hard winter wheat bran.
- Effects of phosphate binders in moderate CKD.
- Encapsulation and retention of chelated-copper inside hydrophobic nanoparticles: Liquid cored nanoparticles show better retention than a solid core formulation.
- Evidence basis for integrated management of mineral metabolism in patients with end-stage renal disease.
- Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.
- Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.
- Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal.
- Fibroblast growth factor 23 and the future of phosphorus management.
- Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling.
- Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation.
- Generation of chemotactic factors in guinea pig serum via activation of the classical and alternate complement pathways.
- Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.
- Hyperostosis with hyperphosphatemia and tumoral calcinosis: a case report.
- Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation.
- Incremental cost-utility of sevelamer relative to calcium carbonate for treatment of hyperphosphatemia among pre-dialysis chronic kidney disease patients.
- Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I.
- Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption.
- Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration.
- Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure.
- Iron deprivation in cancer--potential therapeutic implications.
- Is intravenous urography necessary in the assessment of renal duplex system in children?
- Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus).
- LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).
- Labeling internalizing anti-epidermal growth factor receptor variant III monoclonal antibody with (177)Lu: in vitro comparison of acyclic and macrocyclic ligands.
- Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.
- Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress.
- Luteinizing hormone (LH) drives diverse intracellular calcium second messenger signals in isolated porcine ovarian thecal cells: preferential recruitment of intracellular Ca2+ oscillatory cells by higher concentrations of LH.
- Mechanism of palladium-catalyzed diene cyclization/hydrosilylation: direct observation of intramolecular carbometalation.
- Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
- Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans.
- Mechanisms of neuronal cell death: diverse roles of calcium in the various subcellular compartments.
- Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
- Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.
- Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
- Modifications of boronic ester pro-chelators triggered by hydrogen peroxide tune reactivity to inhibit metal-promoted oxidative stress.
- Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress.
- Nitroxyl anion regulation of the NMDA receptor.
- Non-cholinergic strategies for treating and preventing Alzheimer's disease.
- Oxidants, antioxidants and the ischemic brain.
- PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA.
- Perivascular mural cells of the mouse choroid demonstrate morphological diversity that is correlated to vasoregulatory function.
- Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos.
- Pharmacological activity of metal binding agents that alter copper bioavailability.
- Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion.
- Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease.
- Positive outcome after intentional overdose of dabigatran.
- Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.
- Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.
- Presynaptic calcium signals during neurotransmitter release: detection with fluorescent indicators and other calcium chelators.
- Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress.
- Purification of C1 inhibitor. A new approach for the isolation of this biologically important plasma protease inhibitor.
- Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
- Respiratory epithelial cells demonstrate lactoferrin receptors that increase after metal exposure.
- Responses of normal and sickle cell hemoglobin to S-nitroscysteine: implications for therapeutic applications of NO in treatment of sickle cell disease.
- Role of calcium in the activation of erp72 and heme oxygenase-1 expression on depletion of endoplasmic reticulum calcium stores in rat neuronal cell culture.
- Safety and efficacy of succimer in toddlers with blood lead levels of 20-44 microg/dL. Treatment of Lead-Exposed Children (TLC) Trial Group.
- Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
- Singlet oxygen and superoxide dismutase (cuprein).
- Specific binding of -adrenergic catecholamines to a subcellular fraction from cardiac muscle.
- Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx.
- Stimulus-Responsive Prochelators for Manipulating Cellular Metals.
- Straight and curved conformations of FtsZ are regulated by GTP hydrolysis.
- Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.
- Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: effect of clamping cytoplasmic calcium activity at resting levels.
- The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial.
- The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies.
- The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).
- The selection and evaluation of new chelating agents for the treatment of iron overload.
- The soluble metalloendoprotease required in myoblast fusion remains intracellular.
- Three-step radioimmunotherapy with yttrium-90 biotin: dosimetry and pharmacokinetics in cancer patients.
- Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.
- Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial.
- Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.
- Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
- Zn2+ depletion blocks endosome fusion.
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Keywords of People
- Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Biomedical Engineering
- Field, Greg D., Assistant Professor of Neurobiology, Neurobiology
- Hsu-Kim, Heileen, Professor in the Department of Civil and Environmental Engineering, Civil and Environmental Engineering
- Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology