Chemistry, Physical

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  Subject Areas on Research

  • 3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility. 
  • 31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes. 
  • A combined explicit-implicit method for high accuracy reaction path integration. 
  • A simple method for fabricating artificial kidney stones of different physical properties. 
  • A spatially explicit investigation of phosphorus sorption and related soil properties in two riparian wetlands. 
  • A thermodynamic investigation of reactions catalyzed by tryptophan synthase. 
  • AN OPTICAL ROTATORY DISPERSION STUDY OF ASPARTIC AMINO TRANSFERASE. 
  • Adapting the nudged elastic band method for determining minimum-energy paths of chemical reactions in enzymes. 
  • Altered ultrastructural morphology of self-aggregated low density lipoproteins: coalescence of lipid domains forming droplets and vesicles. 
  • Aminonaphthalenesulfonamides, a new class of modifiable fluorescent detecting groups and their use in substrates for serine protease enzymes. 
  • Amiodarone-liposome interaction: a multinuclear NMR and X-ray diffraction study. 
  • An empirical model for electrostatic interactions in proteins incorporating multiple geometry-dependent dielectric constants. 
  • Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. 
  • Application of the temperature-jump technique to the study of phospholipid dispersions. 
  • Architecture of Limulus polyphemus hemocyanin. 
  • B-DNA to zip-DNA: simulating a DNA transition to a novel structure with enhanced charge-transport characteristics. 
  • Binding of phosphate ligands to ribonuclease A. 
  • Biomembrane templates for nanoscale conduits and networks. 
  • Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction. 
  • Calcium measurements with electron probe X-ray and electron energy loss analysis. 
  • Carrier-free 131I-meta-iodobenzylguanidine: comparison of production from meta-diazobenzylguanidine and from meta-trimethylsilylbenzylguanidine. 
  • Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation. 
  • Comparison of Ca2+/calmodulin-dependent protein kinase II purified from control and diisopropyl phosphorofluoridate (DFP)-treated hens. 
  • Contributions of hydration and steric (entropic) pressures to the interactions between phosphatidylcholine bilayers: experiments with the subgel phase. 
  • Coupling coherence distinguishes structure sensitivity in protein electron transfer. 
  • Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction. 
  • Desmoplakin I and desmoplakin II. Purification and characterization. 
  • Detection thresholds of potassium salts are related to the molar conductivity of the anion. 
  • Differences in the acid-labile component of Candida albicans mannan from hydrophobic and hydrophilic yeast cells. 
  • Drug targeting using thermally responsive polymers and local hyperthermia. 
  • EcoRI methylase. Physical and catalytic properties of the homogeneous enzyme. 
  • Effect of conformation on the binding of flavins to flavoenzymes. 
  • Effect of erionite on the pleural mesothelium of the Fischer 344 rat. 
  • Effect of the beta 73 amino acid on the hydrophobicity, solubility, and the kinetics of polymerization of deoxyhemoglobin S. 
  • Electron microscopy of fibrinogen, its plasmic fragments and small polymers. 
  • Equilibrium and nonequilibrium phase transformations of quaternary solutions based on a physiologic support medium containing NaCl, dimethyl sulfoxide, and glycerol. 
  • Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. 
  • Evidence that Blastocladiella emersonii zoospore maintenance factor is a sulfhydryl group-containing cyclic ribotide. 
  • Exposure to concentrated ambient particles (CAPs): a review. 
  • Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome. 
  • Fe(III) coordination properties of two new saccharide-based enterobactin analogues: methyl 2,3,4-tris-O-[N-[2,3-di(hydroxy)benzoyl-glycyl]-aminopropyl]-alpha-D-glucopyranoside and methyl 2,3,4-tris-O-[N-[2,3-di-(hydroxy)-benzoyl]-aminopropyl]-alpha-D-glucopyranoside. 
  • Femtosecond phase-coherent two-dimensional spectroscopy. 
  • Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. 
  • Hemoglobins from trout: structural and functional properties. 
  • High-resolution, >1 GHz NMR in unstable magnetic fields. 
  • Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. 
  • Hydration and steric pressures between phospholipid bilayers. 
  • Identification of a glutathione S-transferase without affinity for glutathione sepharose in human kidney. 
  • Identification of quantitative trait loci influencing wood specific gravity in an outbred pedigree of loblolly pine. 
  • Induction of selective biological responses to chemoattractants in a human monocyte-like cell line. 
  • Influence of denaturing agents on solvent structure. 
  • Integrated single-walled carbon nanotube/microfluidic devices for the study of the sensing mechanism of nanotube sensors. 
  • Interaction of benzene with bilayers. Thermal and structural studies. 
  • Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. 
  • Isohemagglutinins and xenoreactive antibodies: members of a distinct family of natural antibodies. 
  • Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. 
  • Isolation and characterization of a receptor for type 1 fimbriae of Escherichia coli from guinea pig erythrocytes. 
  • Isolation of an ankyrin-band 3 oligomer from human erythrocyte membranes. 
  • Joint modeling of DNA sequence and physical properties to improve eukaryotic promoter recognition. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • MINORITY CARRIER TRAPPING AND DYE SENSITIZATION. 
  • Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation. 
  • Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter. 
  • Molecular and regulatory properties of adrenergic receptors. 
  • Molecular modeling of phytochrome using constitutive C-phycocyanin from Fremyella diplosiphon as a putative structural template. 
  • Monte Carlo simulation and molecular theory of tethered polyelectrolytes. 
  • Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase. 
  • Optical rotatory dispersion of ribonuclease and ribonuclease--nucleotide complexes. 
  • Optimization of the lariat ether carboxylic acid host structure for ferrioxamine B: demonstration of a second coordination shell chelate effect. 
  • Oxygen dissociation curve of echidna blood. 
  • Photoelectric phenomena in hemoglobin and dyed gelatin. 
  • Physical and chemical properties of rabbit muscle phosphofructokinase cross-linked with dimethyl suberimidate. 
  • Physical characteristics of porous cellulose beads as supporting material for immobilized enzymes. 
  • Physical organic chemistry of supramolecular polymers. 
  • Physicochemical characteristics and biological effects of nickel oxides. 
  • Polymer reversal rate calculated via locally scaled diffusion map. 
  • Production of a retroviral P15E-related chemotaxis inhibitor by IL-1-treated endothelial cells. A possible negative feedback in the regulation of the vascular response to monokines. 
  • Profound increase in viscosity and aggregation of pig gastric mucin at low pH. 
  • Protein design and folding: template trapping of self-assembled helical bundles. 
  • Protein electron transfer rates set by the bridging secondary and tertiary structure. 
  • Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization. 
  • Quadratic string method for determining the minimum-energy path based on multiobjective optimization. 
  • Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. 
  • Quantum mechanics/molecular mechanics minimum free-energy path for accurate reaction energetics in solution and enzymes: sequential sampling and optimization on the potential of mean force surface. 
  • Regulatory domains of erythrocyte ankyrin. 
  • Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with carbamyl phosphate. 
  • Relaxation spectra of enzymatic reactions. 
  • Role of a key cysteine residue in the gating of the acetylcholine receptor. 
  • S-nitrosothiols and the bioregulatory actions of nitrogen oxides through reactions with thiol groups. 
  • Sculpting proteins interactively: continual energy minimization embedded in a graphical modeling system. 
  • Simulation of electron transfer between cytochrome C2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants. 
  • Structural mapping of chloroplast coupling factor. 
  • Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors. 
  • Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo. 
  • Studies of the ethanol-induced interdigitated gel phase in phosphatidylcholines using the fluorophore 1,6-diphenyl-1,3,5-hexatriene. 
  • Surface hydrophobic and hydrophilic protein alterations in Candida albicans. 
  • Surface ripples cause the large fluid spaces between gel phase bilayers containing small amounts of cholesterol. 
  • Synthesis and characterization of a ruthenium(II)-based redox conjugate for reagentless biosensing. 
  • Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. 
  • The Alacoil: a very tight, antiparallel coiled-coil of helices. 
  • The H2O-NaCl-glycerol phase diagram and its application in cryobiology. 
  • The anomalous pKa of Tyr-9 in glutathione S-transferase A1-1 catalyzes product release. 
  • The crystal structure of bovine Cu2+,Zn2+ superoxide dismutase at 5.5-A resolution. 
  • The crystal structure of the collagen-like polypeptide (glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyprolyl)9 at 1.55 A resolution shows up-puckering of the proline ring in the Xaa position. 
  • The dielectric constant of phospholipid bilayers and the permeability of membranes to ions. 
  • The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase. 
  • The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. 
  • The interaction of aspartate aminotransferase with alpha-methylaspartic acid. 
  • The nature of aqueous tunneling pathways between electron-transfer proteins. 
  • The resistance to flow of individual human neutrophils in glass capillary tubes with diameters between 4.65 and 7.75 microns. 
  • The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase. 
  • Towards Raman optical activity calculations of large molecules. 
  • ULTRASONIC ATTENUATION MEASUREMENTS IN POLY-L-GLUAMIC ACID SOLUTIONS. 
  • Ultrasonic absorption measurements in aqueous solutions of glycine, diglycine, and triglycine. 
  • Ultrasonic attenuation measurements in phospholipid dispersions. 
  • Velocity effects on fullerene and oxide nanoparticle deposition in porous media. 
  • Walter Kauzmann: an undergraduate perspective. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Beratan, David N., R.J. Reynolds Professor of Chemistry, Duke University Energy Initiative
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Craig, Stephen L, William T. Miller Professor of Chemistry, Duke University Energy Initiative
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery