Chemotactic Factors

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  Subject Areas on Research

  • A blood-based biomarker panel to detect acute stroke. 
  • A guanine nucleotide regulatory protein controls polyphosphoinositide metabolism, Ca2+ mobilization, and cellular responses to chemoattractants in human monocytes. 
  • A simulation environment for directional sensing as a phase separation process. 
  • Absence of macrophage involvement in the passive serum therapy of Friend leukemia virus-induced disease. 
  • Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase. 
  • Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines. 
  • Blastomyces dermatitidis chemotactic factor: kinetics of production and biological characterization evaluated by a modified neutrophil chemotaxis assay. 
  • Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Changing concepts in pathophysiology of the vasculitides. 
  • Characteristics of the chemotactic activity of heparin cofactor II proteolysis products. 
  • Chemoattractant receptors on phagocytic cells. 
  • Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis. 
  • Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice. 
  • Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line. 
  • Chemotaxis by a CNS macrophage, the microglia. 
  • Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination. 
  • Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. 
  • Corneal organ cultures in tyrosinemia release chemotactic factors. 
  • Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. 
  • Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. 
  • Demonstration of a chemotactic factor receptor on macrophages. 
  • Determination of bioactive peptides using capillary zone electrophoresis/mass spectrometry. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines. 
  • Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. 
  • Disorders of human leukocyte chemotaxis. 
  • Effect of membrane fluidizers on the number and affinity of chemotactic factor receptors on human polymorphonuclear leukocytes. 
  • Effects of culture filtrates of Blastomyces dermatitidis on neutrophil locomotion. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI. 
  • GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neurons. 
  • Generation of a fibroblast chemotactic factor in serum by activation of complement. 
  • Induction of selective biological responses to chemoattractants in a human monocyte-like cell line. 
  • Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. 
  • Inhibition of 125I-chemotactic peptide uptake by protease inhibitors. 
  • Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms. 
  • L-selectin (CD62L) blockade does not impair peritoneal neutrophil emigration or subcutaneous host defense to bacteria in rabbits. 
  • Leukocyte chemoattractant peptides from the serpin heparin cofactor II. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • Male-specific cell migration into the developing gonad. 
  • Malignant melanoma induces migration and invasion of adult mesenchymal stem cells. 
  • Mechanisms of inflammation and leukocyte activation. 
  • Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. 
  • Model for leukocyte regulation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. 
  • Molecular and cellular mechanisms of leukocyte chemotaxis. 
  • Molecular mechanisms of leukocyte activation by chemoattractants. 
  • Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulation. 
  • Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants. 
  • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. 
  • Pharmacologic manipulation of leukocyte chemotaxis. Present knowledge and future trends. 
  • Phosphoproteins involved in bacterial signal transduction. 
  • Production of a retroviral P15E-related chemotaxis inhibitor by IL-1-treated endothelial cells. A possible negative feedback in the regulation of the vascular response to monokines. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. 
  • Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. 
  • Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants. 
  • SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. 
  • Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. 
  • Signal transduction in cells following binding of chemoattractants to membrane receptors. 
  • Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. 
  • Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. 
  • The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations. 
  • The effects of heparin cofactor II-derived chemotaxins on neutrophil actin conformation and cyclic AMP levels. 
  • The human cytokine I-309 is a monocyte chemoattractant. 
  • The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. 
  • The robustness of the transcriptional response to alterations in morphogenetic gradients. 
  • Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. 
  • WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient. 
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  Keywords of People

  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Science & Society