Chemotaxis

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  Subject Areas on Research

  • 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation. 
  • 3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis. 
  • A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. 
  • A cell-intrinsic role for Mst1 in regulating thymocyte egress. 
  • A chemotactic factor for mononuclear leukocytes. 
  • A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. 
  • A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. 
  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. 
  • A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells. 
  • A simulation environment for directional sensing as a phase separation process. 
  • Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. 
  • Abnormalities of leukocyte chemotaxis in human disease. 
  • Activation of pp60c-src is necessary for human vascular smooth muscle cell migration. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis. 
  • An inhibitor of macrophage chemotaxis produced by neoplasms. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Augmentation of human monocyte chemotactic response by levamisole. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility. 
  • Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. 
  • Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. 
  • Carbamylated LL-37 as a modulator of the immune response. 
  • Characterization of chemotactic activity produced in vivo by a cell-mediated immune reaction in the guinea pig. 
  • Chemical waves in cell and developmental biology. 
  • Chemoattractant receptor cross-desensitization. 
  • Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage. 
  • Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. 
  • Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. 
  • Chemotaxis by a CNS macrophage, the microglia. 
  • Chemotaxis of inflammatory cells. 
  • Chemotaxis of mononuclear leukocytes. 
  • Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform. 
  • Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. 
  • Complement in clinical medicine. 
  • Complement-mediated vasoconstriction and graft rejection. 
  • Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. 
  • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. 
  • Crystal structure of activated CheY. Comparison with other activated receiver domains. 
  • Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. 
  • Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase. 
  • Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells. 
  • Defective monocyte function in patients with genitourinary carcinoma. 
  • Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. 
  • Depressed monocyte chemotaxis during acute influenza infection. 
  • Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. 
  • Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. 
  • Diffusion-limited phase separation in eukaryotic chemotaxis. 
  • Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis. 
  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. 
  • Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. 
  • Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. 
  • Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils. 
  • Effect of prostaglandin E 1 on leukocyte migration. 
  • Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. 
  • Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines. 
  • Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. 
  • Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. 
  • Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction. 
  • Evaluation of a cytocentrifuge method for measuring neutrophil granulocyte chemotaxis. 
  • Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells. 
  • Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan. 
  • FGF8 signaling is chemotactic for cardiac neural crest cells. 
  • Factors from saliva and oral bacteria, chemotactic for polymorphonuclear leukocytes: their possible role in gingival inflammation. 
  • Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. 
  • Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 
  • Function of microglia in organotypic slice cultures. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response. 
  • Generation of a fibroblast chemotactic factor in serum by activation of complement. 
  • Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. 
  • Generation of chemotactic factors in guinea pig serum via activation of the classical and alternate complement pathways. 
  • Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. 
  • Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response. 
  • Haptotactic gradients for directed cell migration: stimulation and inhibition using soluble factors. 
  • Hereditary C6 deficiency in man. 
  • Hereditary complement (C2) deficiency with dermatomyositis. 
  • Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. 
  • Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. 
  • Humoral mediators of chemotaxis of mononuclear leukocytes. 
  • Immunological mechanisms of periodontal tissue destruction. 
  • Induction of selective biological responses to chemoattractants in a human monocyte-like cell line. 
  • Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. 
  • Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. 
  • Instrinsic defect of the polymorphonuclear leucocyte resulting in impaired chemotaxis and phagocytosis. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways. 
  • LRRK2 inhibition attenuates microglial inflammatory responses. 
  • Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response. 
  • Leukocyte chemotactic activity from oral bacteria. 
  • Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis. 
  • Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. 
  • Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth complement by macrophage proteinase. 
  • Malignant melanoma induces migration and invasion of adult mesenchymal stem cells. 
  • Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs. 
  • Mechanisms of cell positioning during C. elegans gastrulation. 
  • Mechanisms of excitation and adaptation in Dictyostelium. 
  • Mediators of the chemotaxis of mononuclear leucocytes. 
  • Monocyte chemoattractant activity of Ser195-->Ala active site mutant recombinant alpha-thrombin. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis. 
  • NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. 
  • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. 
  • Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. 
  • Osteoprotegerin in bone metastases: mathematical solution to the puzzle. 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. 
  • PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. 
  • PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment. 
  • Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. 
  • Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. 
  • Phospholipid methylation in macrophages is inhibited by chemotactic factors. 
  • Phosphoproteins involved in bacterial signal transduction. 
  • Potential treatment for clubfeet based on growth factor blockade. 
  • Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. 
  • Production of chemotactic factor and lymphotoxin by human leukocytes stimulated with Herpes simplex virus. 
  • Production of chemotactic peptides by neutrophil degradation of heparin cofactor II. 
  • Prostaglandin E-1: a potential mediator of the inflammatory response. 
  • Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2. 
  • Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity. 
  • Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. 
  • Rapid chemotactic response enables marine bacteria to exploit ephemeral microscale nutrient patches. 
  • Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes. 
  • Reconstitution of the bacterial chemotaxis signal transduction system from purified components. 
  • Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury. 
  • Redox regulation of neuronal migration in a Down Syndrome model. 
  • Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin. 
  • Regulation of microglial function by interferons. 
  • Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis. 
  • Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. 
  • Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. 
  • Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor. 
  • Role of Polarized G Protein Signaling in Tracking Pheromone Gradients. 
  • Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. 
  • Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium. 
  • Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. 
  • Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. 
  • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. 
  • Seven-transmembrane receptor signaling through beta-arrestin. 
  • Should we B-leavin' now? 
  • Signaling Pathways Controlling Microglia Chemotaxis. 
  • Signaling pathways at the leading edge of chemotaxing cells. 
  • Signaling pathways controlling cell polarity and chemotaxis. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase. 
  • Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis. 
  • Stepping between membrane microdomains. 
  • Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. 
  • Studies of the biologic effects of selective C4 deficiency. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. 
  • The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis. 
  • The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins. 
  • The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2. 
  • The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor. 
  • The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin. 
  • The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. 
  • The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. 
  • The regulation of primary mesenchyme cell migration in the sea urchin embryo: transplantations of cells and latex beads. 
  • The relationship of complement to allergic disease. 
  • The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • The role of late complement components and the alternate complement pathway in experimental cryptococcosis. 
  • The role of the granuloma in expansion and dissemination of early tuberculous infection. 
  • The role of the immune response in the development of periodontal disease. 
  • Tissue engraftment of hypoxic-preconditioned adipose-derived stem cells improves flap viability. 
  • Tracking shallow chemical gradients by actin-driven wandering of the polarization site. 
  • Transduction of receptor signals by beta-arrestins. 
  • Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. 
  • Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. 
  • WASP-interacting protein is important for actin filament elongation and prompt pseudopod formation in response to a dynamic chemoattractant gradient. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. 
  • β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells. 
  • β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • He, Siming, William W. Elliott Assistant Research Professor, Mathematics
  • Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology