Chick Embryo

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  Subject Areas on Research

  • 1,25-Dihydroxyvitamin D3 stimulates avian and mammalian cartilage growth in vitro. 
  • 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibition of coronary vasculogenesis is mediated, in part, by reduced responsiveness to endogenous angiogenic stimuli, including vascular endothelial growth factor A (VEGF-A). 
  • 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. 
  • A caudal proliferating growth center contributes to both poles of the forming heart tube. 
  • A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. 
  • A kinetic study of embryonic cell adhesion. 
  • A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension. 
  • A low-serum medium for tendon cells: effects of growth factors on tendon cell growth and collagen production. 
  • A mass spectrometry-based proteomic approach to study Marek's Disease Virus gene expression. 
  • A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion. 
  • A requirement for trypsin-sensitive cell-surface components for cell-cell interactions of embryonic neural retina cells. 
  • Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development. 
  • Adenosine 3',5'-monophosphate: a modulator of embryonic chick cartilage growth. 
  • Affinity-purified antibody as a probe of RNA polymerase II subunit structure. 
  • Agarose gel stiffness determines rate of DRG neurite extension in 3D cultures. 
  • Alteration of early vascular development after ablation of cranial neural crest. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells. 
  • An in vitro bioassay for neurite growth using cryostat sections of nervous tissue as a substratum. 
  • Angiogenic activity in injured rat corneas as assayed on the chick chorioallantoic membrane. 
  • Animal models of sudden unexplained death. 
  • Apoptosis during coronary artery orifice development in the chick embryo. 
  • Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate. 
  • Attachment and extracellular matrix differences between tendon and synovial fibroblastic cells. 
  • Autophagy and mitophagy participate in ocular lens organelle degradation. 
  • BMP signaling modulates hedgehog-induced secondary heart field proliferation. 
  • BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Bending of the looping heart: differential growth revisited. 
  • Binding of catecholamines to receptors in cultured myocardial cells. 
  • Binding of deoxyribonuclease I to actin: a new way to visualize microfilament bundles in nonmuscle cells. 
  • Biochemical and structural changes in cultured heart cells induced by metabolic inhibition. 
  • Biochemical and structural studies of tenascin/hexabrachion proteins. 
  • Blocking hedgehog signaling after ablation of the dorsal neural tube allows regeneration of the cardiac neural crest and rescue of outflow tract septation. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • CD44+/CD24- breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties. 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • Calcitonin stimulates growth and maturation of embryonic chick pelvic cartilage in vitro. 
  • Calcium accumulation by isolated sarcoplasmic reticulum of skeletal muscle during development in tissue culture. 
  • Calcium depletion and repletion in cultured chick heart muscle cells. 
  • Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. 
  • Calcium-dependent and calcium-independent adhesive mechanisms are present during initial binding events of neural retina cells. 
  • Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione. 
  • Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field. 
  • Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. 
  • Characterization and application of an avian in vitro spermatozoa-egg interaction assay using the inner perivitelline layer from laid chicken eggs. 
  • Characterization of avian and viral p60src proteins expressed in yeast. 
  • Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. 
  • Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. 
  • Chick microsomal oxidases. Isolation, properties, and stimulation by embryonic exposure to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane. 
  • Chicken calmodulin promoter activity in proliferating and differentiated cells. 
  • Chicken perinatal troponin Ts are generated by a combination of novel and phylogenetically conserved alternative splicing pathways. 
  • Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. 
  • Chorioallantoic membrane grafting of the embryonic murine kidney. An improved in vitro technique for studying kidney morphogenesis. 
  • Cloning and developmental expression of the chick type II and type III TGF beta receptors. 
  • Conotruncal myocardium arises from a secondary heart field. 
  • Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Correlation between fibronectin and its receptor in chick myoblast differentiation. 
  • Coupled sodium-calcium transport in cultured chick heart cells. 
  • Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • DNA transfer into vascular smooth muscle using fusigenic Sendai virus (HVJ)-liposomes. 
  • Deformation and flow of membrane into tethers extracted from neuronal growth cones. 
  • Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. 
  • Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. 
  • Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart. 
  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model. 
  • Differential expression of a proteasomal subunit during chick development. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distribution of anionic sites on surfaces of retinal cells: a study using cationized ferritin. 
  • Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces. 
  • Dystrophin and utrophin isoforms are expressed in glia, but not neurons, of the avian parasympathetic ciliary ganglion. 
  • ENHANCED GROWTH AND SURVIVAL OF EXPLANTED CHICK EMBRYOS CULTURED UNDER HIGH LEVELS OF OXYGEN. 
  • Effect of ambient levels of power-line-frequency electric fields on a developing vertebrate. 
  • Effect of intron size on splicing efficiency in retroviral transcripts. 
  • Effect of neural crest ablation on development of the heart and arch arteries in the chick. 
  • Effects of bursectomy and rat skin xenografts on natural antibodies in chickens. 
  • Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. 
  • Effects of liver growth factors on hepadnavirus replication in chronically infected duck hepatocytes. 
  • Effects of taxol and Colcemid on myofibrillogenesis. 
  • Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro. 
  • Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Evidence that Hensen's node is a site of retinoic acid synthesis. 
  • Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures. 
  • Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. 
  • Expression of Pax2 and patterning of the chick inner ear. 
  • Expression of ZIC genes in the development of the chick inner ear and nervous system. 
  • Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. 
  • F-actin aggregates in transformed cells. 
  • FGF8 signaling is chemotactic for cardiac neural crest cells. 
  • Fibroblast and hepatocyte behavior on synthetic polymer surfaces. 
  • Field stimulation of isolated chick heart cells: comparison of experimental and theoretical activation thresholds. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Frog oocytes synthesize and completely process the precursor polypeptide to virion structural proteins after microinjection of avian myeloblastosis virus RNA. 
  • G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. 
  • GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. 
  • Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. 
  • Growth of explanted chick embryos on a chemically defined medium and effects of specific amino acid deficiencies. 
  • Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates. 
  • Hepatic monoacylglycerol acyltransferase: ontogeny and characterization of an activity associated with the chick embryo. 
  • Hexabrachion proteins in embryonic chicken tissues and human tumors. 
  • Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro. 
  • Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage. 
  • Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features. 
  • Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. 
  • Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery. 
  • Hydrogel-based three-dimensional matrix for neural cells. 
  • Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. 
  • Identification of putative direct effectors for G alpha o, using yeast two-hybrid method. 
  • Identification of sokotrasterol sulfate as a novel proangiogenic steroid. 
  • Images in cardiovascular medicine. Approaching cardiac development in three dimensions by magnetic resonance microscopy. 
  • Immunohistochemical localization of netrin-1 in the embryonic chick nervous system. 
  • Improved preparation of chick embryonic samples for magnetic resonance microscopy. 
  • Improved techniques for staining and enumerating focus formation in viral infectivity assays. 
  • In vitro chick embryo cell response to strain MC29 avian leukosis virus. 
  • In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. 
  • In vitro inhibition of collagen cross links by catechol analogs. 
  • In vitro stimulation of alkaline phosphatase activity in immature embryonic chick pelvic cartilage by adenosine 3'5'-monophosphate. 
  • In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth. 
  • In vivo spectral domain optical coherence tomography volumetric imaging and spectral Doppler velocimetry of early stage embryonic chicken heart development. 
  • Inhibition of an inflammatory response is mediated by a 38-kDa protein of cowpox virus. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Inhibitory activity of benzoyl hydrazides and hydrazine on the growth of influenza virus in chick embryo lung tissue culture. 
  • Inhibitory proteins in the Newcastle disease virus-induced suppression of cell protein synthesis. 
  • Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae. 
  • Intercellular recognition: quantitation of initial binding events. 
  • Invasiveness of human glioma cell lines in vitro: relation to tumorigenicity in athymic mice. 
  • Isolation of 16L virus: a rapidly transforming sarcoma virus from an avian leukosis virus-induced sarcoma. 
  • Isolation of a cDNA clone complementary to sequences for a 34-kilodalton protein which is a pp60v-src substrate. 
  • Isolation of embryonic chick motoneurons and their survival in vitro. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Lack of Concordance Between Local Investigators, Angiographic Core Laboratory, and Clinical Event Committee in the Assessment of Stent Thrombosis: Results From the TRACER Angiographic Substudy. 
  • Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro. 
  • Ligatin from embryonic chick neural retina inhibits retinal cell adhesion. 
  • Ligatin from embryonic chick neural retina. 
  • Localization and characterization of the src-gene product of Rous sarcoma virus. 
  • Localization and quantitation of hexabrachion (tenascin) in skin, embryonic brain, tumors, and plasma. 
  • Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome. 
  • MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. 
  • MR microscopy of chick embryo vasculature. 
  • Magnetic resonance microscopy in neurologic models. 
  • Magnetic resonance microscopy of chick embryos in ovo. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Microprobe analysis of Tc-MIBI in heart cells: calculation of mitochondrial membrane potential. 
  • Mitochondrial localization and characterization of 99Tc-SESTAMIBI in heart cells by electron probe X-ray microanalysis and 99Tc-NMR spectroscopy. 
  • Modulation of Rho GTPase activity alleviates chondroitin sulfate proteoglycan-dependent inhibition of neurite extension. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Myocardial volume and organization are changed by failure of addition of secondary heart field myocardium to the cardiac outflow tract. 
  • Neural crest and cardiovascular development: a 20-year perspective. 
  • Neural tube closure: the curious case of shrinking junctions. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Neurotrophins affect the pattern of DRG neurite growth in a bioassay that presents a choice of CNS and PNS substrates. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function. 
  • On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes. 
  • Optical coherence tomography: a new high-resolution imaging technology to study cardiac development in chick embryos. 
  • Outer membrane of avian myeloblastosis virus. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PTP mu-dependent growth cone rearrangement is regulated by Cdc42. 
  • Parathyroid hormone stimulates growth of embryonic chick pelvic cartilage in vitro. 
  • Phosphatidylinositol kinase type I activity associates with various oncogene products. 
  • Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. 
  • Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage. 
  • Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. 
  • Preferential expression of the c-fps protein in chicken macrophages and granulocytic cells. 
  • Protein kinase C (calcium/phospholipid-dependent protein kinase) in developing chick heart: selective localization to atrium versus ventricle and changes in activity levels during cardiogenesis. 
  • Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth. 
  • Purification of the specific cell-aggregating factor from embryonic neural retina cells. 
  • Quantitative measurement of blood flow dynamics in embryonic vasculature using spectral Doppler velocimetry. 
  • Quick-freezing of cultured cardiac cells in situ with special attention to the mitochondrial ultrastructure. 
  • RNA sequence and transcriptional properties of the 3' end of the Newcastle disease virus genome. 
  • Rapid analysis of small nucleic acid samples by gel electrophoresis. 
  • Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system. 
  • Reducing the dose of smallpox vaccine reduces vaccine-associated morbidity without reducing vaccination success rates or immune responses. 
  • Regulation of axon guidance and extension by three-dimensional constraints. 
  • Regulation of synaptic vesicle fusion by protein kinase C. 
  • Regulators of G protein signaling proteins as determinants of the rate of desensitization of presynaptic calcium channels. 
  • Response of bone marrow to MC29 avian leukosis virus in vitro. 
  • Response of chick-embryo kidney cells in vitro to two avian tumor viruses. 
  • Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucose. 
  • Revertants and partial transformants of rat fibroblasts infected with Fujinami sarcoma virus. 
  • Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States. 
  • Ribosomal RNA in avian leukosis virus particles. 
  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. 
  • Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. 
  • Sex determination: An avian sexual revolution. 
  • Single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified Hilbert transform. 
  • Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. 
  • Specific nuclear binding of adenosine 3',5'-monophosphate-binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage. 
  • Spectral-domain phase microscopy. 
  • Stimulation of cartilage amino acid uptake by growth hormone-dependent factors in serum. Mediation by adenosine 3':5'-monophosphate. 
  • Stimulation of cartilage macromolecule synthesis by adenosine 3',5'-monophosphate. 
  • Strain MC29 avian leukosis virus release by chick embryo cells infected with the agent. 
  • Structural and elemental characterization of heart cells grown in a collagen matrix. 
  • Studies on the reproductive and cell-converting abilities of avian sarcoma viruses. 
  • Sustained release of nerve growth factor from biodegradable polymer microspheres. 
  • Synthesis and complete processing of a high-molecular-weight precursor polypeptide to viral structural proteins in toad oocytes micro-injected with avian myeloblastosis virus ribonucleic acid [proceedings]. 
  • TGF-beta related genes in development. 
  • Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects. 
  • Temperature-sensitive TREK currents contribute to setting the resting membrane potential in embryonic atrial myocytes. 
  • Temporary contacts formed between developing optic fibers in the chick. 
  • The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth. 
  • The beta-phosphoro[35S]thioate analogue of UDP-Glc is efficiently utilized by the glucose phosphotransferase and is relatively resistant to hydrolytic degradation. 
  • The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. 
  • The disappearance of a cyclin-like protein and the appearance of statin is correlated with the onset of differentiation during myogenesis in vitro. 
  • The effect of fumonisin B1 on developing chick embryos: correlation between de novo sphingolipid biosynthesis and gross morphological changes. 
  • The effects of chloroquine on chick skeletal muscle in vitro. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold. 
  • The metabolism in vivo of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion. 
  • The myogenic regulatory factor MRF4 represses the cardiac alpha-actin promoter through a negative-acting N-terminal protein domain. 
  • The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs. 
  • The receptor protein tyrosine phosphatase mu, PTPmu, regulates histogenesis of the chick retina. 
  • The role of cDermo-1 and cTwist in the avian embryo. 
  • The specificity of retinotectal connections studied by retinal grafts onto the optic tectum in chick embryos. 
  • Three-dimensional configuration of the mitochondria in cultured heart cells. 
  • Three-dimensional magnetic resonance microscopy of the developing chick embryo. 
  • Transcription of orthopoxvirus telomeres at late times during infection. 
  • Transcriptional activity of avian retroviral long terminal repeats directly correlates with enhancer activity. 
  • Transformation of chicken embryo fibroblasts and tumor induction by the middle T antigen of polyomavirus carried in an avian retroviral vector. 
  • Triiodothyronine stimulation of in vitro growth and maturation of embryonic chick cartilage. 
  • Tumor-promoting phorbol esters induce angiogenesis in vivo. 
  • Twist is an integrator of SHH, FGF, and BMP signaling. 
  • Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. 
  • Ultrastructural and biochemical properties of the 120-kDa form of chick kinectin. 
  • Ultrathin coating by plasma polymerization applied to corneal contact lens. 
  • Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles. 
  • Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer. 
  • Utilization of the chick chorioallantoic membrane for in vitro growth of the embryonic murine kidney. 
  • Viral glycoprotein synthesis under conditions of glucosamine block in cells transformed by avian sarcoma viruses. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Virus-infected avian cell lines established in vitro. 
  • [Chicken RNA tumor viruses: a model for virus-induced carcinogenesis]. 
  • cDermo-1 misexpression induces dense dermis, feathers, and scales. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • n-ethylmaleimide and ethacrynic acid inhibit kinesin binding to microtubules in a motility assay. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology