Chimera

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  Subject Areas on Research

  • A functional antigenomic promoter for the paramyxovirus simian virus 5 requires proper spacing between an essential internal segment and the 3' terminus. 
  • A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. 
  • A novel meiotic drive locus almost completely distorts segregation in mimulus (monkeyflower) hybrids. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • Accelerated development of immunity following transplantation of maternal marrow stem cells into infants with severe combined immunodeficiency and transplacentally acquired lymphoid chimerism. 
  • Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. 
  • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. 
  • An engineered liver glycogen phosphorylase with AMP allosteric activation. 
  • An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. 
  • Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. 
  • Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. 
  • Chimerism in children with juvenile dermatomyositis. 
  • Chimerism in myositis. 
  • Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity. 
  • Correction of severe combined immunodeficiency by fetal liver cells. 
  • DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus. 
  • Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: changing impact of risk factors. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis? 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Effect of xenogeneic chimerism in a human/sheep model on natural antibody. 
  • Effects of inversions on within- and between-species recombination and divergence. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 
  • Evidence that Par-4 participates in the pathogenesis of HIV encephalitis. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication. 
  • Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • Gene expression divergence and the origin of hybrid dysfunctions. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Generation of bone marrow and fetal liver chimeric mice. 
  • Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2. 
  • Genome-wide patterns of expression in Drosophila pure species and hybrid males. 
  • Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stages. 
  • HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. 
  • Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement. 
  • Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases. 
  • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. 
  • Immunogenic determinants of a neuropathogenic murine leukemia virus. 
  • Immunologic characterization of CD7-deficient mice. 
  • Immunologic chimerism as evidence of bone marrow graft acceptance in an identical twin with acute lymphocytic leukemia. 
  • Immunophenotyping of chimeric cells in localized scleroderma. 
  • Improved renal function in mouse kidney allografts lacking MHC class I antigens. 
  • In utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys. 
  • In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. 
  • Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus 
  • Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. 
  • Intravital imaging of mouse embryos. 
  • Laboratory study on behavioral responses of hybrid sturgeon, Acipenseridae, to wake flows induced by cylindrical bluff bodies. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilis. 
  • Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. 
  • Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. 
  • Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production. 
  • Mice lacking Bmp6 function. 
  • Microchimerism in children with rheumatic disorders: what does it mean? 
  • Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras. 
  • Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. 
  • Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. 
  • Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques. 
  • P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. 
  • Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. 
  • Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? 
  • Patterns of evolution of genes disrupted in expression in Drosophila species hybrids. 
  • Peripheral blood chimerism in renal allograft recipients transfused with donor bone marrow. 
  • Portal venous donor-specific transfusion in conjunction with sirolimus prolongs renal allograft survival in nonhuman primates. 
  • Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors. 
  • Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. 
  • Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. 
  • Recurrent Glioblastoma Treated with Recombinant Poliovirus. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. 
  • Severe combined immunodeficiency with natural killer-cell predominance: abrogation of graft-versus-host disease and immunologic reconstitution with HLA-identical bone marrow cells. 
  • Spatial models for hybrid zones. 
  • Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks. 
  • Specific transforming potential of oncogenes encoding protein-tyrosine kinases. 
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. 
  • Strategies for tolerance induction in nonhuman primates. 
  • Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. 
  • Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. 
  • Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus. 
  • The Ethics of Experimenting With Human Brain Tissue 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The potential of xenotransplants. 
  • The role of meiotic drive in hybrid male sterility. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase. 
  • Transplant tolerance: converging on a moving target. 
  • Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology