Chlamydia trachomatis

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  Subject Areas on Research

  • A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. 
  • A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation. 
  • A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production. 
  • A chemical mutagenesis approach to identify virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis. 
  • A prospective randomized trial of ofloxacin vs. doxycycline in the treatment of uncomplicated male urethritis. 
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. 
  • Association between elevated neutrophil defensin levels and endometritis. 
  • Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. 
  • Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. 
  • Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor. 
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes. 
  • Chlamydia trachomatis masquerading as a chronic allergic conjunctivitis. 
  • Chlamydia trachomatis. 
  • Chlamydial intracellular survival strategies. 
  • Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. 
  • Clinical trial experience with prophylactic human papillomavirus 6/11/16/18 vaccine in young black women. 
  • Comparing the prevalence of chlamydial infection across populations--what is appropriate? 
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. 
  • Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole. 
  • Differential Translocation of Host Cellular Materials into the Chlamydia trachomatis Inclusion Lumen during Chemical Fixation. 
  • Direct fluorescent antibody testing for endocervical Chlamydia trachomatis: factors affecting accuracy. 
  • Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis. 
  • Forward genetic approaches in Chlamydia trachomatis. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. 
  • IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins. 
  • Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia. 
  • Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis. 
  • Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses. 
  • Multifunctional analysis of Chlamydia-specific genes in a yeast expression system. 
  • Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. 
  • N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF. 
  • Pelvic inflammatory disease. 
  • Pmp-like proteins Pls1 and Pls2 are secreted into the lumen of the Chlamydia trachomatis inclusion. 
  • Predicting adolescents' longitudinal risk for sexually transmitted infection: results from the National Longitudinal Study of Adolescent Health. 
  • Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms. 
  • Raphael Valdivia: how Chlamydia settles in. 
  • Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. 
  • STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. 
  • Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The Chlamydia trachomatis type III secretion chaperone Slc1 engages multiple early effectors, including TepP, a tyrosine-phosphorylated protein required for the recruitment of CrkI-II to nascent inclusions and innate immune signaling. 
  • The Chlamydia type III secretion system C-ring engages a chaperone-effector protein complex. 
  • The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract. 
  • The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance. 
  • The easiest children to reach are most likely to be infected with ocular Chlamydia trachomatis in trachoma endemic areas of Niger. 
  • The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets. 
  • The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. 
  • The vaginal introitus: a novel site for Chlamydia trachomatis testing in women. 
  • Trachoma: an update on prevention, diagnosis, and treatment. 
  • Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins. 
  • Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells. 
  • Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches. 
  • cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. 
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  Keywords of People

  • Taylor, Gregory Alan, Associate Professor in Medicine, Immunology