Chlorides

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  Subject Areas on Research

  • A calcium-activated, nonselective cationic conductance in Aplysia silent neurons. 
  • A fine line between molecular umbrella transport and ionophoric activity. 
  • A multisite phase III study of the safety and efficacy of a new manganese chloride-based gastrointestinal contrast agent for MRI of the abdomen and pelvis. 
  • A selective imidazobenzodiazepine antagonist of ethanol in the rat. 
  • Activation by saccharides of a cation-selective pathway on canine lingual epithelium. 
  • Activation of excitatory amino acid receptors in the rat hippocampal slice increases intracellular Cl- and cell volume. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain. 
  • Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. 
  • Affinity chromatography of H+-translocating adenosine triphosphatase isolated by chloroform extraction of Rhodospirillum rubrum chromatophores. Modification of binding affinity by divalent cations and activating anions. 
  • Alcohols stimulate gamma-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency. 
  • Alkaline low spin form of sulfite reductase hemeprotein subunit. 
  • Alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil. 
  • Alterations of excitatory amino acid receptors in the brain of manganese-treated mice. 
  • Analysis of the effect of three different allosteric ligands on oxygen binding by hemocyanin of the shrimp, Penaeus setiferus. 
  • Antenatal Bartter's syndrome: why is this not a lethal condition? 
  • Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. 
  • Barbiturate and picrotoxin-sensitive chloride efflux in rat cerebral cortical synaptoneurosomes. 
  • Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+. 
  • Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • CFTR regulation of epithelial sodium channel. 
  • Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes. 
  • Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes. 
  • Chloride and pH dependence of cooperative interactions in Limulus polyphemus hemocyanin. 
  • Chloride dependence of hyperpolarization-activated chloride channel gates. 
  • Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. 
  • Chloride transport inhibitors influence recovery from oxygen-glucose deprivation-induced cellular injury in adult hippocampus. 
  • Cholecystokinin, diet palatability, and feeding regulation in rats. 
  • Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells. 
  • Cisplatin-induced changes in sodium, chloride, and urea transport by the frog skin. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Combined effect of bumetanide and metolazone in normal volunteers. 
  • Compartmental analysis of amine storage in bovine adrenal medullary granules. 
  • Compartmental responses to acute osmotic stress in Leishmania major result in rapid loss of Na+ and Cl-. 
  • Concentration-dependent effects of anions on the anaerobic oxidation of hemoglobin and myoglobin. 
  • Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity. 
  • Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --> Arg. 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH. 
  • Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. 
  • Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. 
  • Dehydration and delayed proton equilibria of red blood cells suspended in isosmotic phosphate buffers. Implications for studies of sickled cells. 
  • Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling. 
  • Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication. 
  • Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. 
  • Differential sensitivity of chromium-mediated DNA interstrand crosslinks and DNA-protein crosslinks to disruption by alkali and EDTA. 
  • Direct and Selective 3-Amidation of Indoles Using Electrophilic N-[(Benzenesulfonyl)oxy]amides. 
  • Direct and indirect behavioral pathways to the social transmission of food avoidance. 
  • Drought-induced saltwater incursion leads to increased wetland nitrogen export. 
  • Effects of 2,4-dichlorophenoxyacetic acid and picloram on biotransformation, peroxisomal and serum enzyme activities in channel catfish (Ictalurus punctatus). 
  • Effects of barbiturates on inhibitory and excitatory responses to applied neurotransmitters in Aplysia. 
  • Effects of barium-induced cardiac contraction on large- and small-vessel intramyocardial blood volume. 
  • Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis. 
  • Elemental composition of polyphosphate-containing vacuoles and cytoplasm of Leishmania major. 
  • Elemental microanalysis of organelles in proximal tubules. I. Alterations in transport and metabolism. 
  • Elemental microanalysis of organelles in proximal tubules. II. Effects of oxygen deprivation. 
  • Epithelial responses of rabbit tongues and their involvement in taste transduction. 
  • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. 
  • Factors modulating the sensitivity of the GABA receptor-gated chloride ion channel. 
  • Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. 
  • Fast endocytosis is inhibited by GABA-mediated chloride influx at a presynaptic terminal. 
  • Feedback-mediated dynamics in a model of a compliant thick ascending limb. 
  • Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury. 
  • Fetal surgery for posterior urethral valves: long-term postnatal outcomes. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Fluorescence imaging of changes in intracellular chloride in living brain slices. 
  • Functional differences in the multiple hemocyanins of the horseshoe crab, Limulus polyphemus L. 
  • Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)? 
  • GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. 
  • Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. 
  • Hepatic sulfite oxidase. Effect of anions on interaction with cytochrome c. 
  • Human trabecular meshwork cell volume regulation. 
  • Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure. 
  • Identification of a regulated Na/K/Cl cotransport system in a distal nephron cell line. 
  • Identification of chloride-binding sites in hemoglobin by nuclear-magnetic-resonance quadrupole-relaxation studies of hemoglobin digests. 
  • Identification of muscarinic acetylcholine receptors in isolated canine lingual epithelia via voltage clamp measurements. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line. 
  • Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF). 
  • Increased survival of skin flaps by scavengers of superoxide radical. 
  • Influence of denaturing agents on solvent structure. 
  • Inhibition of GABA-gated chloride channel function by arachidonic acid. 
  • Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel. 
  • Inhibitory effects of a phage-derived peptide on Au nanocrystal nucleation and growth. 
  • Instantaneous and steady-state gains in the tubuloglomerular feedback system. 
  • Interlaboratory validation of a new assay for DNA-protein crosslinks. 
  • Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization. 
  • Ionic content and regulation of cellular volume in rat alveolar type II cells. 
  • Ionic modulation of the effects of heparin on plasminogen activation by tissue plasminogen activator: the effects of ionic strength, divalent cations, and chloride. 
  • Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. 
  • Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis. 
  • Magnesium-calcium antagonism in the contraction of arterioles. 
  • Mathematical model of an avian urine concentrating mechanism. 
  • Measurement of chloride movement in neuronal preparations. 
  • Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. 
  • Meta-analysis of high- versus low-chloride content in perioperative and critical care fluid resuscitation. 
  • Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices. 
  • Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. 
  • Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells. 
  • Mutations of the cystic fibrosis gene and pancreatitis. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. 
  • Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells. 
  • Nucleotide receptors regulate membrane ion transport in renal epithelial cells. 
  • Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. 
  • Optical imaging of intracellular chloride in living brain slices. 
  • Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. 
  • Oxygen binding by Limulus polyphemus hemocyanin: allosteric modulation by chloride ions. 
  • Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. 
  • Pharmacokinetics of cis-diamminedichloroplatinum(II) after administration in hypertonic saline. 
  • Phenotypic dissections of the Blastocladiella emersonii zoospore's developmental choice. 
  • Phosphate treatment by onsite wastewater systems in nutrient-sensitive watersheds of North Carolina's Piedmont. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Potassium recycling pathways in the human cochlea. 
  • Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? 
  • Protein kinase C mediates cholinergically regulated protein phosphorylation in a Cl(-)-secreting epithelium. 
  • Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex. 
  • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Regulation of membrane chloride currents in rat bile duct epithelial cells. 
  • Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. 
  • Role of calcium in monitor peptide-stimulated cholecystokinin release from perifused intestinal cells. 
  • Salt and acid studies on canine lingual epithelium. 
  • Serum electrolyte patterns in end-stage renal disease. 
  • Signal transduction in a compliant short loop of Henle. 
  • Sources of salinity in ground water from Jericho area, Jordan Valley. 
  • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. 
  • Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols. 
  • Structural and functional response of toad urinary bladder to LiCl. 
  • Study on the diuretic activity of Strychnos potatorum Linn. seed extract in albino rats. 
  • Submerged RadBall® deployments in Hanford Site hot cells containing 137CsCl capsules. 
  • Sulfidation of silver nanoparticles: natural antidote to their toxicity. 
  • Surface modification for enhanced silanation of zirconia ceramics. 
  • Suspension of medullary thick ascending limb tubules from the rabbit kidney. 
  • Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function. 
  • The anion in salt taste: a possible role for paracellular pathways. 
  • The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia. 
  • The effect of aldosterone on water and electrolyte composition of incubated rat diaphragms. 
  • The physiological ecology of the supratidal amphipod Talorchestia longicornis. 
  • Total RNA isolation by a rapid centrifugation method. 
  • Transition metal-chelate complexes as relaxation modifiers in nuclear magnetic resonance. 
  • Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. 
  • Trigeminal nerve responses in the rat elicited by chemical stimulation of the tongue. 
  • Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland. 
  • Urine concentrating mechanism in the inner medulla of the mammalian kidney: role of three-dimensional architecture. 
  • Using confocal microscopy and the fluorescent indicator, 6-methoxy-N-ethylquinolinium iodide, to measure changes in intracellular chloride. 
  • Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium. 
  • Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro. 
  • cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes. 
  • gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
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  Keywords of People

  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering