Choline O-Acetyltransferase

• 

  Subject Areas on Research

  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • A novel somatostatin-immunoreactive mossy fiber pathway associated with HSP25-immunoreactive purkinje cell stripes in the mouse cerebellum. 
  • A projection from the parabigeminal nucleus to the pulvinar nucleus in Galago. 
  • A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice. 
  • Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. 
  • Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery. 
  • Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease. 
  • Attention and the frontal cortex as examined by simultaneous temporal processing. 
  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. 
  • Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. 
  • Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. 
  • Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations. 
  • Cholinergic and monoaminergic innervation of the cat's thalamus: comparison of the lateral geniculate nucleus with other principal sensory nuclei. 
  • Cholinergic innervation of the superior colliculus in the cat. 
  • Cholinergic projections from the midbrain reticular formation and the parabigeminal nucleus to the lateral geniculate nucleus in the tree shrew. 
  • Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by [3H]-acetylcholine. 
  • Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. 
  • Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding. 
  • Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata. 
  • Developmental aspects of the cholinergic system. 
  • Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? 
  • Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression. 
  • Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses. 
  • Distributions of choline acetyltransferase and acetylcholinesterase activities in the retinal layers of pigeon red and yellow fields. 
  • Distributions of choline acetyltransferase and acetylcholinesterase activities in the retinal layers of the red-tailed hawk and road runner. 
  • Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. 
  • Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain. 
  • Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. 
  • Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. 
  • Evidence for a striking increase in acetylcholinesterase activity in cultured human fibroblasts which are trisomic for chromosome two. 
  • Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. 
  • Exposure to tobacco smoke containing either high or low levels of nicotine during adolescence: differential effects on choline uptake in the cerebral cortex and hippocampus. 
  • Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. 
  • Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. 
  • Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. 
  • High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy. 
  • Identification of distinct ChAT⁺ neurons and activity-dependent control of postnatal SVZ neurogenesis. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Laminar asymmetry in the distribution of choline acetyltransferase-immunoreactive neurons in the retina of the tree shrew (Tupaia belangeri). 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. 
  • Modeling adolescent nicotine exposure: effects on cholinergic systems in rat brain regions. 
  • Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination. 
  • Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. 
  • Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits. 
  • Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts. 
  • Neurobehavioral teratogenicity of sarin in an avian model. 
  • Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions. 
  • Organization of cholinergic synapses in the cat's dorsal lateral geniculate and perigeniculate nuclei. 
  • Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both. 
  • Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies. 
  • Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. 
  • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. 
  • Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". 
  • Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. 
  • Regulation of hippocampal sympathetic ingrowth: role of afferent input. 
  • Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. 
  • Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds. 
  • Temporal memory in mature and aged rats is sensitive to choline acetyltransferase inhibition. 
  • Transactivation of BKV and SV40 early promoters by BKV and SV40 T-antigens.